1,721,599 research outputs found
sj-pdf-1-cjb-10.1177_00938548231202800 – Supplemental material for Alcohol Consumption and Violent Offending: Findings From a Longitudinal Study on Korean Youth from Mid to Late Adolescence
No full textSupplemental material, sj-pdf-1-cjb-10.1177_00938548231202800 for Alcohol Consumption and Violent Offending: Findings From a Longitudinal Study on Korean Youth from Mid to Late Adolescence by Yeungjeom Lee, Stephanie M. Cardwell and Jihoon Kim in Criminal Justice and Behavior</p
Postinternet Art of the Moving Image and the Disjunctures of the Global and the Local: Kim Hee-cheon and Other Young East Asian Artists
Full text linkJihoon Kim discusses in his Postinternet Art of the Moving Image and the Disjunctures of the Global and the Local: Kim Hee-cheon and Other Young East Asian Artists” ways in which moving image works by East Asian artists Chen Chen-yu, Lu Yang, and Kim Hee-cheon engage the postinternet condition, a situation in which the internet and digital technologies are no longer perceived as new but as fundamentally restructuring our subjectivity and world. By opening a platform for intersecting the postinternet condition with a discourse on globalization, which has yet to be fully discussed in the existing Western-centric discourses on postinternet art, a key specificity of the postinternet art of the moving image by contemporary East Asian artists lies in its attempts to create spreadable images of multiple political, aesthetic, and cultural layers. The artists’ rigorous aesthetic juxtapositions of virtual and physical spaces should be seen not simply as indicating the artists’ cosmopolitan postinternet sensibilities but also as expressing their engagement with the contradictory and unstable disjunctures of the global and local in contemporary East Asia
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the Membrane
Full text linkThe Wnt & beta;-catenin signaling pathway is a highly conserved mechanism that plays a critical role from embryonic development and adult stem cell homeostasis. However, dysregulation of the Wnt pathway has been implicated in various diseases, including cancer. Therefore, multiple layers of regulatory mechanisms tightly control the activation and suppression of the Wnt signal. The E3 ubiquitin ligases RNF43 and ZNRF3, which are known negative regulators of the Wnt pathway, are critical component of Wnt signaling regulation. These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3. This review article summarizes recent findings on RNF43 and ZNRF3 and their potential implications for the development of therapeutic strategies to target the Wnt signaling pathway in various diseases, including cancer.11Nsciescopu
Intestinal Organoid as a Research Platform for the Virus-host Interaction
No full textViral pathogens utilize various human organs for infection, and the gut is one of the primary entry sites for the viral pathogen. The gut epithelium is tightly maintained since multiple harmful substances, including viral pathogens, attack it. The outbreak of new viruses or strains often poses a massive threat to human life, so we need to understand how they develop and how to prevent them by inventing new therapeutic approaches, including new drugs and vaccines. Therefore, biology society is always eager to invent a better way to investigate viral pathogens, including infection mechanism, life cycle, drug response, etc. Therefore, the advances of new research platforms were always critical bottlenecks to researchers. The recent development of the organoid culture system widely opened new opportunities for human diseases related to viral pathogens. In particular, the organoid culture system was quickly applied to severe acute respiratory syndrome coronavirus 2 research, providing massive information about the virus and potential therapeutics such as cellular tropism, drug response, and crucial genes involved in viral replication and infection. This review provides a comprehensive summary of recent advances in intestinal organoid culture systems for viral pathogen research. © 2023, The Korean Society for Mocrobiology / The Korean Society of Virology. All rights reserved.11Nscopuskc
Synergistic nanomedicine by combined gene and photothermal therapy
No full textTo date, various nanomaterials with the ability for gene delivery or photothermal effect have been developed in the field of biomedicine. The therapeutic potential of these nanomaterials has raised considerable interests in their use in potential next-generation strategies for effective anticancer therapy. In particular, the advancement of novel nanomedicines utilizing both therapeutic strategies of gene delivery and photothermal effect has generated much optimism regarding the imminent development of effective and successful cancer treatments. In this review, we discuss current research progress with regard to combined gene and photothermal therapy. This review focuses on synergistic therapeutic systems combining gene regulation and photothermal ablation as well as logically designed nano-carriers aimed at enhancing the delivery efficiency of therapeutic genes using the photothermal effect. The examples detailed in this review provide insight to further our understanding of combinatorial gene and photothermal therapy, thus paving the way for the design of promising nanomedicines. (C) 2015 Published by Elsevier B.V.117351sciescopu
Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges
Full text linkGiven the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS-responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS-responsive functional moieties, a wide range of carrier systems has been designed for ROS-mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS-responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation. In particular, the discussions in this article will mainly focus on polymeric nanoparticles, hydrogels, inorganic nanoparticles, and activatable prodrugs that have been integrated with diverse ROS-responsive moieties for spatiotemporally controlled release of drugs for effective therapy.1149sciescopu
Ontologia para a Hibridez dos Novos Média
No full textReview of Jihoon Kim, Between Film, Video, and the Digital: Hybrid Moving Images in the Post-media Age, New York: Bloomsbury, 2016, 404 pp., ISBN 978-1-6289-2293-6.
In Between Film, Video, and the Digital: Hybrid Moving Images in the Post-media Age, Jihoon Kim tries to describe the ontology of contemporary artworks produced within the universe of New Media Art, particularly the ontology of those works he understands as hybrid moving images, images whose typical materialities are denatured, deconstructed, and resignified when remediated through digital platforms, technical supports or artistic practices initially strange to them. Revising theories by important art critics of the last decades, such as Clement Greenberg and Rosalind Krauss, and combining them with theories by contemporary art critics, such as Lev Manovich and Peter Weibel, Kim provides us new tools for understanding why this New Media hybridity is feasible as visual fruition, as well as why it is progressively capable of grasping new, historically-oriented, image possibilities.Recenção de crítica de Jihoon Kim, Between Film, Video, and the Digital: Hybrid Moving Images in the Post-media Age, New York: Bloomsbury, 2016, 404 pp., ISBN 978-1-6289-2293-6.
Em Between Film, Video, and the Digital: Hybrid Moving Images in the Post-media Age, Jihoon Kim tenta descrever a ontologia das obras de arte contemporânea produzidas no universo da Arte dos Novos Média, particularmente a ontologia das obras que ele entende como imagens em movimento híbridas, imagens cujas caracteristicas típicas são desnaturalizadas, desconstruídas e ressignificadas quando remediadas através de plataformas digitais, suportes técnicos ou práticas artísticas distintas das originais. Revendo as teorias de importantes críticos de arte das últimas décadas, como Clement Greenberg e Rosalind Krauss, e conjugando-as com teorias de críticos de arte contemporânea, como Lev Manovich e Peter Weibel, Kim fornece-nos novas ferramentas para entender por que motivo esta hibridez dos Novos Média é viável como fruição visual, bem como por que é progressivamente capaz de captar novas possibilidades da imagem historicamente orientadas
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Polydopamine Hollow Nanoparticle Functionalized with N-diazeniumdiolates as a Nitric Oxide Delivery Carrier for Antibacterial Therapy
No full textA biocompatible nitric oxide (NO) delivery nanoplatform, whose structure is a hollow nanoparticle composed of polydopamine backbone and diazeniumdiolates functional groups, is developed for antibacterial therapy. This platform liberates high NO quantitis and exerts the antibacterial activity with excellent biocompatibility thus being promising for treating bacterial infections. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim112121sciescopu
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