186,668 research outputs found
Anaphothrips dentatus Cui, Xi and Wang
No full textAnaphothrips dentatus Cui, Xi and Wang Anaphothrips dentatus Cui, Xi & Wang, 2017: 50. This species, known only from Heilongjiang Province, has previously been known only from Sanjiang Plain (47°35.08'N, 133°31.42'E) (Cui et al. 2017), but is here recorded from Nanwenghe national Nature Reserves (51°22.83'N, 124°34.24'E). Specimens examined. China, Heilongjiang Province, Sanjiang Plain, 18.vii.2013, holotype female aptera with 1 male, 1 female paratypes from grasses (Jun Wang); same locality and habitat as holotype, 2.vii.2014, 3 females from grasses (Jun Wang); Nanwenghe National nature reserve (51°22.83'N, 124°34.24'E), 21.vii.2017, 4 female apterae from grasses (Jun Wang).Published as part of Cui, Yanze & Wang, Jun, 2019, The genus Anaphothrips (Thysanoptera, Thripidae) in China, with three new species, pp. 246-258 in Zootaxa 4700 (2) on page 249, DOI: 10.11646/zootaxa.4700.2.4, http://zenodo.org/record/354844
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis
No full textUnderstanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription factor c-Jun are important regulators of this cell death program in post-mitotic neurons following survival-factor withdrawal. Our study demonstrates that ceramide levels increase upon survival-factor withdrawal in primary cultured cortical neurons. Furthermore, survival-factor withdrawal or addition of exogenous c2-ceramide induces JNK pathway activation in these cells. Western blot analyses of JNK and c-Jun using phospho-specific antibodies reveal that JNK and subsequent c-Jun phosphorylation occur hours before the initiation of apoptosis, reflected morphologically by neurite retraction and fragmentation, cell-body shrinkage and chromatin fragmentation. Immunocytochemistry using the same antibodies shows that phospho-JNK are localized in the neurites of control neurons and translocate to the nucleus where phospho-c-Jun concurrently appears upon ceramide-induced apoptosis. To determine if ceramide-induced c-Jun activation is responsible for the induction of the apoptotic program, we performed transient transfections of a dominant negative form of c-Jun, truncated in its transactivation region. Our results show that DNc-Jun partially protects cortical neurons from ceramide-induced apoptosis. Treatment of dominant negative c-Jun-expressing neurons with the pharmacological inhibitor of p38 kinase, SB203580, completely blocked neuronal death. Thus our data show that p38 and JNK/c-Jun pathways cooperate to induce neuronal apoptosis
A Modified inverse integer Cholesky decorrelation method and the performance on ambiguity resolution
No full textOne of the research focuses in the integer least squares problem is the decorrelation technique to reduce the number of integer parameter search candidates and improve the efficiency of the integer parameter search method. It remains as a challenging issue for determining carrier phase ambiguities and plays a critical role in the future of GNSS high precise positioning area. Currently, there are three main decorrelation techniques being employed: the integer Gaussian decorrelation, the Lenstra–Lenstra–Lovász (LLL) algorithm and the inverse integer Cholesky decorrelation (IICD) method. Although the performance of these three state-of-the-art methods have been proved and demonstrated, there is still a potential for further improvements. To measure the performance of decorrelation techniques, the condition number is usually used as the criterion. Additionally, the number of grid points in the search space can be directly utilized as a performance measure as it denotes the size of search space. However, a smaller initial volume of the search ellipsoid does not always represent a smaller number of candidates.\ud
This research has proposed a modified inverse integer Cholesky decorrelation (MIICD) method which improves the decorrelation performance over the other three techniques. The decorrelation performance of these methods was evaluated based on the condition number of the decorrelation matrix, the number of search candidates and the initial volume of search space. Additionally, the success rate of decorrelated ambiguities was calculated for all different methods to investigate the performance of ambiguity validation. \ud
The performance of different decorrelation methods was tested and compared using both simulation and real data. The simulation experiment scenarios employ the isotropic probabilistic model using a predetermined eigenvalue and without any geometry or weighting system constraints. MIICD method outperformed other three methods with conditioning improvements over LAMBDA method by 78.33% and 81.67% without and with eigenvalue constraint respectively. The real data experiment scenarios involve both the single constellation system case and dual constellations system case. Experimental results demonstrate that by comparing with LAMBDA, MIICD method can significantly improve the efficiency of reducing the condition number by 78.65% and 97.78% in the case of single constellation and dual constellations respectively. It also shows improvements in the number of search candidate points by 98.92% and 100% in single constellation case and dual constellations case.\u
Rheocricotopus (Psilocricotopus) orientalis Wang 1995
No full textKey to known adult males of the Rheocricotopus (Psilocricotopus) orientalis group 1 Tergite IX with tufts of setae................................................................... R. villiculus - Tergite IX without tufts of setae.......................................................................... 2 2 Anal point constricted at middle............................................................... R. constricutus - Anal point tapering.................................................................................... 3 3 Superior volsella absent....................................................................... R. orientalis - Superior volsella present............................................................................... 4 4 Tergite VI and VII brown; AR 0.51; inferior volsella digitiform....................................... R. calviculus - Tergite VII and 2/3 anterior of VI yellow; AR 0.35–0.37; inferior volsella broad thumb shaped............. R. kongi sp. n.Published as part of Lin, Xiao-Long, Yu, Hai-Jun, Wang, Qian, Bu, Wen-Jun & Wang, Xin-Hua, 2020, DNA barcodes and morphology confirm a new species of Rheocricotopus (Psilocricotopus) orientalis group (Diptera: Chironomidae), pp. 282-290 in Zootaxa 4768 (2) on page 289, DOI: 10.11646/zootaxa.4768.2.9, http://zenodo.org/record/377978
A Study of the Classical Landscape at the Wang River Villa of Wang Wei
No full textThe landscape of Wang Wei's Wang River Villa is examined by reviewing the essays and papers written about the poetical collaboration, the “Wang River Collection.” The purpose of this paper is to clarify the meaning of villa architecture in China. The author expects that this research will contribute to a mutual understanding between cultures. The villa was a Utopia for Wang. On the other hand, he was a pious Buddhist and Buddhistic concepts are reflected in the landscape. I consider the features of the classical landscape of Xie Lingyun and "Chu Ci," as written in “The Collection,” a reflection of the Buddhistic concept. When considering what the classics meant to Wang Wei, it is apparent that his villa is a representation of the classical landscape. It is not an imitation of the classical landscape, but a unique and original creation of art by Wang.departmental bulletin pape
C/EBPalpha downregualtes c-jun expression
No full textThe transcription factor C/EBPa is crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells. In C/EBPa knockout mice, no mature granulocytes are present. A dramatic increase of c-jun mRNA in C/EBPa knockout mice fetal liver was observed. c-jun, a component of the AP-1 transcription factor complex and a co-activator of the transcription factor PU.1, is important for monocytic differentiation. Here we report that C/EBPa downregulates c-jun expression to drive granulocytic differentiation. Ectopic increase of C/EBPa expression decreases c-jun mRNA level, and the human c-jun promoter activity is downregulated 8 fold in presence of C/EBPa. C/EBPa and c-jun interact through their leucine zipper domains and this interaction prevents c-jun from binding to DNA. This results in downregulation of c-jun’s capacity to autoregulate its own promoter through the proximal AP-1 site. Overexpression of c-jun prevents C/EBPa induced granulocytic differentiation. c-jun expression was higher in AML M2 patients with dominant negative C/EBPa mutations in comparison to AML M2 patients without C/EBPa mutations. Thus, we propose a model in which C/EBPa needs to downregulate c-jun expression and transactivation capacity for promoting granulocytic differentiation.Der Transkriptionsfaktor C/EBPa ist essentiell für die Differenzierung von Granulozyten. Die konditionelle Expression von C/EBPa induziert die neutrophile Differenzierung. Überdies kann C/EBPa die TPA-induzierte Differenzierung von myeloiden Vorläuferzellen zu Monozyten blockieren. In C/EBPa knockout Mäusen gibt es keine reifen Granulozyten. In der fötalen Leber von C/EBPa knockout Mäusen konnte eine stark erhöhte Expression der c-jun mRNA beobachtet werden. c-jun ist eine Komponente des AP-1 Transkriptionsfaktorkomplexes, ein Koaktivator des Transkriptionsfaktors PU.1 und ist wichtig für die Differenzierung von Monozyten. In dieser Arbeit zeigen wir, dass C/EBPa die c-jun Expression herunterreguliert und somit die Differenzierung von Granulozyten induziert. Die Überexpression von C/EBPa reduzierte die c-jun mRNA Menge und die Aktivität des humanen c-jun Promotors war in der Gegenwart von C/EBPa 8-fach herunterreguliert. C/EBPa und c-jun interagieren über ihre Leucin-Zipper Domänen und diese Interaktion verhindert die DNA-Bindung von c-jun. Dies resultiert in einer verminderten Kapazität von c-jun, den eigenen Promotor über die proximale AP-1 Stelle zu regulieren. Die Überexpression von c-jun blockiert die durch C/EBPa induzierte granulozytäre Differenzierung. Die c-jun Expression war in AML-M2 Patienten mit dominant-negativen Mutationen in C/EBPa im Vergleich zu AML-M2 Patienten ohne Mutationen in C/EBPa erhöht. Aufgrund dieser Daten schlagen wir ein Modell vor, in dem C/EBPa die Expression und Transaktivierungskapazität von c-jun herunterregulieren muß, um die granulozytäre Differenzierung zu induzieren
Dataset for Planar Array with Bidirectional Elements for Tunnel Environments
No full textDataset supports:
Wang, R., Wang, B-Z., Ding, X., & Ou, J-Y. (2017). Planar array with bidirectional elements for tunnel environments. Scientific Reports 7, 15421(2017)
Funded by University of Southampton Zepler Institute Research Collaboration Stimulus Fund.</span
First person – Yihua Wang
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Yihua Wang is the first author on ‘Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively’, published in Journal of Cell Science. Yihua is a Lecturer in Biological Sciences at the University of Southampton, studying cell signalling in lung fibrosis and cancer, drug target validation and gene function analysis
XIAO-LONG LIN, HAI-JUN YU, RUI-LEI ZHANG & XIN-HUA WANG (2019) Polypedilum (Cerobregma) heberti sp. n. (Diptera: Chironomidae) from Gaoligong Mountains, Yunnan, China Zootaxa, 4571: 255-262.
No full textLin, Xiao-Long, Yu, Hai-Jun, Zhang, Rui-Lei, Wang, Xin-Hua (2020): XIAO-LONG LIN, HAI-JUN YU, RUI-LEI ZHANG & XIN-HUA WANG (2019) Polypedilum (Cerobregma) heberti sp. n. (Diptera: Chironomidae) from Gaoligong Mountains, Yunnan, China Zootaxa, 4571: 255-262. Zootaxa 4852 (4): 500-500, DOI: 10.11646/zootaxa.4852.4.
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