56 research outputs found
People, Places and Events Captured in Children’s Imagination. The Content of Memorial Books Dedicated to the Jewish Communities of Ciechanowiec, Jedwabne, Łomża and Stawiski
No full textBooks of remembrance dedicated to Jewish communities in Łomża are historical sources as well as cultural reflections, offering a new perspective on the past of places and people. While reading these recollections preserved in the memory of former inhabitants of the Łomża region and Jews of Łomża, we notice the attachment of the narrators to the place of birth and their special memory of neighbors. The way in which they share their memories, particularly those preserved in children’s imagination, opens up our senses, helping the contemporary reader recreate the past times of old inhabitants, bringing back their images with accuracy, and thus reconstructing events that have shaped our regional history. This is instrumental in consciously building up an objective view of the past and balancing the perception of its difficult moments. We discover that we feel the same as the people who are not with us anymore. This recognition surprises us many times, but above all else, it makes us aware of the fact that it is through common memory that we express our respect for past generations. Even more generally, such thinking is certainly a good foundation for building up and consolidating closer relations between groups, communities and nations.MAŁGORZATA KRYSTYNA FRĄCKIEWICZ – dr, adiunkt w Zakładzie Współczesnego Języka Polskiego Instytutu Filologii Polskiej Uniwersytetu w Białymstoku. Zainteresowania badawcze: antroponimia Łomży i pogranicza mazowiecko-podlaskiego; metodyka nauczania języka polskiego, efektywne nauczanie; fonetyka i fonologia języka polskiego, język mówiony mieszkańców Łomży i ziemi łomżyńskiej; język biblijno-religijny. Współredaktorka tomów: (wraz z M. Smakowską) A. Pieńkowski, Pamiętnik drozdowiaka. Pamięć o zwykłych-niezwykłych bohaterach (Łomża 2016) oraz (z A. J. Najdą) Intertekstualność a Słowo Boże, czyli O języku biblijno-religijnym w tekstach kultury (Warszawa 2016). Autorka książek: (wraz z H. Sędziak) Łomżyńskie teksty gwarowe (Łomża 1999); Semantyka i składnia czasowników myślenia w łomżyńskich tekstach gwarowych (Łomża 2007) oraz (z J. Szerszunowicz i E. Awramiuk) Frazeologia w kształceniu językowym (Białystok 2017). Mieszka w Łomży.Uniwersytet w BiałymstokuKsięga pamięci żydowskiej gminy w Stawiskach, tłumacz. M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.Bortliczek M., Symultaniczność kodów w popularnych dyskursach adresowanych do dzieci, [w:] Kształcenie językowe w dobie kultury masowej polisensorycznej, red. U. Kopeć i Z. Sibigi, Rzeszów 2010.Gardner H., Inteligencje wielorakie. Nowe horyzonty w teorii i praktyce, Warszawa 2009.Chemda, Moje miasteczko Stawiski, [w:] Księga pamięci żydowskiej gminy w Stawiskach, tłumacz. M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.Księga pamięci żydowskiej gminy w Ciechanowcu, tłumacz. E. Wroczyńska, A. Król, M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.11713
People, Places and Events Captured in Children’s Imagination. The Content of Memorial Books Dedicated to the Jewish Communities of Ciechanowiec, Jedwabne, Łomża and Stawiski
No full textBooks of remembrance dedicated to Jewish communities in Łomża are historical sources as well as cultural reflections, offering a new perspective on the past of places and people. While reading these recollections preserved in the memory of former inhabitants of the Łomża region and Jews of Łomża, we notice the attachment of the narrators to the place of birth and their special memory of neighbors. The way in which they share their memories, particularly those preserved in children’s imagination, opens up our senses, helping the contemporary reader recreate the past times of old inhabitants, bringing back their images with accuracy, and thus reconstructing events that have shaped our regional history. This is instrumental in consciously building up an objective view of the past and balancing the perception of its difficult moments. We discover that we feel the same as the people who are not with us anymore. This recognition surprises us many times, but above all else, it makes us aware of the fact that it is through common memory that we express our respect for past generations. Even more generally, such thinking is certainly a good foundation for building up and consolidating closer relations between groups, communities and nations.MAŁGORZATA KRYSTYNA FRĄCKIEWICZ – dr, adiunkt w Zakładzie Współczesnego Języka Polskiego Instytutu Filologii Polskiej Uniwersytetu w Białymstoku. Zainteresowania badawcze: antroponimia Łomży i pogranicza mazowiecko-podlaskiego; metodyka nauczania języka polskiego, efektywne nauczanie; fonetyka i fonologia języka polskiego, język mówiony mieszkańców Łomży i ziemi łomżyńskiej; język biblijno-religijny. Współredaktorka tomów: (wraz z M. Smakowską) A. Pieńkowski, Pamiętnik drozdowiaka. Pamięć o zwykłych-niezwykłych bohaterach (Łomża 2016) oraz (z A. J. Najdą) Intertekstualność a Słowo Boże, czyli O języku biblijno-religijnym w tekstach kultury (Warszawa 2016). Autorka książek: (wraz z H. Sędziak) Łomżyńskie teksty gwarowe (Łomża 1999); Semantyka i składnia czasowników myślenia w łomżyńskich tekstach gwarowych (Łomża 2007) oraz (z J. Szerszunowicz i E. Awramiuk) Frazeologia w kształceniu językowym (Białystok 2017). Mieszka w Łomży.Uniwersytet w BiałymstokuKsięga pamięci żydowskiej gminy w Stawiskach, tłumacz. M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.Bortliczek M., Symultaniczność kodów w popularnych dyskursach adresowanych do dzieci, [w:] Kształcenie językowe w dobie kultury masowej polisensorycznej, red. U. Kopeć i Z. Sibigi, Rzeszów 2010.Gardner H., Inteligencje wielorakie. Nowe horyzonty w teorii i praktyce, Warszawa 2009.Chemda, Moje miasteczko Stawiski, [w:] Księga pamięci żydowskiej gminy w Stawiskach, tłumacz. M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.Księga pamięci żydowskiej gminy w Ciechanowcu, tłumacz. E. Wroczyńska, A. Król, M. Reczko, red. wyd. polskiego M. K. Frąckiewicz i M. Reczko, Łomża 2020.11713
From the first to the third Soviet deportation in the Ciechanowiec region
No full textArtykuł prezentuje sytuację społeczności polskiej i żydowskiej na obszarze rejonu ciechanowieckiego pod okupacją sowiecką w pierwszym półroczu 1940 r. Ramy tego okresu wyznaczają pierwsza i trzecia deportacja na Syberię. Oprócz represyjnych wywózek, w tym czasie odbyły się też wybory do Rad Najwyższych Białorusi i Związku Sowieckiego oraz przymusowe wysiedlenia z pasa granicznego. Ludność, zwłaszcza żydowska, próbowała opuszczać badany rejon w celu uniknięcia opresyjności władz okupacyjnych.The article presents the situation of the Polish and Jewish community in the Ciechanowiec region under the Soviet occupation in the first half of 1940. The framework of the period is determined by the first and the third deportation to Siberia. Beside the repressive deportations, also elections to the Supreme Councils of Belarus and the Soviet Union were held, as well as forced evictions from the border belt. The population, in particular Jewish, tried to leave the area under scrutiny in order to avoid the oppressiveness of the occupational [email protected]ław Reczko – dr historii, pracownik Politechniki Białostockiej. Członek i aktywny współpracownik Łomżyńskiego Towarzystwa Naukowego im. Wagów, autor i wydawca wielu albumów fotograficznych oraz wystąpień, artykułów i książek dotyczących historii XX wieku, tłumacz ksiąg pamięciArchiwum Państwowe Federacji Rosyjskiej w Moskwie: zesp. 9401; zesp. 9479Filia Archiwum Obwodowego w Grodnie: zesp. 6195Narodowe Archiwum Republiki Białorusi w Mińsku: zesp. 4Państwowe Archiwum Organizacji Społecznych Obwodu Grodzieńskiego w Grodnie: zesp. 6216Zbiory Muzeum Rolnictwa im. Ks. K. Kluka w CiechanowcuArchiwum ciechanowieckiego NKWDOrgany Gosudarstwiennoj Biezopasnosti SSSR w Wielikoj Otieczestwiennoj Wojnie, Sbornik dokumientow, t. 1, Kniga pierwaja, red. S.W. Stiepaszin et al., Moskwa 1995.Rajonirowanie zapadnych obłastiej Biełorusskoj SSR, Mińsk 1940.Kokoszko J. A.,Wspomnienia z zesłania, „Ciechanowiecki RocznikMuzealny”, 11, 2015.Kuberska M., „To było życie...”. Wspomnienia z Kazachstanu 1936–1996, Warszawa 2006.Leoni E., Ciechanoviec–Bialystok District; Memorial and Records, Tel Aviv 1964.Biłas I., Represywno-karalna systema w Ukrajini 1917–1953. Suspilno-politycznyj ta istoryko-prawowyj analiz, t. 2, Kyjiv 1994.Boćkowski D., Deportacje ludności polskiej w głąb ZSRS (1939–1941), „Biuletyn IPN” 2011, nr 1–2, Warszawa 2011.Boćkowski D., Losy żydowskich uchodźców z centralnej i zachodniej Polski (bieżeńców) przebywających na terenie obwodu białostockiego w latach 1939–1941, „Studia Podlaskie”, 16, 2006.Boćkowski D., Masowe deportacje polskiej ludności cywilnej w głąb ZSRR w latach 1940–1941: próba weryfikacji danych, „Mazowieckie Studia Humanistyczne”, 2/1, 1996.Boćkowski D., Na zawsze razem. Białostocczyzna i Łomżyńskie w polityce radzieckiej w czasie II wojny światowej (IX 1939–VIII 1944), Warszawa 2005.Chackiewicz A., Aresztowania i deportacje społeczeństw zachodnich obwodów Białorusi (1939–1941), [w:] Społeczeństwo białoruskie, litewskie i polskie na ziemiach północno-wschodnich II Rzeczypospolitej (Białoruś Zachodnia i Litwa Wschodnia) w latach 1939–1941, red. M. Giżejewska i T. Strzembosz, Warszawa 1995.Gnatowski M., Deportacja osadników i służby leśnej oraz ich rodzin z regionu łomżyńskiego na wschodnie obszary ZSRR w lutym 1940 roku, „Studia Łomżyńskie”, 7, 1996.Gnatowski M., Polacy–Sowieci–Żydzi w regionie łomżyńskim w latach 1939–1941, t. I: Studia, Łomża 2005.Gnatowski M., Radzieckie dokumenty o polskim podziemiu niepodległościowym w regionie łomżyńskim w latach 1939–1941, „Studia Łomżyńskie”, 5, 1995.Gnatowski M., Region łomżyński w granicach ZSRR (wrzesień 1939–czerwiec 1941). Nowe aspekty i problemy badawcze, „Studia Łomżyńskie”, 3, 1991.Gurianow A., Cztery deportacje 1940–1941, „Karta” 1994, nr 12.Levine H., Kim pan jest, panie Sugihara, przeł. S. Głąbiński, Warszawa 2000.Mosiewicz A., Wojenne losy Henryka Łapiaka i Stanisławy Łapiak z d. Miliszkiewicz z Ciechanowca, „Ciechanowiecki Rocznik Muzealny”, 5, 2009.Paul M., Neighbours on the Eve of the Holocaust. Polish-Jewish Relations in Soviet-Occupied Eastern Poland, 1939–1941, Toronto 2013.Tomaszewski N., Historia Ciechanowca do 1989 roku, Ciechanowiec 2012.Wierzbicki M., Polacy i Żydzi w zaborze sowieckim. Stosunki polsko-żydowskie na ziemiach północno-wschodnich II RP pod okupacją sowiecką (1939–1941), Warszawa 2001.http://search.archives.jdc.orghttp://search.archives.jdc.org/multimedia/Documents/Names%20Databank/Japan%20Emigration%20Lists/Set%20II%20Yeshiva/AR33-44 00053 00859.pdf#searchhttp://search.archives.jdc.org/multimedia/Documents/Names%20Databank/Vilna%20Refugees/Vilna AR33-44 00876 00119.pdf#search2719721
Long-term effectiveness of adjuvant Goserelin in premenopausal women with early breast cancer
No full textBACKGROUND: Systematic reviews have found that luteinizing hormone-releasing hormone (LHRH) agonists are effective in treating premenopausal women with early breast cancer. METHODS: We conducted long-term follow-up (median 12 years) of 2706 women in the Zoladex In Premenopausal Patients (ZIPP), which evaluated the LHRH agonist goserelin (3.6 mg injection every 4 weeks) and tamoxifen (20 or 40 mg daily), given for 2 years. Women were randomly assigned to receive each therapy alone, both, or neither, after primary therapy (surgery with or without radiotherapy/chemotherapy). Hazard ratios and absolute risk differences were used to assess the effect of goserelin treatment on event-free survival (breast cancer recurrence, new tumor or death), overall survival, risk of recurrence of breast cancer, and risk of dying from breast cancer, in the presence or absence of tamoxifen. RESULTS: Fifteen years after the initiation of treatment, for every 100 women not given tamoxifen, there were 13.9 (95% confidence interval [CI] = 17.5 to 19.4) fewer events among those who were treated with goserelin compared with those who were not treated with goserelin. However, among women who did take tamoxifen, there were 2.8 fewer events (95% CI = 7.7 fewer to 2.0 more) per 100 women treated with goserelin compared with those not treated with goserelin. The risk of dying from breast cancer was also reduced at 15 years: For every 100 women given goserelin, the number of breast cancer deaths was lower by 2.6 (95% CI = 6.6 fewer to 2.1 more) and 8.5 (95% CI = 2.2 to 13.7) in those who did and did not take tamoxifen, respectively, although in the former group the difference was not statistically significant. CONCLUSIONS: Two years of goserelin treatment was as effective as 2 years of tamoxifen treatment 15 years after starting therapy. In women who did not take tamoxifen, there was a large benefit of goserelin treatment on survival and recurrence, and in women who did take tamoxifen, there was a marginal potential benefit on these outcomes when goserelin was added
OrthoSelect: a protocol for selecting orthologous groups in phylogenomics
No full textBackground: Phylogenetic studies using expressed sequence tags (EST) are becoming a standard approach to answer evolutionary questions. Such studies are usually based on large sets of newly generated, unannotated, and error-prone EST sequences from different species. A first crucial step in EST-based phylogeny reconstruction is to identify groups of orthologous sequences. From these data sets, appropriate target genes are selected, and redundant sequences are eliminated to obtain suitable sequence sets as input data for tree-reconstruction software. Generating such data sets manually can be very time consuming. Thus, software tools are needed that carry out these steps automatically. Results: We developed a flexible and user-friendly software pipeline, running on desktop machines or computer clusters, that constructs data sets for phylogenomic analyses. It automatically searches assembled EST sequences against databases of orthologous groups (OG), assigns ESTs to these predefined OGs, translates the sequences into proteins, eliminates redundant sequences assigned to the same OG, creates multiple sequence alignments of identified orthologous sequences and offers the possibility to further process this alignment in a last step by excluding potentially homoplastic sites and selecting sufficiently conserved parts. Our software pipeline can be used as it is, but it can also be adapted by integrating additional external programs. This makes the pipeline useful for non-bioinformaticians as well as to bioinformatic experts. The software pipeline is especially designed for ESTs, but it can also handle protein sequences.
Conclusion: OrthoSelect is a tool that produces orthologous gene alignments from assembled ESTs. Our tests show that OrthoSelect detects orthologs in EST libraries with high accuracy. In the absence of a gold standard for orthology prediction, we compared predictions by OrthoSelect to a manually created and published phylogenomic data set. Our tool was not only able to rebuild the data set with a specificity of 98%, but it detected four percent more orthologous sequences. Furthermore, the results OrthoSelect produces are in absolut agreement with the results of other programs, but our tool offers a significant speedup and additional functionality, e.g. handling of ESTs, computing sequence alignments, and refining them. To our knowledge, there is currently no fully automated and freely available tool for this purpose. Thus, OrthoSelect is a valuable tool for researchers in the field of phylogenomics who deal with large quantities of EST sequences. OrthoSelect is written
in Perl and runs on Linux/Mac OS X
Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
No full textBACKGROUND: In mammalians, HIF is a master regulator of hypoxia gene expression through direct binding to DNA, while its role in microRNA expression regulation, critical in the hypoxia response, is not elucidated genome wide. Our aim is to investigate in depth the regulation of microRNA expression by hypoxia in the breast cancer cell line MCF-7, establish the relationship between microRNA expression and HIF binding sites, pri-miRNA transcription and microRNA processing gene expression. METHODS: MCF-7 cells were incubated at 1% Oxygen for 16, 32 and 48 h. SiRNA against HIF-1α and HIF-2α were performed as previously published. MicroRNA and mRNA expression were assessed using microRNA microarrays, small RNA sequencing, gene expression microarrays and Real time PCR. The Kraken pipeline was applied for microRNA-seq analysis along with Bioconductor packages. Microarray data was analysed using Limma (Bioconductor), ChIP-seq data were analysed using Gene Set Enrichment Analysis and multiple testing correction applied in all analyses. RESULTS: Hypoxia time course microRNA sequencing data analysis identified 41 microRNAs significantly up- and 28 down-regulated, including hsa-miR-4521, hsa-miR-145-3p and hsa-miR-222-5p reported in conjunction with hypoxia for the first time. Integration of HIF-1α and HIF-2α ChIP-seq data with expression data showed overall association between binding sites and microRNA up-regulation, with hsa-miR-210-3p and microRNAs of miR-27a/23a/24-2 and miR-30b/30d clusters as predominant examples. Moreover the expression of hsa-miR-27a-3p and hsa-miR-24-3p was found positively associated to a hypoxia gene signature in breast cancer. Gene expression analysis showed no full coordination between pri-miRNA and microRNA expression, pointing towards additional levels of regulation. Several transcripts involved in microRNA processing were found regulated by hypoxia, of which DICER (down-regulated) and AGO4 (up-regulated) were HIF dependent. DICER expression was found inversely correlated to hypoxia in breast cancer. CONCLUSIONS: Integrated analysis of microRNA, mRNA and ChIP-seq data in a model cell line supports the hypothesis that microRNA expression under hypoxia is regulated at transcriptional and post-transcriptional level, with the presence of HIF binding sites at microRNA genomic loci associated with up-regulation. The identification of hypoxia and HIF regulated microRNAs relevant for breast cancer is important for our understanding of disease development and design of therapeutic interventions
The geochemistry of the sedimentary rocks of the Pretoria Group, Transvaal Sequence
No full textThesis (PhD (Geology))--University of Pretoria, 1994.A total of 1203 samples from all formations of the Pretoria Group, including mainly sedimentary rock samples,
some volcanic rocks from the Hekpoort Formation and Machadodorp Volcanic Member as well as diabase sills,
were taken from surface outcrops and drillholes in the main Transvaal basin. All samples were analysed for
major and trace elements with XRF, 275 selected samples were analysed for boron with ICP-AAS, and 50
selected shale samples were analysed for REE, organic carbon and CO2 using liquid chromatography and
LECO. The mineralogy of selected shale samples was established with XRD. The sedimentary and volcanic
sample populations were treated statistically after differentiation in stratigraphic and regional sub-groups, and
average element concentration estimates of the sub-groups were established.
Generally, two distinct groups of shales can be differentiated geochemically and mineralogically, i.e. high-Al
shales with a predominant kaolinite-mica clay mineral assemblage, and high-Mg-Ca-Na shales with a micaplagioclase
mineral assemblage. The high-Al shales dominate the succession from the base of the Pretoria Group
up to the Daspoort Formation, the high-Mg-Ca-Na shales occur mainly in the Silverton and post-Magaliesberg
Formations. The shale samples from the Botswana sampling area are somewhat different from this stratigraphic
trend, as they contain significant amounts of chlorite, which is only an accessory mineral in other parts of the
basin. The geochemistry of the shales generally points to some regional differences, independent of the
stratigraphic signature. The Pretoria Group shale estimate (640 samples) is enriched in Al, Th, Cr and Sc, and
depleted in Mn, Na, Ca, Sr and some base-metals compared to average shale estimates. The Pretoria Group
sandstone estimate (335 samples) is enriched in Cr, Ni and Fe, and depleted in Ca, Na, Ti and K compared to
average sandstone estimates.
The geochemistry of the sedimentary rocks of the Pretoria Group shows evidence for complex source terrains,
with predominantly granitic and sedimentary sources, as well as, possibly, ultramafic sources. Transport
fractionation seems to have influenced the evolving pattern to a certain degree. The syndepositional
palaeoclimate is thought to have been humid-hot, at least for the middle part of the Pretoria Group (Hekpoort
to Daspoort Formations). The basal part of the Pretoria Group has a similar geochemical pattern (i.e. points
to a similar climate), but the possible introduction of reworked and redeposited weathering profiles, related to
the depositional hiatus between the Chuniespoort and Pretoria Groups must be considered in any interpretation.
Penecontemporaneous volcanic activity and proposed tectonic activity obviates an evaluation of syndepositional
climate for the Post-Daspoort formations. The geochemical signature of Pretoria Group sedimentary rocks is
indicative of a divergent margin tectonic setting (intracratonic sag, failed rift/aulacogen or passive margin).
Asthenospheric upwelling related to a rift tectonic setting could provide a simple explanation for the composition
of Pretoria Group volcanic rocks. The geochemistry of boron and REE point to a strong influence of postdepositional
processes, namely diagenesis and/or hydrothermal alteration. Mineral assemblages and trace
element patterns provide some evidence for local source areas, for at least the lower part of the Pretoria Group.
The described geochemical pattern cannot solve the marine/lacustrine nature of the basin.GeologyPhD (Geology)Unrestricte
prot4EST: translating expressed sequence tags from neglected genomes
No full textThe genomes of an increasing number of species are being investigated through generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing errors and typically define incomplete transcripts, making downstream annotation difficult. Annotation would be greatly improved with robust polypeptide translations. Many current solutions for EST translation require a large number of full-length gene sequences for training purposes, a resource that is not available for the majority of EST projects
A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate
No full textSummaryThe canonical Wnt pathway plays a central role in stem cell maintenance, differentiation, and proliferation in the intestinal epithelium. Constitutive, aberrant activity of the TCF4/β-catenin transcriptional complex is the primary transforming factor in colorectal cancer. We identify a nuclear long non-coding RNA, termed WiNTRLINC1, as a direct target of TCF4/β-catenin in colorectal cancer cells. WiNTRLINC1 positively regulates the expression of its genomic neighbor ASCL2, a transcription factor that controls intestinal stem cell fate. WiNTRLINC1 interacts with TCF4/β-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. ASCL2, in turn, regulates WiNTRLINC1 transcriptionally, closing a feedforward regulatory loop that controls stem cell-related gene expression. This regulatory circuitry is highly amplified in colorectal cancer and correlates with increased metastatic potential and decreased patient survival. Our results uncover the interplay between non-coding RNA-mediated regulation and Wnt signaling and point to the diagnostic and therapeutic potential of WiNTRLINC1
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