78 research outputs found
Is T-Wave Alternans a Repolarization Abnormality Marker in COVID-19? An Investigation on the Potentialities of Portable Electrocardiogram Device
No full textBackground: Cardiac arrhythmias are significantly associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients. Microvolt T-wave alternans (TWA) can be automatically quantified and has been recognized as a representation of repolarization hetero-geneity and linked to arrhythmogenesis in various cardiovascular dis-eases. This study aimed to explore the correlation between microvolt TWA and COVID-19 pathology. Methods: Patients suspected of COVID-19 in Mohammad Hoesin General Hospital were consecutively evaluated using Alivecor (R) Kar-diamobile 6LTM portable electrocardiogram (ECG) device. Severe COVID-19 patients or those who are unable to cooperate in active ECG self-recording were excluded from the study. TWA was detected and its amplitude was quantified using the novel enhanced adaptive match filter (EAMF) method. Results: A total of 175 patients, 114 COVID-19 patients (polymer-ase chain reaction (PCR)-positive group), and 61 non-COVID-19 pa -tients (PCR-negative group) were enrolled in the study. PCR-positive group was subdivided according to the severity of COVID-19 pathol-ogy into mild and moderate severity subgroups. Baseline TWA levels were similar between both groups during admission (42.47 +/- 26.52 mu V vs. 44.72 +/- 38.21 mu V), but higher TWA levels were observed during discharge in the PCR-positive compared to the PCR-negative group (53.45 +/- 34.42 mu V vs. 25.15 +/- 17.64 mu V, P = 0.03). The correlation between PCR-positive result in COVID-19 and TWA value was sig-nificant, after adjustment of other confounding variables (R2 = 0.081, P = 0.030). There was no significant difference in TWA levels between mild and moderate severity subgroups in patients with COVID-19, both during admission (44.29 +/- 27.14 mu V vs. 36.75 +/- 24.46 mu V, P = 0.34) and discharge (49.47 +/- 33.62 mu V vs. 61.09 +/- 35.99 mu V, P = 0.33). Conclusions: Higher TWA values can be observed on follow-up ECG obtained during discharge in the PCR-positive COVID-19 patients
KRITIK SOSIAL PADA PERSOALAN GENDER DALAM NOVEL PENGANTIN PESANAN KARYA MYA YE (KAJIAN SOSIOLOGI SASTRA)
No full textAndriyani, Rina. 2020. “Social criticism on gender issues in the novel order bride by Mya Ye: a review of the sociology of literature. Essay S1 Indonesia Literature. Faculty of Cultural Sciences Universitas Diponegoro. Semarang.
One of the novels that contain social criticism is novel order bride by Mya Ye. This novel tells of the struggle of a woman who becomes a mail order bride by marrying a Taiwanese man, in order to improve her standard of living. Experienced by the character Sinta who sacrificed for her family for the future. After marriage, the life that Sinta lived was not what she wanted. She continued to work hard, took care of her husband, in-laws, and continued her business at the Ban Tiao Shop. This study aims to express social criticism on gender issues contained in the novel bride order by Mya Ye. the author uses two theories, namely the fictional structure theory and the sociological theory of literature, which are used to express the social criticism contained in this novel. The object of this research is Mya Ye ordered bridal novel published by PT Gramedia Pustaka Utama in 2018. The method used in this research is a qualitative description, data collection techniques, and data analysis techniques.
The research results are in the form of social criticism on gender issues contained in the novel ordered bridal by Mya Ye, which include: themes and messages, characters and charaterizations, settings, plot and distribution, as well as the social criticism of proverty, criticism of human trafficking, criticism of gender issues, criticism of division in the family, criticism of social and religiois limitations.
Keyword: order bride, social criticism, sociology of literature
Hubungan Obesitas dengan Kejadian Prediabetes pada Wanita Usia Produktif
No full textPrediabetes merupakan kondisi kadar glukosa darah seseorang diatas nilai normal namun belum memenuhi kriteria diabetes melitus. Wanita memiliki risiko lebih tinggi mengalami prediabetes dibanding pria. Peningkatan prevalensi obesitas bersamaan dengan prevalensi diabetes melitus tipe 2. Penelitian ini bertujuan untuk menganalisis hubungan obesitas dengan kejadian prediabetes pada wanita usia produktif. Penelitian ini merupakan studi observasional dengan rancangan kasus kontrol. Penelitian dilaksanakan pada bulan Januari–Maret 2016 di Kota Palembang. Populasi pada penelitian ini adalah wanita di Kota Palembang yang berusia 18 – 40 tahun dan bersedia menandatangani surat persetujuan untuk mengikuti penelitian.Seluruh data diolah dengan menggunakan SPSS versi 22 dan hipotesis akan diuji dengan menggunakan uji Chi-square,untuk mengetahui Odds Ratio digunakan unconditional logistic regression. Pada penelitian ini, diperoleh 196 responden, terdiri dari 98 kasus yakni wanita prediabetes dan 98 kontrol yakni wanita dengan normoglikemik. Pada kelompok kasus, sebagian besar tingkat pendidikan responden adalah tamat SMP maupun SMA (51,7%), memiliki pekerjaan disektor formal (46,1%), berstatus sudah menikah (73%), tidak memiliki riwayat keluarga yang menderita diabetes (83,1%), dan memiliki IMT yang tergolong obesitas (71,9%). Hasil analisa bivariat menunjukkan dari kelima variabel yakni tingkat pendidikan, pekerjaan, status marital, riwayat keluarga, dan obesitas, terdapat tiga variabel yang memiliki hubungan yang signifikan dengan kejadian prediabetes yakni tingkat pendidikan, status marital, dan obesitas.Sedangkan pada analisa multivariat terdapat dua variabel yakni status marital (OR=3,87 CI 95%= 1,98 – 7,60 p value=0,00) dan obesitas (OR=2,63 CI 95%= 1,36 - 5,35 p value=0,05) yang memiliki hubungan yang signifikan dengan kejadian prediabetes
ASSESS PREDIABETES RISK, AS A GOLDEN PERIOD FOR PREVENTION OF DIABETES
No full text Objective: Prediabetes is a high-risk condition for diabetes development and several other health outcomes later in life, but little is known about the factors associated with this condition. On the other hand, by predicting the risk of prediabetes, it is also a golden period for prevent or delay the diabetes conversion. The aim here was to assess the prevalence, risk factor that associated, and build a model to assess prediabetes risk.Methods: A cross-sectional study was conducted in Palembang, Indonesia. Data were collected during January until May 2016. We recruited adult age >15 years from 16 districts in Palembang. Anthropometric, demographic, and clinical history data were measured by standard methods. Capillary blood glucose was measured by finger prick test, followed by confirmatory oral glucose tolerance tests.Results: Of a total of 1241 participants, the prevalence of prediabetes was 27.8% (345 participants) and 72.2% (896 participants) and those were normal blood glucose. Employment, age, exercise, alcohol consumption, body mass index, systolic pressure, diastolic pressure, waist circumference, and hypercholesterol history were screened out as independent factors to build the prediction risk model.Conclusion: The prediabetes prediction model can be used easily and understood by health-related users to assess prediabetes risk. The intervention program, designed based on our prediabetes model to prevent or delay the conversion of prediabetes to diabetes in the population. The discovery of pharmacological therapies to prevent further conversion is needed.Â
ASSESS PREDIABETES RISK, AS A GOLDEN PERIOD FOR PREVENTION OF DIABETES
No full text Objective: Prediabetes is a high-risk condition for diabetes development and several other health outcomes later in life, but little is known about the factors associated with this condition. On the other hand, by predicting the risk of prediabetes, it is also a golden period for prevent or delay the diabetes conversion. The aim here was to assess the prevalence, risk factor that associated, and build a model to assess prediabetes risk.Methods: A cross-sectional study was conducted in Palembang, Indonesia. Data were collected during January until May 2016. We recruited adult age >15 years from 16 districts in Palembang. Anthropometric, demographic, and clinical history data were measured by standard methods. Capillary blood glucose was measured by finger prick test, followed by confirmatory oral glucose tolerance tests.Results: Of a total of 1241 participants, the prevalence of prediabetes was 27.8% (345 participants) and 72.2% (896 participants) and those were normal blood glucose. Employment, age, exercise, alcohol consumption, body mass index, systolic pressure, diastolic pressure, waist circumference, and hypercholesterol history were screened out as independent factors to build the prediction risk model.Conclusion: The prediabetes prediction model can be used easily and understood by health-related users to assess prediabetes risk. The intervention program, designed based on our prediabetes model to prevent or delay the conversion of prediabetes to diabetes in the population. The discovery of pharmacological therapies to prevent further conversion is needed. </jats:p
Association Between Triglyceride-Glucose Index (TyG Index) and Type 2 Diabetes Mellitus: A Systematic Review
No full textBackground: Insulin Resistance has a major role in the pathogenesis of diabetes mellitus where there is a decrease in sensitivity in peripheral tissues. The emergence of insulin resistance, 1-2 decades precedes before the diagnosis of type 2 diabetes mellitus is established. This theory is supported by the usefulness of insulin resistance as a marker of future diabetes or the prevention of type 2 diabetes by insulin-sensitizing agents. Recently, there is evidence that has been suggested to measure insulin resistance as surrogate marker by calculated the triglyceride and glucose which is so called as “Fasting triglyceride-glucose index” or can be shorten as “TyG index”. This study reported a systematic review of association between TyG index and type 2 diabetes mellitus from various literatures to make a conclusion as a basis for further research.
Methods: A literature search in EBSCOhost, ProQuest, MEDLINE, and NCBI database was performed to retrieve and review studies reporting the association between TyG index and type 2 diabetes.
Results: All studies showed that higher TyG index were associated with higher type 2 diabetes (HR 4.36, 10.38, 9.54 for each).
Conclusion: This systematic review provides further evidence about higher TyG index is related to higher risk of development type 2 diabetes. It represents that TyG index can predicting the risk of incident T2DM
Association Between Triglyceride-Glucose Index (TyG Index) and Type 2 Diabetes Mellitus: A Systematic Review
No full textBackground: Insulin Resistance has a major role in the pathogenesis of diabetes mellitus where there is a decrease in sensitivity in peripheral tissues. The emergence of insulin resistance, 1-2 decades precedes before the diagnosis of type 2 diabetes mellitus is established. This theory is supported by the usefulness of insulin resistance as a marker of future diabetes or the prevention of type 2 diabetes by insulin-sensitizing agents. Recently, there is evidence that has been suggested to measure insulin resistance as surrogate marker by calculated the triglyceride and glucose which is so called as “Fasting triglyceride-glucose index” or can be shorten as “TyG index”. This study reported a systematic review of association between TyG index and type 2 diabetes mellitus from various literatures to make a conclusion as a basis for further research.
Methods: A literature search in EBSCOhost, ProQuest, MEDLINE, and NCBI database was performed to retrieve and review studies reporting the association between TyG index and type 2 diabetes.
Results: All studies showed that higher TyG index were associated with higher type 2 diabetes (HR 4.36, 10.38, 9.54 for each).
Conclusion: This systematic review provides further evidence about higher TyG index is related to higher risk of development type 2 diabetes. It represents that TyG index can predicting the risk of incident T2DM
Multipleks PCR Konvensional Untuk Mendeteksi Soil Transmitted Helminths (STH)
No full textSoil Transmitted Helminths (STH) merupakan parasit usus yang paling umum menginfeksi manusia dan masih menjadi masalah kesehatan masyarakat di banyak negara berkembang, terutama terjadi di daerah sub tropis dan tropis termasuk Indonesia. Cacing STH yang paling umum menginfeksi manusia yaitu Ascaris lumbricoides, Trichiuris trichiura dan cacing tambang, Infeksi ini menyebabkan berbagai dampak, deteksi dini dan akurat sangat penting untuk mendukung program pengendalian dan eliminasi STH yang efektif. Seiring dengan perkembangan teknologi, metode polymerase chain reaction (PCR), khususnya multipleks PCR, mulai menarik perhatian karena dapat mendeteksi DNA beberapa spesies parasit sekaligus dalam satu reaksi. Tujuan penelitian untuk mendeskripsikan hasil penelitian terkait dengan metode Multipleks PCR Konvensional mendeteksi STH dibandingkan metode lain. Metode pada penelitian ini adalah Systematic Review dengan menggunakan metode PRISMA, basis data dicari dan mencakup Pubmed, Cochrane, Science Direct, dan Elsevier Clinicalke
ADVANCE STAGE OF HODGKIN LYMPHOMA SHOWS HIGH DENSITY OF PLASMA CELLS BUT LOW ANGIOGENESIS
No full textBackgroundTumor microenvironmental of classical Hodgkin lymphoma (cHL) containing plasma cells and angiogenesis, however their exact roles remained indeterminate. Plasma cells are important prognostic factors of various malignancies. Angiogenesis can be assessed by evaluating of micro vessel density (MVD). Higher MVD is associated with a poor prognosis in various type of malignancies. The objectives of this study were to investigate the density of plasma cells and MVD in the microenvironment of cHL and to determine the association of both components with the stage of cHL.Materials and methodsThe selected 37 paraffin blocks of cHL cases were sectioned. The clinical staging was performed using modification of Ann Arbor staging system. To assess the density of plasma and endothelial cells, anti-CD138 and anti-CD34 antibodies were employed by immunohistochemistry. The association of plasma cells’densities and MVD with cHL stages was measured by statistical analysis using t-test by STATA version 15 with significant consideration if p <0.05.ResultsIn our cohort cHL was occurred in slightly older patients (?40 years; 53.33%), more in male (60%), and majority with nodal location (86.67%). The subtypes was dominated by lymphocyte rich (43.33%); followed by nodular sclerosing (30%) and mixed cellularity (26.67%), while lymphocyte depleted was not found. Statistical analysis revealed that higher density of plasma cells was significantly correlated to the patient higher stages (p=0.0003). While density of micro vessels is not significant correlation (p=0.5564) to the stages of cHLConclusionHigh densities of plasma cells but not angiogenesis correlate to advance stage of Hodgkin lymphoma
Association between household income and gestational weight gain among pregnant women in Palembang
No full textPalembang is the city with the highest incidence of anemia in 2023, a condition that linked to maternal malnutrition. Gestational weight gain (GWG) is one of the indicator of maternal nutritional status. One of the factor that may influence the nutritional status is household income because it determines how a person afford their own nutrition.
This study used a cross-sectional design and was conducted from August to October 2024. Data collection involved body weight measurement using the TANITA BC-601 and structured questionnaires. GWG was calculated as the difference between current body weight and pre-pregnancy weight, then the adequacy of GWG was assessed by comparing current weight with the ideal weight for gestational age. Eligible participants included singleton pregnant women without chronic illnesses who had completed the triple elimination program and received antenatal care at public health centers or private midwifery practices. Data analysis was performed with Chi Square analysis by using SPSS 27th version
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