51 research outputs found
Methodological aspects of building the indicator for revealing distortions in company results
No full textToday it is extremely timely and acute to stir up academic quarters in order to develop methodological basis for assessing the degree of accounts trustworthiness in the interest of all groups of company stakeholders. The article studies theoretical and methodological aspects of assessing accounts manipulation. The author came to the conclusion about availability of shortcomings in the effective tools of assessing accounts manipulation, which are connected with determinism of indicators included in their structure and ignoring specificity of different types of company activity. The article proposes a new approach to probabilistic assessment of distortions in company accounts, which leans on mathematic-statistic models, namely typologization and multi-criteria estimation. This approach makes it feasible not only to find facts of accounts distortion but to identify their trend in the direction of overstating or understating. On the basis of this approach the integral indicator of assessing possibility of finance results’ distortion in company accounting in the direction of their overstating was built. It is connected with companies, whose principle type of activity is food production. The author draws a conclusion that more than a half of joint stock companies in the Russian Federation dealing with food production provide untruthful finance accounting (with the possibility of over 60%), which overstates finance results of its work
Drug reaction with eosinophilia and systemic symptoms (DRESS) caused by sulfasalazine: a case report and literature review
No full textDrug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, potentially fatal systemic reaction characterized by multiorgan damage involving the liver, hematopoietic system and skin, and heterogeneous manifestations of fever, rash, lymphadenopathy and eosinophilia with unpredictable course.We describe a 41-year-old female patient who developed DRESS syndrome after taking sulfasalazine prescribed for non-radiographic axial spondyloarthritis. Treatment with intravenous and then oral glucocorticoids was effective. A review of the literature on this topic is presented
Інклюзивна освіта на українських сільських територіях: проблемні питання та шляхи вирішення на прикладі територіальної громади села Курилівка
No full textThe article proposes the definition of the essence of inclusive education and its compliance with the civilizational strategies of the XXI century. In the framework of the research project, the authors analyzed the European and world experience of implementing inclusion in the educational space. The main models and legal aspects of the implementation of inclusive education in Ukraine are considered. The authors of the article identified key issues that hinder the successful integration of inclusive education into the national education system (on the example of the village of Kurylivka) Mechanisms of effective implementation of the inclusive component of the national education system (for example, the village of Kurylivka) are proposed. General and special methods of cognition, namely institutional, systemic, structural-functional, statistical, analytical, comparative and descriptive, became the theoretical and methodological basis for the study of inclusive education in rural areas of Ukraine. У статті запропоновано визначення сутності інклюзивної освіти та її відповідності цивілізаційним стратегіям ХХІ ст. У рамках дослідницького проекту автори проаналізували європейський та світовий досвід впровадження інклюзії в освітній простір. Розглянуто основні моделі та правові аспекти впровадження інклюзивної освіти в Україні. Автори статті визначили ключові проблеми, які перешкоджають успішній інтеграції інклюзивної освіти в національну систему освіти (на прикладі с. Курилівка). Запропоновано механізми ефективної реалізації інклюзивної складової національної системи освіти (на прикладі с. Курилівка). Теоретико-методологічною основою дослідження інклюзивної освіти на сільських територіях України стали загальні та спеціальні методи пізнання, а саме, інституційний, системний, структурно-функціональний, статистичний, аналітичний, порівняльно-описовий
Experience of preparing students for taking an objective structured clinical examination
No full textThe search for the optimal model of the state exam for graduates of medical
universities is one of the most urgent and at the same time the most difficult tasks
for the medical education system of any developed country in the world. The
graduation certification is a kind of reflection of the quality of the several-year
educational process, which should determine the theoretical training of the students
in the field of basic, general professional and special disciplines, as well as the level
of mastery of clinical competencies for the successful performance of medical duties
and solving professional tasks in the future
SEROLOGICAL DIAGNOSIS OF MODERN CHOLERA USING LIPOSOMAL ENTEROTOXIC DIAGNOSTICUM IN COMPLEMENT FIXATION TEST
No full textAbstract. The possibility of serological diagnosis of cholera using cholera enterotoxic diagnostics kit in complement fixation test to detect anti-enterotoxic antibodies in sera of patients with cholera caused by hybrid variants of the El Tor biovar has been demonstrated. In patients with mild course of cholera anti-enterotoxic antibodies were detected in titres 1:50 and 1:200 in paired sera obtained on the 7th and 14th days of disease, respectively (fourfold titre increase). In patients with the course of medium severity 32-fold titre increase was recorded from the titre 1:100 in serum obtained on the fifth day of disease till the titre 1:3200 — on the twelfth day of disease. Antibodies titers reached 1:1600 and 1:800 were revealed in two medium course patients (adult and infant of 10 months) on the sixth day of disease
Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region
No full textOncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies. The replication-selective mutants AdΔΔ and dl922–947, defective in pRb-binding, have been demonstrated to synergise with the current standard of care, mitoxantrone and docetaxel, in prostate cancer models. While expression of the early viral E1A gene is essential for the enhanced cell killing, the specific E1A-regions required for the effects are unknown. Here, we demonstrate that replicating mutants deleted in small E1A-domains, binding pRb (dl1108), p300/CBP (dl1104) and p400/TRRAP or p21 (dl1102) sensitize human prostate cancer cells (PC-3, DU145, 22Rv1) to mitoxantrone and docetaxel. Through generation of non-replicating mutants, we demonstrate that the small E1A12S protein is sufficient to potently sensitize all prostate cancer cells to the drugs even in the absence of viral replication and the E1A transactivating domain, conserved region (CR) 3. Furthermore, the p300/CBP-binding domain in E1ACR1 is essential for drug-sensitisation in the absence (AdE1A1104) but not in the presence of the E1ACR3 (dl1104) domain. AdE1A1104 also failed to increase apoptosis and accumulation of cells in G2/M. All E1AΔCR2 mutants (AdE1A1108, dl922–947) and AdE1A1102 or dl1102 enhance cell killing to the same degree as wild type virus. In PC-3 xenografts in vivo the dl1102 mutant significantly prolongs time to tumor progression that is further enhanced in combination with docetaxel. Neither dl1102 nor dl1104 replicates in normal human epithelial cells (NHBE). These findings suggest that additional E1A-deletions might be included when developing more potent replication-selective oncolytic viruses, such as the AdΔCR2-mutants, to further enhance potency through synergistic cell killing in combination with current chemotherapeutics
Proceedings of the Workshop on the Okhotsk Sea and Adjacent Areas [Vladivostok, June 1995]
No full textI REPORT OF THE PICES WORKSHOP ON THE OKHOTSK SEA AND ADJACENT AREAS (pdf, 0.1 Mb) 1. Outline of the workshop 2. Summary reports from sessions 3. Recommendations of the workshop 4. Acknowledgments II SCIENTIFIC PAPERS SUBMITTED FROM SESSIONS 1. Physical Oceanography Sessions (pdf, 4 Mb) A. Circulation and water mass structure of the Okhotsk Sea and Northwestern Pacific Valentina D. Budaeva & Vyacheslav G. MakarovSeasonal variability of the pycnocline in La Perouse Strait and Aniva Gulf Valentina D. Budaeva & Vyacheslav G. MakarovModeling of the typical water circulations in the La Perouse Strait and Aniva Gulf region Nina A. Dashko, Sergey M. Varlamov, Young-Ho Han & Young-Seup KimAnticyclogenesis over the Okhotsk Sea and its influence on weather Boris S. Dyakov, Alexander A. Nikitin & Vadim P. PavlychevResearch of water structure and dynamics in the Okhotsk Sea and adjacent Pacific Howard J. Freeland, Alexander S. Bychkov, C.S. Wong, Frank A. Whitney & Gennady I. YurasovThe Ohkotsk Sea component of Pacific Intermediate Water Emil E. Herbeck, Anatoly I. Alexanin, Igor A. Gontcharenko, Igor I. Gorin, Yury V. Naumkin & Yury G. ProshjantsSome experience of the satellite environmental support of marine expeditions at the Far East Seas Alexander A. KarnaukhovThe tidal influence on the Sakhalin shelf hydrology Yasuhiro KawasakiOn the formation process of the subsurface mixed water around the Central Kuril Islands Lloyd D. KeigwinNorthwest Pacific paleohydrography Talgat R. KilmatovPhysical mechanisms for the North Pacific Intermediate Water formation Vladimir A. LuchinWater masses in the Okhotsk Sea Andrey V. Martynov, Elena N. Golubeva & Victor I. KuzinNumerical experiments with finite element model of the Okhotsk Sea circulation Nikolay A. Maximenko, Anatoly I. Kharlamov & Raissa I. GouskinaStructure of Intermediate Water layer in the Northwest Pacific Nikolay A. Maximenko & Andrey Yu. ShcherbinaFine-structure of the North Pacific Intermediate Water layer Renat D. Medjitov & Boris I. ReznikovAn experimental study of water transport through the Straits of Okhotsk Sea by electromagnetic method Valentina V. MorozOceanological zoning of the Kuril Islands area in the spring-summer period Yutaka NagataNote on the salinity balance in the Okhotsk Sea Alexander D. NelezinVariability of the Kuroshio Front in 1965-1991 Vladimir I. Ponomarev, Evgeny P. Varlaty & Mikhail Yu. CheranyevAn experimental study of currents in the near-Kuril region of the Pacific Ocean and in the Okhotsk Sea Stephen C. Riser, Gennady I. Yurasov & Mark J. WarnerHydrographic and tracer measurements of the water mass structure and transport in the Okhotsk Sea in early spring Konstantin A. Rogachev & Andrey V. VerkhunovCirculation and water mass structure in the southern Okhotsk Sea, as observed in summer, 1994 Lynne D. TalleyNorth Pacific Intermediate Water formation and the role of the Okhotsk Sea Anatoly S. Vasiliev & Fedor F. KhrapchenkovSeasonal variability of integral water circulation in the Okhotsk Sea B. Sea ice and its relation to circulation and climate V.P. Gavrilo, G.A. Lebedev & A.P. PolyakovAcoustic methods in sea ice dynamics studies Nina M. Pestereva & Larisa A. StarodubtsevaThe role of the Far-East atmospheric circulation in the formation of the ice cover in the Okhotsk Sea Yoshihiko SekineAnomalous Oyashio intrusion and its teleconnection with Subarctic North Pacific circulation, sea ice of the Okhotsk Sea and air temperature of the northern Asian continent C. Waves and tides Vladimir A. LuchinCharacteristics of the tidal motions in the Kuril Straits George V. ShevtchenkoOn seasonal variability of tidal constants in the northwestern part of the Okhotsk Sea D. Physical oceanography of the Japan Sea/East Sea Mikhail A. Danchenkov, Kuh Kim, Igor A. Goncharenko & Young-Gyu KimA “chimney” of cold salt waters near Vladivostok Christopher N.K. Mooers & Hee Sook KangPreliminary results from a numerical circulation model of the Japan Sea Lev P. YakuninInfluence of ice production on the deep water formation in the Japan Sea 2. Fisheries and Biology Sessions (pdf, 2.8 Mb) A. Communities of the Okhotsk Sea and adjacent waters: composition, structure and dynamics Lubov A. BalkonskayaExogenous succession of the southwestern Sakhalin algal communities Tatyana A. Belan, Yelena V. Oleynik, Alexander V. Tkalin & Tat’yana S. LishavskayaCharacteristics of pelagic and benthic communities on the North Sakhalin Island shelf Lev N. Bocharov & Vladimir K. OzyorinFishery and oceanographic database of Okhotsk Sea Victor V. LapkoInterannual dynamics of the epipelagic ichthyocen structure in the Okhotsk Sea Valentina I. LapshinaQuantitative seasonal and year-to-year changes of phytoplankton in the Okhotsk Sea and off Kuril area of the Pacific Lyudmila N. LuchshevaBiological productivity in anomalous mercury conditions (northern part of Okhotsk Sea) Inna A. NemirovskayaOrigin of hydrocarbons in the ecosystems of coastal region of the Okhotsk Sea Tatyana A. ShatilinaElements of the Pacific South Kuril area ecosystem Vyacheslav P. Shuntov & Yelena P. DulepovaBiota of the Okhotsk Sea: Structure of communities, the interannual dynamics and current status B. Abundance, distribution, dynamics of the common fishes of the Okhotsk Sea Yuri P. DiakovInfluence of some abiotic factors on spatial population dynamics of the West Kamchatka flounders (Pleuronectidae) Gordon A. McFarlane, Richard J. Beamish & Larisa M. ZverkovaAn examination of age estimates of walleye pollock (Theragra chalcogramma) from the Sea of Okhotsk using the burnt otolith method and implications for stock assessment and management Larisa P. NikolenkoMigration of Greenland turbot (Reinhardtius hippoglossoides) in the Okhotsk Sea Galina M. PushnikovaFisheries impact on the Sakhalin-Hokkaido herring population Vidar G. WespestadIs pollock overfished? C. Salmon of the Okhotsk Sea: biology, abundance and stock identification Vladimir A. Belyaev, Alexander Yu. ZhigalinEpipelagic Far Eastern sardine of the Okhotsk Sea Yuri E. Bregman, Victor V. Pushnikov, Lyudmila G. Sedova & Vladimir Ph. IvanovA preliminary report on stock status and productive capacity of horsehair crab Erimacrus isenbeckii (Brandt) in the South Kuril Strait Natalia T. DolganovaMezoplankton distribution in the West Japan Sea Vladimir V. Efremov, Richard L. Wilmot, Christine M. Kondzela, Natalia V. Varnavskaya, Sharon L. Hawkins & Maria E. MalininaApplication of pink and chum salmon genetic baseline to fishery management Vyacheslav N. Ivankov & Valentina V. AndreyevaStrategy for culture, breeding and numerous dynamics of Sakhalin salmon populations Alla M. Kovalevskaya, Natalia I. Savelyeva & Dmitry M. PolyakovPrimary production in Sakhalin shelf waters Tatyana N. KrupnovaSome reasons for resource reduction of Laminaria japonica (Primorye region) Lyudmila N. Luchsheva & Anatoliy I. BotsulMercury in bottom sediments of the northeastern Okhotsk Sea Pavel A. Luk’yanov, Natalia I. Belogortseva, Alexander A. Bulgakov, Alexander A. Kurika & Olga D. NovikovaLectins and glycosidases from marine macro and micro-organisms of Japan and Okhotsk Seas Boris A. Malyarchuk, Olga A. Radchenko, Miroslava V. Derenko, Andrey G. Lapinski & Leonid L. SolovenchukPCR-fingerprinting of mitochondrial genome of chum salmon, Oncorhynchus keta Alexander A. MikheevChaos and relaxation in dynamics of the pink salmon (Oncorhynchus gorbuscha) returns for two regions Yuri A. Mitrofanov & Larisa N. LesnikovaFish-culture of Pacific Salmons increases the number of heredity defects Larisa P. NikolenkoAbundance of young halibut along the West Kamchatka shelf in 1982-1992 Sergey A. NizyaevLiving conditions of golden king crab Lithodes aequispina in the Okhotsk Sea and near the Kuril Islands Ludmila A. Pozdnyakova & Alla V. SilinaSettlements of Japanese scallop in Reid Pallada Bay (Sea of Japan) Galina M. PushnikovaFeatures of the Southwest Okhotsk Sea herring Vladimir I. Radchenko & Igor I. GlebovPresent state of the Okhotsk herring stock and fisheries outlook Alla V. Silina & Ida I. OvsyannikovaDistribution of the barnacle Balanus rostratus eurostratus near the coasts of Primorye (Sea of Japan) Galina I. VictorovskayaDependence of urchin Strongylocentrotus intermedius reproduction on water temperature Anatoly F. Volkov, Alexander Y. Efimkin & Valery I. ChuchukaloFeeding habits of Pacific salmon in the Sea of Okhotsk and in the Pacific waters of Kuril Islands in summer 1993 Larisa M. Zverkova & Georgy A. OktyabrskyOkhotsk Sea walleye pollock stock status Tatyana N. Zvyagintseva, Elena V. Sundukova, Natalia M. Shevchenko & Ludmila A. ElyakovaWater soluble polysaccharides of some Far-Eastern seaweeds 3. Biodiversity Program (pdf, 0.2 Mb) A. Biodiversity of island ecosystems and seasides of the North Pacific Larissa A. GaykoProductivity of Japanese scallop Patinopecten yessoensis (IAY) culture in Posieta Bay (Sea of Japan) III APPENDICES 1. List of acronyms 2. List of participants (Document pdf contains 431 pages)ISSN: 1198-273
МІФ ЯК КОНЦЕПТ
No full textIntroduction. The article examines myth as a transhistorical phenomenon of human existence in the aspect of its functions that are significant for modern times. The aim of the study is to analyze the phenomenon of myth in the context of its positive and negative impact on the sociocultural development of modern humanity. Research tasks are to analyze the features and basic principles of the mythological type of human consciousness; and show the expediency of considering myth as a concept of spiritual and sociocultural development in scientific discourse. The core of the research methodology is based on historical and philosophical, semiotic, scientific and systematic approaches, as well as cognitive and value settings of hermeneutics. Research results. In the current stage of the globalization process, there is an increasing role of myth as a phenomenon of specific thinking and language that contributes to the formation of a certain image of reality. In the spiritual and cultural aspect, myth serves as a connecting link between eras, traditions and modern cultures, which has a positive effect on the consciousness of modern human. Myth plays a negative role if it is considered as the only possible way of functioning of globalist relations. Discussion. The research emphasized: firstly, the investigation of mythology as the primordial type of human worldview self-awareness, alongside the persistence of "archaic" (mythological) elements in the sociocultural processes of contemporary society (P. Gurevich, M. Eliade, E. Canetti, O. Polysaev, E. Rezhabek, K. Hübner); secondly, the examination of scientific discourse on mythology within the context of its politicization and evolution into a social phenomenon (H. Ortega-y-Gasset, V. Reich, J. Sorel, N. Taleb, C. Flood, E. Fromm, F. Fukuyama and others); and thirdly, the exploration of the myth's specificity and role in the current globalization process (L. Drotianko, J. Campbell, S. Ordenov, Yu. Pavlenko, M. Savelyeva, V. Fadeev, A. Vusatiuk and others). To grasp the concept of myth, works dedicated to defining the concept within modern philosophical and scientific discourse were consulted (A. Zalevskaya, S. Neretina, V. Ryzhko). Conclusions. The examination of modern civilization's trajectory in the early 21st century, marked by globalism, reveals myth's transhistorical nature of myth as a sociocultural phenomenon, a type of thinking and ideological self-awareness of a human. Cognitive indistinction between rational and irrational, natural and supernatural, meaning and sense, "I" and "we", etc. as structural elements of sensual and figurative mythological thinking, distorts our contemporary worldview, laying the groundwork for the manipulation of human consciousness. Viewing myth through the lens of "concept" frames it as an idea or scientific notion, as the "property" of an individual or social group. This perspective sheds light on myth's impact on globalization, including its reinforcement, the emergence of global ideologies, and shifts in ethical understandings within global relations.У статті розглядаються особливості міфу як трансісторичного феномена людського буття. Актуальність теми обґрунтовується посиленням ролі міфу як соціокультурного феномену, типу мислення та розуміння, світоглядної самосвідомості людини в умовах домінування глобалізму як тенденції історичного розвитку сучасного людства. Зроблено висновок: міф як концепт дозволяє представити його як певну ідею, об’єкт (предмет) думки, як «надбання» індивіда чи соціальної групи, що сприяє подоланню міфології як «єдиного» способу розуміння дійсності, що насправді спотворює картину сучасного світу, у тому числі і сенс глобалістських відносин
Comparative Study of Free Amino Acid Profiles in Underground Organs of Several Species of the Genus Rumex During Different Phases of the Vegetation Cycle
No full textIntroduction. Amino acids (AA), the primary metabolites in plants, play a crucial role in various physiological processes, including the synthesis of phenolic compounds. Drug products and dietary supplements made from medicinal plants can become a rich source of both nonessential and essential amino acids. High levels of free amino acids found in herbal raw material often indicate the presence of biotic and abiotic stress in the plants. Therefore, understanding the dynamics of bioactive compound accumulation in plants throughout their phenological phases of development is critical to optimizing their potential health benefits.Aim. To compare qualitative composition and dynamics of AA accumulation in the underground organs of four representatives of the Rumex genus: R. confertus, R. crispus L., R. obtusifolius L., R. aquaticus L. of three different vegetative phases.Materials and methods. Water extracts from underground organs of the studied plants were analyzed using two different methods for qualitative and quantitative analysis. Extracts were applied to the chromatographic plates TLS Silica gel 60 F254 (Merk, Germany) 20 × 20 cm with a micro-syringe (LLC "Tsvet", Russia). After elution, the plates were treated with a 2 % ninhydrin solution. Quantitative analysis was carried out using the SF-2000 spectrophotometer (LLC "OKB Spectr", Russia).Results and discussion. The amino acid profile of the underground organs of R. confertus, R. crispus L., R. obtusifolius L., R. aquaticus L. during three vegetative phases was determined using the TLC method; the quantitative analysis performed using spectrophotometry.Conclusion. The most diverse amino acid (AA) profiles were found in the withering phase in all Rumex species, with up to 9 amino adsorption zones. In contrast, the least diverse AA profiles were observed in the flowering phase, ranging from 2 to 4 adsorption zones. The quantitative content of AA was lowest in the flowering phase, increased during the regrowth phase, and peaked in the withering phase. However, R. crispus L. showed an unusual pattern, with the highest quantitative content of AA detected in the regrowth phase
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