260 research outputs found
Estudi experimental del tractament de la meningitis pneumocòcica produïda per soques resistents a cefalosporines de tercera generació. Virulència, eficàcia i resposta inflamatòria
No full text[cat] La meningitis pneumocòcica és una malaltia associada a una elevada mortalitat (20-40) i a l'aparició de seqüeles neurològiques en un 30% dels pacients, nens i adults, que sobreviuen. Des del punt de vista farmacològic, és una malaltia complicada:- La penetració dels antibiòtics a través de la barrera hematoencefàlica és reduïda.- Es genera una resposta inflamatòria greu en l'espai subaracnoidal, responsable del dany cerebral associat.- L'aparició de soques de "S.pneumoniae" multiresistents no garanteix l'eficàcia del tractament empíric.En els darrers anys s'han detectat soques amb un elevat nivell de resistència a cefalosporines de tercera generació (C3G). La baixa prevalença d'aquests aïllaments dificulta per una banda, el coneixement del seu comportament in vivo i per l'altra, la valoració de l'eficàcia dels tractaments estàndard.En aquesta tesi s'ha demostrat la capacitat d'una soca de "S.pneumoniae" amb un elevat nivell de resistència a C3G a l'hora d'induir meningitis i provocar una resposta inflamatòria greu en el LCR en el model animal. Els nostres experiments demostren que l'adquisició de resistència antibiòtica no ha alterat ni la patogenicitat ni la virulència d'aquestes soques. Les combinacions ceftriaxona més vancomicina, ceftriaxona més rifampicina i rifampicina més vancomicina es van revelar eficaces en la meningitis pneumocòcica per una soca amb un elevat grau de resistència a C3G, tant per la millora de l'eficàcia com per l'atenuació de la resposta inflamatòria respecte a les monoteràpies. Aquests resultats reforcen les recomanacions dels experts i proporcionen una base experimental per a que siguin aplicables en meningitis causades per "S. pneumoniae" sigui quin sigui el seu nivell de resistència a beta-lactàmics. La fosfomicina ha demostrat una elevada penetració a través de la barrera hematoencefàlica en el model animal en conill. No obstant, el desenvolupament de resistència antibiòtica en el model experimental descarta el seu ús en monoteràpia. A més a més, en base als fracassos terapèutics observats proposem revisar els punts de tall de la sensibilitat de "S. pneumoniae" a fosfomicina en la infecció meníngia.Les combinacions de fosfomicina estudiades han demostrat una excel·lent activitat envers dues soques de pneumococ resistent a beta-lactàmics, així com un efecte protector davant el desenvolupament de mutants resistents. A partir dels nostres resultats, recomanaríem com alternatives terapèutiques la combinació fosfomicina més ceftriaxona en pacients amb intolerància a glicopèptids o amb insuficiència renal; i la combinació fosfomicina més vancomicina en pacients al·lèrgics a beta-lactàmics
Discordant Identities and Disjunctive Authority in a Perverse Narrative: Julieta Campos’ Tiene los cabellos rojizos y se llama Sabina
No full textIntroduction: In The Spanich American Regional Novel: Modernity and Autochthony, Carlos Alonso argues that the movement away from modernity became discursively and politically institutionalized as a continual search for identity that provided that foundation for an intrinsically Spanish American cultural enterprise. His more recent book, The Burden of Modernity: The Rhetoric of Cultural Discourse in Spanish America, seeks to document: "[...] that moment in which the gesture of allegiance and obeisance toward the modern is eschewed - however ambiguously or paradoxically - by recourse to a given textual practice that renders that gesture problematic (Alonso 1998: v)." Conglating the two meanings of modernity - both a concept or aesthetic ideal and a socioeconomic reality or phase of Western historical development - he looks at the specifics of the Spanish American writer's relationship to modernity, arguing that the "[...] intrinsic discordances and disjunctions, which are characteristic of all writing, become more salient in the Spanish American text given the particular nature of the rhetorical situation in which it is inscribed (ibid.: 5)." Alonso's provocative discussion of modernity and postmodernity in the Spanish American context provides certain points of departure for a discussion of the problematics of identity and authority in Julieta Campos' Tiene los cabellos rojizos y se llama Sabina, a postmodern novel whose intrinsic discordances and disjunctions are perhaps its most salient features."
Topological Network Traffic Compression
No full textThe surge in computer network traffic, fueled by emerging applications and technology advancements, is creating a pressing need for efficient techniques to store and analyze massive traffic traces. This paper introduces a novel approach to address this challenge by employing Topological Deep Learning (TDL) for lossy traffic compression. Unlike Graph Neural Networks (GNNs), which rely on the binary interactions and local neighborhoods defined by graph representations, TDL methods can naturally accommodate higher-order relations among arbitrary network elements, thus offering more expressive representations beyond the graph domain. In particular, our proposed traffic compression framework aims to detect higher-order correlated structures within traffic data and employs Topological Neural Networks to generate compressed representations within these sets. This work assesses if this approach can outperform conventional Machine Learning (ML) compression architectures by better exploiting multi-datapoint interactions, potentially capturing correlations between distant network elements. We evaluate our method on two real-world networking datasets, comparing it against GNN-based architectures and a Multi-Layer Perceptron autoencoder designed for this task. The results demonstrate significant improvements w.r.t. ML baselines - from 30% up to 90% better reconstruction errors across all scenarios - , establishing our topological framework as a strong baseline for lossy neural traffic compression
Computational models for the assessment of manufactured nanomaterials: development of model reporting standards and mapping of the model landscape
No full textDifferent types of computational models have been developed for the prediction of biokinetics, environmental fate, and the estimation of exposure levels and toxicological effects of chemicals and manufactured nanomaterials (MNs). However, these models are not described in a consistent manner in the scientific literature, which is one of the barriers to their broader use and acceptance, especially for regulatory purposes. Quantitative structure-activity relationships (QSARs) are in silico models based on the assumption that the activity of a substance is related to its chemical structure. These models can be used to provide information of (eco)toxicological effects in hazard assessment. In the context of an environmental risk assessment, environmental exposure models can be used to estimate the predicted environmental concentration (PEC). In addition, physiologically based kinetic (PBK) models can be used in various ways to support a human health risk assessment. In this paper, we propose model reporting templates for systematically and transparently describing models that could potentially be used to support regulatory risk assessments of MNs, for example under the REACH regulation. The model reporting templates include (a) the adaptation of the QSAR Model Reporting Format (QMRF) to report models for MNs, and (b) the development of a model reporting template for PBK and environmental exposure models applicable to MNs. Second, we show the usefulness of these templates to report different models, resulting in an overview of the landscape of available computational models for MNs.Different types of computational models have been developed for predicting the biokinetics, environmental fate, exposure levels and toxicological effects of chemicals and manufactured nanomaterials (MNs). However, these models are not described in a consistent manner in the scientific literature, which is one of the barriers to their broader use and acceptance, especially for regulatory purposes. Quantitative structure-activity relationships (QSARs) are in silico models based on the assumption that the activity of a substance is related to its chemical structure. These models can be used to provide information on (eco)toxicological effects in hazard assessment. In an environmental risk assessment, environmental exposure models can be used to estimate the predicted environmental concentration (PEC). In addition, physiologically based kinetic (PBK) models can be used in various ways to support a human health risk assessment. In this paper, we first propose model reporting templates for systematically and transparently describing models that could potentially be used to support regulatory risk assessments of MNs, for example under the REACH regulation. The model reporting templates include (a) the adaptation of the QSAR Model Reporting Format (QMRF) to report models for MNs, and (b) the development of a model reporting template for PBK and environmental exposure models applicable to MNs. Second, we show the usefulness of these templates to report different models, resulting in an overview of the landscape of available computational models for MNs
Physiologically based mathematical models of nanomaterials for regulatory toxicology: A review
No full textThe development of physiologically based (PB) models to support safety assessments in the field of nanotechnology has grown steadily during the last decade. This review reports on the availability of PB models for toxicokinetic (TK) and toxicodynamic (TD) processes, including in vitro and in vivo dosimetry models applied to manufactured nanomaterials (MNs). In addition to reporting on the state-of-the-art in the scientific literature concerning the availability of physiologically based kinetic (PBK) models, we evaluate their relevance for regulatory applications, mainly considering the EU REACH regulation. First, we performed a literature search to identify all available PBK models. Then, we systematically reported the content of the identified papers in a tailored template to build a consistent inventory, thereby supporting model comparison. We also described model availability for physiologically based dynamic (PBD) and in vitro and in vivo dosimetry models according to the same template. For completeness, a number of classical toxicokinetic (CTK) models were also included in the inventory. The review describes the PBK model landscape applied to MNs on the basis of the type of MNs covered by the models, their stated applicability domain, the type of (nano-specific) inputs required, and the type of outputs generated. We identify the main assumptions made during model development that may influence the uncertainty in the final assessment, and we assess the REACH relevance of the available models within each model category. Finally, we compare the state of PB model acceptance for chemicals and for MNs. In general, PB model acceptance is limited by the absence of standardised reporting formats, psychological factors such as the complexity of the models, and technical considerations such as lack of blood:tissue partitioning data for model calibration/validation
Cabellos de Sansón [Material gráfico] / T. L. Enguid. de ag. fte. ; Alex.o Blanco concl.
No full textInscripción en la parte superior: "Lam. 12; Tom. 1º. Pag. 179"Inscripción: "Importunado Sanson por su amada Dálila, reveló á esta que su milagrosa fuerza consisitía en no haberse jamás cortado los cabellos; y esta muger pérfida, sobornada por los Filistéos, proporcionó que durmiendo Sanson descuidado en el seno de ella, le cortasen sus enemigos el cabello. Asi le ataron facilmente, le sacaron los ojos, y sufrió mil ultrages hasta que, habiendole crecido nuevamente el cabello, derribó un templo, en cuyas ruinas quedó sepultado con sus enemigos."Sansón aparece recostado. Dalila detrás. Un hombre cortando el pelo a Sansón. Fondo compuesto por escenográficas cortinas.Páez Ríos, Elena: Repertorio..., II, 1227-4Páez Ríos, Elena: Iconografía Hispana..., III, 7565-2Estampa suelta de:: Compendio de la historia universal o Pintura histórica de todas las naciones su origen, vicisitudes y progresos hasta nuestros días / obra escrita en francés por Mr. Anquetil ; y traducida por el P.D. Francisco Vázquez. - Madrid: Imprenta que fue de Fuentenebro, 1829-1830. T.I (517 p., h. de lám. 1-47
Assessment of fissionable material behaviour in fission chambers
No full textA comprehensive study is performed in order to assess the pertinence of fission chambers coated with different fissile materials for high neutron flux detection. Three neutron scenarios are proposed to study the fast component of a high neutron flux: (i) high neutron flux with a significant thermal contribution such as BR2, (ii) DEMO magnetic fusion reactor, and (iii) IFMIF high flux test module.
In this study, the inventory code ACAB is used to analyze the following questions: (i) impact of different deposits in fission chambers; (ii) effect of the irradiation time/burn-up on the concentration; (iii) impact of activation cross-section uncertainties on the composition of the deposit for all the range of burn-up/irradiation neutron fluences of interest. The complete set of nuclear data (decay, fission yield, activation cross-sections, and uncertainties) provided in the EAF2007 data library are used for this evaluation
IP-layer soft handoff implementation in ILNP
No full textDate of Acceptance: 14/07/2014We present the first results of an implementation of IP-layer soft handoff, based on the Identifier Locator Network Protocol (ILNP). In our testbed experiments, we show minimal gratuitous packet loss in vertical handoff scenarios (WiFi-3G). Unlike the IETF Mobile IP proposals, the ILNP uses a purely end-to-end architecture, and does not require proxies, middleboxes or tunnelling to support mobility. Our testbed is based on an in-kernel implementation using a modified Linux IP stack
Diseño y formulación de un champú a base de extracto alcohólico de Urtica urens L. para su aplicación contra la caída del cabello
No full textIntroducción: la caída de cabello es un tema que nos tiene muy pendientes de cuántos cabellos se nos caen y cómo evitarlo. Podemos prevenir algún tipo de caída o actuar en estadios iniciales de un proceso de caída para mejorar el estado del cabello, para favorecer el crecimiento del cabello más saludable y fortalecido o contribuir en prolongar los ciclos de vida del cabello. Objetivo: Diseñar y formular el Champú conteniendo el extracto alcohólico de Urtica urens L. Diseño: analítico, experimental y comparativo. Lugar: Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú. Material y método: hojas de la planta. Conejos blancos, raza neozelandesa machos (Ensayo irritación para evaluación biológica de productos sanitarios). Formaron parte del presente estudio personas diagnosticadas con caída del cabello de origen no patológico, en número de 10 personas que fueron evaluados por un profesional médico, por espacio de 21 días. Se sometieron a observación microscópica los cabellos caídos a diario para evaluar si existe aumento del diámetro del cabello comparándolos al inicio y al final del estudio. Se obtuvo el recuento de cabellos caídos por día durante todo el tratamiento. Utilizando el método de recuento de cabellos estandarizado por 60 segundos. Resultados: el porcentaje de reducción de caída del cabello fue de 56,8% para el grupo de personas que utilizaron el champú a una concentración al 2% y 32,1% para el grupo de personas que utilizaron el champú a una concentración al 5%. Se compararon los promedios de diámetro de cabellos caídos y evaluación de recuento de pelos caídos por día, utilizando el método de recuento de cabellos estandarizado por 60 segundos. Conclusiones: se pudo diseñar y formular un champú conteniendo extracto alcohólico de Urtica urens L.; demostrando su efectividad en el tratamiento contra la caída del cabello logrando una mejora mayor al 50% y además se determinó que no produce irritabilidad dérmica.Introduction: Hair loss is a topic that has us very aware of how many hairs we fall and how to avoid it. We can prevent any type of fall or act on early stages of a process of falling to improve the condition of the hair, to promote the growth of healthier, stronger hair or contribute to prolonging the life cycle of hair. Objective: To design and develop Shampoo containing the alcoholic extract of Urtica urens L. Design: Analytical, experimental and comparative study. Location: College of Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Methods: plant leaves. White rabbits, New Zealand breed males (irritation test for biological evaluation of medical devices). They formed part of this study diagnosed with hair loss of non-pathological origin, numbering 10 people were evaluated by a medical professional, for 21 days. Microscopic observation underwent the fallen hair daily to assess whether there is increased hair diameter compared to the beginning and end of the study. Fallen hair count per day throughout the treatment was obtained. Using the method of standardized hair count by 60 seconds. Results: the percentage reduction in hair loss was 56.8% for the group of people who used the shampoo at a concentration of 2% and 32.1% for the group of people who used the shampoo at a concentration 5 %. Average diameter of fallen hairs counting and evaluation fallen hairs per day were compared, using the method of standard hair count for 60 seconds. Conclusions: it was possible to design and formulate a shampoo containing alcoholic extract of Urtica urens L. ; proving its effectiveness in treating hair loss improves achieving greater than 50% and also determined not produce skin irritability.
Keywords: Hair Shampoo, alcoholic extract of Urtica urens L., standard hair count by 60 seconds.Tesi
Dr. Gerardo Antonio Pineda
No full text"Formato rectangular vertical. Representación de figura masculina en posición frontal y formato de busto, lleva anteojos, barba, bigote y escasos cabellos blancos peinados hacia atrás, camisa blanca con botones del mismo color, corbatín azul oscuro y saco de solapa ancha de similar color. El fondo de la composición esta realizado en degradaciones de color verde claro. Hacia el costado inferior izquierdo de la obra la firma del artista: J. I. ZAMBRANO L. Sobre el cabezal inferior una placa con la siguiente inscripción:
DR. GERARDO ANTONIO PINEDA BENEFACTOR DE LA FACULTAD DE ODONTOLOGIA 1954
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