80 research outputs found
Generalized dual expression for set relations by means of sublinear scalarization functions (Study on Nonlinear Analysis and Convex Analysis)
No full textIn the literature, characterization for set relations are of various application to optimality conditions of set optimization problems, variational principles for set-valued maps, theorems of the alternative, certain robustness of vector optimization problems, and so on. In this paper, the author presents properties of scalarization functions as dual expression of set relations. Comparing to existing results, one can confirm their uniqueness in their relaxed conditions. Also, we show our results suggest some robust positive semi-definite optimization problems
ネズミマラリア原虫Plasmodium yoeliiのErythrocyte Binding-Likeタンパク質は赤血球侵入過程における不可逆的結合形成に重要である
No full textPlasmodium malaria parasites multiply within erythrocytes and possess a repertoire of proteins whose function is to recognize and invade these vertebrate host cells. One such protein involved in erythrocyte invasion is the micronemal protein, Erythrocyte Binding-Like (EBL), which has been studied as a potential target of vaccine development in Plasmodium vivax (PvDBP) and Plasmodium falciparum (EBA-175). In the rodent malaria parasite model Plasmodium yoelii, specific substitutions in the EBL regions responsible for intracellular trafficking (17XL parasite line) or receptor recognition (17X1.1pp. parasite line), paradoxically increase invasion ability and virulence rather than abolish EBL function. Attempts to disrupt the ebl gene locus in the 17XL and 17XNL lines were unsuccessful, suggesting EBL essentiality. To understand the mechanisms behind these potentially conflicting outcomes, we generated 17XL-based transfectants in which ebl expression is suppressed with anhydrotetracycline (ATc) and investigated merozoite behavior during erythrocyte invasion. In the absence of ATc, EBL was secreted to the merozoite surface, whereas following ATc administration parasitemia was negligible in vivo. Merozoites lacking EBL were unable to invade erythrocytes in vitro, indicating that EBL has a critical role for erythrocyte invasion. Quantitative time-lapse imaging revealed that with ATc administration a significant number of merozoites were detached from the erythrocyte after the erythrocyte deformation event and no echinocytosis was observed, indicating that EBL is required for merozoites to establish an irreversible connection with erythrocytes during invasion.長崎大学学位論文 学位記番号:博(医歯薬)甲第1093号 学位授与年月日:平成30年9月5日Author: Yuto Kegawa, Masahito Asada, Takahiro Ishizaki, Kazuhide Yahata, Osamu KanekoCitation: Parasitology International, 67(6), pp.706-714; 201
The possibility of holistic safety education in Japan: From the perspective of Education for Sustainable Development (ESD)
No full textAbstractThis paper studies modes of safety education, that is, education required for the development of a safe and secure society (i.e., a resilient and sustainable society), particularly in the context of Japan. In addition, this paper aims to verify what kind of safety education should be provided through the new educational concept of “Education for Sustainable Development” (ESD). In recent years, Japan has suffered a number of serious incidents in school zones, cases of children being kidnapped or killed, as well as the damage caused by the Great East Japan Earthquake & Tsunami of March 11, 2011, and other natural disasters. Consequently, the safety and security of children has become the responsibility of society as a whole, not just of educators. Based on this awareness, this paper will discuss a new mode of safety education that can contribute to the design of mobility for the coming age.There are two main findings from this study. First, the paper identifies the need to provide multiple software support for existing safety education. Few safety education programs have sufficiently incorporated the perspective of understanding safety in a comprehensive manner, instead focusing on a particular area of traffic, disasters, or daily life. In light of this issue, this paper recognizes the importance of incorporating the perspective of problem-solving and participation-oriented ESD into a holistic understanding of safety education. Second, awareness surveys conducted by the author on parents and teachers revealed that the respondents demonstrated a high interest traffic safety relative to other safety education areas. It would thus appear to be possible to make “traffic” the starting point for safety education and then broaden the scope to daily life and disasters. The survey also clarified that related parties considered raising children's awareness to be the most important aspect in safety education.This paper concludes that it is imperative to make continued research efforts to present a new mode of safety education, an initiative that represents one of the important efforts in designing mobility for the future
STUDY ON A RELAXATION FOR THEOREMS OF THE ALTERNATIVE FOR SETS (Study on Nonlinear Analysis and Convex Analysis)
No full textIn the literature, characterization for set relations are of various application to optimality conditions of set optimization problems, variational principles for set-valued maps, theorems of the alternative, certain robustness of vector optimization problems, and so on. In this paper, the author presents properties of scalarization functions as dual expression of set relations. Comparing to existing results, one can confirm their uniqueness in their relaxed conditions using convex cone-compactness and closedness. Also, we show the results implies generalized Gordan's theorems of the alternative at the last part of the thesis
Development of Method to Estimate Enclosure Index in Urban Areas using Airborne LiDAR
No full text都市の景観を管理する上では景観の統一性・連続性が重要であるが，これらを分析するには広範囲における景観の把握が必要である．航空機LiDAR(Light Detection and Ranging)は，広範囲の3次元の座標を高速に取得することができる．本研究では航空機LiDARで計測したDSM(Digital SurfaceModel)，DTM(Digital Terrain Model)のデータを用いて，広範囲における任意の地点での囲繞度を推定する手法を提案する．囲繞度は，視野の立体角に対する地物の立体角の占める割合として定義した．京都市東山区を対象に提案手法を適用した結果，やや過小評価気味ではあったが，囲繞度を誤差約3％で推定することができた．This paper proposes a methodology to estimate an "enclosure index" in urban areas using airborne LiDAR. The index is defined as a ratio of occluded area to whole of area in azimuth angle-elevation angle space. The index can be applied to assess local landscape, and it is expected to estimate it in a wide area at low cost. The author examined the methodology to estimate it using airborne LiDAR data measured in last-pulse mode. The estimated index map was validated with the ground truth data, and the error was acceptable, approximately 3%. Even though the last-pulse mode data may underestimate actual digital surface model (DSM), it was found that the proposed methodology is effective to estimate the index in a wide area at low cost
Non-archimedean SYZ fibrations via tropical contractions
No full textWe consider a toric degeneration of Calabi--Yau complete intersections of
Batyrev--Borisov in the Gross--Siebert program. The author showed in his
previous work that there exists an integral affine contraction map called a
tropical contraction, from the tropical variety obtained as its tropicalization
to the dual intersection complex of the toric degeneration. In this article, we
prove that the dual intersection complex is isomorphic to the essential
skeleton of the Berkovich analytification as piecewise integral affine
manifolds, and the composition of the tropicalization map and the tropical
contraction is an affinoid torus fibration with a discriminant of codimension
, which induces the same integral affine structure as the one coming from
the toric degeneration. This is a generalization of the earlier work by
Pille-Schneider for a specific degeneration of Calabi--Yau hypersurfaces in
projective spaces.Comment: 33 page
Copper-Catalyzed Enantioselective Coupling between Allylboronates and Phosphates Using a Phenol-Carbene Chiral Ligand: Asymmetric Synthesis of Chiral Branched 1,5-Dienes
No full textDetails of the Cu-catalyzed enantioselective allyl-allyl coupling reaction between allylboronates and (Z)-allylic phosphates using a new chiral N-heterocyclic carbene (NHC) ligand containing a phenolic hydroxy group are presented. The copper catalysis delivers enantioenriched chiral 1,5-dienes with a tertiary stereogenic center. Compatibility with various functional groups and the use of earth-abundant and relatively low-toxicity copper as a metal are attractive features of this protocol. The utility of the chiral phenol-NHC ligand for enantioselective copper catalysis with organoboron compounds is demonstrated and enantiodiscrimination models are discussed
Hausdorff dimension of sets with restricted, slowly growing partial quotients in semi-regular continued fractions
No full textWe determine the Hausdorff dimension of sets of irrationals in whose partial quotients in semi-regular continued fractions obey certain restrictions and growth conditions. This result substantially generalizes that of the second author [Proc. Amer. Math. Soc. {\bf 151} (2023), 3645--3653] and the solution of Hirst\u27s conjecture [B.-W. Wang and J. Wu, Bull. London Math. Soc. {\bf 40} (2008), 18--22], both previously obtained for the regular continued fraction. To prove the result, we construct non-autonomous iterated function systems well-adapted to the given restrictions and growth conditions on partial quotients, estimate the associated pressure functions, and then apply Bowen\u27s formula.13 pages, 1 figure. Former title: The dimension theory of semi-regular continued fraction
Induction of cardiac alternans in human iPS-derived cardiomyocytes through β-adrenergic receptor stimulation
No full text東京女子医科大学博士(医学)博士(医学)甲第810号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Yuto HINATA, Daisuke SASAKI, Katsuhisa MATSUURA, Tatsuya SHIMIZU, タイトル:Induction of cardiac alternans in human iPS-derived cardiomyocytes through β-adrenergic receptor stimulation，掲載誌:Physiological reports (2051-817X)，巻・頁・年:12巻 24号 p.e70152.(2024)，著作権関連情報:Copyright This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.，DOI:10.14814/phy2.70152doctoral thesi
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