515 research outputs found

    Kolozsvár - Ferencz József-utca : levelező-lap (28)

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    Kolozsvár - Ferencz József-utca [material iconografic] : levelező-lap (28). - [S. l.] : [s. n.], [191-?]. - 1 ilustrată : color ; 10x15 cm. - Denumirea actuală: strada Horea. Denumiri vechi: Horthy út, Ferenc József út, str. Regele Ferdinand, Nagy utcza

    Kolozsvár - Deák Ferencz-utca : levelező-lap

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    Kolozsvár - Deák Ferencz-utca [material iconografic] : levelező-lap. - [S. l.] : [s. n.], [191-?]. - 1 ilustrată : color ; 9x14 cm. - Denumirea actuală: Bulevardul Eroilor. Denumiri vechi: str. Regina Maria, str. Dr. Petru Groza, Belső-Közép utca, Közép utca, Deák Ferenc utca, Hősök útja

    Genetic and lifestyle influences on memory, brain structure, and dementia

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    This doctoral thesis investigated genetic, inflammatory, and lifestyle influences on cognition, brain structure, and dementia. The influence of TOMM40 polymorphisms (Study I), a PICALM, BIN1 and CLU genetic risk score (GRS; Studies II, III), and inflammatory cytokines (Study IV) was assessed, as well as potential interactions with physical activity (Studies II-IV). All studies were based on the Swedish National study on Aging and Care in Kungsholmen (SNAC-K), including a subsample that had participated in magnetic resonance imaging (MRI).In Study I, the influence of TOMM40 polymorphisms (rs11556505 and rs2075650) on episodic memory and hippocampal volume was investigated. There was no independent influence of TOMM40 polymorphisms on episodic memory and hippocampal volume. However, carriers of an APOE ε4 allele who also harbored TOMM40 risk alleles relied more heavily on hippocampal volume for episodic memory performance. Study II confirmed our hypothesis that high genetic risk (GRS >4) based on Alzheimer’s disease (AD) candidate genes (PICALM rs3851179, rs541458, BIN1 rs744373, and CLU rs11136000) was associated with worse episodic memory performance in non-demented older adults. Interestingly, there was an interaction between physical activity and GRS. The combination of physical inactivity and high genetic risk was most detrimental to memory performance, whereas a high GRS could be compensated for by physical activity. In Study III, we investigated if the same GRS was associated with incident dementia, primarily AD. Despite the associations with memory performance in Study II, there was no effect of GRS on incident dementia during a follow-up period of 6 years. Nonetheless, we did replicate previous work showing that physical inactivity is associated with increased risk of dementia. Study IV investigated the influence of inflammatory cytokines and physical activity on graymatter volume and global cognitive decline. Although there was no relation between inflammatory cytokines and brain volume, high levels of IL-12p40 in individuals who were physically inactive were associated with smaller lateral prefrontal cortex and hippocampal volumes, as well as with global cognitive decline over 6 years. This suggests that levels of inflammation may be especially detrimental for brain and cognitive integrity in individuals who are physically inactive.In summary, the studies in this thesis suggest that physical inactivity is associated with reduced episodic memory performance, compromised structural brain volume, and dementia risk. Moreover, physical inactivity in combination with a high GRS or systemic inflammation was especially detrimental to episodic memory as well as to frontal and hippocampal volumes, respectively.List of scientific papersI. Ferencz, B., Laukka, E. J., Lövdén M., Kalpouzos, G., Keller, L., Graff, C., Wahlund, L. O., Fratiglioni, L., & Bäckman, L. (2013). The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age. Frontiers in Human Neuroscience. 22(7), 198. https://doi.org/10.3389/fnhum.2013.00198 II. Ferencz, B., Laukka, E. J., Welmer, A. K., Kalpouzos, G., Angleman, S., Keller, L., Graff, C., Lövdén, M., & Bäckman, L. (2014). The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1 and CLU risk alleles on episodic memory functioning. Psychology and Aging. 29(2), 440-449. https://doi.org/10.1037/a0035465 III. Ferencz, B., Bäckman, L., Fratiglioni, L., & Laukka, E. J. Effects of a genetic risk score and physical inactivity on dementia incidence: A 6-year follow-up. [Manuscript]IV. Papenberg, G., Ferencz, B., Mangialasche, F, Mecocci, P., Cecchetti, R., Kalpouzos, G., Fratiglioni, L., & Bäckman, L. (2016). Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging. Human Brain Mapping. 37(10), 3462-3473. https://doi.org/10.1002/hbm.23252 </p

    Kolozsvár - A kolozsvári "Marianum" leánynevelő intézet Ferencz József-úti homlokzata : levelező-lap (892)

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    Kolozsvár - A kolozsvári "Marianum" leánynevelő intézet Ferencz József-úti homlokzata [material iconografic] : levelező-lap (892) / tervezte Hübner Jenő. - [S. l.] : [s. n.], [191-?]. - 1 ilustrată : in sepia ; 10x14 c

    Physical activity and inflammation: effects on gray‐matter volume and cognitive decline in aging

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    Physical activity has been positively associated with gray-matter integrity. In contrast, pro-inflammatory cytokines seem to have negative effects on the aging brain and have been related to dementia. It was investigated whether an inactive lifestyle and high levels of inflammation resulted in smaller gray-matter volumes and predicted cognitive decline across 6 years in a population-based study of older adults (n = 414). Self-reported physical activity (fitness-enhancing, health-enhancing, inadequate) was linked to gray-matter volume, such that individuals with inadequate physical activity had the least gray matter. There were no overall associations between different pro-and anti-inflammatory markers (IL-1β, IL-6, IL-10, IL-12p40, IL-12p70, G-CSF, and TNF-α) and gray-matter integrity. However, persons with inadequate activity and high levels of the pro-inflammatory marker IL-12p40 had smaller volumes of lateral prefrontal cortex and hippocampus and declined more on the Mini-Mental State Examination test over 6 years compared with physically inactive individuals with low levels of IL-12p40 and to more physically active persons, irrespective of their levels of IL-12p40. These patterns of data suggested that inflammation was particularly detrimental in inactive older adults and may exacerbate the negative effects of physical inactivity on brain and cognition in old age. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc

    Veterinarius 1. évf. 21. szám

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    Az anyagcsere a szövetekben. L. — A szaktársakhoz. Czike Ferencz. — Mérgezés Phosphor gyúanyaggal. Dr. Nádaskay. — Kisebb közlemények. — Különfélék. — Szerkesztői közlemény

    Történelmi közlemények Abauj-Torna vármegye és Kassa multjából

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    Előszó. Irta: dr. Békefi Remig II. Rákóczi Ferencz fejedelem istállója. Irta: Csorna József Abaujvármegye és Kassa városa az I. Rákóczi Ferencz- és Thököly-féle fölkelések korában. (1670—1685.) Irta: Szabó Adorján A kassai református egyház levéltára. Irta: Révész Kálmán Abauj- és Tornavármegye a honfoglalás előtt. Irta: Csorna József Kassa küzdelme a német katonaság beszállásolása ellen. Közli: Kerekes György Családtörténet. Abauj- és Tornavármegye nemeseinek összeírásai. Közli: dr. Czobor Alfréd A Tornavármegyében kihirdetetett czimeres nemeslevelek. Közli: dr. Czobor Alfréd Vegyesek. II. Rákóczi Ferencz Abaujvármegye közgyűlésén. Közli: dr. Cz. A. Két községi szabadalomlevél. Közli: K. L. Palatínus urunk őnagysága vendégségére való költségnek rendi. Irta: Kemény Lajos Miért húzták meg sz. Jakab napján az Orbán-harangot. Irta: K. L. Irodalo

    A Magyar Tudományos Akadémia elhunyt tagjai fölött tartott emlékbeszédek 12.

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    1903. - 1. szám: Taine Hippolyte emlékezete Alexander Bernát lev. tagtól 1 1904. - 2. szám: Heller Ágost emlékezete Fröhlich Izidor r. tagtól 45 1904. - 3. szám: Kerékgyártó Alajos Árpád emlékezete Békefi Remig lev. tagtól 87 1904. - 4. szám: Plósz Pál emlékezete Lengyel Béla r. tagtól 117 1904. - 5. szám: Bethlenfalvi Balássy Ferencz emlékezete Szentkláray Jenő l. tagtól 137 1904. - 6. szám: Kondor Gusztáv lev. tag emlékezete Kövesligethy Radó l. tagtól 183 1904. - 7. szám: Emlékbeszéd Krones Ferencz k. tag felett Wertheimer Ede l. tagtól 213 1904. - 8. szám: Emlékbeszéd Bertrand Sándor k. tag fölött Wosinsky Mór l. tagtól 233 1905. - 9. szám: Emlékbeszéd Torma Károly r. tag fölött Téglás Gábor l. tagtól 255 1905. - 10. szám: Emlékbeszéd Czobor Béla r. tag fölött Békefi Remig l. tagtól 291 1905. - 11. szám: Emlékbeszéd Ráth Zoltán l. tag fölött Vargha Gyula l. tagtól 33

    Photo 1940 - Case 9 Prosecution Staff

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    Case 9 - Ohlendorff or Einsatz Case Members of Prosecution staff, Case 9 (L to R): Benjamin B. Ferencz, Arnost Horlik-Hochwald, and John E. Glancy.https://digitalcommons.law.uga.edu/trial_photos/1038/thumbnail.jp
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