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Schizophrenia of Mahalingam Expressed in Kathugal Puthinam novel
Get PDFThe psychology of mutation has several stages. The individual changes slightly from his nature and undergoes various stages of mutation. One of them is Schizophrenia. The most serious of mental illnesses is Schizophrenia. Mahalingam was a believer of God. Born in a business family. Suffers from Schizophrenia that is prominent in mutant elements. Mahalingam is afflicted by the dullness of the senses, which has been distinguished among the types of Schizophrenia. Among them, voices arouse within him affects him mentally. He faces innumerable tribulations and tragedies in his family life. Eventually he gets rid of the disease through spiritual practice. This study aims to explain the Schizophrenia of the Mahalingam
Tumor of the follicular infundibulum: An epidermal reaction pattern?
No full textOur recent experience indicates that the desmoplastic variant of tumor of the follicular infundibulum (TFI) is not, as previously believed, entirely uncommon. To clarify the defining clinical and microscopic features of TFI with special relevance to the histologic variants, we retrospectively reviewed cases with a histologic diagnosis of TFI between 1999 and 2008. Of the 74 cases retrieved, 53 TFI cases in 50 patients were identified with an incidence approximating 17 per 100,000. Clinically, TFI seems to be slightly more common in men (52percent vs. 48percent) and more common on the head and neck (around 77percent) and presents as plaques (approximately 47percent) and as multiple lesions (6percent). Histologically, the majority showed classic features of a horizontal plate-like proliferation of large, bland-appearing, pale epithelial cells. Other features included an eosinophilic cuticle (70percent), ductal differentiation (45percent), cornoid lamellae (17percent), and desmoplasia (11percent). Of interest, approximately one fourth (25percent) were associated with other cutaneous lesions, which included basal cell carcinoma, actinic keratosis, desmoplastic malignant melanoma, junctional melanocytic nevus, tricholemmoma, and epidermal inclusion cyst. In addition to expanding the constellation of the clinical and histopathologic findings, the increased association with other cutaneous lesions in the current study suggests that TFI may represent an epidermal reaction pattern. © 2009 Lippincott Williams and Wilkins, Inc.Ackerman AB, 1993, NEOPLASMS FOLLICULAR; Brocq L, 1902, ANN DERMATOL SYPHIL, V4, P1; Cheng ACC, 2004, DERMATOL SURG, V30, P1246, DOI 10.1111-j.1524-4725.2004.30385.x; CRIBIER B, 1995, J AM ACAD DERMATOL, V33, P979, DOI 10.1016-0190-9622(95)90290-2; CRIBIER B, 1991, ANN DERMATOL VENER, V118, P281; DARIER J, 1902, ANN DERMATOL SYPHIL, V3, P1; HORN TD, 1995, J CUTAN PATHOL, V22, P281, DOI 10.1111-j.1600-0560.1995.tb00751.x; Hutchinson KW, 2001, CLIN EXP OPHTHALMOL, V29, P100, DOI 10.1046-j.1442-9071.2001.00386.x; Inaloz HS, 2002, AM J DERMATOPATH, V24, P406, DOI 10.1097-01.DAD.0000030927.22626.4C; Kantrow SM, 2007, AM J DERMATOPATH, V29, P462; Kolenik SA, 1996, INT J DERMATOL, V35, P282, DOI 10.1111-j.1365-4362.1996.tb03003.x; KOSSARD S, 1983, ARCH DERMATOL, V119, P267, DOI 10.1001-archderm.119.3.267; KOSSARD S, 1989, J AM ACAD DERMATOL, V21, P361, DOI 10.1016-S0190-9622(89)80035-0; LeBoeuf NR, 2007, J CUTAN PATHOL, V34, P865, DOI 10.1111-j.1600-0560.2007.00737.x; Mahalingam M, 2001, J CUTAN PATHOL, V28, P314, DOI 10.1034-j.1600-0560.2001.028006314.x; MEHREGAN AH, 1961, ARCH DERMATOL, V83, P294; MEHREGAN AH, 1971, DERMATOLOGICA, V142, P177; SCHNITZLER L, 1987, ANN DERMATOL VENER, V114, P551; TELLECHEA O, 1992, AM J DERMATOPATH, V14, P107, DOI 10.1097-00000372-199204000-00004; TRUNNELL TN, 1979, CUTIS, V24, P317; Vin-Christian K, 1999, Arch Dermatol, V135, P463, DOI 10.1001-archderm.135.4.463-a; VINCHRISTIAN K, 1999, ARCH DERMATOL, V135, P466; Wade T R, 1980, Am J Dermatopathol, V2, P5, DOI 10.1097-00000372-198000210-000029141
The grenz zone
No full textThe grenz zone is a narrow area of the papillary dermis uninvolved by underlying pathology. Historically believed to be a feature unique to granuloma faciale, this feature has also been observed in other cutaneous inflammatory conditions, infectious entities, and neoplastic benign and malignant tumors. This review attempts to enumerate cutaneous entities commonly displaying a grenz zone with an emphasis on histopathological features that help in their differentiation. It also attempts to answer the obvious question of why select entities have this histopathologic feature by ascertaining the defining structure of a grenz zone. Copyright © 2013 by Lippincott Williams and Wilkins.Arai E, 2005, HUM PATHOL, V36, P505, DOI 10.1016-j.humpath.2005.02.012; Baldassano MF, 1999, AM J SURG PATHOL, V23, P88, DOI 10.1097-00000478-199901000-00010; BHAWAN J, 1976, J CUTAN PATHOL, V3, P5, DOI 10.1111-j.1600-0560.1976.tb00841.x; BOERSMA D, 1951, AMA ARCH DERM SYPH, V63, P520; Britton WJ, 2004, LANCET, V363, P1209, DOI 10.1016-S0140-6736(04)15952-7; Buchner SA, 1985, AM J DERMATOPATHO, V7, P109; Burg G, 2005, J CUTAN PATHOL, V32, P647, DOI 10.1111-j.0303-6987.2005.00495.x; Chaudhry IH, 2005, HISTOPATHOLOGY, V47, P179, DOI 10.1111-j.1365-2559.2005.02192.x; Cheng L, 1997, AM J SURG PATHOL, V21, P711, DOI 10.1097-00000478-199706000-00012; Chimenti S, 1999, J CUTAN PATHOL, V26, P379, DOI 10.1111-j.1600-0560.1999.tb01861.x; Cho-Vega JH, 2008, AM J CLIN PATHOL, V129, P130, DOI 10.1309-WYACYWF6NGM3WBRT; Colli C, 2004, J CUTAN PATHOL, V31, P232, DOI 10.1111-j.0303-6987.2003.00167.x; Dayrit JF, 2011, J CUTAN PATHOL, V38, P475, DOI 10.1111-j.1600-0560.2011.01680.x; de Almeida LS, 2008, AM J DERMATOPATH, V30, P207, DOI 10.1097-DAD.0b013e3181716e6b; Gadelha AR, 1983, DERMATOPATOLOGIA, P125; Gauger A, 2005, BRIT J DERMATOL, V153, P454, DOI 10.1111-j.1365-2133.2005.06752.x; GERSTEIN W, 1963, J INVEST DERMATOL, V41, P445, DOI 10.1038-jid.1963.139; Grabbe J, 2000, BRIT J DERMATOL, V143, P415, DOI 10.1046-j.1365-2133.2000.03673.x; Han TY, 2011, ANN DERMATOL, V23, P185, DOI 10.5021-ad.2011.23.2.185; Hantschke M, 2010, AM J SURG PATHOL, V34, P216, DOI 10.1097-PAS.0b013e3181c7d8b2; HAY ED, 1963, DEV BIOL, V7, P152, DOI 10.1016-0012-1606(63)90114-3; Job CK, 1999, INT J LEPROSY, V67, P164; Kaddu S, 1999, J AM ACAD DERMATOL, V40, P966, DOI 10.1016-S0190-9622(99)70086-1; Kaddu S, 2002, AM J SURG PATHOL, V26, P35, DOI 10.1097-00000478-200201000-00004; Kaur I, 2009, BRIT J DERMATOL, V160, P305, DOI 10.1111-j.1365-2133.2008.08899.x; Klemke CD, 2003, J AM ACAD DERMATOL, V49, pS233, DOI 10.1067-S0190-9622(03)00037-9; Lazar AJF, 2005, AM J SURG PATHOL, V29, P927, DOI 10.1097-01.pas.0000157294.55796.d3; LEBOIT PE, 1991, AM J SURG PATHOL, V15, P48; Loser Karin, 2007, Adv Dermatol, V23, P307, DOI 10.1016-j.yadr.2007.07.014; Luzar B, 2010, J CUTAN PATHOL, V37, P301, DOI 10.1111-j.1600-0560.2009.01425.x; Ly Hoang, 2005, Australas J Dermatol, V46, P44, DOI 10.1111-j.1440-0960.2005.00137.x; Mahalingam M, 2001, AM J DERMATOPATH, V23, P299, DOI 10.1097-00000372-200108000-00004; Malhotra Purnima, 2010, Indian J Dermatol, V55, P337, DOI 10.4103-0019-5154.74535; Marcoval J, 2004, J AM ACAD DERMATOL, V51, P269, DOI 10.1016-j.jaad.2003.11.071; MARTENS U, 1984, INT J LEPROSY, V52, P55; Miller DD, 2011, MODERN PATHOL, DOI [10.1038-modpathol.2011.196, DOI 10.1038-M0DPATHOL.2011.196]; Miranda MFR, 2010, AN BRAS DERMATOL, V85, P39, DOI 10.1590-S0365-05962010000100005; Ortonne N, 2005, J AM ACAD DERMATOL, V53, P1002, DOI 10.1016-j.jaad.2005.08.021; Pande S, 2007, DERMATOPATHOL PRACT, V13, P28; Philip H, 1995, AUSTRIAN ARMY 1740 8, P13; Plaza JA, 2011, AM J DERMATOPATH, V33, P649, DOI 10.1097-DAD.0b013e3181eeb433; Plaza JA, 2010, AM J DERMATOPATH, V32, P129, DOI 10.1097-DAD.0b013e3181b34a19; Rastogi R, 2011, ROM J MORPHOL EMBRYO, V52, P165; Rathi Sanjay K, 2005, Indian J Dermatol Venereol Leprol, V71, P250; Sangueza OP, 1997, AM J DERMATOPATH, V19, P214, DOI 10.1097-00000372-199706000-00003; Sehgal VN, 2009, AM J DERMATOPATH, V31, P268, DOI 10.1097-DAD.0b013e318185d1d0; Servitje O, 2002, BRIT J DERMATOL, V147, P1147, DOI 10.1046-j.1365-2133.2002.04961.x; Shafer D, 2008, ARCH DERMATOL, V144, P1155, DOI 10.1001-archderm.144.9.1155; Sharath Kumar BC, 2011, INDIAN J DERMATOL VE, V77, P498; Singh N, 1998, J CUTAN PATHOL, V25, P95, DOI 10.1111-j.1600-0560.1998.tb01696.x; Smith JG JR, 1965, J SOC COSMET CHEM, V16, P527; SMOLLER BR, 1993, J CUTAN PATHOL, V20, P442, DOI 10.1111-j.1600-0560.1993.tb00668.x; Swetter SM, 2004, ARCH DERMATOL, V140, P99, DOI 10.1001-archderm.140.1.99; Twersky JM, 2004, J AM ACAD DERMATOL, V51, P123, DOI 10.1016-j.jaad.2003.12.027; Wahl CE, 2005, AM J DERMATOPATH, V27, P397, DOI 10.1097-01.dad.0000175526.89249.be; WAYNER EA, 1993, J CELL BIOL, V121, P1141, DOI 10.1083-jcb.121.5.1141; YIANNIAS JA, 1992, J AM ACAD DERMATOL, V26, P38, DOI 10.1016-0190-9622(92)70003-X; Ziemer M, 2011, J CUTAN PATHOL, V38, P876, DOI 10.1111-j.1600-0560.2011.01760.x1
Sphingosine kinase 1 in viral infections
No full textAbstract not availableJillian M. Carr, Suresh Mahalingam, Claudine S. Bonder and Stuart M. Pitso
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles
Get PDFEquol is a non-steroidal estrogen metabolite produced by microbial conversion of daidzein, a major isoflavone phytoestrogen in soybean, in the gut of some humans and many animal species. Previous studies indicate that isoflavones and their metabolites can affect endogenous estradiol production, action, and metabolism via several mechanisms, which could in turn influence ovarian follicle growth. However, no studies have examined the direct effects of equol on intact antral follicles, which are responsible for sex steroid synthesis and further development into ovulatory follicles. The present study tested the hypothesis that equol inhibits antral follicle growth, increases follicle atresia, and inhibits steroidogenesis in the adult mouse ovary. Ovarian antral follicles from adult CD-1 mice were cultured with vehicle control or equol (600 nM, 6 µM, 36 µM, 100 µM) for 48 and 96 h. Follicle diameters were measured every 24 h to monitor follicle growth, and at 48 and 96 h, follicles were subjected to gene expression analysis and media were subjected to measurement of hormone levels. Follicles were also subjected to western blot analysis of certain steroidogenic enzymes, as well as histological evaluation of atresia following 96 h of culture. Equol (100 µM) inhibited follicle growth and induced follicle atresia. Further, equol decreased the levels of estradiol, testosterone, androstenedione, and progesterone, and decreased mRNA levels of cholesterol side-chain cleavage, steroid 17-α-hydroxalase, and aromatase compared to control. Collectively, these data suggest that equol alters antral follicle function by inhibiting growth, increasing atresia, and inhibiting steroidogenesis.Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2016-07-07 without embargo termsThe student, Sharada Mahalingam, accepted the attached license on 2016-04-11 at 10:36.The student, Sharada Mahalingam, submitted this Thesis for approval on 2016-04-11 at 10:54.This Thesis was approved for publication on 2016-04-11 at 13:33.DSpace SAF Submission Ingestion Package generated from Vireo submission #9184 on 2016-07-07 at 13:29:50Made available in DSpace on 2016-07-07T19:53:37Z (GMT). No. of bitstreams: 2
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Previous issue date: 2016-04-1
Introductions to Persian Philosophy, Indian Philosophy, Buddhist Philosophy, Chinese Philosophy, Japanese Philosophy and Islamic Philosophy
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