197 research outputs found
Analysis of mitochondrial DNA of an endangered beech species, Fagus hayatae Palibin ex Hayata
No full textAuthor in Gesaku. Author's Gesaku
Full text linkpdfThat "play" (ge) equals "writing" (saku) is the premise of gesaku, which is maintained as a stance not only by early bushi-class authors but also by later ones who were professional, and sometimes best-seller, authors. Writing is a game in which the reader is invited to participate, the work being an open arena for the play of writing and interpretation rather than a finished product to be read for cohesive meaning. Thus gesaku is characterized by word-play and self-referentiality. This lecture traces these two features in eighteenth-century British poetry and prose and in gesaku writings of the later Edo period, drawing examples from several works in which the author's self-portrait is prominent.
In comical poetry, Alexander Pope, in his "An Epistle to Dr. Arbuthnot," sets up the poet himself as an ideal against which vices are to be attacked and by which the satirist is to be defended for his writing. Jonathan Swift's "On the death of Dr. Swift" portrays the poet as the worst embodiment of human hypocrisy thereby inducing the reader to laugh at himself while laughing at the author. In prose fiction, Laurence Sterne's Tristram Shandy is a "picture of himself," as he calls it, in the sense that the very act of narrating replaces any objective narrative arrangement. Play, not necessity, seems to be the mother of literary invention. Pope invents the mock-epic couplet in which the sublime and the vulgar are mercilessly mixed ; Swift, the plain-style conversation in which the true and dispicable self is exposed ; and Sterne, the free-form narrative in which tricks of sound and spelling open up multiple possibilities for interpretation.
Similarly, Edo gesaku writers are creators of new language. Hiraga Gennai's sense of the self is a match with Pope's, and, indeed, his Hohiron Part II is as much a "bill of complaint" as Pope's "Arbuthnot " Gennai's self-image, however, is double-sided : it is as proud as Pope's while being as self-debasing as Swift's, so that he simultaneously achieves the former's satirical dimension and the latter's depth. His mock-Chinese (kanbun-yomikudashi) style is more complex and open to interpretation than Pope's mockheroic couplet. The ludicrously lovable nose which Santô Kyôden assigns to his own face in his sketches indicates his inclination toward commercial popularity. His "yellow cover "(kibyôshi) books play on the reading of pictures as well as of the written texts. Particularly, his Kiji Nakazawa features the reader rather than the author so that reading constitutes narration, thus challenging Tristram Shandy for the title of the world's strangest narration. His Sakusha Tainai Totsuki no Zu, showing the formation of a book from its conception to publication as an embryo growing in the author’s masculine “womb,” epitomizes the late gesaku of bringing forward the backstage of writing. Many of Jippensha Ikku’s works are of this type but lacking Kyôden’s fictionality. In his Naruhodo Nekkara Ikku ga Saku, a slapstick comedy about the struggle of the author in search of ideas, Ikku, the popular author, depends on the reader’s indulgence in laughing at, and sympathizing with, the misery of the actual author. Here the author-reader relationship is extremely close, to such a degree to invalidate the written work, a case of a game losing its raison d’être by the conspiracy of the players.conference pape
Cyclooxygenase-2 Blockade Is Crucial to Restore Natural Killer Cell Activity before Anti-CTLA-4 Therapy against High-Grade Serous Ovarian Cancer
Full text linkChronic inflammation influences the tumor immune microenvironment (TIME) in high-grade serous ovarian cancer (HGSOC). Specifically, cyclooxygenase-2 (COX-2) overexpression promotes cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) expression. Notably, elevated COX-2 levels in the TIME have been associated with reduced response to anti-CTLA-4 immunotherapy. However, the precise impact of COX-2, encoded by PTGS2, on the immune profile remains unknown. To address this, we performed an integrated bioinformatics analysis using data from the HGSOC cohorts (TCGA-OV, n = 368; Australian cohort AOCS, n = 80; GSE26193, n = 62; and GSE30161, n = 45). Employing Gene Set Variation Analysis (GSVA), MIXTURE and Ecotyper cell deconvolution algorithms, we concluded that COX-2 was linked to immune cell ecosystems associated with shorter survival, cell dysfunction and lower NK cell effector cytotoxicity capacity. Next, we validated these results by characterizing circulating NK cells from HGSOC patients through flow cytometry and cytotoxic assays while undergoing COX-2 and CTLA-4 blockade. The blockade of COX-2 improved the cytotoxic capacity of NK cells against HGSOC cell lines. Our findings underscore the relevance of COX-2 in shaping the TIME and suggest its potential as a prognostic indicator and therapeutic target. Increased COX-2 expression may hamper the effectivity of immunotherapies that require NK cell effector function. These results provide a foundation for experimental validation and clinical trials investigating combined therapies targeting COX-2 and CTLA-4 in HGSOC.Fil: Gómez Valenzuela, Fernán. Pontificia Universidad Católica de Chile; ChileFil: Wichmann, Ignacio. Pontificia Universidad Católica de Chile; ChileFil: Suárez, Felipe José. Pontificia Universidad Católica de Chile; ChileFil: Kato, Sumie. Pontificia Universidad Católica de Chile; ChileFil: Ossandón, Enrique. Pontificia Universidad Católica de Chile; ChileFil: Hermoso, Marcela. Universidad de Chile.; ChileFil: Fernandez, Elmer Andres. Fundación Para El Progreso de la Medicina; Argentina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Cuello, Mauricio A.. Pontificia Universidad Católica de Chile; Chil
An apple atp9 pseudogene is maintained at high copy number in 'Golden Delicious'-type mitochondria but is present substoichiometrically in 'Delicious'-type mitochondria
Full text linkIn this study, the mitochondrial atp9 gene sequence of an apple cultivar 'Golden Delicious' was found to exist in one intact version and two truncated versions (termed φatp9-1 and φatp9-2). Interestingly, the φatp9-1 sequence is maintained at high copy number in the six 'Golden Delicious'-cytotype cultivars examined but present substoichiometrically in eight 'Delicious'-cytotype cultivars. Our data also suggest that φatp9-1 originated in a homologous recombination event mediated by the short repeat in a common ancestral mitochondrial genome of 'Golden Delicious' and 'Delicious', and was preferentially amplified in an evolutionary lineage that gave rise to the 'Golden Delicious'-type genome. On the other hand, φatp9-2 was revealed to be present in high abundance in all 14 cultivars examined
An intact mitochondrial cox1 gene and a pseudogene with different genomic configurations are present in apple cultivars 'Golden Delicious' and 'Delicious': Evolutionary aspects
Full text linkWe have characterized the mitochondrial cox1 gene copies in two apple cultivars 'Golden Delicious' and 'Delicious'. Both the cultivars contained an intact copy and a truncated copy of cox1. The intact 'Golden Delicious' and 'Delicious' cox1 genes, designated G-cox1 and D-cox1, respectively, were both found to be actually transcribed to give an RNA of approximately 1.7 kb. The two intact cox1 and two truncated copies (G-φcox1 and D-φcox1) shared a common 1115-bp segment flanked by four combinations of two different 5'- and 3'-sequences. PCR assay demonstrated that the configurations bearing G-cox1 and G-φcox1 existed in substoichiometric amounts within the mitochondrial genome of 'Delicious' whereas substoichiometric molecules carrying D-φcox1 were present in the 'Golden Delicious' mitochondrial genome. Although ancestor/descendant relationships cannot be inferred between the G-cox1 and D-cox1 arrangements, the results led us to hypothesize that (1) the 1115-bp segment containing part of the progenitor cox1 was duplicated, thereby generating a pseudo-cox1 copy, and (2) this was followed by homologous recombination across a portion of the 1115-bp repeats which gave rise to the descendant cox1 and pseudo-cox1 arrangements
On Tanka Poems by HONGO Sumie — The Significance of Depicting the Glory and Decline of Nishijin, Kyoto —
Full text linkThis article aims to demonstrate three significances of tanka poems by HONGO Sumie (1934～), who has lived for sixty years in Nishijin, Kyoto: the significance of her poems in depicting the glory and decline of Nishijin fabric industry and the ever-inspiring historic places of and figures in Kyoto; the beauty and artistry of her poems in exploiting a variety of rhetorical expressions; the possibility of making ordinary Japanese people realize the beauty and richness of the Japanese language. Among her conspicuous rhetorical expressions is the use of onomatopoeia like saya-saya, light and rhythmic sounds of a bamboo or a small waterfall, describing a Nishijin fabric machine and a small waterfall in a well-known garden in Kyoto. Another is the frequent use of hikari or light, referring to encouraging aspects of the world around her. In a tanka poem her late husband is associated with light (hikari) and a shield (tate). Not well-known to the tanka-related people, the poet deserves, the author believes, to be accepted as a distinguished Nishijin- and Kyoto- related poet. (Kyoto and Nishijin need a poet who gives literary description of its glorious culture and history.) Her use of uta-kotoba or words frequently used in tanka poems like modasu or ‘to remain silent’ might enable ordinary Japanese people to be impressed with not-daily-used beautiful Japanese expressions, thereby being more interested in their native language.departmental bulletin pape
A pilot study on the effectiveness of a school-based cognitive-behavioral anxiety intervention for 8- and 9-year-old children: A controlled trial in Japan
No full textPoston 1 county fair, [part 1]
No full textPage 78 of "Out of the Desert" the Poston I High School Junior Red Cross Correspondence Album. The entire album can be seen at SFSU_SCRB_0001Marguerite Archer Collection of Historic Children's Materials contains approximately 3,500 historical children's books, textbooks, and periodicals, ephemera, and realia, including puzzles, toys and educational games. The collection, originally based upon the Peter Parley to Penrod Bibliography, is considered to be a major scholarly resource showing the progressive development and growth of American children's literature from the 1820s to the 1920s, and includes many original editions of literary classics, as well as early textbooks and related teaching aids
Poston 1 county fair, [part 2]
No full textPage 79 of "Out of the Desert" the Poston I High School Junior Red Cross Correspondence Album. The entire album can be seen at SFSU_SCRB_0001Marguerite Archer Collection of Historic Children's Materials contains approximately 3,500 historical children's books, textbooks, and periodicals, ephemera, and realia, including puzzles, toys and educational games. The collection, originally based upon the Peter Parley to Penrod Bibliography, is considered to be a major scholarly resource showing the progressive development and growth of American children's literature from the 1820s to the 1920s, and includes many original editions of literary classics, as well as early textbooks and related teaching aids
Employment department
No full textPage 70 of "Out of the Desert" the Poston I High School Junior Red Cross Correspondence Album. The entire album can be seen at SFSU_SCRB_0001Marguerite Archer Collection of Historic Children's Materials contains approximately 3,500 historical children's books, textbooks, and periodicals, ephemera, and realia, including puzzles, toys and educational games. The collection, originally based upon the Peter Parley to Penrod Bibliography, is considered to be a major scholarly resource showing the progressive development and growth of American children's literature from the 1820s to the 1920s, and includes many original editions of literary classics, as well as early textbooks and related teaching aids
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