1,271 research outputs found
Gestão Estratégica da Imagem e da Identidade Organizacional em Instituições de Ensino Superior
No full textEsta pesquisa se propõe a verificar a existência de congruência entre a identidade organizacional e a imagem projetada, percebida pelos públicos relevantes internos, de uma Instituição privada de Ensino Superior de um Estado brasileiro. A pesquisa apóia-se em um estudo de caso de natureza qualitativa e interpretativa por permitir a visão dos atores sobre a realidade organizacional e a sua correspondente imagem institucional. A partir da análise dos conteúdos expressos nas entrevistas individuais e semi-estruturadas realizadas com o público interno definido previamente, foi possível identificar respostas individualizadas e formas diferentes e subjetivas de perceberem a identidade e a imagem da instituição pesquisada. Percebe-se que, muitas vezes, as estratégias de projeção da imagem têm um efeito negativo sobre determinados atores organizacionais por não encontrar congruência com a identidade institucional. Este fato pode estar relacionado à busca incessante das universidades privadas por alunos, em função da competitividade crescente na área de ensino superior
3D_DIG_Moho_and_LAB_Model_EChambers2024.nc
No full textREAD ME File For '3D_DIG_Moho_and_LAB_Model_EChambers2024_INTERPOLATED.nc'
Dataset DOI:
ReadMe Author: Emma L. Chambers, Dublin Institute for advanced Studies, ORCID: https://orcid.org/0000-0001-6969-2920
This dataset supports the publication:
AUTHORS: Emma L. Chambers*, Javier Fullea, Duygu Kiyan, Sergei Lebedev, Christopher J. Bean, Pat Meere, J. Stephen Daly, Nicola Willmot Noller, Robert Raine, Sarah Blake, Brian M. O’Reilly
TITLE: A new 3D temperature model for Ireland from joint geophysical-petrological inversion of seismic, surface heat flow and petrophysical data
JOURNAL: Geophysical Journal International
PAPER DOI IF KNOWN:
PREPRINT: EarthArXiv
PREPRINT DOI: https://doi.org/10.31223/X5RX3P
This dataset contains:
"3D_DIG_Moho_and_LAB_Model_EChambers2024_INTERPOLATED.nc" which has the final Moho and LAB depth models. Also included are latitude and longitude coordinate variables in both WGS84 and ITM coordinates. The model has been interpolated to 0.025 degree spacing laterally from an original 0.2 degree spacing.
This file is in NetCDF format. NetCDF files can be opened in most data analysis environments. For example in MATLAB use the netcdf.open command or in python xr.open_dataset(dataset.nc).
Date of data collection:
10/09/2024
Information about geographic location of data collection:
Dataset covers the Republic of Ireland and Northern Ireland in both WGS84 (latitude and longitude, EPSG:4326) and ITM coordinates (latITM and lonITM, EPSG:2157).
Licence:
CC BY-SA 4.0
Related projects and datasets:
3D_DIG_Temp_and_RMS_Model_EChambers2024.nc
3D_DIG_Temp_and_RMS_Model_EChambers2024_INTERPOLATED.nc
3D_DIG_Moho_and_LAB_Model_EChambers2024.n
Optimal Lojasiewicz-Simon Inequalities and Morse-Bott Yang-Mills Energy Functions
No full textFor any compact Lie group G, we prove that the Yang–Mills energy function obeys an optimal gradient inequality of Łojasiewicz–Simon type (exponent 1/2) near the critical set of flat connections on a principal G-bundle over a closed Riemannian manifold of dimension d ≥ 2 and so its gradient flow converges at an exponential rate to that critical set. We establish this optimal Łojasiewicz–Simon gradient inequality by three different methods. Our first proof gives the most general result by direct analysis and relies on our extension of a theorem due to Uhlenbeck [86] that gives existence of a flat connection on a principal G-bundle supporting a connection with L^d/2 -small curvature, existence of a Coulomb gauge transformation, and W^1,p Sobolev distance estimates for p > 1. Our second proof proceeds by first establishing an optimal Łojasiewicz–Simon gradient inequality for abstract Morse–Bott functions on Banach manifolds, generalizing an earlier result due to the author and Maridakis [31, Theorem 4]. Our third proof establishes the optimal Łojasiewicz–Simon gradient inequality by direct analysis near a given flat connection that is a regular point of the curvature map. We prove similar results for the self-dual Yang–Mills energy function near regular anti-self-dual connections over closed Riemannian four-manifolds and for the full Yang–Mills energy function over closed Riemannian manifolds of dimension d ≥ 2, when known to be Morse–Bott at a given Yang–Mills connection
Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis
No full textMonozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non-genetic component has remained poorly defined. We hypothesized that epigenetic variation could underlie some of the non-genetic component of T1D aetiology and, thus, performed an epigenome-wide association study (EWAS) for this disease. We generated genome-wide DNA methylation profiles of purified CD14(+) monocytes (an immune effector cell type relevant to T1D pathogenesis) from 15 T1D-discordant MZ twin pairs. This identified 132 different CpG sites at which the direction of the intra-MZ pair DNA methylation difference significantly correlated with the diabetic state, i.e. T1D-associated methylation variable positions (T1D-MVPs). We confirmed these T1D-MVPs display statistically significant intra-MZ pair DNA methylation differences in the expected direction in an independent set of T1D-discordant MZ pairs (P = 0.035). Then, to establish the temporal origins of the T1D-MVPs, we generated two further genome-wide datasets and established that, when compared with controls, T1D-MVPs are enriched in singletons both before (P = 0.001) and at (P = 0.015) disease diagnosis, and also in singletons positive for diabetes-associated autoantibodies but disease-free even after 12 years follow-up (P = 0.0023). Combined, these results suggest that T1D-MVPs arise very early in the etiological process that leads to overt T1D. Our EWAS of T1D represents an important contribution toward understanding the etiological role of epigenetic variation in type 1 diabetes, and it is also the first systematic analysis of the temporal origins of disease-associated epigenetic variation for any human complex disease
O papel da controladoria no suporte ao processo de geração de informações voltadas ao controle e gestão operacional em empresa prestadora de serviços de hemodinâmica: Bibiani Borges Dias ; orientadora, Ilse Maria Beuren
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.O objetivo do presente estudo consiste em verificar como a controladoria pode dar suporte ao processo de geração de informações voltadas ao controle operacional em uma empresa da área de saúde. A metodologia utilizada quanto ao problema foi a qualitativa, utilizando o estudo de caso para analisar o sistema de informação, as políticas para elaboração do planejamento, os tipos de controles operacionais e indicadores de desempenho para avaliação e acompanhamento das operações de um centro de cardiologia e radiologia intervencionista inserido em um hospital da grande Goiânia. Os dados foram obtidos através de entrevistas realizadas com a gerente administrativa. O trabalho inicia-se com revisão da literatura sobre conceitos de gestão, sistema organizacional, etapas do processo de gestão, enfatizando o planejamento, o controle, e o sistema de informações contábeis e gerenciais. Na seqüência, mostra a origem, a importância, o papel e a influência da controladoria no planejamento e no controle operacional, e a sua responsabilidade pelo sistema de informações gerenciais. Em seguida, apresenta uma proposta de um modelo de controladoria com base na fundamentação teórica e no levantamento e análise das operações e dos controles existentes no Centro de Cardiologia e Radiologia Intervencionista. Conclui propondo algumas recomendações e sugestões quanto aos custos e o faturamento do Centro de Cardiologia e Radiologia Intervencionista
Neoathripsodes holzenthali Dias, Quinteiro & Calor, 2015, new species
No full textNeoathripsodes holzenthali, new species (Figs. 2–3) Diagnosis. The new species differs from the type species of the genus by the following characters: Segment IX is long ventrally and short dorsally when observed in lateral view; segment X is broad basally and apically, with a constriction in the middle region in dorsal view. The superior appendages each have a truncate base in dorsal view. The phallus has a phallobase with a basodorsal spine projected dorsad and a pair of long dorsolateral parameres in lateral view. Adult. Length of each forewing 4.7–5.6 mm (n= 18); length of each hind wing 3.8–4.6 mm (n= 10). Head. Color dark brown (in alcohol). Antennae long, about twice as long as forewings. Maxillary palps dark brown, all segments subequal in length and width, except second segment which is 1 / 3 rd longer than the others. Labial palps dark brown, each 3 -segmented. Thorax. Dark brown; tibial spur formula 1,2,2; first pair of legs with apical tibial spur small; mid- and hind tibiae each with two apical spurs, one short and one long. Abdomen. Segments I–VIII subequal, without modifications. Male. Length of each forewing 4.8–5.6 mm (n= 10). Length of each hind wing 4.0– 4.6 mm (n= 10). Thorax. Forewings dark brown, with forks I and V (Fig. 2 A); fork I sessile; R 1 vein thickened in its distal half; veins R 2 + 3, R 4 + 5 and Cu 1 b very thick (Fig. 2 A); discoidal cell narrow, almost obliterated by thickened nature of R 2 + 3 and R 4 + 5 and sectoral crossvein (Fig. 2 A); crossveins r-m and m-cu present, fork V very deep, originating before mcu crossvein (Fig. 2 A). Hind wing dark brown, narrow, with forks I and V present, crossvein r-m absent (Fig. 2 B). Abdomen. Segment IX annular, with anterior margin smoothly sinuate and concave dorsolaterally in lateral view (Fig. 2 C), this segment longer ventrally than dorsally; with blunt posteromesal projection in dorsal view (Fig. 2 D). Segment X with apex divided dorsomesally along 1 / 3 rd of its total length, broad basally and apically, with Vshaped lateral constrictions at midlength and with eight apical setae in dorsal view (Fig. 2 D); in lateral view, broad basally, with apex pointed and directed dorsad (Fig. 2 C). Superior appendages quadrate, their basolateral margins acute in lateral and dorsal views (Fig. 2 C, 2 D), apically truncate in lateral view (Fig. 2 C) or rounded in dorsal view (Fig. 2 D). Inferior appendages each 2 -segmented, robust, bent dorsad with constriction near base and with incision in its distal half, forming two lobes; apicoventral lobe slender and shorter than dorsal lobe; dorsal lobe digitate with row of setae on dorsal margin and apex curved dorsad in lateral view (Fig. 2 C); harpago with broad base, tapering apically to strongly curved apex hooked mesad in ventral view (Fig. 2 G). Phallobase well developed and sclerotized with dorsal spine curved dorsad in basal region in lateral view (Fig. 2 E); phallicata membranous dorsally in lateral view (Fig. 2 E); pair of long parameres present dorsolaterally in lateral view (Fig. 2 E); in ventral view, two pairs of symmetrical parameres (Fig 2 F); phallotremal sclerite triangular in lateral view (Fig. 2 E), in ventral view U-shaped (Fig 2 F). Female (Fig. 3). Length of each forewing 4.7–5.5 mm (n= 8). Length of each hind wing 3.8–4.5 mm (n= 8). Thorax. Similar to male except each forewing with veins R 2 + 3 and R 3 + 4 not thickened, discoidal cell large and broad, crossvein m-cu absent, forks I, III and V present, fork I sessil, fork V much shallower than that of male (Fig. 3 A); Hind wings each with veins Sc and R forming thickened cell at base, crossvein r-m present (Fig. 3 B). Abdomen. Pair of low sclerotic bulges IXa longitudinally short in lateral view (Fig. 3 C), with pair of invaginations distally separating them from lateral bases of setose bulges IXb in dorsal view (Fig. 3 D); bulges IXb transverse, rounded apicodorsally with row of apicodorsal setae in lateral and dorsal views (Figs. 3 C, 3 D). Bulges IXc produced in triangular lamellae, in lateral view (Fig. 3 C) broad basally and pointed apically, their apices exceeding paired apices of external parts of gonopods VIII and IX (e.gon.VIII+IX) in length (Figs. 3 C, 3 D, 3 E). In ventral view (Fig. 3 E), these latter sclerites e.gon.VIII+IX collectively broad basally, tapering distally, apically terminating in pair of pointed, digitate processes near middle (Figs. 3 D, 3 E). Spermatheca sclerite complex, cylindrical, rounded, and with blunt process anteriorly in dorsal and ventral views (Figs. 3 D, 3 E). Immatures. Unknown. Holotype male. BRAZIL: Bahia: Camacan, Reserva Particular do Patrimônio Natural Serra Bonita, stream after the dam supply, 15 ° 23 ’ 26.6 ”S, 039° 33 ’ 57.2 ”W, el. 828 m, 26.xi. 2011, UV Light Pan trap, F.B. Quinteiro, E.S. Dias & T. Duarte (alcohol; MZUSP). Paratypes. same data as holotype, except 10 males, 3 females (alcohol; MZUSP); same data, except 6 males, 3 females (alcohol; UMSP); same data, except 14.ii. 2014, A.R. Calor &V. Gomes, 8 males; same data, except 15.ii.2013, 19 males, 4 females; same data, except 15 ° 23 ’ 28 ”S, 039° 33 ’ 66 ”W, el. 820 m, 31.vii. 2008, UV Light Pan trap, A.R. Calor, L.S. Lecci, L.C. Pinho & R.A. Moretto, 2 males, 1 female (alcohol; UFBA); same data, except 15 ° 23 ’ 28 ”S, 039° 33 ’ 57 ”W, el. 833 m, 04.xi. 2009, A.R. Calor, F.B. Quinteiro & D. França, 1 male (alcohol; UFBA); same data, except 15 ° 23 ’ 26 ”S, 039° 33 ’ 58 ”W, el. 822 m, iv. 2009, Malaise trap 2, A.R. Calor, L.S. Lecci, L.C. Pinho & R.A. Moretto, 2 males (pinned, UFBA); same data, except Fazenda Valdemar da Farmácia, 15 ° 25 ’ 18.6 ”S, 039° 33 ’ 59.3 ”W, el. 309 m, 28.iii. 2011, UV Light Pan trap, A.R. Calor, F.B. Quinteiro, D. França & H. Barreto, 1 male (alcohol; UFBA); same data, except 15 ° 23 ’ 31.1 ”S, 039° 33 ’ 52.2 ”W, el. 798 m, 29.iii. 2011, UV Light Pan trap, F.B. Quinteiro, D. França & H. Barreto, 2 males (alcohol; UFBA); same data, except 15 ° 23 ’ 15.7 ”S, 039° 33 ’ 57.3 ”W, el. 821 m, 25.xi. 2011, UV Light Pan trap, F.B. Quinteiro, R. Mariano, E.S. Dias, T. Duarte & V. Silva, 2 males, 2 females (alcohol; UFBA); same data, except 15 ° 23 ’ 36.1 ”S, 039° 33 ’ 52.7 ”W, el. 774 m, 25.xi. 2011, UV Light Pan trap, F.B. Quinteiro, R. Mariano, E.S. Dias, T. Duarte & V. Silva, 1 male (alcohol; UFBA); same data, except 15 ° 23 ’09.1”S, 039° 34 ’03.1”W, el. 816 m, 27.xi. 2011, UV Light Pan trap, F.B. Quinteiro, E.S. Dias & T. Duarte, 1 male, 3 females (alcohol; UFBA); same data, except 15 ° 23 ’ 17.6 ”S, 039° 33 ’ 56.3 ”W, 27.xi. 2011, UV Light Pan trap, F.B. Quinteiro, E.S. Dias & T. Duarte, 1 female (alcohol; UFBA). Distribution. Brazil (BA). Etymology. The specific name is in honor of Dr. Ralph W. Holzenthal, the author of the genus Neoathripsodes, who has been instrumental in contributing to our knowledge of Neotropical caddisflies. Taxonomic remarks. The new species presents many morphological differences from its congener. The males of Neoathripsodes holzenthali n. sp. have forewings each with its discoidal cell more elongated longitudinally, placed in the middle of the wing. The male R 1 vein is thickened, especially distal to the discoidal cell, differently from N. anomalus. Additionally, male fork V is much deeper than that of N. anomalus (originating nearly at the fork of Cu 1 and M) and crossvein r-m is absent in the male hind wings of the new species. The presence of a r-m crossvein in each hind wing was thought to be a diagnostic character in the genus (Holzenthal 1989). However, N. holzenthali n. sp. contradicts this assertion, since r-m is not present in the hind wings of the male of the new species, although it is present in the female. While the male genitalia of N. holzenthali n. sp. have the dorsal posteromesal margin of segment IX broad and quadrate, in dorsal view, N. anomalus has the same structure narrow and acuminate. Segment X of the new species is wide in its apex and base, but constricted at midlength in dorsal view, while in N. anomalus it is large, from the base to the middle portion, without constriction, and the apex is narrower than in the new species, in dorsal view. The superior appendages of N. holzenthali n. sp. are apically rounded (dorsal view) or truncate (lateral view) and truncate at the anterior basolateral margins in dorsal and lateral views. In Neoathripsodes anomalus this appendage is ovoid in dorsal and lateral views, with smooth edges. The inferior appendages of the new species are more robust, each having a row of setae on the anterodorsal margin, and the distal half of each inferior appendage is curved dorsad, while the anterior margin of each inferior appendage in N. anomalus does not have a row of setae and is straight. Differing from the generic diagnosis, the female forewings do not have veins R 2 + 3 and R 4 + 5 thickened at the discoidal cell and fork III is present (vein M 1 + 2 branched into M 1 and M 2). Intraspecific variation can be seen in males in the direction of the dorsal spine on the phallobase (upcurved in lateral view), the shape of the anterobasal border of the phallobase (enlarged, lateral view), and the shape of the apex of the slightly rounded dorsal margin of segment IX (in lateral view).Published as part of Dias, Everton S., Quinteiro, Fabio B. & Calor, Adolfo R., 2015, A new species of Neoathripsodes Holzenthal, 1989 (Trichoptera: Leptoceridae) with new generic and species records in Bahia State, Brazil, pp. 370-380 in Zootaxa 4032 (4) on pages 372-375, DOI: 10.11646/zootaxa.4032.4.2, http://zenodo.org/record/23732
O perfil dos trabalhos acadêmicos de conclusão do curso de Ciências Contábeis da Universidade Federal de Santa Catarina no período de 2001 a 2005
No full textTCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisA sociedade, inserida em um cenário de mudanças cada vez mais rápidas e com a facilidade do intercâmbio de informações, passou a exigir com mais vigor a indissociabilidade entre o ensino, pesquisa e extensão, que é o tripé fundamental não só para a existência, mas para a própria manutenção e progresso da universidade. Neste contexto, a pesquisa científica está inserida também no processo de conclusão de curso de graduação e, conseqüentemente, na instituição de ensino. Sendo assim, o objetivo do presente trabalho consiste em evidenciar o perfil dos trabalhos acadêmicos (TCCs) de final de curso de Ciências Contábeis da Universidade Federal de Santa Catarina (UFSC), considerando-se o período de 2001 a 2005. Para tanto, foram identificadas as áreas temáticas pesquisadas nos TCCs correlacionadas com professor orientador das mesmas. Além disso, constatou-se a metodologia de pesquisa adotada e examinou-se o tipo de material pesquisado utilizado nas referências das monografias. Por último, verificou-se a geração de trabalhos científicos em cooperação com os alunos de graduação por meio do Currículo Lattes do professor. O estudo caracteriza-se como descritivo, os procedimentos adotados na coleta dos dados são bibliográfico e documental e a abordagem do problema é qualitativa e quantitativa. Na pesquisa será utilizada a técnica de análise de conteúdo. O perfil dos trabalhos acadêmicos de final de curso de Ciências Contábeis da UFSC no período analisado caracteriza-se por ser fortemente de natureza exploratória, bibliográfica, concentrado em áreas tradicionais da ciência contábil, coincidindo com área de orientação da maioria dos docentes, alicerçado em estudos de caso, com predominância da abordagem qualitativa. A pesquisa bibliográfica, largamente utilizada, respalda-se basicamente em livros, com ínfimo destaque para teses e dissertações. Há indícios de que a relação científica entre orientador/aluno encerra-se com a apresentação da monografia perante a banca examinadora
Efficacy of a map on search, orientation and access behaviour in a hypermedia system
No full textMany researchers have proposed hypertext and hypermedia as superior learning environments over traditional linear-based approaches. At the same time, reports of disorientation amongst students working in these environments has become a topic of major concern. The study reported in this paper sets out to investigate the efficacy of the provision of maps on students' ability to search, orientation and access information in a hypertext-based learning task. The domain used required students to learn about the theory of tectonic plates. The results indicate that the greater use of maps led to less relevant searching behaviour and less effective search effort. In conclusion, it is argued that the concept of the spatial metaphor has not served the designers and students of hypertext and hypermedia environments well. Further, it is proposed that designers of non-linear learning environments would be better served by concentrating on the fundamental usability of their systems rather than attempting to introduce navigational aids, which themselves are a symptom of poor design
3D_DIG_Temp_and_RMS_Model_EChambers2024.nc
No full textREAD ME File For '3D_DIG_Temp_and_RMS_Model_EChambers2024_INTERPOLATED.nc'
Dataset DOI:
ReadMe Author: Emma L. Chambers, Dublin Institute for advanced Studies, ORCID: https://orcid.org/0000-0001-6969-2920
This dataset supports the publication:
AUTHORS: Emma L. Chambers*, Javier Fullea, Duygu Kiyan, Sergei Lebedev, Christopher J. Bean, Pat Meere, J. Stephen Daly, Nicola Willmot Noller, Robert Raine, Sarah Blake, Brian M. O’Reilly
TITLE: A new 3D temperature model for Ireland from joint geophysical-petrological inversion of seismic, surface heat flow and petrophysical data
JOURNAL: Geophysical Journal International
PAPER DOI IF KNOWN:
PREPRINT: EarthArXiv
PREPRINT DOI: https://doi.org/10.31223/X5RX3P
This dataset contains:
"3D_DIG_Temp_and_RMS_Model_EChambers2024_INTERPOLATED.nc" which has the final best temperature model and associated uncertainty. Also included are latitude, longitude and depth coordinate variables in both WGS84 and ITM coordinates. The model has been interpolated to 0.025 degree spacing laterally from an original 0.2 degree spacing. See dataset without INTERPOLATED for actual final model.
This file is in NetCDF format. NetCDF files can be opened in most data analysis environments. For example in MATLAB use the netcdf.open command or in python xr.open_dataset(dataset.nc).
Date of data collection:
10/09/2024
Information about geographic location of data collection:
Dataset covers the Republic of Ireland and Northern Ireland in both WGS84 (latitude and longitude, EPSG:4326) and ITM coordinates (latITM and lonITM, EPSG:2157).
Licence:
CC BY-SA 4.0
Related projects and datasets:
3D_DIG_Moho_and_LAB_Model_EChambers2024.nc
3D_DIG_Moho_and_LAB_Model_EChambers2024_INTERPOLATED.nc
3D_DIG_Temp_and_RMS_Model_EChambers2024.n
Neuralgia do trigêmio: estudo de mecanismos e avaliação da participação das endotelinas em um modelo experimental
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Este estudo avaliou as respostas nociceptivas evocadas por estímulos de diferentes modalidades em ratos submetidos à constrição do nervo infraorbital, um modelo de dor neuropática orofacial, bem como a participação das endotelinas e de seus receptores. A constrição do nervo infraorbital induziu hipernocicepção térmica (ao frio e ao calor) unilateral entre 2 e 12 dias, hipernocicepção mecânica bilateral a partir do 12º dia e potencializou a fase II da resposta à formalina (1%) 12, 20 e 40 dias após a cirurgia. A desnervação neonatal com capsaicina aboliu a hipernocicepção ao frio e ao calor por 6 e 8 dias, respectivamente, e reduziu em 60% a fase II da resposta à formalina. A hipernocicepção térmica foi resistente ao tratamento com AINEs (indometacina, 4 mg/kg e celecoxibe, 10 mg/kg), mas reduzida pelo tratamento com dexametasona (0,5 mg/kg), anticonvulsivantes (carbamazepina, oxcarbazepina e gabapentina, 3 a 30 mg/kg), cloridrato de morfina (2,5 mg/kg) ou de lidocaína (10 mg/kg). A hipernocicepção mecânica só foi modificada por estes dois últimos tratamentos. A injeção de ET-1 (10 pmol) no lábio superior de ratos não operados induziu hipernocicepção mecânica e térmica. Nestes animais, receptores ETA e ETB são expressos no gânglio do trigêmeo, e a expressão dos mesmos é aumentada 15 dias, mas não 4 dias, após a constrição do nervo infraorbital. Em gânglios de animais não operados, receptores ETA foram identificados em fibras A e C, enquanto que receptores ETB foram detectados em fibras C e células da glia. Em gânglios de animais constritos, a presença destas fibras é menos evidente, de modo que a expressão de ambos receptores é menos nítida. No entanto, a expressão de receptores ETA em fibras A, bem como de receptores ETB em células da glia permanece bastante clara. A hipernocicepção térmica foi reduzida por antagonistas de receptores ETA (atrasentan, 10 mg/kg; BQ-123, 3 a 30 nmol), ETB (A-192621, 20 mg/kg; BQ-788, 3 a 30 nmol), ou de ambos (bosentan, 10 mg/kg). Em contraste, a hipernocicepção a estímulos químicos e mecânicos envolveu a ativação de receptores ETA e ETB, respectivamente. Estes resultados sugerem que as endotelinas são importantes mediadores da hipernocicepção orofacial e que receptores ETA e ETB podem constituir alvos terapêuticos potencialmente relevantes para o controle da dor neuropática trigeminal
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