771 research outputs found
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Satellite-retrieved direct radiative forcing of aerosols over North-East India and adjoining areas: climatology and impact assessment
No full textThe article by J. Biswas et al. contained an update in affiliation of author Binita Pathak. The author would like to add another affiliation to her name. Her updated affiliations are the following
Biswas-Milovic model and its optical solitons
No full textInternational Conference on Numerical Analysis and Applied Mathematics 2018, ICNAAM 2018 -- 13 September 2018 through 18 September 2018 -- -- 149843In this work, optical solitons are obtained for the Biswas - Milovic equation as a generalized model via the extended generalizing Riccati mapping method. This method reveals several optical solitons including traveling wave solutions. The found solutions are identified with two different forms including the hyperbolic functions, the rational functions and the trigonometric functions. Reliability of our solution is given graphical consequens. © 2019 Author(s)
On connections on principal bundles
No full textAbstractA new construction of a universal connection was given in Biswas, Hurtubise and Stasheff (2012). The main aim here is to explain this construction. A theorem of Atiyah and Weil says that a holomorphic vector bundle E over a compact Riemann surface admits a holomorphic connection if and only if the degree of every direct summand of E is zero. In Azad and Biswas (2002), this criterion was generalized to principal bundles on compact Riemann surfaces. This criterion for principal bundles is also explained
Correction: De Francesco et al. In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions. Animals 2021, 11, 3231
No full textReetuparna Biswas was not included as an author in the original publication [...
Auto-Scaling Techniques for Clouds Processing Requests with Service Level Agreements
No full textAuto-scaling mechanisms allow applications running on Cloud environments to maintain a guaranteed Quality of Service while efficiently utilizing resources and keeping operational costs low for the service providers. However, creating such an auto-scaling framework may be challenging due to the need to precisely estimate resource usage while the workload patterns vary significantly.The research presented in this thesis focuses on automatic provisioning of compute resources in the Cloud performed by an intermediary enterprise for a single client enterprise. The enterprise hosting a broker uses techniques for dynamically controlling the number of resources used by the client enterprise. The research introduces three auto-scaling techniques: a reactive, a proactive and a hybrid technique. These techniques allow resources to be scaled based on user demand.The primary goal of these auto-scaling techniques is to achieve a profit for the intermediary enterprise while maintaining the desired grade of service for the client enterprise. A secondary goal is to generate a lower cost for the client enterprise in comparison to the situation in which the client acquires resources directly from the cloud provider. The techniques support both on-demand requests as well as requests with service level agreements (SLAs). The effectiveness of the proposed auto-scaling techniques is demonstrated through experiments performed on proof of concept prototypes and simulations. The experimental results show that for a number of different combinations of system and workload parameters experimented with, the proposed algorithms lead to a significant broker profit and a lower user cost in comparison to a conventional non-auto-scaling system
Satellite-based study of physico-optical properties of aerosols over a westernmost location of Brahmaputra valley
No full textThis study examines the long term trend of the radiatively active atmospheric aerosols which can influence the Earth’s energy budget directly by scattering and absorbing radiation and indirectly by acting as cloud condensation nuclei. MODIS sensor on board the NASA Earth Observing System Terra and Aqua satellite based Aerosol Optical Depth (AOD) data are used for long term analysis of aerosols over Bongaigaon, Assam for the period August, 2002 to March, 2017. Highest AOD values are observed in pre-monsoon (March-May) season due to long range transportation as well as intense biomass burning activities especially as a part of Jhum cultivation. In general, AOD values are low in post-monsoon (October-November) season which may be due to wash out of aerosols by rain in the preceding months without enough replacement. The monthly AOD values vary from its highest value 0.949 in April, 2016 to its lowest value 0.107 in November, 2002 for the study period. From the comparison of MODIS Terra and Aqua AOD at 550 nm, it is clearly seen that generally Terra AOD at 10:30 hr is higher than the Aqua AOD at 13:30hr. A slowly increasing trend of both Aqua and Terra AOD at 550 nm is observed over the study location. The observed Ångström exponent value varies from its minimum value in monsoon season to its maximum value in winter season. With increasing AOD values, horizontal visibility decreases over Bongaigaon
El proceso de creación de la película Bridge (2016): El proceso alquímico de transformarse individual y socialmente
No full textThe author and director of the film Bridge (2016), Amit R. Biswas, reflects on the process
of film-making, using strategies that deal with self (and, therefore, social) transformation
through art. In a sort of inner confession monologue, he delves not only into the more
anecdotal part of the logistics and economic tour-de-force problems that producing a film
involve; but also, and more interestingly, in the causes, nuances, and psychological details
that are contained in the plot. Seen as a process of catharsis and posterior anagnorisis, the
film unveils the subtle influences that underlie human contact, the transformation of the
human psyche by means of compassionate attitudes, and the mutual redemption suffered by
the seeming victim and his apparent saviour, in a sort of alchemic metempsychosis released
by mutual understanding and empathy.El autor y director de la película Bridge (2016), Amit R. Biswas, reflexiona sobre el proceso
de creación y producción cinematográficas, utilizando para ello estrategias que tienen que ver
con la transformación del yo (y, por ende, de la sociedad) a través del arte. En una suerte de
monólogo-confesión interior, el director profundiza no solo sobre esa parte más anecdótica
de la logística y de los enormes problemas económicos que se suscitan cuando se produce
un largometraje; lo hace también, lo que es más interesante, sobre las causas, matices y
detalles psicológicos que están contenidos en la trama. Visto el film como un proceso de
catarsis y posterior anagnórisis, se desvelan en él las sutiles influencias que subyacen en el
contacto humano, la transformación de la psique por medio de unas actitudes compasivas,
y la redención mutua que sufren la aparente víctima y el que parece su salvador, en una
metempsícosis alquímica catalizada por la comprensión y la empatía mutuas
El proceso de creación de la película Bridge (2016): el proceso alquímico de transformarse individual y socialmente
No full textThe author and director of the film Bridge (2016), Amit R. Biswas, reflects on the process of film-making, using strategies that deal with self (and, therefore, social) transformation through art. In a sort of inner confession monologue, he delves not only into the more anecdotal part of the logistics and economic tour-de-force problems that producing a film involve; but also, and more interestingly, in the causes, nuances, and psychological details that are contained in the plot. Seen as a process of catharsis and posterior anagnorisis, the film unveils the subtle influences that underlie human contact, the transformation of the human psyche by means of compassionate attitudes, and the mutual redemption suffered by the seeming victim and his apparent saviour, in a sort of alchemic metempsychosis released by mutual understanding and empathy.El autor y director de la película Bridge (2016), Amit R. Biswas, reflexiona sobre el proceso de creación y producción cinematográficas, utilizando para ello estrategias que tienen que ver con la transformación del yo (y, por ende, de la sociedad) a través del arte. En una suerte de monólogo-confesión interior, el director profundiza no solo sobre esa parte más anecdótica de la logística y de los enormes problemas económicos que se suscitan cuando se produce un largometraje; lo hace también, lo que es más interesante, sobre las causas, matices y detalles psicológicos que están contenidos en la trama. Visto el film como un proceso de catarsis y posterior anagnórisis, se desvelan en él las sutiles influencias que subyacen en el contacto humano, la transformación de la psique por medio de unas actitudes compasivas, y la redención mutua que sufren la aparente víctima y el que parece su salvador, en una metempsícosis alquímica catalizada por la comprensión y la empatía mutuas
Layer-by-layer hybrid chemical doping for high transmittance uniformity in graphene-polymer flexible transparent conductive nanocomposite
No full textA traditional transparent conducting film (TCF) such as indium tin oxide (ITO) exhibits poor mechanical flexibility and inconsistent transmittance throughout the UV-VIS-NIR spectrum. Recent TCFs like graphene films exhibit high sheet resistance (Rs) due to defect induced carrier scattering. Here we show a unique hybrid chemical doping method that results in high transmittance uniformity in a layered graphene-polymer nanocomposite with suppressed defect-induced carrier scattering. This layer-by-layer hybrid chemical doping results in low Rs (15 sq at >90% transmittance) and 3.6% transmittance uniformity (300-1000 nm) compared with graphene (17%), polymer (8%) and ITO (46%) films. The weak localization effect in our nanocomposite was reduced to 0.5%, compared with pristine (4.25%) and doped graphene films (1.2%). Furthermore, negligible Rs change (1.2 times compared to 12.6 × 103 times in ITO) and nearly unaltered transmittance spectra were observed up to 24 GPa of applied stress highlighting mechanical flexibility of the nanocomposite film. © 2018 The Author(s
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