41 research outputs found
Gideon Sundback fonds, 1942, 1952, 1985-1986, 1991, 2004, n.d.
No full textGideon Sundback was born in Stockholm, Sweden in 1880. He was educated as an engineer and settled in the United States in 1905. While working for the Universal Fastener Company, New Jersey in 1913 he developed and patented a “separable fastener”, which improved on an earlier version of what today is known as the zipper. He later moved his family to Meadville, Pennsylvania and sought a Canadian location for the production of his new invention. He settled on St. Catharines as it was an easy commute from his Pennsylvania home and opened The Lightning Fastener Company on Niagara Street. Sundback died on June 21, 1954 and is interred in Meadville, Pennsylvania. The plant continued to operate, but with increased foreign competition the manufacture of the zipper declined. The plant closed in 1981.
Source: The St. Catharines Standard, July 3, 2004
Harold Fox was a noted lawyer, academic, businessman, author and a leading authority on intellectual property. He was engaged by Gideon Sunback and the Lightening Fastening Company to combat patent infringements by Colonial Fastener in the 1930s. The relationship continued when Fox was asked to become the managing director of the company, which he did until 1949. Fox lived in St. Catharines at his home “Foxcroft” until his death in 1969.
Source: http://thefoxfund.com/harold.htm (November 2, 2009)1 cm of textual material; 2 78 rpm recordings; 2 compact disc
Proteome studies of carp and frog exposed to endocrine disrupting compounds
No full textVitellogenin (Vtg) is a well established plasma biomarker for endocrine disrupting compounds with estrogenic properties in fish. In the EU-project EASYRING carp were exposed to estrogens (17-ethynyl-estradiol, EE2), anti-estrogens (tamoxifen), androgens (17-methyldihydrotestosterone), and anti-androgens (flutamide), as well as to caging in polluted stretches of the Rivers Po and Lambro in Northern Italy. Monoclonal antibodies to carp Vtg were used for specific detection of Vtg in 1D- and 2D-western blotting, and in a quantitative sandwich ELISA and a qualitative lateral flow immunoassay (LFIA) dipstick, for measuring Vtg levels in plasma and mucus. Proteomic-based analysis using 2D-gel electrophoresis and mass spectrometry (MALDI-TOF, LC-MS/MS) identified Vtg as a prominent protein in liver, plasma, and mucus after EE2 exposure. At 64 ng EE2/l induction of multiple Vtg forms was observed in all tissues analyzed. In plasma a total of 30 EE2 inducible Vtg spots was identified, a response accompanied by alterations in the levels of other proteins identified as novel biomarker candidates. The induction and presence of numerous Vtg forms was confirmed by 1-D and 2-D western blot analysis. Quantitative Vtg ELISA showed a dose-dependent increase in plasma and mucus-Vtg, significantly different from control after 4 ng EE2/l in mucus, and 16 ng EE2/l in plasma. Regression analysis of plasma vs. mucus Vtg levels gave strong positive correlations for all groups, except for the fish from tamoxifen and field exposure. Analysis of river sediments using YES revealed a mixture of estrogens, and anti-androgens, suggesting that plasma vs. mucus Vtg profiles may be influenced by the nature of endocrine disrupting chemicals present in the environment
Vitellogenin profiling in liver, plasma and mucus of carp (Cyprinus carpio) exposed to endocrine disrupting chemicals: new facets of an old biomarker gem.
No full textProtocol handbook for NICE-Nitrogen cycling in estuaries: a project under the EU research programme. Marine Science and Technology (MAST III)
No full textApariţia şi evoluţia fermoarului în industria uşoară
No full textÎn lucrare este prezentat un studiu teoretic privind istoria fermoarului. Studiul a fost realizat vizând problema apariţiei şi evoluţiei fermoarului, precum şi nominalizat inventatorul acestui „dispozitiv de închidere automată a hainelor”, cum era numit iniţial fermoarul.La apariţia şi îmbunătăţirea acestei invenţii şi-au adus contribuţii trei savanţi renumiţi ca Elias Howe, Whitcomb L. Judson şi Gideon Sundback care mai era numit Otto Friedrik. Fiecare din ei la momentul său au contribuit la evoluţia acelui dispozitiv de închidere care astăzi îl cunoaştem sub denumirea de fermoar
Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites
No full text[EN] Polyesters based on polyols and sebacic acid, known as poly(polyol sebacate) s (PPS) are good candidates to develop degradable materials, due to their combination of flexibility and degradability, which are both useful properties in the context of soft-tissue engineering (Z. Sun, C. Chen, M. Sun, C. Ai, X. Lu, Y. Zheng, B. Yang and D. Dong, Biomaterials, 2009, 30, 5209, C. Sundback, J. Shyu, Y. Wang, W. Faquin, R. Langer, J. Vacanti and T. Hadlock, Biomaterials, 2005, 26, 5454, D. Motlagh, J. Yang, K. Lui, A. Webb and G. Ameer, Biomaterials, 2006, 27, 4315, A. Mahdavi, L. Ferreira, C. Sundback, J. W. Nichol, E. P. Chan, D. J. D. Carter, C. J. Bettinger, S. Patanavanich, L. Chignozha, E. Ben-Joseph, A. Galakatos, H. Pryor, I. Pomerantseva, P. T. Masiakos, W. Faquin, A. Zumbuehl, S. Hong, J. Borenstein, J. Vacanti, R. Langer and J. M. Karp, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 2307). However, PPS generally display poor mechanical properties, in particular a low modulus, that limit the true potential of these materials in the biomedical field. Here, we introduce an approach to obtain nanocomposites based on poly(mannitol sebacate) (PMS) matrices reinforced with cellulose nanocrystals (CNCs) in order to improve the application range of these materials. Different strategies were used based on varying the feed ratios between mannitol : sebacic acid (1 : 1 and 1 : 2), crosslinking conditions and CNCs content, resulting in different degrees of crosslinking and, therefore, mechanical and degradation behavior. All of the developed nanocomposites displayed the expected mass loss during the degradation studies in simulated body fluid (SBF) similar to the neat matrix, however, doubling the sebacic acid feed ratio or extending the curing temperature and time, resulted in higher mechanical properties, structural integrity, and shape stability during a degradation time lessening mass loss rate. Changing mannitol : sebacic acid reaction ratios from 1 : 1 to 1 : 2 and for low crosslinking degree neat samples, the Young's modulus increases four-fold, while mass loss after 150 days of incubation is reduced by half. The Young's modulus range obtained with this process covers the range of human elastic soft tissues to tough tissues (0.7-200 MPa).The authors gratefully acknowledge financial support received from Spanish Ministry of Economy and Competitiveness (Project MAT2010/21494-C03), as well as the support of FPU grant from MED (MED-FPU; AP2009-2482) and the Adolphe Merkle Foundation.Sonseca Olalla, A.; Sahuquillo, O.; Foster, EJ.; Giménez Torres, E. (2015). Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites. RSC Advances. 5(69):55879-55891. https://doi.org/10.1039/c5ra06768eS558795589156
NK cell inhibitory receptor interactions with MHC class I molecules
No full textNatural killer (NK) cells represent the third population of lymphocytes in size after B- and T-cells. NK mediated killing of target cells is strongly influenced by MHC class I molecules expressed on target cells. In contrast to T-cells, NK cells can be inhibited by MHC class I molecules through the action of specific inhibitory NK cell receptors. In the mouse, the Ly49 family represents the dominating receptors for recognition of classical MHC class I molecules. The Ly-49 family consists of at least 24 family members, Ly-49A to Ly-49W, with both inhibitory and activating receptors in the family.This thesis is devoted to the study of the inhibitory Ly-49 NK cell receptors and how they interact with MHC class I molecules. The interaction was studied on a molecular level with the aim to pinpoint the key contacts that determine the outcome of the Ly-49 receptor - ligand interaction. This has been accomplished by studies of Ly-49A contact sites in H-2D, and by studies of the Ly-49C receptor in terms of ligand recognition and characterization of residues involved in MHC class I binding.In the first study the role of the a-domains of H-2D in Ly-49A mediated inhibition was investigated. Studies of exon shuffled chimeric H-2D molecules showed that inhibition of Ly-49A expressing NK cells required the presence of the alpha2-domain of H-2D. In contrast, inhibition mediated by several human NK cell inhibitory receptors had been reported to depend on residues in the alpha1-domain of the MHC class I molecule. In the following study, the Ly-49A recognition area on MHC class I molecules was studied further by site directed mutagenesis of H-2D. Mutations introducing a hydrophobic ridge in the floor of the antigen binding groove of H-2D affected the interaction with Ly-49A. This indicated a possible involvement of the MHC bound peptides in the interaction.It had previously been shown that Ly-49A receptor expression on NK cells is low in presence of the MHC class I ligand in the host. It was therefore of interest to investigate whether the same rules applied to the Ly-49C receptor, using H-2K b as its major ligand. Ly-49C expression did not only vary depending of the MHC haplotype of the mice tested, the expression was also strongly influenced by the NK gene complex of the mice. It was hypothesized that this influence was due to an allelic variation in the Ly49C gene itself, with consequences for receptor specificity. An allelic variation was indeed confirmed by RTPCR cloning and sequencing of Ly-49C cDNA from the mouse strains C57BL/6 and A/Sn. This was the first cloning of the C57BL/6 allele of Ly-49C. Later studies by several groups suggest that this allelic variation is not influencing receptor specificity, and other factors explaining the original interpretation are discussed in the thesis.Inhibition via some human inhibitory NK receptors is known to be influenced by the peptides bound to MHC class I molecules, in contrast to the mouse Ly-49A receptor which is peptide dependent but not selective. The influence of peptides in the recognition by the Ly-49C receptor was investigated in this thesis. Ly-49C+ NK cells were inhibited efficiently by some but not all H-2K b binding peptides loaded on the TAP deficient cell line RMA-S. Residue 7 in the peptide was crucial in mediating the inhibition via Ly- 49C. Thus, Ly-49C mediated inhibition was peptide selective in context of H-2K b.The studies described above involved investigations of different contact areas in the MHC ligand. The last study of this thesis focused on potential contact residues in the Ly-49C receptor, selected on the basis of a molecular model of this protein. Site directed mutated Ly-49C cDNA was expressed in reporter cells, and tested for binding to H-2 class I tetramers refolded with different peptides. Three out of nine mutations in Ly-49C led to reduced or complete loss of binding of H-2D b, H-2D d and H-2Kb AMC class I tetramers. The three mutations that affected MHC class I binding were compared to the crystal structure of the Ly-49A - H-2D d co-complex. It was concluded that Ly-49C used partly the same residues as Ly49A to bind MHC class I ligands, suggesting that both receptors may bind MHC class I molecules in a similar fashion. A model based on this notion and the formation of multiple receptor-ligand lattices in the interface between the NK cell and the target cell is discussed.List of scientific papersI. Sundback J, Nakamura MC, Waldenstrom M, Niemi EC, Seaman WE, Ryan JC, Karre K (1998). "The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. " J Immunol 160(12): 5971-8 https://pubmed.ncbi.nlm.nih.gov/9637511II. Waldenstrom M, Sundback J, Olsson-Alheim MY, Achour A, Karre K (1998). "Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft. " Eur J Immunol 28(9): 2872-81 https://pubmed.ncbi.nlm.nih.gov/9754574III. Sundback J, Karre K, Sentman CL (1996). "Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes. " J Immunol 157(9): 3936-42 https://pubmed.ncbi.nlm.nih.gov/8892625IV. Franksson L, Sundback J, Achour A, Bernlind J, Glas R, Karre K (1999). "Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C. " Eur J Immunol 29(9): 2748-58 https://pubmed.ncbi.nlm.nih.gov/10508249V. Sundback J, Achour A, Michaelsson J, Lindstrom H, Karre K (2001). "NK cell inhibitory receptor Ly49C resiudes involved in MHC class I binding." (Manuscript)</p
Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice
No full textBook reviews
No full textForging a new self: the Adamic protagonist and the emergence of a Jewish-American author as revealed through the novels of Bernard Malamud (Pirjo Ahokas, 1991) is reviewed by Paul Levine.EN TREUER KETZER. Studien zu Manès Sperbers Romantrilogie "We eine Träne im Ozean" (Claudia Sternberg, 1991, diss.) is reviewed by Margit Frank.Vilna on the Seine. Jewish intellectuals in France since 1968 (Judith Friedlander, 1990) is reviewed by Juhani Ihanus.Suomen juutalaisten aseveljeys (Hannu Rautakallio, 1989) is reviewed by Tapani Harviainen.Karaites and dejudaization. A historical review of an endogenous and exogenous paradigm (Roman Freund, 1991) is reviewed by Tapani Harviainen.Hakkorset och Wasakärven. En studie av nationalsocialismen i Sverige 1924–1950 (Heléne Lööw, 1990) and Führerns trogna följeslagare. Den finländska nazismen 1932–1944 (Henrik Ekberg, 1991) are reviewed by Lauri Karvonen.Juden in der Soziologie. Eine öffentliche Vortragsreihe an der Universität Konstantz 1989 (ed. Erhard R. Wiehn, 1989) is reviewed by Susan Sundback.Bibeln: tillägg till gamla testamentet: de apokryfa eller deuterokanoniska skrifterna (1986) and God och nyttig läsning: om gamla testamentets apokryfer (P. Block, J. Blomqvist, G-B Sundström, C. Åsberg, 1988) are reviewed by Nils Martola.Tradition og nybrud: jødedommen i hellenistisk tid (eds. Troels Engberg-Pedersen, Niels Lemche, 1990) is reviewed by Nils Martola.Short notice by Nils Martola.Jerusalem ja Rooma (Pauli Huuhtanen, 1989) is reviewed by Nils Martola.Minnen och tankar (Bruno Bettelheim, 1991) is reviewed by Karl-Johan Illman.Jødiske høytider i evangelisk lys (Dag Bughaug, 1991) is reviewed by Karl-Johan Illman.Antisemitismen. En historisk skildring i ord och bild (Hans Jansen, Janrense Boonstra, Joke Kniesmeyer, 1991) is reviewed by Karl-Johan Illman.Kyrkan och det judiska folket (Svenska kyrkans mission, 1991) is reviewed by Karl-Johan Illman.Mellan ord och tystnad. Essäer (Mona Vincent, 1991) is reviewed by Karl-Johan Illman.
