4,901 research outputs found
Yves-Heng Lim
No full textYves-Heng Lim est enseignant-chercheur au Département d’Etudes de Sécurité et de Criminologie de l’Université Macquarie, Sydney. Il est l’auteur de China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014). Yves-Heng Lim is a lecturer at the Department of Security Studies and Criminology, Macquarie University. He is the author of China’s Naval Power: An Offensive Realist Approach (Ashgate, 2014)
Professional attachment report [with] Chio Lim & Associates.
No full textThis report serves as a summary of the professional attachment. Besides touching on author experiences working with Chio Lim & Associates (CLA), it wil also touch on other issues before, during and after the program
Lim-inf convergence and its compactness
No full textAbstract- We describe the Mizar formalization of the proof of compactness of lim-inf convergence given in [W33] according to [CCL]. Lim-inf convergence formalized in [W28] is a Moore-Smith convergence investigated in [Y6] and involves the concept of nets. The proof is based on the equivalence of two approaches to convergence in topological spaces: filter convergence and Moore-Smith (net) convergence. The equivalence is worked out in [Y19] and different characterizations of compactness are also given there. These efforts are a continuation of the international project of formalizing the theory of continuous lattices headed by the first author
LIMD1 (LIM domains containing 1)
Get PDFReview on LIMD1 (LIM domains containing 1), with data on DNA, on the protein encoded, and where the gene is implicated
Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
Get PDFThe highly conserved Hippo kinase cascade is critical for both regulation of organ size in development and tumor suppression. Several mechanisms, such as cell-cell contact in vitro and organ size in vivo, have been implicated in the activation of the Hippo pathway, leading to inactivation of the YAP/TAZ transcriptional coactivators and growth arrest. Previous work from our lab has identified the Ajuba LIM proteins as novel negative regulators of the Hippo pathway in both Drosophila and mammals. However, the mechanism by which the Ajuba LIM proteins prevent Hippo pathway activity is not known. Using contact inhibition of proliferation as a functional assay of Hippo pathway activity, we find that the Ajuba LIM proteins bind to the Ndr-kinase Lats1/2 and inhibit Hippo pathway mediated inactivation of YAP only in low density, proliferating cells, suggesting that the Ajuba LIM proteins function to keep the Hippo pathway off in contexts where cell proliferation is needed, but are unable to prevent activation of the pathway by signals such as cell density. We demonstrate that the Ajuba LIM proteins enhance association of the core kinase complex, and, using a panel of LIM domain mutants of the Ajuba LIM protein, LIMD1, identify the domains required for sequestering active Lats2 in the core kinase complex. Using Drosophila wing size as an in vivo read-out of Hippo activity, we find that only the domain mutants that increase complex association suppress Hippo-mediated YAP inactivation. We also determine the role of subcellular localization in Ajuba LIM-mediated inhibition of the Hippo pathway. It has previously been shown that targeting the complex to the plasma membrane, using a membrane targeted Mob1, can lead to its activation; interestingly, we find that LIMD1 is unable to associate with or enhance the association of this membrane-targeted complex. Conversely, targeting LIMD1 to the plasma membrane also abrogates its ability to bind to, and enhance the association of, the cytoplasmic core kinase complex. Given that LIMD1 and the Hippo complex are both recruited to the plasma membrane in high density, growth-arrested cells, these results provide a model for Ajuba LIM-mediated inhibition of Hippo pathway signaling, in which the Ajuba LIM proteins physically interact with the core kinase complex in the cytoplasm of low-density, proliferating cells, thereby preventing inactivation of YAP and premature growth arrest
“Survival – to keep writing”: An interview with Shirley Geok-lin Lim
No full textIn this e-mail interview conducted in 2016, author and scholar Shirley Geok-lin Lim addresses the changing social and political conditions in the United States. Lim discusses the affective relationship between aesthetics and politics in her work, the anxiety of multilingual stylistics, and the in-between nature of the transnation. She also reflects on the academic marginalization she has experienced as a result of her immigrant designation and subjectivity, as well as the indirect influence of China and Chineseness on her writing. Commenting on her memoir Among the White Moon Faces, Lim notes the difficulty of titling, and addresses the impact of anglophone literature upon her during her colonial Malaysian upbringing
Majelis Ta’lim Sebagai Alternatif Pusat Pendidikan Islam (Studi Kasus pada Majelis Ta’lim Se Kecamatan Natar Lampung Selatan)
Get PDFIn the public, living we see routine activities what is done. The routine activities are religious and non religious. Usually, religious activities are done in majelis ta’lim. Majelis ta’lim that grow in the community can to became alternative for central of islamic education if the managed well. Therefore, the author want to discuss about this issue with expectation to know of factors that cause the failure religious building in majelis ta’lim especially in Natar, so to know activities that required to done so as really became alternative for central of Islamic education. This research is quantitative research with collecting data from majelis ta’lim which became this research object. The collecting data is done with instruments: as observation, interview, and documentation. From this research, we can know that style and methode is done by the teacher is principal key to success in majelis ta’lim. Therefore, the inovation is required in majelis ta’lim activities so that can interest of more pilgrims and make him the alternative for central of Islamic education
Interactions between LHX3-And ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans
No full text© 2017 The Author(s). LIM-Homeodomain (LIM-HD) transcription factors are highly conserved in animals where they are thought to act in a transcriptional 'LIM code' that specifies cell types, particularly in the central nervous system. In chick and mammals the interaction between two LIM-HD proteins, LHX3 and Islet1 (ISL1), is essential for the development of motor neurons. Using yeast two-hybrid analysis we showed that the Caenorhabditis elegans orthologs of LHX3 and ISL1, CEH-14 and LIM-7 can physically interact. Structural characterisation of a complex comprising the LIM domains from CEH-14 and a LIM-interaction domain from LIM-7 showed that these nematode proteins assemble to form a structure that closely resembles that of their vertebrate counterparts. However, mutagenic analysis across the interface indicates some differences in the mechanisms of binding. We also demonstrate, using fluorescent reporter constructs, that the two C. elegans proteins are co-expressed in a small subset of neurons. These data show that the propensity for LHX3 and Islet proteins to interact is conserved from C. elegans to mammals, raising the possibility that orthologous cell specific LIM-HD-containing transcription factor complexes play similar roles in the development of neuronal cells across diverse species
“Survival -- to keep writing”: an interview with Shirley Geok-lin Lim
No full textIn this e-mail interview conducted in 2016, author and scholar Shirley Geok-lin Lim addresses the changing social and political conditions in the United States. Lim discusses the affective relationship between aesthetics and politics in her work, the anxiety of multilingual stylistics, and the in-between nature of the transnation. She also reflects on the academic marginalization she has experienced as a result of her immigrant designation and subjectivity, as well as the indirect influence of China and Chineseness on her writing. Commenting on her memoir Among the White Moon Faces, Lim notes the difficulty of titling, and addresses the impact of anglophone literature upon her during her colonial Malaysian upbringing
- …
