583 research outputs found
The phenomenon of Yulia Tymoshenko in politics of Ukraine
No full textYulia Tymoshenko's leadership style and leadership are analy¬zed and described in this article. The author stated that political opposition was a natural element for Tymoshenko. Her time as Prime Minister was rather controversial, hence the assessements of her successes and failures propensities to vary. A description of Tymoshenko as a political party leader that included the way she chose people to work with was also given
"Yulia" by N. M. Karamzin: the first experience of creating a high society story in Russian literature
No full textВ статье рассматривается повесть Н. М. Карамзина "Юлия" в аспекте жанра. В ходе анализа приводятся дополнительные аргументы в пользу того, что "Юлия" является первой в отечественной литературе светской повестью, давшей начало перспективной жанровой традиции.In the article N. M. Karamzin's story "Yulia" is considered in aspect of a genre. During the analysis the author of the article brings the additional arguments in favor of the fact that "Yulia" is the first "high society story" in the domestic literature. Such a story opened a perspective genre tendency for further literature
"Yulia" by N. M. Karamzin: the first experience of creating a high society story in Russian literature
No full textВ статье рассматривается повесть Н. М. Карамзина "Юлия" в аспекте жанра. В ходе анализа приводятся дополнительные аргументы в пользу того, что "Юлия" является первой в отечественной литературе светской повестью, давшей начало перспективной жанровой традиции.In the article N. M. Karamzin's story "Yulia" is considered in aspect of a genre. During the analysis the author of the article brings the additional arguments in favor of the fact that "Yulia" is the first "high society story" in the domestic literature. Such a story opened a perspective genre tendency for further literature
UPAYA-UPAYA ROOM ATTENDANT DALAM MEMELIHARA KENYAMANAN TAMU DI VASA HOTEL SURABAYA
No full textThe goal to be achieved in this research is to find out the efforts made by the room
attendant in maintaining guest comfort at Vasa hotel Surabaya so that guests feel
happy, satisfied and want to visit again at Vasa Hotel Surabaya. The author makes
observations of the room attendant's efforts in maintaining guest comfort. The
author concludes that the efforts made by the room attendant in maintaining guest
comfort at Vasa hotel Surabaya are as follows: Maintain cleanliness, greet guests
and offer assistance, pause and say hello when meeting guests in the corridor area
or other places other than the room. , and provides towel folding services (towel
art) and has also carried out standard operating room attendant procedures
The roles of structural variability and amphiphilicity of TMC278/rilpivirine in mechanisms of HIV drug resistance avoidance and enhanced oral bioavailability
No full textNon-nucleoside reverse transcriptase inhibitors (NNRTIs) are small hydrophobic drug molecules that bind to a hydrophobic pocket of the HIV-1 reverse transcriptase (RT). A number of molecules from diarylpyrimidine (DAPY) class of NNRTIs have exceptional inhibitory properties against a broad range of known drug-resistant viral strains of HIV-1 and good oral bioavailability in humans. Biophysical, structural, and computational methods were applied to study DAPY NNRTIs with differing RT inhibitory and bioavailability properties with a goal to define the mechanisms by which the dual success of the selected DAPY NNRTIs is achieved.
Exceptional bioavailability properties of selected DAPY NNRTIs were hypothesized to stem from their ability to form self-formulated spherical drug aggregates, ~60 nm in diameter, that are trafficked from the gastrointestinal tract into systemic circulation through a lymphatic uptake pathway. Using dynamic light scattering (DLS) and electron microscopy (EM), formation of drug aggregates was demonstrated. Drug aggregation was determined to be surfactant independent. Based on this observation, it was hypothesized that the drug molecules were able to achieve surface-active properties. Using X-ray crystallography and all atom MD simulations of the drug aggregate/water interface it was determined that amphiphilic properties of the selected DAPY NNRTI molecules depend on the availability of the protonation site at the pyrimidine ring and structural variability of the drug molecules at the linker moieties.
Ability of the late phase DAPY NNRTI drug molecules to inhibit the broad range of drug-resistant HIV-1 mutants has been previously linked to the ability of the molecules to sample multiple binding modes within the binding pocket of HIV-1 RT (Das et al., 2004). Using computational methods, conformational sampling by TMC278 (a DAPY NNRTI in multiple Phase III trials) in the pocket of the wild-type and the mutant NNRTI-binding pocket (NNIBP) was evaluated. Results of this work support the concept that structural variability is important in overcoming drug resistance mechanisms.
We propose that the implementation of drug aggregation testing and the evaluation of torsional flexibility of highly hydrophobic compounds in the context of the lead identification strategies will allow for better selection of potent and orally bioavailable hydrophobic drug candidates.Ph.D.Includes bibliographical references (139-146)by Yulia Frenke
Scanning tunneling microscopy and spectroscopy of topological materials and heterostructures in thin films and devices
No full textThis dissertation reports the results of scanning tunneling microscopy experiments probing the physics of thin films of topological materials. A 3D topological insulator Bi2Te3 and a 2D topological insulator WTe2, grown epitaxially, are studied with atomic resolution, and their physics is probed using in-situ back gating. The development of the back-gating process in a scanning tunneling microscope is one of the main results of this work and is reported in detail. The band structure of the monolayer WTe2 is observed to be drastically changing upon the application of electric field through the back gate. The complex effect of the gate-induced electric field on monolayer WTe2 is explored and discussed. A study of the spatial extent of 1D edge states of WTe2 is presented. A new process combining nanopatterned superconductors and topological materials is proposed and implemented. The proposed geometry in devices suitable for scanning tunneling microscopy studies opens up many new possibilities to explore the proximity effect in topological materials for future Majorana platform realization.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2022-05-01The student, Yulia Maximenko, accepted the attached license on 2020-04-02 at 03:39.The student, Yulia Maximenko, submitted this Dissertation for approval on 2020-04-02 at 03:46.This Dissertation was approved for publication on 2020-04-06 at 14:22.DSpace SAF Submission Ingestion Package generated from Vireo submission #14932 on 2020-08-25 at 17:39:50Made available in DSpace on 2020-08-27T00:49:52Z (GMT). No. of bitstreams: 2
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APHERP symposium session IV : Higher education, job opportunities and transgenerational inequality
No full textPresented Titles: Massification and Transnationalisation of Higher Education: Challenges for Graduate Employment and Transgenerational Inequality in China [Authors: Joshua Ka-ho Mok; Guo-guo Ke; Tian Zhen] Expanding Higher Education during Economic Downturns: Why China’s Lessons are Hard to Learn From? [Authors: Wing-kit Chan; Jiarun Li] Multiple Factors Affecting Graduate Employability: What Implications for Graduates? [Authors: Yuzhuo Cai; Yulia Shumilova] Graduate Employability and Labour Market Relevance of Norwegian Higher Education: Perspectives from Students [Author: Dian Liu
Awareness of oral cancer and precancer among final year dental undergraduates in Ukraine
No full textKolenko Yulia. Awareness of oral cancer and precancer among final year dental undergraduates in Ukraine. Journal of Education, Health and Sport. 2016;6(3):106-112. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.47867
http://ojs.ukw.edu.pl/index.php/johs/article/view/3426
https://pbn.nauka.gov.pl/works/721251
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.01.2016. Revised 12.02.2016. Accepted: 27.02.2016.
AWARENESS OF ORAL CANCER AND PRECANCER AMONG FINAL YEAR DENTAL UNDERGRADUATES IN UKRAINE
Kolenko Yulia1
1Bogomolets National medical university, Kyiv, Ukraine
Correspondence: Kolenko Yulia, associate professor of Operative Dentistry department, Bogomolets National medical university, Zoollogichna street, 1, Kyiv, Ukraine. Tel: +380 50 772 7375. E-mail: [email protected]
Abstract
Background: Oral cancer presents with high mortality rates, and the likelihood of survival is remarkably superior when detected early. Health care providers, particularly dentists, play a critical role in early detection of oral cancers and should be knowledgeable and skillful in oral cancer diagnosis. Purpose: The objective of the present study was to assess the comprehensive awareness of final year dental undergraduates of Medical Universities and Institutes Ukraine concerning oral cancer and oral potentially malignant disorders. Materials and Methods: A pretested self-administered questionnaire was distributed to fifth year dental students. Questions relating to knowledge of oral cancer, risk factors, and opinions on oral cancer prevention and practices were posed. Results: Only a small proportion of both groups of students expressed confidence in their knowledge and skills in oral cancer prevention and detection. This study revealed areas of deficiency in the awareness of these students concerning oral cancer and OPMD. It points to a necessity to strengthen these aspects of medical and dental undergraduate curricula. Conclusions : The findings of the present study suggest that here is a need to reinforce the undergraduate dental curriculum with regards to oral cancer education, particularly in its prevention and early detection.
Keywords: dental students, knowledge, opinions, dental education, oral cancer, oral potentially malignant disorders, curriculum
Author Correction: Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction
No full textA Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20668-
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