1,788,357 research outputs found
Letter from Mag McMillan, West Union, West Virginia, to friend, March 12, 1889
No full textA letter written by Mag McMillan of West Union, West Virginia, to a friend about the mumps and consumption
MAG Impact Review 2017
No full textMines Advisory Group (MAG) summarizes the impact of donor funding to the organization during the 2017 calendar year
Differential expression and MAL-dependent targeting of the L-MAG and S-MAG isoforms to myelin membranes
Get PDFMany degenerative diseases of the nervous system, including Multiple Sclerosis and peripheral neuropathies, are triggered by an impaired interaction between the axons and their surrounding myelin sheaths. The cause for this disturbed axon-myelin interaction, and the secondary neuronal damage that produces the clinical symptoms, lies in a primary defect of the myelin sheath. The myelin sheath itself is formed and maintained by oligodendrocytes and Schwann cells, the myelinating glial cells of the central and peripheral nervous system, respectively. The isoforms of the myelin-associated glycoprotein (MAG) are thought to be potential key elements of axon-myelin interaction, since these immunoglobulin-like cell signalling proteins are known to be localized in the periaxonal and paranodal myelin membranes. The MAG isoforms each display one of two possible intracellular C-termini as a result of alternative mRNA splicing. The C-terminus of the large isoform (L-MAG) has been shown to mediate downstream signals via the non-receptor tyrosine kinase Fyn, while the Cterminus of the short isoform (S-MAG) is thought to interact with the glial cytoskeleton. We have investigated the regulation and differential expression of L- and S-MAG in oligodendroglial cells and in transgenic mice by the use of genomic constructs that encode individually green fluorescent protein-tagged MAG isoforms. In the oligodendroglial cells LMAG was the dominant isoform prior to the stimulation of cells with cyclicAMP, whereas upon cyclicAMP stimulation, S-MAG was predominantly expressed in cells exhibiting advanced morphological differentiation. The investigation of our transgenic mice revealed that the two MAG isoforms are differentially expressed in distinct fibre tracts of the striatum and that S-MAG seems to be predominantly expressed in the long projecting fibres of the corpus callosum. Thus, the two MAG isoforms appear not only to be differentially expressed during development and in the adult, but they seem to mediate isoform-specific aspects of the axon-myelin interaction in distinct regions of the adult brain. A major question in the formation and maintenance of the myelin-axon interaction concerns the coordinated targeting of myelin signalling molecules and lipids to the different myelin compartments. Recent results suggest that glycolipid-enriched microdomains, socalled 'lipid-rafts', are involved in special sorting and trafficking mechanisms of membrane proteins and lipids. Furthermore, they are thought to serve as platforms for signal transduction processes. This makes them to interesting candidates for axon-myelin interactions, as well as for interactions between the apposed myelin membranes. The integral membrane protein 'Myelin and Lymphocyte Protein' (MAL) is suggested to be involved in lipid-raft-mediated protein targeting and signalling in myelinating cells. Our investigation of adult brain tissue of MAL-deficient mice showed that the incorporation of particular myelin components, such as MAG, into myelin membranes was significantly reduced. Thus, the targeting of L- and S-MAG to the myelin membranes appears to be dependent on the lipid-raft protein MAL. Furthermore, the MAL-deficient mice showed several ultra structural alterations comparable to those of the MAG-deficient mice and that reflect an impaired axon-myelin interaction. Our data supports the idea that-raft mediated trafficking of myelin constituents, such as MAG, to the different myelin compartments is a major task of adult oligodendrocytes in the context of maintaining the axonal contact of the myelin sheath. With the use of the isoform specific tagged MAG expressing mice, it will be possible for the first time, to investigate their differential function in axon-glia interaction as well as their dependence on MAL in vivo
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[Old Mag(1)]
No full textPhotograph of a head shot of a mule, Old Mag, owned by the father of the photographer
MAG-kegg-decoder-out-ex.html
No full textMAG-kegg-decoder-out-ex.htmlhttps://hackmd.io/@astrobiomike/GL-add-MAG-fun-ann-sums</div
Soldagem MIG/MAG em transferência metálica por curto-circuito controlado aplicada ao passe de raiz
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós Graduação em Engenharia Mecânica.O presente trabalho consiste no estudo e desenvolvimento do Processo de Soldagem MIG/MAG em Transferência Metálica por Curto-circuito com Controle de Corrente (CCC), dedicado à execução do passe de raiz da solda de dutos, na construção offshore de linhas dutoviárias petrolíferas
nf-core/mag: mag 2.5.2
No full text<h3><code>Added</code></h3>
<ul>
<li><a href="https://github.com/nf-core/mag/pull/562">#562</a> - Add CAT summary into the global bin_summary (by @maxibor)</li>
<li><a href="https://github.com/nf-core/mag/pull/565">#565</a> - Add warning of empty GTDB-TK results if no contigs pass completeness filter (by @jfy133 and @maxibor)</li>
</ul>
<h3><code>Changed</code></h3>
<ul>
<li><a href="https://github.com/nf-core/mag/pull/562">#563</a> Update to nf-core v2.12 <code>TEMPLATE</code> (by @CarsonJM)</li>
<li><a href="https://github.com/nf-core/mag/pull/566">#566</a> - More logical ordering of MultiQC sections (assembly and bin sections go together respectively) (fix by @jfy133)</li>
</ul>
<h3><code>Fixed</code></h3>
<ul>
<li><a href="https://github.com/nf-core/mag/pull/548">#548</a> - Fixes to (reported by @maxibor, @PPpissar, @muniheart, @llborcard, fix by @maxibor)<ul>
<li>GTDBK-TK execution</li>
<li>CAT/QUAST/DEPTH bin summary file name collisions</li>
<li>BUSCO database parsing</li>
<li>Correct CAT name files</li>
</ul>
</li>
<li><a href="https://github.com/nf-core/mag/pull/558">#558</a> - Fix bug in run merging when dealing with single end data (reported by @roberta-davidson, fix by @jfy133)</li>
</ul>
Analysis of hybrid Nd:Yag laser-MAG arc welding processes.
Get PDFIn the hybrid laser-arc welding process, a laser beam and an electric arc are coupled in order to combine the advantages of both processes: high welding speed, low thermal load and high depth penetration thanks to the laser; less demanding on joint preparation/fit-up, typical of arc welding. So the hybrid laser-MIG/MAG (Metal Inert or Active Gas) arc welding has very interesting properties: the improvement of productivity results in higher welding speeds, thicker welded materials, joint fit-up allowance, better stability of molten pool, and improvement of joint metallurgical quality. The understanding of the main relevant involved physical processes are therefore necessary if one wants for example elaborate adequate simulations of this process. Also, for an efficient use of this process, it is necessary to precisely understand the complex physical phenomena that govern this welding technique. This paper investigates the analysis of the effect of the main operating parameters for the laser alone, MAG alone and hybrid Laser/MAG welding processes. The use of a high speed video camera allows us to precisely characterize the melt pool 3-D geometry such as the measurements of its depression and its length and the phenomena occurring inside the melt pool through keyhole-melt pool-droplet interaction. These experimental results will form a database that is used for the validation of a three-dimensional thermal model of hybrid welding process for a rather wide range of operating parameters where the 3-D geometry of the melt pool is taken into account
Anti-MAG antibodies in 202 patients: clinicopathological and therapeutic features.
No full textTo assess the clinicopathological and therapeutic features of patients with low (≥1000 to <10 000 Bühlmann Titre Units) (BTU), medium (10 000-70 000) or high (≥70 000) anti-myelin-associated glycoprotein (anti-MAG) antibody titres.
We retrospectively and prospectively analysed standardised report forms and medical records of 202 patients from 14 neuromuscular centres.
Mean age at onset and mean time between symptom onset to last follow-up were respectively 62.6 years (25-91.4) and 8.4 years (0.3-33.3). Anti-MAG antibody titres at diagnosis were low, medium or high in 11%, 51% and 38% of patients. Patients presented with monoclonal gammopathy of undetermined significance in 68% of cases. About 17% of patients presented with 'atypical' clinical phenotype independently of anti-MAG titres, including acute or chronic sensorimotor polyradiculoneuropathies (12.4%), and asymmetric or multifocal neuropathy (3%). At the most severe disease stage, 22.4% of patients were significantly disabled. Seventy-eight per cent of patients received immunotherapies. Transient clinical worsening was observed in 12% of patients treated with rituximab (11/92). Stabilisation after rituximab treatment during the 7-12-month follow-up period was observed in 29% of patients. Clinical response to rituximab during the 6-month and/or 7-12-month follow-up period was observed in 31.5% of patients and correlated with anti-MAG titre ≥10 000 BTU.
Our study highlights the extended clinical spectrum of patients with anti-MAG neuropathy, which appears unrelated to antibody titre. Besides, it may also suggest beneficial use of rituximab in the early phase of anti-MAG neuropathy
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