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Get PDFDetecting pathogens and mounting immune responses upon infection is crucial for animal health. However, these responses come at a high metabolic price (McKean and Lazzaro, 2011, Kominsky et al., 2010), and avoiding pathogens before infection may be advantageous. The bacterial endotoxins lipopolysaccharides (LPS) are important immune system infection cues (Abbas et al., 2014), but it remains unknown whether animals possess sensory mechanisms to detect them prior to infection. Here we show that Drosophila melanogaster display strong aversive responses to LPS and that gustatory neurons expressing Gr66a bitter receptors mediate avoidance of LPS in feeding and egg laying assays. We found the expression of the chemosensory cation channel dTRPA1 in these cells to be necessary and sufficient for LPS avoidance. Furthermore, LPS stimulates Drosophila neurons in a TRPA1-dependent manner and activates exogenous dTRPA1 channels in human cells. Our findings demonstrate that flies detect bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.sponsorship: Vlaams Instituut voor Biotechnologie Alessia Soldano Luis Franco Guangda Liu Natalia Mora Emre Yaksi Bassem A Hassanr Fonds Wetenschappelijk Onderzoek G.0702.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0077.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0680.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0681.10 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0503.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0654.15 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0761.10N Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0596.12 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar Fonds Wetenschappelijk Onderzoek G.0565.07 Alessia Soldano Yeranddy A Alpizar Brett Boonen Alejandro Lopez-Requena Natalia Mora Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven GOA/14/011 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar European Commission IUAP P7/13 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekensr KU Leuven OT/12/091 Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talaverar KU Leuven PF-TRPLe Alessia Soldano Yeranddy A Alpizar Brett Boonen Luis Franco Alejandro Lopez-Requena Guangda Liu Natalia Mora Emre Yaksi Thomas Voets Rudi Vennekens Bassem A Hassan Karel Talavera (Vlaams Instituut voor Biotechnologie, Fonds Wetenschappelijk Onderzoek|G.0702.12, Fonds Wetenschappelijk Onderzoek|G.0077.15, Fonds Wetenschappelijk Onderzoek|G.0680.10, Fonds Wetenschappelijk Onderzoek|G.0681.10, Fonds Wetenschappelijk Onderzoek|G.0503.12, Fonds Wetenschappelijk Onderzoek|G.0654.15, Fonds Wetenschappelijk Onderzoek|G.0761.10N, Fonds Wetenschappelijk Onderzoek|G.0596.12, KU Leuven|GOA/14/011, KU Leuven|OT/12/091, European Commission|IUAP P7/13, KU Leuven PF-TRPLe)status: Publishe
Marriage record of Lopez, Alejandro and Valdes, Rosario
No full textMarriage license for Alejandro Lopez and Rosario Valdes. Joseph A. Lopez was the Notary Public
Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection
Get PDFLopez-Rincon A, Martinez-Archundia M, Martinez-Ruiz GU, Schönhuth A, Tonda A. Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection. BMC Bioinformatics. 2019;20(1): 480
The blind spots of secularization
Get PDFAccording to several international surveys Spain is among the western countries with the most negative views of Jews. While quantitative data on the topic accumulates, there is a significant lack of interpretative approaches that might explain the particular Spanish case. This paper presents the background, methodology and major results of a discussion group-based study on antisemitism, which was conducted in Spain in the autumn of 2009. The study identifies and locates in different socio-economic and ideological milieus the range of stereotypical discourses on Jews, Judaism and the Arab–Israeli conflict in Spain. Analysis of the group meetings shows that, despite growing secularization in Spanish society, the central explanatory variable for persisting and resurging antisemitism in this country is still religion in a broad cultural sense.N
Caracterización del perfil composicional, microbiológico y sanitario de la leche de burra
Get PDFFil: Saino, Verónica. Universidad Nacional Villa María; Argentina..Fil: Bachetti, Romina. Universidad Nacional Villa María; Argentina..Fil: Larriestra, Alejandro. Universidad Nacional Villa María; Argentina..Fil: Lopez, Julia. Universidad Nacional Villa María; Argentina..Fil: Morgante, Carolina A.. Universidad Nacional Villa María; Argentina..Fil: Bonetto, César Celestino. Universidad Nacional Villa María; Argentina..Fil: Lamberti, Maximiliano. Universidad Nacional Villa María; Argentina.
Going for Gold: Gold Open Access publishing
No full textAlejandro Lopez Cobos gave this presentation as part of the University of Exeter's Open Access Week events in October 2012.BioMed Central was a pioneer of the open access model, and over the last twelve years has seen great changes in the marketplace and perception of open access publishing. Gold Open Access publishing is in the news globally now especially with the recent endorsement of the Finch report and the funding announcement from RCUK. There are developments abroad also with the EU 2020 project and the White House investigations into public access to research. Alejandro Lopez Cobos, BioMed Central's Southern Europe, Middle East and Latin America Sales Executive, will cover these developments in detail together with outlining the benefits to authors of publishing in Gold Open Access Journals
La presencia de lo grotesco en Domar a la divina garza, de Sergio Pitol
Get PDF"Son tres los objetos de estudio que rigen este trabajo: la categoría estética de lo grotesco –que se observa desde diversos puntos de vista, pero con especial acento en la visión que tiene Mijaíl Bajtín (1895-1975)–, la novela Domar a la divina garza (Anagrama, 1988) y la figura autoral del mexicano Sergio Pitol (1933-2018). A partir de estas tres áreas de investigación, que sirven como conceptos, a la vez que temas, objetos artísticos y representación del quehacer e inventiva humana, surgen las preguntas: ¿cómo se construye una novela desde una categoría estética? ¿Por qué Sergio Pitol se interesa tanto por las teorías de Bajtín? ¿Es posible que Domar a la divina garza, segunda novela del Tríptico del Carnaval, esté pensada, arquitectónicamente hablando, desde lo grotesco? ¿Qué presencia tiene dicha estética en la obra del Premio Cervantes 2005?
Del silencio a la autoría : la Academia Dominical Literaria de Señoritas en el Porfiriato potosino (1885-1908)
Get PDF"El objetivo principal de este trabajo, es aborda un apartado en la historia de las mujeres; analizar la presencia de un grupo de maestras escritoras de finales del siglo XIX y los primeros alis del XXl, profesionales pertenecientes a la capital de San Luis Potosí, integrantes de la "Academia Dominical Literaria de Señoritas", agrupación que se desenvolvió con éxito en el Porfiriato potosino de 1885 a 1890"
Going for Gold: Gold Open Access publishing
No full textBioMed Central was a pioneer of the open access model, and over the last twelve years has seen great changes in the marketplace and perception of open access publishing. Gold Open Access publishing is in the news globally now especially with the recent endorsement of the Finch report and the funding announcement from RCUK. There are developments abroad also with the EU 2020 project and the White House investigations into public access to research. Alejandro Lopez Cobos, BioMed Central's Southern Europe, Middle East and Latin America Sales Executive, will cover these developments in detail together with outlining the benefits to authors of publishing in Gold Open Access Journals
Astronomy in the Chaco Region, Argentina
No full textUsing the example of our own work about astronomies in the Argentinian Chaco, we show the fruitfulness of a regional approach to ethnoastronomical studies. Our interest is to highlight the relevance of thinking the astronomical systems from a dynamic and historical point of view. These systems of representations and practices about the sky are the result of complex inter-ethnic relations and not the production of isolated cultural groups. We seek to emphasize the special importance of studying aboriginal and creolle astronomies in a related way.Fil: Lopez, Alejandro Martin. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Ciencias Antropológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
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