1,722,322 research outputs found
ICT Workshops
No full textThis resource was funded by the LSN as part of the Q projects programme. The resource was designed & produced by Gateshead College and Northumberland College.
Longitudinal Siamese network (LSN) architecture.
No full textLongitudinal Siamese network (LSN) architecture.</p
Notkun LSN á Íslandi 2008 - 2017: Ferilrannsókn á lyfjanotkun
No full textInngangur: Notkun á lágskammta naltrexone (LSN) hefur farið vaxandi við meðhöndlun á heila- og mænusiggi, svæðisgarnabólgu og vefjagigt. Takmarkaðar upplýsingar eru til um virkni og umfang slíkrar meðferðar á heimsvísu, þó liggja fyrir upplýsingar, meðal annars úr þremur blindum slembirannsóknum, þar sem litlir hópar sjúklinga með ofangreinda sjúkdóma hefur verið fylgt eftir. Niðurstöður blindra slembirannsókna benda til þess að LSN hafi marktæk bætandi áhrif á líðan þátttakenda. Litlar upplýsingar eru hins vegar að finna um umfang notkunar á LSN á Íslandi. Tilgangur rannsóknarinnar var að gefa skýrari mynd af notkun LSN á Íslandi frá 2008 – 2017.
Efniviður og aðferðir: Sótt var um leyfi hjá embætti landlæknis um að fá aðgang að upplýsingum varðandi LSN meðferð á rannsóknartímabilinu úr lyfjagagnagrunni. Fengnar voru upplýsingar um fjölda einstaklinga sem leystu út ávísun fyrir LSN auk kyns, aldurs, fjölda ávísana og afgreiðsluár ásamt upplýsingum um meðferðaraðila. Jafnframt var óskað eftir fjölda einstaklinga sem leystu út LSN samhliða ópíóð lyfjum.
Niðurstöður: Fyrsta lyfjaávísunin af LSN var leyst út árið 2010 og voru tveir einstaklingar sem leystu út ávísun fyrir LSN það árið, samanborið við 292 árið 2013 og 734 árið 2016. Hlutfall þeirra einstaklinga sem leystu út ávísun fyrir LSN árið 2016 var 0,22% af þjóðinni. Konur voru í miklum meirihluta eða rúm 87,3% og 57,0% einstaklinga voru í aldursflokknum 40–55 ára. Á einum áratug hafa 7.405 ávísanir fyrir LSN verið leystar út. Á árunum 2015 og 2016 voru samtals 3.542 ávísanir leystar út eða 47,8%. Frá 2013 - 2017 voru 34,8% einstaklinga sem leystu út ávísun fyrir LSN samhliða ópíóð lyfjum.
LSN er framleitt af tveimur fyrirtækjum á Íslandi; Árbæjarapóteki frá því 2012 og Pharmarctica frá 2017. Árbæjarapótek hefur tekið á móti 7.280 ávísunum eða 98,3% af heildarfjölda ávísana. Pharmarctica hefur tekið á móti 144 ávísunum. Skammtastærðir fyrir LSN eru einstaklingsbundnar en skammtur á bilinu 3 – 4,5 ml er algengastur (3 – 4,5 mg). Árbæjarapótek framleiðir 1 mg/ml af LSN í 135 ml flöskur en Pharmarctica framleiðir 1 mg/ml af LSN í 100 ml flösku. Frá 2013 til 2017 fengu 47,9% einstaklinga aðeins eina til þrjár pakkningar af LSN. Í heildina var 531 læknir sem gaf út ávísun fyrir LSN á rannsóknartímabilinu. Af þeim voru 57,1% með skráða sérgrein. Fleiri karlkyns (N = 335) en kvennkyns (N = 185) gáfu út ávísun fyrir LSN og voru karlarnir eldri (μ = 52,0 ár) en konurnar (μ = 40,2 ár). Langflestir meðferðaraðilar voru með sérfræðimenntun á sviði heimilislækninga.
Ályktanir: Töluverð aukning hefur átt sér stað í ávísunum á LSN frá 2013 á Íslandi. Sambærileg aukning átti sér stað í Noregi þar sem 0,3% af landsmönnum þar í landi hafði leyst út LSN frá 2013 til 2014. Konur eru í miklum meirihluta meðal þeirra sem leysa út ávísun fyrir LSN og meirihluti einstaklinga eru í aldursflokki 40 – 55 ára, sem kemur ekki á óvart þar sem grunur leikur á að meirihluti einstaklinga fái LSN gegn vefjagigt. Þá er athyglisvert að langflestir fá eingöngu eina til þrjár uppáskriftir á LSN, sem bendir til þess að skoða þurfi virkni lyfsins sérstaklega og er vinna í þeim efnum hafin. Frá 2013 til 2017 voru 34,8% sem leystu út ávísun fyrir LSN samhliða ópíóð lyfjum og væri fróðlegt að skoða hvort að breytingar á ópíóðnotkun hafi átt sér stað hjá einstaklingum sem leystu út fjórar eða fleiri ávísanir af LSN samanborið við einstaklinga sem leystu út færri en fjórar ávísanir
Characterization of Satellite Cells Derived from Chickens with the Low Score Normal (LSN) Muscle Weakness
No full textSeventy nine myogenic satellite cell clones were established from the pectoralis major muscle (PM) of chickens with the Low Score Normal (LSN) muscle weakness and Controls, using a Quixell robotic cell transfer system. LSN birds are characterized as having difficulty in righting themselves from a supine position. The percentage of cells which attached to substrata and began to proliferate was higher for the Control line than the LSN line (53% vs. 29%). Furthermore, of those clones which initiated growth, 64 % of the Control cells and only 33% of the LSN cells proliferated to confluency in 25 cm2 flasks. Clones possessing the fastest growth rates, good cell morphology and ability to form myotubes were chosen from both lines for further study. Of the eight different combinations of media, sera and growth factors tested, McCoys 5A + 10% chicken serum (CS)+ 5% horse serum (HS)+ 20 ng/ml fibroblast growth factor (FGF) was shown to support the greatest rates of chicken satellite cell proliferation. Using this medium, proliferation rates were significantly lower with LSN satellite cells than with Controls (P\u3c0.05). A chicken serum dose response curve conducted between 0 and 10% CS in the presence of 5% HS demonstrated that LSN satellite cells were less responsive to the mitogenic effects of chicken serum at all levels tested (P\u3c0.05). Differentiation rates of LSN satellite cells (as measured by creatine kinase levels) in low serum containing medium were significantly lower compared with Controls (P\u3c0.05). There was a greater (P\u3c0.05) number of insulin-like growth factor receptors on LSN satellite cells compared to Controls. However, the IGF receptor binding affinities (Kds) were similar (P\u3e0.05) between the two cell lines. Protein synthesis rates between Control and LSN satellite cells were similar, but protein degradation rates were higher in the LSN satellite cells. The results suggest that a defect in satellite cell physiology may contribute to the skeletal muscle weakness seen in the LSN line
PERAN LSM LSN DALAM IDENTIFIKASI POTENSI DESA
Full text linkPenelitian ini dilaksanakan bertujuan untuk menganalisis peran LSN dalam melakukan
identifikasi potensi desa, yang nantinya dokumen ini digunakan dalam perubahan
penyusunan perencanaan pembangunan jangka menengahDesa. Lokasi sebagai studi
kasus adalah Desa Beji Kecamatan Ngawen Kabupaten Gunung Kidul Daerah
Istimewa Yogyakarta. Penulis dalam penelitian ini menggunakan metode penelitian
kualitatif, sumber data primer didapat dari wawancara dengan Narasumber, sedangkan
data sekunder diperoleh dari dokumen yang mendukung penelitian ini.
Hasil dari penelitian ini menunjukan bahwa LSN sangat membantu desa dalam
mengidentifikasi potensi yang ada di desa yang apabila direncanakan dan dikelolah
dengan baik akan meningkatkan pendapatan desa yang sekaligus meningkatkan
kesejahtraan bagi masyarakat. Potensi yang diidentifikasi adalah potensi pertanian dan
pariwisata. Dalam menganalisa potensi menggunakan analisa SWOT sehingga potensi
yang ada dikaji dari aspek kekuatan, kelemahan, peluang dan ancaman, dari aspek
tersebut diperoleh berbagai alternatif strategi untuk dilaksanakan, strategi ini yang
nantinya dimanfaatkan sebagai dasar menyusun perencanaan pembangunan Desa
PT contra a LSN
No full textPolitical poster informing the public about the judicial process against the leaders of PT (Partido dos Trabalhadores). On the right side of the poster are eleven small photos of PT leaders. To the right of the photos is the inscription, The leaders of the Workers Party are charged by LSN Law of National Security. At the bottom of the poster is a photo that shows the destruction caused by the bombing of a buidling. Above the photo is the title, PT against attacks. It also includes the inscription, Those who are responsible for these aggressions are still free. Supported by PT (Partido dos Trabalhadores
Commit LSN: A Novel and Simple Method for Reducing Locking and Latching in Transaction Processing Systems
No full textmnha/vr~lhm.com Abstract This paper presents a novel and simple method, called CommitYLSN, for determining if a piece of data is in the commltted state in a transaction pro-cessing system. This method is a much cheaper alter-native to the locking approach used by the prior art for this purpose. The method takes advantage of the concept of a log sequence number (LSN). In many systems. an LSN is recorded in each page of the data base to relate the state of the page to the log of update actions for that page. Our method uses information about the LSN of the first log record (call it Commit-LSN) of the oldest update transaction still executing in the system to infer that all the updates in pages with page_LSN less than Commit LSN have been committed. This reduces locking and latching. In addition. the method may also increase the level of concurrency that could be supported. The Commit LSN method makes it possible to use fine-granulazty locking without unduly penalizing transactions which read numerous records. It also benefits update transactions by reducing the cost of fine-granularity lock-ing when contention is not present for data on a page. We discuss in detail many applications of this method and illustrate its potential benefits for various environ-ments. In order to apply the Commit-LSN method, ex-tensions are also proposed for those systems in which (1) LSNs are not associated with pages (AS1400, ’ SQLIDS, System R), (2) LSNs are used only partially (IMS), and/or (3) not all objects ’ changes are logged (AS1400, SQL/DS. System R). 1
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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