89,864 research outputs found
Adrian Caesar speaking at Alex Miller author: A Celebration, held at the National Library, Canberra, 30 October 2011 /
No full textTitle from information supplied by photographer.; Part of the collection: Alex Miller author: A Celebration, held at the National Library of Australia theatre, 30 October 2011.; Mode of access: Online.; Photographed by a staff member of the National Library of Australia
Kinks in the Electronic Specific Heat
No full textWe find that the heat capacity of a strongly correlated metal presents striking changes with respect to Landau Fermi-liquid theory. In contrast with normal metals, where the electronic specific heat is linear at low temperature (with a T(3) term as a leading correction), a dynamical mean-field study of the correlated Hubbard model reveals a clear kink in the temperature dependence, marking a rapid change from a low-temperature linear behavior and a second linear regime with a reduced slope. Experiments on LiV(2)O(4) support our findings, implying that correlated materials are more resistive to cooling at low T than expected from the intermediate temperature behavior
K-theory for group C*-algebras
No full textThese notes are based on a lecture course given by the first author in the Sedano Winter School on K-theory held in Sedano, Spain, on January 22-27th of 2007. They aim at introducing K-theory of C*-algebras, equivariant K-homology and KK-theory in the context of the Baum-Connes conjectur
Control of herpes simplex virus type 1 latency in human trigeminal ganglia
No full textHerpes simplex virus type 1 (HSV-1) is a double-stranded DNA virus that infects humans and, after a primary lytic infection, establishes lifelong latency in the sensory neurons of the trigeminal ganglia (TG). HSV 1 latency is accompanied by a chronic immune cell infiltration of the TG, the infiltrate being mainly composed of CD8+ T cells. These T cells are believed to control viral latency, but cellular and viral factors like viral microRNAs are also considered to play a crucial role in the establishment and maintenance of viral latency.
In the present work, it was investigated whether the tissue-infiltrating T cells are clonally expanded, which would indicate that these T cells are activated by antigen. By applying complementarity determining region 3 (CDR3) spectratyping and immunohistochemistry, several clonal expansions were identified in the TG-resident T cells. In addition, several T cells were present that seemed to be unspecific bystander T cells. Strikingly, some expanded T cell clones were present in the right and left TG of the same individual. This strongly suggests that similar antigens are present in both TG and that the infiltration of immune cells to the TG is driven by antigen.
The morphology of the TG was investigated by immunohistochemistry and in situ hybridiza¬tion. Analysis of the distribution of T cells throughout the TG provided puzzling results: unexpectedly, most neurons surrounded by T cells did not harbour the only known prominent transcript during latency, the latency associated transcript (LAT). Whether these neurons do actually harbour latent virus was addressed by a combination of LAT in situ hybridisation, T cell immunohistochemistry, and single cell analysis of laser microdissected sensory neurons by PCR. This analysis revealed that only LAT+ neurons were harbouring HSV 1 DNA and viral microRNAs. Also, mRNA for a viral gene product was only detected in LAT+ neurons. All analysed LAT– neurons were devoid of viral microRNAs and DNA of HSV 1. DNA of HSV 2 or varicella-zoster virus (VZV) was not detected in any of the excised neurons. Alto¬gether this indicates that in the vast majority of infected human neurons, HSV 1 latency is not directly controlled by T cells, but rather by cellular or viral factors like the miRNAs. Our data suggest that CD8+ T cells only come into action if these mechanisms are overrun
Calling the judiciary to account for the past : transitional justice and judicial accountability in Nigeria
No full textInstitutional and individual accountability is an important feature of societies in transition from conflict or authoritarian rule. The imperative of accountability has both normative and transformational underpinnings in the context of restoration of the rule of law and democracy. This article argues a case for extending the purview of truth-telling processes to the judiciary in postauthoritarian contexts. The driving force behind the inquiry is the proposition that the judiciary as the third arm of government at all times participates in governance. To contextualize the argument, I focus on judicial governance and accountability within the paradigm of Nigeria’s transition to democracy after decades of authoritarian military rule
Models of Democracy
No full textThe first two editions of Models of Democracy have proven immensely popular among students and specialists worldwide. In a succinct and far-reaching analysis, David Held provides an introduction to central accounts of democracy from classical Greece to the present and a critical discussion of what democracy should mean today.
This new edition has been extensively revised and updated to take account of significant transformations in world politics, and a new chapter has been added on deliberative democracy which focuses not only on how citizen participation can be increased in politics, but also on how that participation can become more informed.
Like its predecessor, the third edition of Models of Democracy combines lucid exposition and clarity of expression with careful scholarship and originality, making it highly attractive to students and experts in the field. The third edition will prove essential reading for all those interested in politics, political theory and political philosophy.
A companion website to Models of Democracy provides lecturer and student resources; including a study guide, an interview with the author and links to develop the reader's understanding of the topics covered
Immunologically augmented cancer treatment using modern radiotherapy
No full textRadiation oncology has recently seen tremendous technical advances, resulting in increasing cancer cures. However, malignant neoplasias are systemic diseases and may be lethal even with an excellent tumor local control. Immune therapy has grown to a mature approach in oncology, delivering results impossible only a few years ago. Treatment-limiting mechanisms such as the immune suppressive tumor microenvironment are now to a large extent deciphered, allowing for pharmacological intervention. Interestingly, radiation-based treatment effects have been shown to depend to a large degree on the immune system. Applying the recent advances in radiation therapy in conjunction with immune therapy can be a turning point towards the long-standing aim of curing cancer. Only a detailed understanding of the molecular mechanisms can guide the implementation of combined therapy modalities. © 2013 Elsevier Ltd
Dynamical vertex approximation for the two-dimensional Hubbard model
No full textRecently, diagrammatic extensions of dynamical mean field theory (DMFT) have been proposed for including short- and long-range correlations beyond DMFT on an equal footing. We employ one of these, the dynamical vertex approximation (D Gamma A), and study the two-dimensional Hubbard model on a square lattice. We define two transition lines in the phase diagram which correspond, respectively, to the opening of the gap in the nodal direction and throughout the Fermi surface. Our self-energy data show that the evolution between the two regimes occurs in a gradual way (crossover) and also that at low enough temperatures the whole Fermi surface is always gapped. Furthermore, we present a comparison of our DTA calculations at a parameter set where data obtained by other techniques are available. (C) 2015 Elsevier B.V. All rights reserved
Momentum structure of the self-energy and its parametrization for the two-dimensional Hubbard model
No full textWe compute the self-energy for the half-filled Hubbard model on a square lattice using lattice quantum Monte Carlo simulations and the dynamical vertex approximation. The self-energy is strongly momentum-dependent, but it can be parametrized via the noninteracting energy-momentum dispersion epsilon(k), except for pseudogap features right at the Fermi edge. That is, it can be written as Sigma (epsilon(k), omega), with two energylike parameters (epsilon, omega) instead of three (k(x), k(y), and omega). The self-energy has two rather broad and weakly dispersing high-energy features and a sharp omega = epsilon(k) feature at high temperatures, which turns to omega = -epsilon(k) at low temperatures. Altogether this yields a Z-and reversed-Z-like structure, respectively, for the imaginary part of Sigma (epsilon(k), omega). We attribute the change of the low-energy structure to antiferromagnetic spin fluctuations
Kimmerle conjecture for the Held and O'Nan sporadic simple groups
No full textUsing the Luthar--Passi method, we investigate the Zassenhaus and
Kimmerle conjectures for normalized unit groups of integral group rings of the
Held and O'Nan sporadic simple groups. We confirm the Kimmerle conjecture for
the Held simple group and also derive for both groups some extra information
relevant to the classical Zassenhaus conjecture
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