373 research outputs found
Non-oculomotor eye involvement in Moebius sequence
No full textMoebius sequence is a congenital disorder that not only affects the oculomotor system but also the eyes themselves. Ocular involvement might be sight-threatening and needs regular follow-up by an ophthalmologist
Revisión bibliométrica del síndrome Moebius-Poland
No full textEl síndrome de Moebius consiste en la parálisis congénita, de los músculos inervados por los nervios craneales VII (Facial) y VI (Oculomotor externo ó Abducens) por agenesia o destrucción de sus núcleos de origen en el tronco encefálico. En algunos casos, también pueden verse afectados otros nervios craneales, siendo los más frecuentemente comprometidos los nervios hipogloso (XII), vago (X), estato-acústico (VIII) y glosofaríngeo (IX). Otras alteraciones son: malformaciones músculoesqueléticas como pies zambos (contractura congénita de pies), oligodactilia (falta de desarrollo ó ausencia completa de dedos de la mano y/ó pies), e hipoplasia del músculo pectoral mayor (anomalía de Poland). Realizamos una revisión bibliográfica de artículos publicados en la base de datos online internacional: PubMed. Utilizando las palabras claves: síndrome de Moebius, síndrome de Poland. Hemos incluido la revisión de artículos publicados en los últimos 10 años hasta el 29 de Febrero de 2016. Obtenemos en total 288 artículos en PubMed con la denominación de síndrome de Moebius. Se reduce a 51 publicaciones con el filtro de los últimos 10 años y “free full text”. Realizando la búsqueda con las palabras clave elegidas: síndrome de Moebius y síndrome de Poland se minimiza el contenido a 7 artículos, en los cuáles nos hemos basado para el presente trabajo. Se señala que la relación síndrome de Moebius-Poland es, con frecuencia, muy estrecha. La patogénesis no está determinada, pero sugieren una interrupción en la morfogénesis del tronco encefálico en el período embrionario, perturbaciones vasculares fetales o teratógenos
Moebius Syndrome Misdiagnosed as Duane Retraction Syndrome: A Case Report
No full textMoebius syndrome and Duane Retraction Syndrome (DRS) are Congenital Cranial Dysinnervation Disorders (CCDDs) characterised as congenital, non progressive groups of diseases caused by abnormal development of cranial nerve nuclei or their axonal connections. Due to their overlapping features, distinguishing between these disorders can be challenging, leading to potential diagnostic oversights. This is a case report of a 10-year-old female with Moebius syndrome misdiagnosed as DRS. She had 6th and 7th nerve palsies with exposure keratopathy. Probably the cause for misdiagnosis was the presence of an abduction deficit-a characteristic shared by both disorders. Additionally, it is crucial to examine the facial nerve, as it is exclusively affected in Moebius syndrome. DRS is significantly more common than Moebius syndrome; the rarity of Moebius syndrome might contribute to the misdiagnosis. Conducting a thorough examination is essential for differentiating between these conditions, thereby facilitating comprehensive management
Moebius Strip Like Pathology: Mechanisms, Diagnosis, Treatment Correction
No full textProposed and tested an algorithm for diagnosis of Moebius strip like pathology, as prerequisite for treatment correction. The algorithm is reduced to initialization of study objects as a Moebius strip, in particular symptoms, syndromes, diseases, multimorbid states; clarification of investigation objects as non-orientable two-dimensional surface; cutting a Moebius strip like clinical data, variability to form two disjoint Moebius strips; clarification of chirality Moebius strip turn; the determination of Moebius strip like constituents as the object of research and their 3D representation; clarification of Moebius strips turn chiralities of constituents; the adoption of diagnostic and therapeutic solutions based on geometry of the pathogenetic and sanogenetic mechanisms. Thus, our algorithm may be basis for making diagnosis and treatment decisio
Moebius Strip Like Pathology: Mechanisms, Diagnosis, Treatment Correction
No full textProposed and tested an algorithm for diagnosis of Moebius strip like pathology, as prerequisite for treatment correction. The algorithm is reduced to initialization of study objects as a Moebius strip, in particular symptoms, syndromes, diseases, multimorbid states; clarification of investigation objects as non-orientable two-dimensional surface; cutting a Moebius strip like clinical data, variability to form two disjoint Moebius strips; clarification of chirality Moebius strip turn; the determination of Moebius strip like constituents as the object of research and their 3D representation; clarification of Moebius strips turn chiralities of constituents; the adoption of diagnostic and therapeutic solutions based on geometry of the pathogenetic and sanogenetic mechanisms. Thus, our algorithm may be basis for making diagnosis and treatment decisio
Kirja-arvostelu : Ursula K. Le Guin (suom Titia Schuurman): Kompassiruusu
No full textArvio teoksesta Ursula K. Le Guin: Kompassiruusu (The Compass Rose). Suom. Titia Schuurman. Moebius 2024. 304 s.nonPeerReviewe
On Iterates of Moebius transformations on fields
No full textThis article has been published in the October 1997 issue of Mathematics of Computation.Let p be a quadratic polynomial over a splitting field K, and S be the set of zeros of p. We define an associative and commutative binary relation on G ≡ K ∪ {∞ } -S so that every Moebius transformation with fixed point set S is of the form x plus" c for some c. This permits an easy proof of Aitken acceleration as well as generalizations of known results concerning Newton's method, the secant method, Halley's method, and higher order methods. If K is equipped with a norm, then we give necessary and sufficient conditions for the iterates of a Moebius transformation m to converge (necessarily to one of its fixed points) in the norm topology. Finally, we show that if the fixed points of m are distinct and the iterates of m converge, then Newton's method converges with order 2, and higher order generalizations converge accordingly.SUNY Plattsburg
Autism spectrum disorders in children and adolescents with Moebius sequence
No full textMoebius sequence is a rare congenital disorder usually defined as a combination of facial weakness with impairment of ocular abduction. A strong association of Moebius sequence with autism spectrum disorders (ASDs) has been suggested in earlier studies with heterogenous age groups. The primary caregivers of all children and adolescents with Moebius sequence aged 6–17 years known to the German Moebius foundation were anonymously asked to complete two screening measures of ASD [Behavior and Communication Questionnaire (VSK); Marburger Asperger’s Syndrome Rating Scale (MBAS)]. For those who reached the cut-off for ASD, well standardized diagnostic instruments (Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, WISC-III, and Kinder-DIPS) should be administered. Minimal diagnostic criteria for Moebius sequence were congenital facial weakness (uni- or bilateral) and impairment of ocular abduction (uni- or bilateral). Familiar cases should be excluded. The primary caregivers of 35/46 children and adolescents (18 males, 17 females, mean age 11.5 years) sent back completed questionnaires, but only 27 subjects met inclusion criteria. According to the primary caregivers, none of these subjects showed mental retardation. Two probands (both males 9 and 16 years old) reached the cut-off of the MBAS whereas the results of the VSK did not indicate ASDs in any of the patients. The 9 year old boy could be examined personally and did not meet diagnostic criteria of ASD. ASDs might be not as frequent as reported in previous studies on patients with Moebius sequence, at least not in patients without mental retardation
Soziologische Zeitdiagnostik in der Weimarer Republik. Alfred Weber, Max Scheler, Karl Mannheim
No full textKruse V. Soziologische Zeitdiagnostik in der Weimarer Republik. Alfred Weber, Max Scheler, Karl Mannheim. In: Acham K, Moebius S, eds. Soziologie der Zwischenkriegszeit. Ihre Hauptstörmungen und zentralen Themen im deutschen Sprachraum Bd. 1. Wiesbaden: Springer VS; 2021: 327--352
Bacterial photosynthetic reaction centers in trehalose glasses: Coupling between protein conformational dynamics and electron-transfer kinetics as studied by laser-flash and high-field EPR spectroscopies
No full textThe coupling between electron transfer (ET) and the conformational dynamics of the cofactor-protein complex in photosynthetic reaction centers (RCs) from Rhodobacter sphaeroides in water-glycerol solutions or embedded in dehydrated polyvinyl alcohol (PVA) films or trehalose glasses is reported. Matrix effects have been studied by time-resolved 95 GHz high-field EPR spectroscopy at room (290 K) and low (150 K) temperature. ET from the photo-reduced quinone acceptor (QA-) to the photo-oxidized donor (P+) is strongly matrix dependent at room temperature: In the trehalose glasses the recombination kinetics of P+QA- , probed by EPR and optical spectroscopy, are faster and broadly distributed as compared to RCs in solution, reflecting the inhibition of the RC relaxation from the dark- to the light-adapted conformational substate and the hindrance of substate interconversion. Similarly accelerated kinetics were observed also in PVA at a water-to-RC molar ratio 10-fold lower than in trehalose. In spite of the matrix dependence of the ET kinetics, cw EPR and electron spin echo (ESE) analysis of the photo-generated P+ and QA- radical ions and P+QA- radical pairs do not reveal significant matrix effects, neither at 290 K nor at 150 K, indicating no change in the molecular radical-pair configuration of the P+ and QA- cofactors. Furthermore, the field dependence of the transverse relaxation times T2 of QA- essentially coincides in trehalose and PVA at 290 K. T2 is similar in these two matrices and in the glycerol-water system at 150 K, implying that the librational dynamics of QA- are also unaffected by the matrix. We infer that the relative geometry of the primary donor and acceptor, as well as the local dynamics and hydrogen bonding of QA in its binding pocket, are not involved in the stabilization of P+QA-. We suggest that the RC relaxation occurs rather by changes throughout the protein-solvent system. The control of the RC dynamics and ET by the environment is discussed, particularly with respect to the extraordinary efficacy of trehalose matrices in restricting the RC motional degrees of freedom at elevated temperatures
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