932 research outputs found

    A Florentine family in crisis: the Strozzi in the fifteenth century.

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    PhDIn 1434 the Strozzi lineage had held a leading position in Florentine society and government for at least one hundred and fifty years, and was one of the largest and wealthiest of the city's patrician lineages. The records of the catasto of 1427 and of the scrutiny of 1433 are used to give a profile of the dominant social, economic and political position of the Strozzi before the advent of Medicean dominance. Their record of electoral success, and the political and cultural leadership of influential and respected men such as Palla di Nofri and Matteo di Simone, with other factors, put the Strozzi amongst the greatest enemies of the victorious Medicean regime of late 1434. The effects of political opposition and exile on the lineage are examined both directly, through records of office-holding, and indirectly through such indicators as marriage alliances and household wealth. The two most prominent lines of the Strozzi were exiled after 1434. Palla di Nofri's life and preoccupations in his Paduan exile are examined, together with the lives of his sons; none of these Strozzi ever returned to Florence, pursued as they were by the enmity of the Medicean regime. The very different careers of Filippo di Matteo and his brother Lorenzo are also examined: how they succeeded in founding a lucrative bank in Naples, and in returning to Florence to 'rebuild' (rifare) the position of the Strozzi lineage there. The final decades of the century saw the Strozzi in an economically more secure position, due substantially to the efforts of Filippo. Except for a very small number of its members admitted into the regime, most of the lineage is here shown to have remained excluded from significant political office until after the fall of the Medici regime in 1494

    Age-related heart rate response to exercise in heart transplant recipients. Functional significance

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    The heart rate (HR) and O(2) uptake (VO(2)) responses to cycle ergometer exercise and the role of O(2) transport in limiting submaximal and maximal aerobic performance were assessed in 33 heart transplant recipients (HTR) [14 children (P-HTR), 11 young adults (YA-HTR) and 8 middle-age adults (A-HTR)] and in 28 age-matched control subjects (CTL). In 7 P-HTR ("responders") the HR response to the onset of exercise (on-response) was as fast as that of CTL, whereas in all other patients ("non-responders") the HR on-response was typical of the denervated heart. Compared with non-responder P-HTR, responder P-HTR were also characterized by a normal peak HR (177+/- 16 vs. 151+/- 25 beats/min), an equally slow time constant for the VO(2) on-response (tau: 54 +/- 11 vs. 62+/- 13 s) and a similar low (approximately 60% of that of CTL) peak VO(2) (28 +/- 7 vs. 26 +/- 10 ml/kg per min). On the other hand non-responder YA-HTR and A-HTR were characterized by a relatively low peak HR (151 +/- 21 and 144 +/- 29 beats/min, respectively), a slow tau for the on-response (63 +/- 12 and 70 +/- 11 s) and a low peak (28 +/- 7 and 19 +/- 6 ml/kg per min). In conclusion, a sizeable number of paediatric patients (responder P-HTR) may reacquire the normal HR response to exercise, both in terms of kinetics and maximal level. Despite the almost complete recovery of cardiovascular function, and, probably, oxygen delivery, both the kinetics of the VO(2) on-response and the maximal aerobic power of the responder P-HTR were similar to those of non-responder P-HTR. The latter finding is probably attributable to peripheral limitations, due to inborn and/or pharmacological muscle deterioration

    Vues présentes sur le celtique cisalpin

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    Present views on Cisalpine Celtic. During the last twenty years, the knowledge of Lepontic and of Italian Gaulish has been notably enriched by very important finds, and also by numerous studies. The author proposes a synthesis of all new linguistical and cultural data provided by epigraphy in this particular resort.Dans les vingt dernières années la connaissance du lépontique et du gaulois d’Italie a été notablement enrichie par certaines trouvailles fort importantes ainsi que par de nombreuses études. Tableau synthétique des nouvelles données linguistiques et culturelles apportées par l’épigraphie de ce domaine.Motta Filippo. Vues présentes sur le celtique cisalpin. In: Etudes Celtiques, vol. 29, 1992. Actes du IXe congrès international d'études celtiques. Paris, 7-12 juillet 1991. Deuxième partie : Linguistique, littératures. pp. 311-318

    The heart rate response to exercise and circulating catecholamines in heart transplant recipients

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    The plasma concentration of noradrenaline ([NA]) is higher than that of adrenaline ([A]) both in normal subjects and in heart transplant recipients (HTR). Since in both groups the myocardial density of beta1-adrenergenic receptors is much greater than that of beta2-adrenergenic receptors, the chronotropic response of a denervated heart to changes in plasma [NA] and [A] in the absence of reinnervation should be similar to that of agonist stimulation of beta1-receptors. To test this hypothesis, 17 HTR and 9 healthy subjects (CTL) performed incremental exercise on a cycle ergometer to voluntary exhaustion. Heart rate (HR) was recorded by electrocardiography. [NA] and [A] were measured by high-pressure liquid chromatography at rest and at increasing workloads (w). In both groups, HR and [NA+A] increased with w, and HR with [NA+A]. Normalized HR values, plotted against the logarithm of [NA+A], fitted significantly logistic curves. The affinity constants were different, i.e. 2599+/-350 and 487+/-37 ng.l(-1), for HTR and CTL, respectively. The chronotropic effect of changes in [NA+A] in HTR was similar to that of combined beta1- and beta2-adrenergic activation evoked by applying isoprenaline to isolated heart myocytes (Brodde OE, Pharmacol Ther 60:405-430, 1993). These findings suggest that over time sympathetic reinnervation and the modulation of beta-receptors may take place in HTR, ruling out the hypothesis of persistent heart denervation

    Occhi pieni e mani vaganti. Movimenti, emozioni, astrazioni.

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    Filippo FIMIANI, Occhi pieni e mani vaganti. Movimenti, emozioni, astrazioni, «Fata Morgana», 12/2010, pp. 147-164. ISSN 1970-5786. ITALIANO. Una piccola sequenza da un episodio della serie televisiva Mad Men in cui la relazione sensoriale emozionale tra lo spettatore e un corpo in movimento, precisamente un corpo danzante, è l’oggetto di questo articolo, che intende così verificare la cosiddetta naturalizzazione della fenomenologia e del corpo vissuto operata dalle scienze cognitive applicate agli studi visuali. L’autore mostra anche i rapporti tra la cosiddetta simulazione incarnata e una memoria simbolica e iconografica profonda, e discute in particolare la polarità tra proiezione e introiezione, attività e passività nell’esperienza empatica delle immagini in movimento.A short filmic example from the AMC's award-winning series Mad Men in which the sensorial and emotional relationship between the spectator and a moving body, i.e., a dancing body, is explicitly put into play. The essay wants to deal with the so called naturalization of phenomenology and of the living body, trained by the cognitive sciences reading the visuality. The author shows the relationship between the so called ‘embodied Simulation’ and a symbolic and iconographic deep memory of the pictures, and he gives an in-depth attention to the polarity between projections and introjections, activity and passivity of the spectator’s body during the empathic experience of the moving pictures

    Multiple political geographies

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    This chapter delves into the multifaceted realm of political geography within the context of the journal Political Geography. The author, who has held various editorial positions within the journal, navigates the intricate terrain of diversity and inclusion, exploring the challenges posed by linguistic and cultural biases inherent in academic publishing. The chapter critically examines efforts to mitigate barriers and broaden the scope of political geography, questioning the adequacy of current approaches. Through a reflective analysis, the author elucidates the complex dynamics of political geography as a subdiscipline, shedding light on both the impediments and possibilities it offers to researchers and students

    Recombinant human erythropoietin may correct erythropoietin-deficient hyporegenerative anaemia in children given cardiac transplantation

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    Cyclosporin-A reduces erythropoietin production and, together with the inhibitory effect of cytokines on erythropoiesis, may be potentially responsible for the anaemia observed in some patients after heart transplantation. Two children given cardiac transplantation and receiving cyclosporin-A developed transfusion-dependent hyporegenerative anaemia. Erythropoietin production was inappropriately low for the degree of anaemia, with an observed/predicted log(serum EPO) ratio of 0.54 and 0.49, respectively. The children were treated with rHuEPO at a dose of 75 U/kg three times weekly for 1 month and then twice weekly via subcutaneous injection. No further transfusion was necessary and restoration of normal erythroid activity was obtained, with normal haemoglobin values. No adverse effects were observed. Our experience suggests that recombinant human erythropoietin may be useful in treating the anaemia associated with cardiac transplantation

    Erratum to: Lung Tissue Damage Caused by Heat Accumulation from Adjacent Laser Application: Surgical Implications (Thoracic and Cardiovascular Surgeon (2014) DOI: 10.1055/s-0034-1389086)

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    It has been brought to the Publisher's attention that the author names "Filippo Lococo" and "Alfredo Cesario" were not listed correctly in the above-mentioned article, published on eFirst on September 5, 2014. DOI of the original article is DOI: 10.1055/s-0034-1389086. The names should be read as "Filippo Lococo" and "Alfredo Cesario" in place of "Lococo Filippo" and "Cesario Alfredo."

    Fasti di Lodovico XIV. il Grande : esposti in versi in occasione dell'esser levato al sacro fonte il primogenito del marchese Filippo cavalier Sampieri in nome di S.M. Cristianissima.

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    Illustrated with etchings, comprising a portrait of Louis XIV by Francesco Maria Francia, and 12 plates by Lodovico Mattioli.Each of the twelve cantos is by a different author. Names supplied in manuscript in table of contents, p. [1] at end.Dedication signed: Filippo Sampieri.Imprint from colophon.Signatures: pi⁴ A-O⁸ P⁴.Mode of access: Internet.Bound in old vellum; ink title and library shelf mark on spine

    Filippo da Novara, Des .iiij. tenz d'aage d'ome: un'edizione critica

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    The work consists in a critical edition of the moral treatise Des .iiij. ages d'ome. The Author is the italian writer, historian and jurist Filippo de Novara (half XIII century). The edition includes the critical text and the Italian translation of the work,plus notes to text, introduction and language notesIl lavoro consiste in una edizione del trattato di morale di Filippo da Novara (scrittore, storico e giurista) Des .iiij. ages d'ome, opera in lingua d'oil. All'edizione si accompagnano note al testo, una introduzione, una nota linguistica,una traduzione in italian
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