12 research outputs found
Using Business Data in Customs Risk Management: Data Quality and Data Value Perspective
No full textWith the rise of data analytics use in government, government organizations are starting to explore the possibilities of using business data to create further public value. This process, however, is far from straightforward: key questions that governments need to address relate to the quality of this external data and the value it brings. In the domain of global trade, customs administrations are responsible on the one hand to control trade for safety and security and duty collection and on the other hand they need to facilitate trade and not hinder economic activities. With the increased trade volumes, also due to growth in eCommerce, customs administrations have turned their attention to the use of data analytics to support their risk management processes. Beyond the internal customs data sources, customs is starting to explore the value of business data provided by business infrastructures and platforms. While these external data sources seem to hold valuable information for customs, data quality of the external data sources, as well as the value they bring to customs need to be well understood. Building on a case study conducted in the context of the PROFILE research project, this contribution reports the findings on data quality and data linking of ENS customs data with external data (BigDataMari) and other customs (import declaration) data and we discuss specific lessons learned and recommendations for practice. In addition, we also develop a data quality and data value evaluation framework applied to customs as high-level framework to help data users to evaluate potential value of external data sources. From a theoretical perspective this paper further extends earlier research on value of data analytics for government supervision, by zooming on data quality.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog
Identifying the value of data analytics in the context of government supervision: Insights from the customs domain
No full texteCommerce, Brexit, new safety and security concerns are only a few examples of the challenges that government organisations, in particular customs administrations, face today when controlling goods crossing borders. To deal with the enormous volumes of trade customs administrations rely more and more on information technology (IT) and risk assessment, and are starting to explore the possibilities that data analytics (DA) can offer to support their supervision tasks. Driven by customs as our empirical domain, we explore the use of DA to support the supervision role of government. Although data analytics is considered to be a technological breakthrough, there is so far only a limited understanding of how governments can translate this potential into actual value and what are barriers and trade-offs that need to be overcome to lead to value realisation. The main question that we explore in this paper is: How to identify the value of DA in a government supervision context, and what are barriers and trade-offs to be considered and overcome in order to realise this value? Building on leading models from the information system (IS) literature, and by using case studies from the customs domain, we developed the Value of Data Analytics in Government Supervision (VDAGS) framework. The framework can help managers and policy-makers to gain a better understanding of the benefits and trade-offs of using DA when developing DA strategies or when embarking on new DA projects. Future research can examine the applicability of the VDAGS framework in other domains of government supervision.Information and Communication TechnologyScience Centre & Programmerin
Radiation therapy for the treatment of vestibular schwannoma: a critical evaluation of the state of the literature.
No full textOBJECTIVE: Review publications reporting radiation treatment of vestibular schwannomas (VS) and describe how data, patient characteristics, and study endpoints were reported. DATA SOURCES: PubMed search for English language articles on radiation treatment of VS published from January 2002 to July 2007. STUDY SELECTION: Studies presenting outcomes were selected, yielding 56 articles (58 studies) in journals of neurosurgery (30), oncology (18), otolaryngology (6), and other (2). DATA EXTRACTION-SYNTHESIS: Data included type of study, number of subjects, demographics, follow-up times, type of radiation, tumor size, tumor control definition, control rates, facial nerve function measure and outcome, type of hearing and vestibular testing and outcomes, and complications. Descriptive statistics were performed. RESULTS: Studies (72.9percent) were retrospective reviews with stated sample sizes ranging from 5 to 829. Gamma-knife (49.2percent), linear accelerator (35.6percent), and proton beam (6.8percent) were used with various doses. Average follow-up was less than 5 years in 79.6percent of studies, and 67.4percent included patients at less than or equal to 1 year. Tumor size was reported as diameter (23.7percent), volume (49.2percent), both (11.9percent), other (3.4percent), or not reported (11.9percent). Definition of tumor control varied: less than or equal to 2 mm growth (22.0percent), no visible-measurable change (16.9percent), required surgery (10.2percent), other (17.0percent), and not clearly specified (33.9percent). Facial nerve outcome was reported as House-Brackmann (64.4percent), normal-abnormal (11.9percent), other (1.7percent), or was not reported (22percent). CONCLUSION: The lack of uniform reporting criteria for tumor control, facial function and hearing preservation, and variability in follow-up times make it difficult to compare studies of radiation treatment for VS. We recommend consideration of reporting guidelines such as those used in otology for reporting VS resection results.Acoustic Neuroma Association, 2007 2008 PAT SURV; American Academy of Otolaryngology-Head and Neck Surgery Foundation Inc., 1995, OTOLARYNGOL HEAD NEC, V113, P179, DOI DOI 10.1016-S0194-5998(95)70101-X; Balasubramaniam A, 2007, NEURO-ONCOLOGY, V9, P447, DOI 10.1215-15228517-2007-027; Brackmann DE, 2007, OTOLARYNG HEAD NECK, V136, P773, DOI 10.1016-j.otohns.2006.10.009; Chopra R, 2007, INT J RADIAT ONCOL, V68, P845, DOI 10.1016-j.ijrobp.2007.01.001; Coelho DH, 2008, LARYNGOSCOPE, V118, P1909, DOI 10.1097-MLG.0b013e31818226cb; del Valle R, 2005, J NEUROSURG, V102, P140; Friedman RA, 2005, LARYNGOSCOPE, V115, P1827, DOI 10.1097-01.mlg.0000175063.76948.75; Hasegawa T, 2006, NEUROSURGERY, V58, P1119, DOI 10.1227-01.NEU.0000215947.35646.DD; Humphriss RL, 2003, OTOL NEUROTOL, V24, P661, DOI 10.1097-00129492-200307000-00021; Karpinos M, 2002, INT J RADIAT ONCOL, V54, P1410, DOI 10.1016-S0360-3016(02)03651-9; Kondziolka D, 1998, NEW ENGL J MED, V339, P1426, DOI 10.1056-NEJM199811123392003; LINTHICUM FH, 1980, ARCH OTOLARYNGOL, V106, P729; LINTHICU.FH, 1972, ANN OTO RHINOL LARYN, V81, P433; Lunsford LD, 2005, J NEUROSURG, V102, P195; Mathieu D, 2007, NEUROSURGERY, V60, P468; Mathieu D, 2007, NEUROSURGERY, V60, P460, DOI 10.1227-01.NEU.0000255340.26027.53; Okunaga T, 2005, J NEUROSURG, V103, P53, DOI 10.3171-jns.2005.103.1.0053; Pollock BE, 2006, NEUROSURGERY, V59, P77, DOI 10.1227-01.NEU.0000219217.14930.14; Pollock BE, 2006, NEUROSURGERY, V58, P241, DOI 10.1227-01.NEU.0000194833.66593.8B; Rowe JG, 2003, J NEUROL NEUROSUR PS, V74, P1288, DOI 10.1136-jnnp.74.9.1288; Slattery WH, 2003, OTOL NEUROTOL, V24, P666, DOI 10.1097-00129492-200307000-00022; Slattery WH, 1998, AM J OTOL, V19, P638; STROUP DF, 2009, JAMA-J AM MED ASSOC, V283, P15; Surber G, 2004, J NEUROSURG, V101, P334; Wowra B, 2005, J NEUROSURG, V102, P114; Yu CP, 2000, J NEUROSURG, V93, P82; Zohar S, 2008, CLIN TRIALS, V5, P478, DOI 10.1177-174077450809665319212
Reductive Disproportionation of CO2 with Bulky Divalent Samarium Complexes
No full textbibtex: ISI:000418109700020 bibtex\location:'1155 16TH ST, NW, WASHINGTON, DC 20036 USA',publisher:'AMER CHEMICAL SOC',type:'Article',affiliation:'Nocton, G (Reprint Author), Univ Paris Saclay, CNRS, Ecole Polytech, LCM, Route Saclay, F-91128 Palaiseau, France. Xemard, Mathieu; Goudy, Violaine; Braun, Augustin; Tricoire, Maxime; Cordier, Marie; Ricard, Louis; Nocton, Gregory, Univ Paris Saclay, CNRS, Ecole Polytech, LCM, Route Saclay, F-91128 Palaiseau, France. Castro, Ludovic; Louyriac, Elisa; Kefalidis, Christos E.; Maron, Laurent, Univ Toulouse, CNRS, UMR 5215, LPCNO,INSA,UPS, Toulouse, France. Clavaguera, Carine, Univ Pari Saclay, Univ Paris Sud, CNRS, Lab Chim Phys, 15 Ave Jean Perrin, F-91405 Orsay, France.','author-email':'[email protected]',da:'2018-12-05','doc-delivery-number':'FQ1IG',eissn:'1520-6041','funding-acknowledgement':'French National Agency [ANR-15-CE29-0019]; CNRS; Ecole polytechnique; DGA','funding-text':'This project was financed by the French National Agency with grant number ANR-15-CE29-0019. We thank the CNRS and Ecole polytechnique for funding. M.X. is grateful to the DGA for funding. L.M. is a member of the Institut Universitaire de France.','journal-iso':'Organometallics','keywords-plus':'BIPYRIDYL THORIUM METALLOCENE; SOLID-STATE STRUCTURES; RARE-EARTH-ELEMENTS; CARBON-MONOXIDE; ORGANOMETALLIC COMPOUNDS; LANTHANIDE COMPLEXES; CRYSTAL-STRUCTURE; ACTIVATION; REACTIVITY; COORDINATION','number-of-cited-references':'65','orcid-numbers':'Clavaguera, Carine/0000-0001-5531-2333','research-areas':'Chemistry','researcherid-numbers':'Clavaguera, Carine/A-1433-2013 Nocton, Greg/D-4435-2009','times-cited':'3','unique-id':'ISI:000418109700020','usage-count-last-180-days':'7','usage-count-since-2013':'14','web-of-science-categories':'Chemistry, Inorganic & Nuclear; Chemistry, Organic'\International audienceThe base-free divalent samarium complex (Cp2Sm)-Sm-tt (1; Cp-tt = 1,3-(Bu-t)(2)(C5H3)) has been synthesized in diethyl ether by salt metathesis of SmI2. Crystals of 1 suitable for X-ray study have been obtained by sublimation at 116 degrees C under reduced pressure. The dissolution of 1 in thf and pyridine solution leads to the solvent adducts (Ce2Sm)-Sm-tt(thf)(2) (3) and (Ce2Sm)-Sm-tt(py) (4), respectively, while drying 3 under reduced pressure yields (CpSm)-Sm-tt(thf) (5). The reaction of CO2 with the base-free divalent samarium complexes (Cp2Sm)-Sm-tt (1) and (Cp2Sm)-Sm-ttt (2; Cp-ttt =1,2,4-(Bu-t)(3)(C5H2)) leads to the clean formation of bridged carbonate samarium dimers [(Cr2Sm)-Sm-ttt](2)(mu-CO3) (7) and [(Cp2Sm)-Sm-tt](2)(mu-CO3) (8). This is indicative of the reductive disproportionation of CO2 in both cases with release of CO. This contrasts with the formation of the oxalate-bridged samarium dimer reported from the reaction of CO2 with the Cp*Sm-2(thf)(2) complex. Otherwise, the reaction with CO does not proceed with the bulky complexes, while traces of O-2 have led to the formation of the original bridged peroxo samarium dimer [Cp(2)(ttt)sm](2)(mu-O-2) (6). The mechanism for these reactions is studied herein by experiments and also by theoretical computations. The key result is that the different pathways are rather close in energy, which also explains why the nature of the final product, if only one is present, is difficult to predict a priori in this chemistry
Visualising product-service system business models
No full textCopyright © 2014. Copyright in each paper in this conference’s proceedings is the property of
the author(s). Permission is granted to reproduce copies of these works for purposes relevant
to the above conference, provided that the author(s), source and copyright notice are included
on each copy. For other uses, including extended quotation, please contact the author(s).The paper addresses the issue of how to visualise innovative business models at various stages of the design and development process. The focus is on a particular type of business model, defined Product-Service Systems (PSSs), characterised by an integrated product-service offering, but can be generalised to other business model innovations. The paper presents a visualisation system based on a formalised business model ontology and a set of visualisation tools, and discusses how it can be used to enhance internal and external communication and improve dialogue and co-design activities inside the company and with external stakeholders
Using Business Data in Customs Risk Management: Data Quality and Data Value Perspective
No full textWith the rise of data analytics use in government, government organizations are starting to explore the possibilities of using business data to create further public value. This process, however, is far from straightforward: key questions that governments need to address relate to the quality of this external data and the value it brings. In the domain of global trade, customs administrations are responsible on the one hand to control trade for safety and security and duty collection and on the other hand they need to facilitate trade and not hinder economic activities. With the increased trade volumes, also due to growth in eCommerce, customs administrations have turned their attention to the use of data analytics to support their risk management processes. Beyond the internal customs data sources, customs is starting to explore the value of business data provided by business infrastructures and platforms. While these external data sources seem to hold valuable information for customs, data quality of the external data sources, as well as the value they bring to customs need to be well understood. Building on a case study conducted in the context of the PROFILE research project, this contribution reports the findings on data quality and data linking of ENS customs data with external data (BigDataMari) and other customs (import declaration) data and we discuss specific lessons learned and recommendations for practice. In addition, we also develop a data quality and data value evaluation framework applied to customs as high-level framework to help data users to evaluate potential value of external data sources. From a theoretical perspective this paper further extends earlier research on value of data analytics for government supervision, by zooming on data quality
Service, services and products: rethinking operations strategy
No full textPurpose – This paper proposes a new approach to operations and supply strategy in the light of recent developments in the analysis of the respective roles of products and services in delivering benefits to customers. Design/methodology/approach – Reviews and synthesises concepts from operations management (OM), marketing, economics and related areas. Examples of product and service combinations are considered, drawing attention to the ways in which services may be distinguished from products. An institutional basis for defining services is favoured over IHIP. A corollary of this is how services are made tradable: the modularity theory of the firm is used to do this. The paper then outlines, considers and compares various approaches to the combination of products and services: “service-dominant logic”, support services, product-service systems, systems integration, performance-based logistics, bundling and, finally, the notion of “the offering”. Findings – It is found that the notion of the business model is useful as an integrating concept. This focuses on four areas: network structure, how transactions are made, how revenue models and incentives interact and how capabilities are accessed. Implications for future research in OM are considered. Research limitations/implications – Hitherto, operations strategy (OS) has concentrated on intra-firm capabilities, which is only part of one of the four areas identified. Therefore, an extensive agenda for research into inter-firm capabilities and the other three areas identified is presented. Originality/value – This is among the first papers in OM to break completely with IHIP as a basis for service definition and to work through the implications for OS. It is also the first to develop systematically an understanding of how the emerging concept of the business model can inform OM
Avaliação dos efeitos citotóxicos de cardenolídeos em células tumorais
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaOs cardenolídeos são metabólitos secundários encontrados na natureza e assim denominados em razão de sua ação inibitória na bomba de Na+/K+ (Na+/K+ATPase) e decorrentes efeitos sobre o músculo cardíaco. Por esta razão, cardenolídeos, tais como digoxina, digitoxina e ouabaína, são clinicamente utilizados para o tratamento da insuficiência cardíaca congestiva e algumas arritmias atriais. Nos últimos anos, vários estudos relataram a potencial atividade citotóxica, antitumoral e anticâncer de alguns cardenolídeos. Mundialmente, o câncer de pulmão é um dos principais responsáveis pela alta taxa de mortalidade atribuída ao câncer. O tratamento atual deste câncer depende do estágio do paciente e são utilizadas abordagens combinadas ou individuais, tais como excisão cirúrgica, radioterapia e quimioterapia. A taxa de sobrevivência dos pacientes, no entanto, não é elevada, tornando a busca por novos agentes no combate a este câncer uma necessidade. Neste trabalho, foi realizada uma triagem citotóxica, em células tumorais humanas A549, com 64 cardenolídeos e um dos compostos mais citotóxicos (CI50<100 nM) foi selecionado para investigação do seu mecanismo de ação, através de vários ensaios. Este composto, que se apresentou mais tóxico e mais seletivo para células tumorais foi o glucoevatromonosídeo e para a avaliação de seu mecanismo de ação uma série de ensaios foi realizada. Inicialmente, ele provocou o bloqueio do ciclo celular na fase G2/M, o que foi atribuído à diminuição da expressão da proteína ciclina B1, necessária para a progressão do ciclo celular. A indução de morte celular, por ele causada, não ocorreu por apoptose ou necrose, sendo provavelmente por autofagia, processo observado com a marcação de partículas acídicas, características deste tipo de morte celular. O envolvimento deste composto em vias de sinalização de morte celular foi constatado por alterações na expressão de proteínas das vias AKT, MAPK e NF-?B. Por fim, a atividade anti-ATPásica detectada não mostrou correlação da inibição desta enzima com a atividade citotóxica apresentada pelos compostos selecionados na triagem. A citotoxicidade promissora do glucoevatromonosídeo foi investigada e confirmada sua indução de morte celular independente de apoptose em células A549.Cardenolides are secondary metabolites found in nature and named after their known inhibitory action on the sodium pump (Na+/K+ATPase), and effect on the heart muscle. For this reason cardenolides as digoxin, digitoxin and ouabain are used in the treatment of congestive heart failure and atrial arrhythmias. In the past years, many were the reports on the citotoxic, antitumoral and anticancer activities of cardenolides. Lung cancer is one of the leading causes of death by cancer worldwide. Current treatment of lung cancer depends on the stage of the patient and both combined and individual approaches are used, such as surgery, radiotherapy and chemotherapy. However, the observed survival rate is not high, which stimulates the search for new agents for the treatment of this cancer. In the present work a cytotoxic screening with 64 cardenolides was performed and the most cytotoxic compound selected (CI50<100 nM) to further investigate its mechanism of action. The most cytotoxic and selective compound for cancer cell lines was glucoevatromonoside and to evaluate its mechanism of action a series of assays was carried out. Initially, this compound was able to block phase G2/M of cell cycle, which was attributed to the decrease in the expression of cyclin B1 protein, essential to the cell cycle progression. The investigation of the cytotoxic effect of this compound showed that the induced cell death was not apoptosis or necrosis mediated, and so might be through autophagy, as observed with the acridine orange marked acidic particles, a characteristic event of this type of cell death. Involvement of this compound in signaling pathways was verified through its ability to trigger alterations in the expression of AKT, MAPK and NF-?B proteins. The detected anti ATPase activity did not show correlation of the enzyme inhibition with the cytotoxic activity presented by the compounds selected in the screening. Hereby, the promising cytotoxic activity of glucoevatromonoside was investigated and confirmed its apoptosis-independent cell death induction in A549 cells. It was suggested that cell death was caused by cell cycle arrest and autophagy induction with signaling pathways involved
Alzheimer's disease -related genes and pathways special emphasis on seladin-1, [delta]opioid receptor 1 and BACE1
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