6,966 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
L’ÉCRITURE DE LYDIA FLEM, HÉRITIÈRE « TRADUCTRICE »
No full textLa production autobiographique de l’écrivaine et analyste belge Lydia Flem, dont les
parents ont survécu à la déportation, est traversée par les thèmes du deuil, de la perte et de
la séparation. Héritière d’un passé traumatique que ses parents ne lui ont transmis que tacitement, elle trouve dans l’écriture et dans l’analyse la possibilité de s’affranchir de l’expérience familiale et d’entamer une nouvelle vie. En faisant appel aux études de l’essayiste,
traductrice et psychanalyste française Janine Altounian, nous nous proposons de mettre
en parallèle son expérience de l’écriture et de la parole du trauma à celle de la traduction
Satuja ja kertomuksia
No full textOnnettaren lahja / kirjoittanut Elisabeth Lundberg ; kuvittanut Lydia Skottsberg. Kuinka velhot veivät makeuden talonpojan joulujuomasta ja joululeivästä / kirjoittanut Anna Tengström ; kuvittanut Lydia Skottsberg. Maunu Ahnuri / kirjoittanut Sophie Linge ; kuvittanut E. Hedberg. Setä Yrjänä / kirjoittanut Elin Afzelius ; kuvittanut Elin Westman. Vanha rahakaappi / kirjoittanut Anna Wahlenberg ; kuvittanut Elin Westman. Hyrrä / kirjoittanut N.P. Ödman ; kuvittanut Anna Ch. Sjöberg. Kun kukko piti vieraspidot / kirjoittanut Hugo Gyllander ; kuvittanut Louis Moe. Joulukuusi / kirjoittanut Paul Nilsson ; kuvittanut Karl Aspelin. Mufti mestariluotsi ja jäälautalla purjehtija / kirjoittanut Alfred Smedberg ; kuvittanut Nils Larson. Prinsessa, joka ei tahtonut mennä naimisiin / kirjoittanut Sigrid Sköldberg-Pettersson ; kuvittanut Lisa Lindberg. Suuri joululahja / kirjoittanut Hedvig Lagerlöf ; kuvittanut Brita Ellström
Supplementary Material, AUT687988_Supplementary_Material – Understanding self-reported difficulties in decision-making by people with autism spectrum disorders
No full textSupplementary Material, AUT687988_Supplementary_Material for Understanding self-reported difficulties in decision-making by people with autism spectrum disorders by Lydia Vella, Howard A Ring, Mike RF Aitken, Peter C Watson, Alexander Presland and Isabel CH Clare in Autisms</p
Supplementary Material, AUT687988_Lay_Abstract – Understanding self-reported difficulties in decision-making by people with autism spectrum disorders
No full textSupplementary Material, AUT687988_Lay_Abstract for Understanding self-reported difficulties in decision-making by people with autism spectrum disorders by Lydia Vella, Howard A Ring, Mike RF Aitken, Peter C Watson, Alexander Presland and Isabel CH Clare in Autisms</p
Les diminutifs basques avec ch
No full textSe presentan formaciones similares a los diminutivos vascos con "ch" en España y América latina. Se dan ejemplosThe author introduces similar formations to the Basque diminutive "ch" in Spain and Latin America. Examples are provide
COUPLING OF THE C-H STRETCH TO LARGE-AMPLITUDE TORSION AND INVERSION MOTIONS: COMPARISON OF CHCH, CHOH AND CHNH
No full textAuthor Institution: Department of Polymer Science and Department of Chemistry, The University of Akron; Department of Chemistry, The University of Akron, OH 44325In each of the title molecules, torsional and inversion tunneling occurs between six equivalent minima. Coupling of these degrees of freedom to the CH stretch occurs via variation of the C-H stretching force constants as a function of the torsional () and inversion () angles. Maps of the couplings have been computed at the MP2/6-311++G(3df,2p) level. Both the single bond CH stretch force constants and the bilinear couplings between CH bonds are presented as a function of and . Although the torsional barriers differ by more than a factor of 20, the torsion-inversion-vibration coupling patterns are very similar for CHNH and CHCH. On the other hand, the torsion-inversion-vibration coupling in the charged species CHOH is much weaker
Reply to the Ch. Lagrange’s note
No full textThe author answers to a Ch. Lagrange’s note who refutes his theory on the diurnal nutation.L’auteur répond à une note de Ch. Lagrange qui réfute sa théorie sur la nutation diurne
NATURE OF TORSION-INVERSION COUPLING IN CHNH, CHOH AND CHCH
No full textAuthor Institution: Department of Chemistry, The University of Akron, OH; 44325-3601Two-dimensional torsion-inversion surfaces for methylamine, protonated methanol and ethyl radical were calculated and fit to a function containing a polynomial in the inversion angle() and trigonometric functions of the torsional angle(). Calculations were done at the B3LYP, MP2, and CCSD(T) levels with the 6-311++G(d,p) and 6-311++G(3df, 2p) basis sets and partial optimization. CHNH, CHOH and CHCH have G symmetry with 6-equivalent minima which are located by the various calculations at inversion angles 6.5 to 11; 42 to 45.5 and 52.5 to 55 degrees respectively on either side of planar. The three molecules have very different barriers to inversion ranging from no barrier for CHCH to 838 cm for CHOH to 1837 cm for CHNH. The dominant torsion-inversion coupling term in all cases has the form
Note about Mr. Ch. Lagrange’s recent communication
No full textThe author establishes a note about Mr. Ch. Lagrange’s communication on the Eulerian nutation period.L’auteur établit une note au sujet d’une communication de Ch. Lagrande sur la période de la nutation eulérienne
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