1,721,227 research outputs found
Application of liquid chromatography-mass spectrometry to biomonitoring of exposure to industrial chemicals.
No full textApplication of liquid chromatography-mass spectrometry to biomonitoring of exposure to industrial chemicals.
No full textLiquid chromatography-mass spectrometry in occupational toxicology: a novel approach to the study of biotransformation of industrial chemicals.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Novel approach to separation and identification of organometallic compounds in complex mixtures by means of particle beam liquid chromatography/mass spectrometry: the case of diphosphine-substituted selenido iron and ruthenium clusters
No full textDetermination of dichloromethane, trichloroethylene and perchloroethylene in urine samples by headspace solid phase microexxtraction gas chromatography-mass spectrometry
No full textSecondary Targets of Nitrite-Derived Reactive Nitrogen Species: Nitrosation/Nitration Pathways, Antioxidant Defense Mechanisms and Toxicological Implications
No full textA review. Nitrite, the primary metabolite of nitric oxide (NO) and a widely diffused component of human diet, plays distinct and increasingly appreciated roles in human physiol. However, when exposed to acidic environments, typically in the stomach, or under oxidative stress conditions, it may be converted to a range of reactive nitrogen species (RNS) which in turn can target a variety of biomols. Typical consequences of toxicol. relevance include protein modification, DNA base deamination and the formation of N-nitrosamines, among the most potent mutagenic and carcinogenic compds. for humans. Besides primary biomols., nitrite can cause structural modifications to a variety of endogenous and exogenous org. compds., ranging from polyunsatd. fatty acids to estrogens, tocopherol, catecholamines, furans, retinoids, dietary phenols, and a range of xenobiotics. The study of the interactions between nitrite and key food components, including phenolic antioxidants, has therefore emerged as an area of great promise for delineating innovative strategies in cancer chemoprevention. Depending on substrates and conditions, diverse reaction pathways may compete to det. product features and distribution patterns. These include nitrosation and nitration but also oxidn., via electron transfer to nitrosonium ion or nitrogen dioxide. This contribution aims to provide an overview of the main classes of compds. that can be targeted by nitrite and to discuss at chem. levels the possible reaction mechanisms under conditions that model those occurring in the stomach. The toxicol. implications of the nitrite-modified mols. are finally addressed, and a rational chem. approach to the design of potent antinitrosing agents is illustrated
determinazione dell'acrilonitrile urinario tramite microestrazione in fase solida accoppiata alla gascromatografia/spettrometria di massa
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