749 research outputs found
OLHA (N-oleoylhistamine) modulates activity of mouse brain histaminergic neurons
No full textHistaminergic (HA) neurons are located in the tuberomamillary nucleus (TMN) of the posterior hypothalamus, from where they project throughout the whole brain to control wakefulness. We examined the effects of Nα-oleoylhistamine (OLHA), a non-enzymatic condensation product of oleic acid (OLA) and histamine, on activity of mouse HA neurons in brain slices. OLHA bidirectionally modulated the firing of HA neurons. At 10 nM OLHA inhibited or had no action, whereas at 1 μM it evoked excitatory and inhibitory responses. Inhibition was not seen in presence of the histamine receptor H3 (H3R) antagonist clobenpropit and in calcium-free medium. Pre-incubation with a histamine-reuptake blocker prevented the decrease in firing by OLHA. OLHA-evoked increase in firing (EC50 ∼44 nM) was insensitive to blockers of cannabinoid 1 and 2 receptors and of the capsaicin receptor, but was significantly impaired by the peroxisome proliferator-activated receptor-alpha (PPAR-alpha) antagonist MK886, which suppressed also the rise in intracellular calcium level caused by OLHA. The OLHA-evoked excitation was mimicked by synthetic PPAR-alpha agonists (gemfibrozil and GW7647) and was abolished by the PKA inhibitor H-89. The H3R affinity (Ki) for histamine, measured in HEK293 cells with stable expression of human H3R, was higher than for OLHA (Ki: 42 vs 310 nM, respectively). Expression of PPAR-alpha was not different between TMN regions of males and females, responses to OLHA did not differ. Molecular modelling of PPAR-alpha bound to either OLHA or OEA showed similar binding energies. These findings shed light on a novel biotransformation product of histamine which may play a role in health and disease
The Golden Rain of Pushyk’s Poems
Get PDFPushyk S. Ya dlia Vkrainy Zhyv: u 2 t.
[For Ukraine I lived: in 2 vols.]
/ Olha Slonovska, editor and author of foreword
“Zolotyi Doshch Pusykovykh Poezii”
[The Golden Rain of Pushyk’s Poems].
Misto-NV, Ivano-Frankivsk, 2019
Urban Administrative Reforms of Princess Olha (1)
No full textСтаттю присвячено дослідженню фрагмента літописної статті 947 року про встановлення київською княгинею Ольгою погостів у Новгородській землі. Автор доводить, що первісний текст є штучно прив’язаним до північної Новгородщини. Натомість його слід розглядати в контексті подій на Південному Заході Русі, спровокованих київсько-древлянською війною.The article discusses a fragment of the 947 chronicle text. It describes an episode when Princess Olha establishes the pohosts on the Novhorod lands. The author argues that the primary text was artificially attached to the Northern Novhorodshchyna; however, it should be considered in context of the development on the south-western part of Rus which was precipitated by the Kyiv-Drevlyanian war
Urban Administrative Reforms of Princess Olha (1)
Get PDFСтаттю присвячено дослідженню фрагмента літописної статті 947 року про встановлення київською княгинею Ольгою погостів у Новгородській землі. Автор доводить, що первісний текст є штучно прив’язаним до північної Новгородщини. Натомість його слід розглядати в контексті подій на Південному Заході Русі, спровокованих київсько-древлянською війною.The article discusses a fragment of the 947 chronicle text. It describes an episode when Princess Olha establishes the pohosts on the Novhorod lands. The author argues that the primary text was artificially attached to the Northern Novhorodshchyna; however, it should be considered in context of the development on the south-western part of Rus which was precipitated by the Kyiv-Drevlyanian war
Culturaland artistic letters to the artist Olha Pleshkan
No full textОпубліковано з відповідним коментарем листи до української художниці Ольги Плешкан (1898–1985) від її колег – учнів мистецької школи О. Новаківського. Автор отримав їх від О. Плешкан на початку 1980-х рр. і публікує вперше. Ці листи є одним із джерел для дослідження культурно-мистецького (малярського) життя на Західній Україні в 1920–1930‑х рр.The letters to the Ukrainian artist Olha Pleshkan (1898-1985) from her colleagues, the students of Novakivskyi’s art school, are published in the article with corresponding commentaries. The author of the article received these letters from Pleshkan at the beginning of the 1980s and publishes them for the first time. These letters represent a source of research of cultural and artistic life in the Western Ukraine in the 1920s–1930s
Culturaland artistic letters to the artist Olha Pleshkan
No full textОпубліковано з відповідним коментарем листи до української художниці Ольги Плешкан (1898–1985) від її колег – учнів мистецької школи О. Новаківського. Автор отримав їх від О. Плешкан на початку 1980-х рр. і публікує вперше. Ці листи є одним із джерел для дослідження культурно-мистецького (малярського) життя на Західній Україні в 1920–1930‑х рр.The letters to the Ukrainian artist Olha Pleshkan (1898-1985) from her colleagues, the students of Novakivskyi’s art school, are published in the article with corresponding commentaries. The author of the article received these letters from Pleshkan at the beginning of the 1980s and publishes them for the first time. These letters represent a source of research of cultural and artistic life in the Western Ukraine in the 1920s–1930s
Culturaland artistic letters to the artist Olha Pleshkan
Get PDFОпубліковано з відповідним коментарем листи до української художниці Ольги Плешкан (1898–1985) від її колег – учнів мистецької школи О. Новаківського. Автор отримав їх від О. Плешкан на початку 1980-х рр. і публікує вперше. Ці листи є одним із джерел для дослідження культурно-мистецького (малярського) життя на Західній Україні в 1920–1930‑х рр.The letters to the Ukrainian artist Olha Pleshkan (1898-1985) from her colleagues, the students of Novakivskyi’s art school, are published in the article with corresponding commentaries. The author of the article received these letters from Pleshkan at the beginning of the 1980s and publishes them for the first time. These letters represent a source of research of cultural and artistic life in the Western Ukraine in the 1920s–1930s
Phsychopoetics of Olha Kobylyanska’s prose: the conflict of temperaments
No full text(uk) Особливості психопоетики прозових творів Ольги Кобилянської, залежність митецької праці від психофізіологічних характеристик особистості досліджуються у статті на основі вивчення мемуарів; висвітлюються унікальність параметрів вишої нервової діяльності авторки, амбівалентність її темпераменту.(ru) Особенности психапоэтики прозаических произведений Ольги Кибылянской, зависимость художественной роботы от психофизиологических характеристик личности исследуются в статье на основании изучения материалов; освещаются уникальность параметров высшей нервной деятельности автора, амбивалентность ее характера.(en) The peculiarities of phsychopoetics of Olha Kobylyanska’s prose, the dependence of artistry on phsychophysiological characteristics o f a personality are examined in the article on the material of the memories study; the unique character o f the parameters o f higher nervous activity of the author, the ambivalency of her temperament are highlighted
The EU response to the development in Belarus in 2021: the human rights scope
No full textEuropean Politics and Society: Václav Havel Joint Master Programme Charles University The EU response to the development in Belarus in 2021: the human rights scope Master's Thesis Abstract Author: Olha Kotielnikova Supervisor: Mgr. Daniela Kolenovská, Ph.D. Year of defence: 2022 Length of the thesis: 18892 words Abstract Human rights abuse in Belarus has again become a topical issue on the European Union's agenda alongside political rights violations since 2020. The Union sees its role in influencing the internal policy of the proclaimed Belarusian government for it to start respecting human rights. As a united body, it has instruments to exercise its foreign policy instruments, such as restrictive measures, negotiations, and communication. The dynamics of their usage have been changing, but there is still potential to review and adapt possible European responses. Keywords European Union, Belarus, foreign policy, human rights, human rights defence, resolution, sanctions, restrictive measures
Odpověď EU na vývoj Běloruska v roce 2021: lidskoprávní rovina
No full textEuropean Politics and Society: Václav Havel Joint Master Programme Charles University The EU response to the development in Belarus in 2021: the human rights scope Master's Thesis Abstract Author: Olha Kotielnikova Supervisor: Mgr. Daniela Kolenovská, Ph.D. Year of defence: 2022 Length of the thesis: 18892 words Abstract Human rights abuse in Belarus has again become a topical issue on the European Union's agenda alongside political rights violations since 2020. The Union sees its role in influencing the internal policy of the proclaimed Belarusian government for it to start respecting human rights. As a united body, it has instruments to exercise its foreign policy instruments, such as restrictive measures, negotiations, and communication. The dynamics of their usage have been changing, but there is still potential to review and adapt possible European responses. Keywords European Union, Belarus, foreign policy, human rights, human rights defence, resolution, sanctions, restrictive measures.Department of European StudiesKatedra evropských studiíFakulta sociálních vědFaculty of Social Science
- …
