80 research outputs found
Spheroid morphology of lung cancer cell lines correlates with oncological profiles
No full textNagasaki University (長崎大学)博士(医学)We assessed the correlation between Multicellular tumor spheroids (MCTS) morphology and the oncological profile of lung cancer cells. MCTS were generated in five lung cancer cell lines and classified into Type–A MCTS, which showed strong aggregation, and Type–B MCTS, which showed weak aggregation. Drug resistance was higher in Type–A MCTS, and invasive ability was higher in Type–B MCTS. The oncologic profile of lung cancer cell lines correlated with MCTS morphology. MCTS morphology could thus be used in basic oncology research and as a clinical prognostic tool.長崎大学学位論文 学位記番号:博(医歯薬)甲第1708号 学位授与年月日:令和7年6月4日Author: Kaido Oishi, Keitaro Matsumoto, Shintaro Hashimoto, Fumitake Uchida, Ryosuke Hara, Masato Nishimuta, Takamune Matsumoto, Mayumi Iwatake, Koichi Tomoshige, Ryoichiro Doi, Ryusuke Machino, Tomohiro Obata, Takeshi NagayasuCitation: Discover Oncology, 16, art. no. 627: 2025Nagasaki University (長崎大学), 博士(医学) (2025-06-04)doctoral thesi
I remember entertainment at the Poston II internment camp
No full textSunkie Oye, a resident of Seabrook, recalls the three years her family was interned at the Poston II internment camp in the desert out west. Because of the war, her father had been incarcerated in Santa Fe, New Mexico, but was allowed to rejoin the family at Poston a year later. When he arrived, he recruited volunteers to help build an ampitheater for entertainment. Among the internees at Poston were professional actors, actresses, and costume designers. Everyone chipped in to put on shows and skits. Sunkie was an accomplished Japanese classical dancer and played the shamisen well. She remembers how much fun she had performing on the stage that her father had helped design and build. The Seabrook Educational and Cultural Center has been soliciting current and past residents of Seabrook Farms for an "I remember" project. Residents are asked to create narratives regarding their experiences at Seabrook Farms. These memories help preserve the history and multi-cultural heritage of Seabrook Farms
バイオ3Dプリンティング技術を用いた組織工学的手法による気管再生
No full textOBJECTIVES: Currently, most of the artificial airway organs still require scaffolds; however, such scaffolds exhibit several limitations. Alternatively, the use of an autologous artificial trachea without foreign materials and immunosuppressants may solve these issues and constitute a preferred tool. The rationale of this study was to develop a new scaffold-free approach for an artificial trachea using bio-3D printing technology. Here, we assessed the circumferential tracheal replacement using scaffold-free trachea-like grafts generated from isolated cells in an inbred animal model. METHODS: Chondrocytes and mesenchymal stem cells were isolated from F344 rats. Rat lung microvessel endothelial cells were purchased. Our bio-3D printer generates spheroids consisting of several types of cells to create 3D structures. The bio-3D-printed artificial trachea from spheroids was matured in a bioreactor and transplanted into F344 rats as a tracheal graft under general anaesthesia. The mechanical strength of the artificial trachea was measured, and histological and immunohistochemical examinations were performed. RESULTS: Tracheal transplantation was performed in 9 rats, which were followed up postoperatively for 23 days. The average tensile strength of artificial tracheas before transplantation was 526.3 ± 125.7 mN. The bio-3D-printed scaffold-free artificial trachea had sufficient strength to transplant into the trachea with silicone stents that were used to prevent collapse of the artificial trachea and to support the graft until sufficient blood supply was obtained. Chondrogenesis and vasculogenesis were observed histologically. CONCLUSIONS: The scaffold-free isogenic artificial tracheas produced by a bio-3D printer could be utilized as tracheal grafts in rats.長崎大学学位論文 学位記番号:博(医歯薬)甲第1035号 学位授与年月日:平成30年3月20日Author: Daisuke Taniguchi, Keitaro Matsumoto, Tomoshi Tsuchiya, Ryusuke Machino, Yosuke Takeoka, Abdelmotagaly Elgalad, Kiyofumi Gunge, Katsunori Takagi, Yasuaki Taura, Go Hatachi, Naoto Matsuo, Naoya Yamasaki, Koichi Nakayama, Takeshi NagayasuCitation: Interactive CardioVascular and Thoracic Surgery, 26(5), pp.745–752; 201
わたしのくすり箱 絵本の窓から眺めたこと
No full textapplication/pdfMore than forty picturebooks were brought to the author while she was in hospital for treatment of cancer. The paper tells how picturebooks supported her in the struggle with fear caused by the disease, and talks about the medicinal effect picturebooks may have. The picturebooks referred to in the paper include Errol Le Cain’s Mr Mistoffelees with Mungojerrie and Rumpelteazer, Margaret Wise Brown’s Good Night, Moon, Antoine de Saint-Exupéry’s The Little Prince, Verma Aardema’s Bringing the Rain to Kapiti Plain, and so on, along with works by Japanese artists, such as Mitsumasa Anno, Ryusuke Saito, Heijiro Taki, and Hideko Ise.departmental bulletin pape
A case of left S8+9 segmentectomy involving a lung cancer patient with a mediastinal inferior lobar branch of the pulmonary artery
No full textEffects of soil water content and grass recycling on N2O emission in an urban lawn under laboratory incubation study
No full textDielectric study of acetophenone and its derivatives
No full textComplex permittivity measurements on acetophenone and its derivatives o-hydroxybenzaldehyde, o-methylacetophenone, and o-hydroxyacetophenone are performed at frequencies between 1 MHz and 20 GHz at temperatures from 273 to 323 K. The parameters obtained from the fitting of the complex permittivity are analyzed in order to study the effects of the hydroxyl group within a molecule on the dielectric relaxation phenomenon in these liquids. The analysis indicates that dynamical properties are affected not only by the intermolecular hydrogen bond but also by the slight change in molecular structure. This conclusion differs from those obtained from the results of other experiments
N2O emissions during the freezing and thawing periods from six fields in a livestock farm, southern Hokkaido, Japan
No full textIn many countries, high nitrous oxide (N2O) emissions have been observed during soil freezing and thawing periods. Quantification of those emissions is crucial to evaluate annual N2O emissions. For this study, we measured N2O and NO fluxes along with soil N2O concentrations at a corn field and five grasslands during a winter-spring period in Southern Hokkaido, Japan. We also measured denitrification activities of the soils from those sites. During the observation period, the soils froze to a maximum depth of 370 mm under saturated conditions and the lowest soil temperature at a 50 mm depth was -4.5℃. After 6 March 2005, daily air temperature rose above 0℃, but the soil temperature remained approximately 0℃ for about two weeks. These two weeks were defined as the 'transition period,' while the periods before and after the transition period were defined as the 'freezing' and the 'thawing' periods, respectively. During the freezing and transition periods, N2O concentration increased in the frozen soils relative to the unfrozen soils and the highest values were observed in the frozen soils during the transition period. During the thawing period, the N2O concentration in the soils decreased. N2O emissions were much higher during the thawing period than during the freezing and transition periods, and remarkably higher N2O emissions were observed at the corn site compared to those at the grassland sites. NO emissions were also observed during the thawing period but at much lower levels than N2O emissions at all the sites. N2O-N/NO-N ratio exceeded one at all the sites during the entire period, indicating N2O production through denitrification. At the corn site, denitrification activity was much lower and N2O/(N2O+N2) was much higher than at the grasslands. The result indicated that high N2O emissions at the corn site were caused by complementary processes: (1) high accumulated N2O through denitrification in the frozen soil during the freezing and transition periods, and (2) low N2O reduction rate during the thawing period
Predicting local-scale impact of climate change on rice yield and soil organic carbon sequestration : A case study in Roi Et Province, Northeast Thailand
No full textClimate change poses a serious threat to rice production and soil quality in tropical monsoon areas where it is the lifeline of regional food security. In this study, the Environmental Policy Integrated Climate (EPIC) model was evaluated for the reliability of model calibration and validation procedures using local-scale data. The model was then employed to evaluate the possible impact of climate change on rice yield and soil organic carbon (SOC) sequestration in Roi Et Province, Northeast Thailand. The dominant factors that influence the changes in rice yield and SOC sequestration were identified. Four Representative Concentration Pathway (RCP) scenarios (RCPs 2.6, 4.5, 6.0, and 8.5) and Sixteen General Circulation Models under four future time periods; near future (2020-2039), mid future (2040-2059), far future (2060-2079), and very far future (2080-2099) from the Coupled Model Intercomparison Project Phase 5 (CMIP5) were used as future climate projections. The findings revealed that climate change will impact rice yields positively, which will benefit farmers, especially in rain-fed areas, by +2.6% (RCP8.5: 2080-2099) to +22.7% (RCP6.0: 2080-2099). Rice yields in all case tend to increase significantly by + 0.7% (RCP8.5: 2060-2079) to +18.8% (RCP6.0: 2080-2099), with the exception of 2080-2099 under RCP8.5, which results in a decline of rice yield by -8.4%. The precipitation is the most important factor for rice yield in this area. Although rising temperatures will bring a slight rice yield reduction, its impact will be negated by large amounts of increased CO2 concentration and precipitation. Conversely, SOC decreased significantly in all time periods. The highest decreased SOC was a -32.0% decline under RCP8.5 in the very far future. This is because rises in temperature and precipitation, with precipitation being the most important driver, negated the enrichment of CO2 fertilization, resulting in accelerated SOC decomposition rates, which may increase nitrogen availability to the soil and increase yield
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