108,138 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
How are empowering leadership, self-efficacy and innovative behavior related to nurses' agency in distributed leadership in Denmark, Italy and Israel?
No full textAim: The purpose of the study was to introduce the concept of distributed leadership to international nursing management by conducting a cross-national investigation of its relationships with empowering nursing leadership, nurses' work self-efficacy and nurses' innovative behaviour. Background: Distributed leadership theory suggests that when more people lead processes together, innovation will be superior to solo leadership. However, we need knowledge about how nurse managers may enhance nurses' distributed leadership agency (DLA), and whether such results are generalizable across countries. Method: The cross-national survey with an overall purposeful sampling method used questionnaire data from hospital nurses from Israel (n = 239), Italy (n = 226) and Denmark (n = 709). We used validated scales measuring Empowering Leadership, Self-efficacy, Innovative Work Behavior and DLA. Results: The results from all three countries showed that empowering leadership and work self-efficacy were positively related to DLA, which, in turn, was also related to more innovation. Conclusion: The results may imply that nursing managers can increase workplace innovativeness by adopting an empowering leadership style that supports nurses' self-efficacy and distributes leadership tasks. Implications for Nursing Management: The cross-country robustness of the results may encourage further research in distributed leadership in nurse management, notably with a focus on causal mechanisms
Tsjernobyl - sluttrapport fra NINAs radioøkologiske program 1986 - 1990
No full textGaare, E., Jonsson B., og Skogland T. Tsjernobyl - sluttrapport fra NINAs radioøkologiske program 1986 - 1990 NINA temahefte 2:1-7
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A covariant formalism of spin precession with respect to a reference congruence
No full textWe derive an effectively three-dimensional relativistic spin precession formalism. The formalism is applicable to any spacetime where an arbitrary timelike reference congruence of worldlines is specified. We employ what we call a stopped spin vector which is the spin vectorthat we would get if we momentarily make a pure boost of the spin vector to stop it relative to the congruence. Starting from the Fermi transport equation for the standard spin vector we derive a corresponding transport equation for the stopped spin vector. Employing a spacetime transport equation for a vector along a worldline, corresponding to spatial parallel transport with respect to the congruence, we can write down a precession formula for a gyroscope relative to the local spatial geometry defined by the congruence. This general approach has already been pursued by Jantzen et al (see e.g. Jantzen R T, Carini P and Bini D 1992 Ann. Phys. 215 1-50), but the algebraic form of our respective expressions differs. We are also applying the formalism to a novel type of spatial parallel transport introduced in Jonsson (2006 Class. Quantum Grav. 23 1), as well as verifying the validity of the intuitive approach of aforthcoming paper (Jonsson 2006 forthcoming) where gyroscope precession is explained entirely as a double Thomas type of effect. We also present the resulting formalism in explicit three-dimensional form (using the boldface vector notation), and give examples of applications
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Mass spectrometry in protein structure analysis
No full textMass spectrometry is an important analytical tool in biological and biochemical research. The speed, accuracy and sensitivity is unmatched by conventional analytical techniques. Identification of proteins and characterisation of their primary structure is a rapidly growing field in the post-genomic era, where matrix-assisted laser desorption/ionisation time-of-flight peptide mass fingerprinting combined with electrospray tandem mass spectrometry is well suited to solve the questions. This thesis deals with the strength and diversity of applying mass spectrometry to biochemical projects. The study covers sample preparation, protein identification, characterisation of post-translational modifications and mechanistic aspects of gas-phase cleavage of protonated peptides.The characteristics of a quadrupole - time-of-flight tandem mass spectrometer, used throughout this study, were investigated in a project where the thyroid hormone receptor ligand binding domain (TR-LBD) was analysed. Carboxymethylation of the TR-LBD in its folded conformation and identification of the alkylated Cys residues allowed estimates of tertiary structure relationships within the protein. In the tryptic digest, the peptides were mass measured with an accuracy of 2 ppm, and product ions generated by tandem mass spectrometry were measured to an accuracy of 20 ppm when internal calibrants were used.Proline-rich proteins (PRPs) are predominant in saliva and nano-electrospray mass spectrometry was employed to identify their degradation products after treatment with Streptococcus and Actinomyces microorganisms. Several of the peptides generated had a Cterminal Pro-Gln bacteria binding sequence, and release of a pentapeptide with innate immunity properties was suggested. In another study it was shown that PRP-1 and its Cterminally truncated form PRP-3 are present in two forms in human saliva, one of which is 0hexuronidated at Ser 17 in the biologically active N-terminal segment. Nano-electrospray tandem mass spectrometry of PRP-1 tryptic peptides was carried out to determine the 0hexuronidation. It was then also found that peptides containing the PQGPPQQGG consensus repeat reveal a facile cleavage of the Gln 2-Gly 3 peptide bond in the gas-phase upon collision-induced dissociation. The data indicate involvement of the G1n side-chain in the fragmentation mechanism.Phosphorylation is a common post-translational modification of proteins but only known in a few prohormone precursors. Using nano-electrospray tandem mass spectrometry, a phosphorylated form of porcine peptide YY was now identified and the modification was localised to Ser 13.In-gel digestion of gel-separated proteins has many advantages in terms of sensitivity and high-throughput for protein identification. However, the coverage of the primary structure by mass spectrometric analysis for detection of post-translational modifications is generally poor. An alternative method was developed that uses electroblotting of the gel-separated proteins to polyvinylidene difluoride membranes followed by protein extraction and digestion in solution. Compared to in-gel digestion, this procedure results in improved sequence coverage (by approximately 30%) and it was applied to identify protein methylation and acetylation sites.DNasel affinity chromatography in combination with nano-electrospray tandem mass spectrometry identified a specific subset of actin-associated heterogeneous nuclear ribonucleoproteins (hnRNP) from rat liver pre-messenger RNP particles. The proteins were identified as being a novel hnRNP A2 isoform, three hnRNP A3 forms and a novel A/B type of hnRNP designated DBP-40. DBP-40 binds directly to actin in vivo, and it is also capable of individually binding RNA as well as hnRNP A2 and A3 in the presence of actin.List of scientific papersI. Jonsson AP, Carlquist M, Husman B, Ljunggren J, Jornvall H, Bergman T, Griffiths WJ (1999). "Structural analysis of the thyroid hormone receptor ligand binding domain: studies using a quadrupole time-of-flight tandem mass spectrometer. " Rapid Commun Mass Spectrom 13(18): 1782-91 https://pubmed.ncbi.nlm.nih.gov/10482889II. Li T, Bratt P, Jonsson AP, Ryberg M, Johansson I, Griffiths WJ, Bergman T, Stromberg N (2000). "Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal streptococcus and actinomyces species. " Infect Immun 68(9): 5425-9 https://pubmed.ncbi.nlm.nih.gov/10948176III. Jonsson AP, Griffiths WJ, Bratt P, Johansson I, Stromberg N, Jornvall H, Bergman T (2000). "A novel Ser O-glucuronidation in acidic proline-rich proteins identified by tandem mass spectrometry. " FEBS Lett 475(2):: 131-4 https://pubmed.ncbi.nlm.nih.gov/10858503IV. Jonsson AP, Bergman T, Jornvall H, Griffiths WJ, Bratt P, Stromberg N (2001). "Gln-Gly cleavage: correlation between collision-induced dissociation and biological degradation. " J Am Soc Mass Spectrom 12(3): 337-42 https://pubmed.ncbi.nlm.nih.gov/11281609V. Jonsson AP, Bergman T, Jornvall H, Griffiths WJ (2001). "Gln-Gly cleavage: a dominant dissociation site in the fragmentation of protonated peptides. " Rapid Commun Mass Spectrom 15(9): 713-20 https://pubmed.ncbi.nlm.nih.gov/11319794VI. Chen Z, Eriste E, Jonsson AP, Norberg A, Nepomuceno D, Lovenberg TW, Bergman T, Efendic S, Jornvall H, Sillard R (2001). "Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity" FEBS Lett 492(1-2): 119-22 https://pubmed.ncbi.nlm.nih.gov/11248248VII. Jonsson AP, Palmberg C, Percipalle P, Assouni Y, Nordling E, Daneholt B, Jornvall H, Bergman T (2001). "Recovery of proteins from gel separations for inslution digestion and mass spectrometry." Anal Chem (Submitted)VIII. Percipalle P, Jonsson AP, Nashchekin D, Bergman T, Guialis A, Daneholt B (2001). "Actin is associated with a specific subset of hnRNP proteins and transferred with mRNA into the cytoplasm." Mol Cell Biol (Manuscript)</p
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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