1,720,959 research outputs found

    Comparison of the Civil Service System in Croatia and France

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    U radu je provedena komparativna analiza službeničkog sustava u Hrvatskoj i Francuskoj s ciljem istraživanja i usporedbe karakteristika, strukture i uloga službeničkog sustava u navedene dvije zemlje. U radu se definira opći pojam i značaj službeničkog sustava, uključujući klasifikaciju poslova u državnoj službi. Na temelju provedene analize se utvrđuju ključne sličnosti i razlike između dviju zemalja te se iznose prijedlozi za unapređenje službeničkog sustava u Hrvatskoj. Provedbom istraživanja se teži doprinijeti boljem razumijevanju službeničkih sustava u različitim nacionalnim kontekstima u okviru EU kao i pružiti prijedloge za unapređenje službeničkog sustava u RH.In the paper, a comparative analysis of the civil service system in Croatia and France was carried out with the aim of researching and comparing the characteristics, structure and roles of the civil service system in the two mentioned countries. The paper defines the general concept and significance of the civil service system, including the classification of jobs in the civil service. Based on the analysis, the key similarities and differences between the two countries are determined, and suggestions are made for improving the civil service system in Croatia. By carrying out the research, the aim is to contribute to a better understanding of civil service systems in different national contexts within the EU, as well as to provide proposals for improving the civil service system in the Republic of Croatia

    Biological therapy and other new therapeutic approaches to inflammatory bowel disease treatment in children

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    Kronična upalna bolest crijeva zauzima značajno mjesto u bolestima gastrointestinalnog sustava u djetinjstvu i adolescenciji, a uključuje Crohnovu bolest, ulcerozni kolitis i nerazvrstani kolitis. U otprilike 25% pacijenata s kroničnom upalnom bolesti crijeva, bolest se dijagnosticira prije navršene osamnaeste godine života. Etiologija bolesti je nepoznata, ali se smatra da interakcija okolišnih i genetskih faktora s imunološkim sustavom rezultira neadekvatnim imunološkim odgovorom, s posljedičnom upalom crijevne sluznice. Cilj liječenja je inducirati remisiju bolesti i postići mukozno cijeljenje te svesti nuspojave lijekova na najmanju moguću mjeru. Isključiva enteralna prehrana je učinkovita terapija za indukciju remisije u djece s Crohnovom bolesti i trebala bi biti prva terapijska linija u bolesnika s blažom ili umjereno teškom, nekompliciranom bolesti. Iskorak u liječenju kronične upalne bolesti crijeva napravila je biološka terapija te u novije vrijeme i bioslični lijekovi sa sličnim profilom sigurnosti i učinkovitosti. Biološki lijekovi mogu modificirati tijek bolesti te zaustaviti njezinu progresiju inhibicijom upalne kaskade koja se nalazi u podlozi kronične upalne bolesti crijeva. Pokazali su se učinkovitim u liječenju težih oblika bolesti i bolesti refraktornoj na konvencionalnu terapiju. Noviji pristupi liječenju kronične upalne bolesti crijeva su transplantacija fekalne mikrobiote i antibiotska terapija. Ovi terapijski pristupi mogu utjecati na tijek bolesti promjenom sadržaja crijevnog mikrobioma. Također, noviji pristup je primjena talidomida i transplantacija matičnih stanica. Noviji načini liječenja su se pokazali učinkoviti u indukciji remisije, ali su potrebne dodatne studije za evaluaciju njihove sigurnosti i dugotrajnije učinkovitosti u pedijatrijskoj populaciji.Inflammatory bowel disease occupies a significant place among gastrointestinal diseases in childhood and adolescence and includes Crohn’s disease, ulcerative colitis, and undetermined colitis. About 25% of inflammatory bowel disease patients are diagnosed before the age of 18. The etiology of the disease is unknown, but it is considered that interaction of environmental and genetic factors with the immune system, results in an dysregulated immune response responsible for chronic intestinal inflammation. The treatment goal is to induce clinical remission, to achieve mucosal healing while minimizing the drug’s side effects. Exclusive enteral nutrition is an effective treatment for induction of remission in pediatric Crohn’s disease and should be the first-line treatment in patients with mild and moderate, uncomplicated disease. A step forward in inflammatory disease treatment was achieved with biological therapy and recently with biosimilars that have shown similar safety and efficacy profiles. Biological drugs can alter the disease course and limit its progression through inhibition of the inflammatory process underlying inflammatory bowel disease and are useful in treatment of patients with severe disease or with disease refractory to conventional therapy. New treatment modalities are fecal microbiota transplantation and antibiotic therapy. They may influence the course of the disease by altering the composition of intestinal microbiota. Also new therapeutic approaches are use of thalidomide and stem cell transplantation. New treatment modalities have been effective in remission induction but additional studies to determine their long term efficacy and safety in pediatric population are needed

    Milosrđe kao put ostvarenja čovještva u misli Ivana Pavla II.

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    Cilj ovoga rada, podijeljenog na četiri dijela, je prikazati Božje milosrđe onako kako ga je u svom pontifikatu naučavao papa Ivan Pavao II., kojem je govor o milosrđu u središtu života i djelovanja. Prvo poglavlje govori o čovjeku u misli pape Ivana Pavla II. U drugom poglavlju osvrnut ćemo se na govor o milosrđu kao očitovanju Božje ljubavi od stvaranja do prvoga grijeha te vremenu i povijesti nakon počinjenoga grijeha. Treće poglavlje govori o milosrđu kao putu ostvarenja čovještva, što je ujedno ključna točka i vrhunac ovoga rada. Ovo poglavlje progovara o istinskoj humanizaciji čovjeka u Crkvi kroz sakralizaciju i življenje kulture milosrđa u konkretnoj ljubavi prema malenima, slabima, bijednima, bolesnima, potlačenima i poniženima, svima koji nepravedno trpe i koji su odbačeni. Četvrto poglavlje govori o Crkvi kao svjedokinji Božjeg milosrđa u svijetu te o nekim posebnostima govora o milosrđu kod pape Benedikta XVI. i pape Franje koje je na poseban način obilježilo njihov život

    Comparison of the Civil Service System in Croatia and France

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    U radu je provedena komparativna analiza službeničkog sustava u Hrvatskoj i Francuskoj s ciljem istraživanja i usporedbe karakteristika, strukture i uloga službeničkog sustava u navedene dvije zemlje. U radu se definira opći pojam i značaj službeničkog sustava, uključujući klasifikaciju poslova u državnoj službi. Na temelju provedene analize se utvrđuju ključne sličnosti i razlike između dviju zemalja te se iznose prijedlozi za unapređenje službeničkog sustava u Hrvatskoj. Provedbom istraživanja se teži doprinijeti boljem razumijevanju službeničkih sustava u različitim nacionalnim kontekstima u okviru EU kao i pružiti prijedloge za unapređenje službeničkog sustava u RH.In the paper, a comparative analysis of the civil service system in Croatia and France was carried out with the aim of researching and comparing the characteristics, structure and roles of the civil service system in the two mentioned countries. The paper defines the general concept and significance of the civil service system, including the classification of jobs in the civil service. Based on the analysis, the key similarities and differences between the two countries are determined, and suggestions are made for improving the civil service system in Croatia. By carrying out the research, the aim is to contribute to a better understanding of civil service systems in different national contexts within the EU, as well as to provide proposals for improving the civil service system in the Republic of Croatia

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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