178,705 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Memorandum from A. E. Demaray to E. C. Finney
No full textFour letters of correspondence about the purchase of Bright Angel Trail between A. E. Demaray, Acting Director of the Grand Canyon National Park; E. C. Finney, Department of the Interior First Assistant Secretary; Carl T. Hayden, Representative (AZ); and Stephen T. Mather, Director of the National Park Service
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Taeyeung Kim
No full text학위논문(석사)--아주대학교 일반대학원 :의생명학과,2011. 2Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 5
A. HBV plasmid DNA construction 5
B. Cell culture and transfection 8
C. Isolation of core particles 9
D. RNase protection assay (RPA) 9
E. Core particle Western blotting 10
F. Southern blotting 11
G. SDS-PAGE and Western blotting 11
Ⅲ. RESULT 12
A. HBV P constructs containing DHBV P residues in RNase H domain 12
B. Amino acid residues from 800 to 826 in C-terminus of the RNase H are critical for pgRNA encapsidaion and DNA synthesis. 14
C. The small motif substituted HBV RNase H domain mutants at C-terminus have ability to support
HBV DNA synthesis. 21
D. The small motif substituted HBV RNase H domain mutants at C-terminus have ability to support
HBV pgRNA encapsidation. 23
E. A leucine residue at position 806 in HBV P protein is important for viral genome replication. 26
F. A leucine residue at position 806 in HBV P protein is important for pgRNA encapsidation. 28
Ⅳ. DISCUSSION 29
Ⅴ. CONCLUSION 31
REFERENCES 32
국문요약 38MasterHepatitis B Virus (HBV) DNA polymerase (P) protein consisting of terminal protein (TP), spacer, reverse transcriptase (RT), and RNase H, plays critical roles in viral assembly and replication. RNase H domain is required for HBV DNA replication, however critical motif or amino acid residues in the RNase H domain for the HBV replication has not been extrensively demonstrated yet. In the present study, several chimeras of P protein by substituting Duck hepatitis B virus (DHBV) sequences were constructed. Accordingly, we tested a series of P protein chimeras in which several substitution mutants were disigned to contain various amino acids of DHBV P protein. It is found that amino acid residues from 800 to 826 (800SRPLLRLPFQPTTGRTSLYAVSPSVPS826) in C -terminus of the RNase H domain are required to complete HBV replication. HBV P protein mutants in which single amino acid residue was substituted were examined for the rescue of HBV replication. Among these mutants tested, L806T mutant P protein have a defect in pgRNA encapsidation and viral DNA synthesis, demonstrating that leucine at position 806 is critical for HBV replication
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Uroptychus zezuensis Kim 1972
No full textUroptychus zezuensis Kim, 1972 Uroptychus zezuensis Kim, 1972: 53, figs 1, 2 (off Seogwipo, Jeju Island, 60 m). — Kim, 1973: 171, fig. 17, pl. 64, figs 4a, b (off Seogwipo, Jeju Island). — Baba, 2005: 64, fig. 23, 232 (synonymies, key, Nagasaki, Japan and Philippines, 188–311 m). Type data: holotype, ovigerous female, SNU. Type locality: off Seogwipo, Jeju Island, 60 m.Published as part of Baba, Keiji, Macpherson, Enrique, Poore, Gary C. B., Ahyong, Shane T., Bermudez, Adriana, Cabezas, Patricia, Lin, Chia-Wei, Nizinski, Martha, Rodrigues, Celso & Schnabel, Kareen E., 2008, Catalogue of squat lobsters of the world (Crustacea: Decapoda: Anomura-families Chirostylidae, Galatheidae and Kiwaidae), pp. 1-220 in Zootaxa 1905 (1) on page 46, DOI: 10.11646/zootaxa.1905.1.1, http://zenodo.org/record/513458
Airfoil noise reductions through leading edge serrations
No full textThis paper provides an experimental investigation into the use of leading edge (LE) serrations as a means of reducing the broadband noise generated due to the interaction between the aerofoil’s LE and impinging turbulence. Experiments are performed on a flat plate in an open jet wind tunnel. Grids are used to generate isotropic homogeneous turbulence. The leading edge serrations are in the form of sinusoidal profiles of wavelengths, ?, and amplitudes, 2h. The frequency and amplitude characteristics are studied in detail in order to understand the effect of LE serrations on noise reduction characteristics and are compared with straight edge baseline flat plates. Noise reductions are found to be insignificant at low frequencies but significant in the mid frequency range (500 Hz–8 kHz) for all the cases studied. The flat plate results are also compared to the noise reductions obtained on a serrated NACA-65 aerofoil with the same serration profile. Noise reductions are found to be significantly higher for the flat plates with a maximum noise reduction of around 9 dB compared with about 7 dB for the aerofoil. In general, it is observed that the sound power reduction level (?PWL) is sensitive to the amplitude, 2h of the LE serrations but less sensitive to the serration wavelength, ?. Thus, this paper sufficiently demonstrates that the LE amplitude acts as a key parameter for enhancing the noise reduction levels in flat plates and aerofoils
Young Sun Kim
No full text학위논문(박사)--아주대학교 일반대학원 :의학과,2010. 2TABLE OF CONTENTS
ABSTRACT i
TABLE OF CONTENTS iii
LIST OF FIGURES v
ABBREVIATION vi
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 6
A. Materials 6
B. Subjects 6
C. Cell culture and viability 7
D. Transfection and depletion of siRNA 7
E. Immunocytochemistry 8
F. Co-immunoprecipitation and immunoblot analysis 8
G. Two-dimensional electrophoresis 9
H. Subcellular fractionation 10
I. Immunohistochemistry 10
J. Statistical analysis 11
Ⅲ. RESULTS 12
A. Localization of Prx III and Srx in A549 cells 12
B. Oxidation of Prx III in mink lung epithelial cells 12
C. Srx dependent regulation of Prx III oxidation in A549 cells 15
D. Srx is translocated into the mitochondria under oxidative stress 15
E. Overexpression of Prx I and III isoforms in human lung cancer 19
F. Nrf2 dependent expression of ARE-proteins in human lung cancer 19
G. Overexpression of Srx in human lung cancer 19
H. Survival of patients with lung cancer based on Srx expression 26
I. Expression of Srx in human lung cancer tissue 26
Ⅳ. DISCUSSION 28
Ⅴ. CONCLUSION 30
REFFERENCE 32
국문요약 40Maste
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Discipline Mobility of Academic Scientists: Implications for the Knowledge Production Patterns
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