1,721,281 research outputs found
Principi generali del reclutamento del personale docente e ricercatore nelle Università: analisi della giurisprudenza
No full textLa monografia costituisce un esame della giurisprudenza relativa ai concorsi per docente universitari
Editorial comment on: core biopsies of renal tumors: a study on diagnosticaccuracy, interobserver, and intraobserver variability.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Perivascular epithelioid cell
No full textDescription of a new cell type: Perivascular epithelioid cel
Angiomyolipoma of the liver. Pathology of Liver Trasplantation, Viral Hepatitis and Tumours.
No full textNon disponibil
Grading systems in renal cell carcinoma
No full textPURPOSE: We reviewed updated literature data concerning several issues of renal
cell carcinoma grading systems.
MATERIALS AND METHODS: We performed a nonsystematic review of the literature.
Data were identified by a MEDLINE search using a strategy including MeSH and free
text protocols. From the MEDLINE search we collected 184 records.
RESULTS: Although the original study was published in 1982, the independent
predictive value of nuclear grades was only revealed in 2000 by the team from
University of California-Los Angeles. Subsequently further data from our group
and the group at the Mayo Clinic reconfirmed those findings, although similar
cancer specific survival probabilities were noted among different grades. The
prognostic relevance of nuclear grade justified the inclusion of that variable in
algorithms and nomograms predictive of cancer specific survival, such as those
provided by University of California-Los Angeles, the Mayo Clinic and Memorial
Sloan-Kettering Cancer Center. Despite the routine clinical use of nuclear grade,
several drawbacks have affected grading systems, such as interobserver and
intra-observer reproducibility, and variability of the cancer specific survival
probabilities stratified by grade. Several studies showed that intra-observer and
interobserver agreement with regard to grade are only moderate with up shifting
in all series. That issue might be due to the heterogeneity of renal cell
carcinoma as well as to the lack of consensus about the minimal size of high
grade tumor to be considered significant. Moreover, recent data underscore the
role of histological subtypes.
CONCLUSIONS: Grade is one of the most powerful prognostic factors in patients
with renal cell carcinoma. The Fuhrman grading system is currently most widely
used by pathologists in Europe and the United States. However, there is still a
need for better standardization of nuclear criteria to improve interobserver
reproducibility and a major consensus should be achieved by uropathologists
Bowen's disease in a renal transplant recipient treated with topical imiquimod: serious adverse skin reaction with favourable clinical outcome.
No full textWe report on a 73-year-old female with BD that
completely regressed after a severe localized cutaneous
reaction induced by a single application of imiquimod
TNM staging system for renal-cell carcinoma: current status and future perspectives
No full textThe Tumour, Nodes, and Metastasis (TNM) staging system is a method of stratifying patients with cancer and is based on data obtained from large multicentre studies that involved large numbers of patients, and have a good level of evidence. However, despite continual revisions to the methodology to incorporate evidence from new clinical studies, the optimum stratification of patients with renal-cell carcinoma (RCC) using the TNM staging system remains controversial and further revisions, in our opinion, are needed. Revision of the TNM staging system for renal-cell cancer could also result in the simultaneous update of the integrated prognostic systems that are currently used along side this traditional method of staging. These integrated systems could become key instruments for guiding patient counselling, for appropriate follow up strategies, for patient selection for clinical trials, and for appropriate assessment of results if the perception that they are complex is overcome. This perception is driven by the presence of more than one system, the heterogeneity of clinical and pathological variables included in the methodology, and the need for robust comparative studies between the various systems. Therefore, in everyday clinical practice, the TNM system is regarded as a more reliable method of staging. In this Essay, we aim to highlight the problems associated with the current version of the TNM staging system and highlight areas in which this grading instrument can be improved in future to become a more refined and standardised method of communication between all clinicians involved in clinical management of RCC
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