93 research outputs found
JARINGAN SYARAF TIRUAN MENGGUNAKAN ALGORITMA HEBB PADA PENYAKIT GIGI DAN MULUT
Get PDFIn the current era, the development of computer technology is growing rapidly, especially in the health sector. Computerized systems are very necessary nowadays, especially in treating disease. One of these diseases is dental and oral disease which is very common in society due to a lack of maintaining healthy teeth and mouth. This disease has several types and also different symptoms so it has different treatments. Diseases that often occur include gingivitis, cavities and sensitive teeth. Where the symptoms include bad breath, gum pain, fever and a bitter taste in the mouth. Therefore, the author implemented the Hebb rule algorithm in the diagnosis of oral and dental diseases with the aim of minimizing the risk of disease problems occurring in patients
The shocking transit of WASP-12b : modelling the observed early ingress in the near ultraviolet
No full text4 pages, 2 figuresNear ultraviolet observations of WASP-12b have revealed an early ingress compared to the optical transit lightcurve. This has been interpreted as due to the presence of a magnetospheric bow shock which forms when the relative velocity of the planetary and stellar material is supersonic. We aim to reproduce this observed early ingress by modelling the stellar wind (or coronal plasma) in order to derive the speed and density of the material at the planetary orbital radius. From this we determine the orientation of the shock and the density of compressed plasma behind it. With this model for the density structure surrounding the planet we perform Monte Carlo radiation transfer simulations of the near UV transits of WASP-12b with and without a bow shock. We find that we can reproduce the transit lightcurves with a wide range of plasma temperatures, shock geometries and optical depths. Our results support the hypothesis that a bow shock could explain the observed early ingress.Peer reviewe
A further study of retinal locus as a factor in the recognition of English and Jewish words.
No full textEver since 1929, when Lashley (14) published the results of his brain-extirpation experiments and Kohler (11) his critique of associationism and behaviorism, psychologists have been prone to tacit acceptance of the equipotentiality hypothesis. For over two decades, many a contemporary theorist has conceded Lashley’s argument and, consequently, has assumed that some form of configuration theory constitutes the only adequate attack upon behavioral problems. [...] The recognition-differential for Jewish words, although in the opposite direction from the English differential, was small and, consequently, one could argue that the conditions for Jewish-word recognition were, in some way, qualitatively different from that of the English words. It appeared to the present author that, if one could find more fluent readers of both English and Jewish, one might obtain more conclusive evidence one way or the other. Such evidence is necessary before the broader significance of Mishkin and Forgays’ work can be established: that the locus of excitation plays a determining role in the recognition of visually perceived words
A Manifesto of Nodalism
Get PDFThis paper proposes the notion of Nodalism as a means describing contemporary culture and of understanding my own creative practice in electronic music composition. It draws on theories and ideas from Kirby, Bauman, Bourriaud, Deleuze, Guatarri, and Gochenour, to demonstrate how networks of ideas or connectionist neural models of cognitive behaviour can be used to contextualize, understand and become a creative tool for the creation of contemporary electronic music
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'Et in arcadia ego': the politics of pirates in the 'Old Arcadia', 'New Arcadia' and 'Urania'
No full textAbstract 2466: Sequential tumor and immune targeted immunotherapy: Anti-tumor activity of antibody drug conjugate Trastuzumab Emtansine (T-DM1) with CD137 stimulation in HER-2+ breast cancer therapy
No full textInternational audienceThe mainstay of HER2+ breast cancer treatment has been monoclonal antibody therapy with Trastuzumab, a humanized antibody that targets HER-2. However, the efficacy of Trastuzumab monotherapy is only 10-15%. Therefore, strategies are being developed to enhance its therapeutic efficacy. Our previous study demonstrated that stimulation of NK cells with an anti-CD137 agonistic mAb enhanced Trastuzumab-mediated Antibody Dependent Cellular Cytotoxicity (ADCC). Anti-CD137 agonistic mAb enhanced anti-breast cancer activity of Trastuzumab in vivo in a xenotransplanted human breast cancer model (Kohrt et al. J Clin. Invest, 2012, 22:3). We have developed a treatment regimen consisting of sequential administration of Trastuzumab followed by CD137 antibody as three weekly injections. This regimen demonstrated more potent antitumor activity than administration of anti-CD137 mAb followed by Trastuzumab. Our combination therapy was superior to Traztuzumab alone in a primary HER2-overexpressing-breast tumor xenotransplant model but was ineffective in low HER-2 expressing breast cancer model. Next, we evaluated the therapeutic efficacy of FDA approved antibody drug conjugate Trastuzumab Emtansine (T-DM1) in combination with CD137 antibody. We used HER2 over-expressing HER18 xenograft model and an SU-258 primary breast cancer model in our studies. Following tumor inoculation, mice received either T-DM1 on day 3 (for HER18 xenograft), or day 30 (for SU-258) and anti-CD137 antibody on day 4(or HER18) or day 31(for SU-258) with each treatment repeated weekly for a total of three weeks. Sequential antibody strategy with T-DM1 and CD137 significantly improved survival compared to T-DM1 alone or with Trastuzumab and CD137 antibody. Our results demonstrate that T-DM1 retains its potency and demonstrates synergistic activity with anti-CD137 mAb therapy against HER2-overexpressing breast cancer models. Our results support a novel, sequential antibody approach against HER-2+breast cancer, by targeting first the tumor with an antibody drug conjugate and then the host immune system. Clinical investigations are now planned to determine the clinical outcome of our immunotherapy strategy. Citation Format: Suparna Dutt, Narendiran Rajasekaran, Aurelien Marabelle, Roch Houot, Mohith Sadaram, Jonathan Hebb, Idit Sagiv-Barfi, Sid Ambulkar, Amanda Rajapaksa, Cariad Chester, Erin Waller, Holbrook Kohrt. Sequential tumor and immune targeted immunotherapy: Anti-tumor activity of antibody drug conjugate Trastuzumab Emtansine (T-DM1) with CD137 stimulation in HER-2+ breast cancer therapy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2466. doi:10.1158/1538-7445.AM2015-246
Equilibrium Properties of Temporally Asymmetric Hebbian Plasticity
Get PDFA theory of temporally asymmetric Hebb rules, which depress or potentiate synapses depending upon whether the postsynaptic cell fires before or after the presynaptic one, is presented. Using the Fokker-Planck formalism, we show that the equilibrium synaptic distribution induced by such rules is highly sensitive to the manner in which bounds on the allowed range of synaptic values are imposed. In a biologically plausible multiplicative model, the synapses in asynchronous networks reach a distribution that is invariant to the firing rates of either the presynaptic or postsynaptic cells. When these cells are temporally correlated, the synaptic strength varies smoothly with the degree and phase of their synchrony
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