13 research outputs found
Psychometric Properties of Turkish versions of the Leyton Obsessional Inventory-Child Version (LOI-CV) and Obsessive Beliefs Questionnaire-Child Version (OBQ-CV)
No full textObjective: Juvenile obsessive-compulsive disorder has been increasingly recognized in the literature. However, the developmentally sensitive screening tools for obsessive-compulsive disorder (OCD) in children and adolescents still lag behind psychometric tools developed for adult OCD. The Leyton Obsessional Inventory-Child Version is the most widely utilized screening tool for juvenile OCD assessment. Our aim was to assess psychometric properties of the Leyton Obsessional Inventory-Child Version (LOI-CV) and Obsessive Beliefs Questionnaire-Child Version (OBQ-CV)
Low Serum Level alpha-Synuclein and Tau Protein in Autism Spectrum Disorder Compared to Controls
No full textalpha-Synuclein (alpha-syn) and tau proteins are thought to be related with the synaptic loss and cell death underlying several important neurodegenerative diseases. The aim of our study was to investigate serum alpha-syn and tau levels in autism. Serum levels of alpha-syn and tau were measured, and autism spectrum disorder (ASD) severity was assessed at admission using the Childhood Autism Rating Scale (CARS) total score. The mean CARS score of the autism group on admission was 47.91 points (SD: 5.97). The results indicated that the mean serum alpha-syn and serum tau levels were significantly (p < 0.001) lower in children with ASD as compared with normal cases (33.01 +/- 20.78 and 55.19 +/- 15.34 ng/mL and 241.23 +/- 290.5 and 509.78 +/- 269.25 ng/mL, respectively). There was a significant positive correlation between seruma-syn levels and serum levels of tau identified by Pearson correlation analysis (r = 0.922, n = 28, p < 0.001). Synaptic abnormality in autism may result from microglial activity. Furthermore, alpha-syn and tau aggregation may lead to synaptic dysfunction, and this may contribute to either neuronal or synaptic dysfunction or neurodegeneration. Our preliminary study suggests that low levels of serum alpha-syn and tau may be implicated in the relationship between synaptic activity and autism
P38 Assessment of neurodevelopment and school performance of late and moderate preterms at 11–12 years of age
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Should We Continue Methylphenidate Treatment Despite Orofacial or Extremity Dyskinesias?
No full textDüşük serum UCH-L1 ve TDP-43 düzeyleri otizmde bozulmuş ubikuinasyon sürecini yansıtabilir mi?
No full textWOS: 000412669100014PubMed ID: 29033641Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system. Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission. Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p< 0.001, 506.21 +/- 780.97 ng/L and 1245.80 +/- 996.76 ng/L, respectively; 3.08 +/- 5.44 ng/mL and 8.64 +/- 6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r= 0.947, n= 24, p< 0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82). Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism.Amaç: Protein ubikitinlenme ile ilgili bozuklukların nöronal gelişim sorunlarına nasıl yol açtığı açıklanamamıştır. Bu çalışmada, ubikuitin proteozom sistemine üye olan ubikuitin c-terminal hidrolaz-L1 (UCH-L1) ve transaktif yanıtlı DNA-bağlayıcı protein (TDP-43) düzylerinin otizm ile ilişkisi araştırılmıştır.Yöntemler: Bu bağlamda 24 otizm tanılı çocuk ve 24 sağlıklı çocukta serum TDP-43 ve UCH-L1 düzeylerine bakılmıştır. Otizm şiddet derecesi Çocukluk Otizm Derecelendirme Ölçeği (ÇODÖ) ile değerlendirilmiştir. Bulgular: Otizm tanılı çocukların başvuru sırasında ortalama ÇODÖ puanları 48.91 (SD: 5.82) idi. Sağlıklı gruba göre otizmli grupta serum TDP-43 ve Serum UCH-L1 düzeyleri anlamlı olarak düşüktü (sırasıyla 506,21±780,97 ng/L ve 1245,80±996,76 ng/L; 3,08±5,44 ng/mL ve 8,64±6,67 ng/mL; p<0.001). Serum TDP-43 and UCH-L1 düzeyleri arasında pozitif korelasyon anlamlı olarak tespit edildi (r=0.947, n= 24, p<0.001).Sonuç: Sonuç olarak, düşük UCHL-L1 ve TDP-43 düzeylerinin, otizmde bozulmuş ubikitinlenme sürecini yansıtabileceği düşünülmüştür.Batman University Scientific Research Project Coordination Center [BTUBAP-2015-YL1]This research was supported by Grants from Batman University Scientific Research Project Coordination Center (BTUBAP-2015-YL1
Biological Rhythm Disturbances in Drug-Free Adult ADHD Patients
No full textObjective: The aim of study was to examine the biological rhythms in drug-free ADHD patients with healthy controls in a cross-sectional study. Methods: 50 adult ADHD patients %26 female) between 17 and 42 years old (M=27.76 SD:6.80) and healthy controls (%56.6 female) between 18 and 63 years old (M=31.39 SD:8.12) were recruited from Health Sciences University's Bakirkoy Mental Health Training and Research Hospital. Participants were assessed with clinical interview, Wender-Utah Adult ADHD Rating Scale and the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). Results: Adult ADHD patients scored higher on total scores (t=8.75, p<0.001), eating patterns (t=2.55, p<0.001), sleep patterns-social rhythm (t=3.41, p=0.001) and activity levels (t=3.0, p<0.001) in regarding to biologic rhythms. In the BRIAN subdomains; activity levels (t=4.59, p<0.001) and sleep-eating patterns (t=3.62, p<0.001) were also significantly different between the two groups. Conclusions: Our findings suggested that there was a significant difference between ADHD patients and healthy controls in most dimensions of biorhythm.</p
Association of Dissociation with Suicide Attempt and Non-Suicidal Self Injury in Adolescents with a History of Sexual Abuse
No full text© 2022 The Washington School of Psychiatry.Objective: Dissociative symptoms are considered risk factors for suicide and non-suicidal self-injury (NSSI). In this study, the relationship between suicidal behaviors and NSSI with dissociative symptoms in adolescents with a history of Child Sexual Abuse (CSA) was investigated. Methods: A total of 100 adolescents with a history of CSA were evaluated with a detailed forensic psychiatric interview. Dissociative symptoms were measured with the self-report Adolescent Dissociative Experiences Scale (A-DES) and the parent-reported Child Dissociative Checklist (CDC). Results: While dissociative symptoms did not differ between adolescents with and without suicide attempts (CDC; p = .068 and A-DES; p = .060), they were significantly higher in adolescents with non-suicidal self-harming behavior (CDC; p < .001 and A-DES; p = .001). Suicide attempts and NSSI were more common in those who reported genital touching as a type of sexual abuse (respectively, p = .003; p = .048). In regression analysis; history of psychiatric treatment (OR = 9.09 [95% CI = 1.52, 54.29]) and NSSI (OR = 8.18 [95% CI = 2.01, 33.23]) were independently associated with suicide attempts. In addition, parent-reported dissociative symptoms (CDC scores) (OR = 1.27 [95% CI = 1.06, 1.53] and suicide attempt (OR = 8.09 [95%CI = 1.96,33.42] showed independent association with NSSI. Conclusions: Dissociative symptoms may be predictive factors for NSSI and should be considered in risk assessment of adolescents with a history of CSA
Relationship between the Psychiatric Symptoms in Expecting Parents and Postpartum Depression and Infantile Colic: A Multicenter Follow up Study
No full textObjective: The aim of this study is to evaluate the relationship between postpartum depression (PPD), infantile colic (IC) and different psychosocial variables, psychiatric symptoms, attachment style and perceived social support in expecting parents. Method: Two hundred forty five expecting mothers and 150 expecting fathers were first interviewed between the 22-34 weeks of pregnancy Sociodemografic data form, Adult Attachment Style Scale (AASS), State Anxiety Inventory (SAT), Edinburgh Postnatal Depression Scale (EPDS), Multidimensional Scale of Perceived Social Support (MSPSS) and Brief Symptom Inventory (BSI) were filled out by each expecting parent. Second interview was conducted between the postpartum 4-24 weeks. Data form consisting health, nutrition, sleep and crying problems of the infant and EPDS and SAI were filled out by mothers and SAI by fathers. Results: One in every four mothers had PPD symptoms above the threshold on EPDS. Maternal and paternal insecure attachment style, maternal psychiatric symptoms and postpartum anxiety level were found to be the predictors of PPD. One in every five infants had IC and maternal education level, hostility score and PPD symptoms along with paternal insecure attachment style and psychiatric symptoms were the main predictors of IC. Conclusion: Results about PPD and IC regarding maternal variables are consistent with the literature. In addition, paternal insecure attachment style is found to be an important risk factor for both PPD and IC. Fathers should also be included in further studies exploring PPD or IC
Evaluation of the Relationship between Attention Deficit Hyperactivity Disorder Symptoms and Chronotype
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