1,721,287 research outputs found
Sensibility and Specificity of Growth Factors in GH Deficiency.
No full textThe diagnosis of childhood onset GH
deficiency (GHD) is often problematic especially
for idiopathic, isolated GHD. No single physiologic
or provocative test or combination of tests
has proven to have sufficient specificity for the
diagnosis of GHD. Due to their GH dependency
and relative stability in the circulation, IGF-I and
IGFBP-3 serum concentrations were proposed as
reliable markers of daily GH secretion. Although
specificity of the assays is high, multiple factors
affect the measurements, reducing the sensitivity.
In our experience, IGF-I sensitivity ranges from 70
to 75%, with a specificity ranging from 80 to 90%.
IGFBP-3 assessment has low sensitivity, approximately
30%, and high specificity, approximately
100%. In conclusion, the sensitivity of assays
for IGF-I and IGFBP-3 is too low to exclude the
diagnosis of GHD on the basis of a normal value
of the parameters. On the other hand, due to the
high specificity, subnormal concentrations of IGF-I
and/or IGFBP-3 strongly support the diagnosis of
GHD. Finally, combining the assessment of height
velocity with IGF-I measurement, sensitivity and
specificity achieve a value equal to or above 95%
Ottimizzazione dei parametri d’interazione suolo-cingolo nei veicoli fuoristrada
No full textViene proposto un nuovo modello di locomozione in grado di prevedere le condizioni di interazione con un suolo "soffice" e di ottimizzarne i parametri con l'ausilio di un adatto software. La versatilità del modello ha reso possibile lo studio di un fuoristrada capace di assumere una configurazione variabile per meglio adattarsi alle diverse condizioni del terren
Galindent: The reference metrological system for the verification of the geometrical characteristics of Rockwell and Vickers diamond indenters
No full textThe paper describes the GALINDENT system that LTF – Galileo Hardness Testing Department, in
co-operation with the Institute of Metrology "G. Colonnetti", has developed for the geometrical
verification of Rockwell, Vickers diamond indenters, as prescribed by ISO Standards. This system
consists of two instruments: an Interferometric Sine-Bar, for angular, straightness and flatness
measures and a Rotary Table, for the verification of the spherical tip of Rockwell indenters. These
two devices can be set up in one workstation, interfaced with the same computer for data analysis.
A software package has been specifically developed to manage the entire system. The measurement
test cycle is completely automated in order to ensure objective and reliable results. The operator
interface, based on a graphic window menu in the Windows® environment, is extremely user friendly
and it does not require any programming knowledge
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Al bando le periferie. Etnografia, applicazione e implicazione nel Borgo di Chiaravalle (Milano)
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