277 research outputs found
Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms
No full textTranslation initiation factor 2 (IF2) is involved in the early steps of bacterial protein synthesis. It promotes the stabilization of the initiator tRNA on the 30S initiation complex (IC) and triggers GTP hydrolysis upon ribosomal subunit joining. While the structure of an archaeal homologue (a/eIF5B) is known, there are significant sequence and functional differences in eubacterial IF2, while the trimeric eukaryotic IF2 is completely unrelated. Here, the crystal structure of the apo IF2 protein core from Thermus thermophilus has been determined by MAD phasing and the structures of GTP and GDP complexes were also obtained. The IF2-GTP complex was trapped by soaking with GTP in the cryoprotectant. The structures revealed conformational changes of the protein upon nucleotide binding, in particular in the P-loop region, which extend to the functionally relevant switch II region. The latter carries a catalytically important and conserved histidine residue which is observed in different conformations in the GTP and GDP complexes. Overall, this work provides the first crystal structure of a eubacterial IF2 and suggests that activation of GTP hydrolysis may occur by a conformational repositioning of the histidine residue
ERP software system comparison between Odoo and Microsoft Dynamics NAV
No full textThe purpose of the thesis was to compare the two ERP software systems Odoo and Microsoft Dynamics NAV. The thesis sought to find out if Odoo can replace the existing Microsoft Dynamics core functionalities.
The commissioner is Lasse Seppänen, a principal lecturer at HAMK (Häme University of Applied Sciences) in Finland. The university currently uses Microsoft Dynamics NAV to teach students about business information systems.
The thesis explores the Microsoft Dynamics NAV system’s current features and asks how Odoo meets these requirements. The objective is also to determine which ERP system serves the university best.
First, the thesis explains central concepts related to ERP systems. In order to compare the two ERP systems evaluation criteria investigated through literary research. The thesis proceeds by discussing the current ERP requirements. Based on this data Odoo and Microsoft Dynamics were analyzed.
The research compares the two ERP solutions. The outcome of the analysis shows that Odoo is an alternative in comparison to Microsoft Dynamics NAV. The author recommends that the university implement Odoo through the Odoo Education platform
Fictionality and Literature: Core Concepts Revisited
No full textAuthor / Henrik Zetterberg-Nielsen -- Narrator / Sylvie Patron -- Plot / Wendy Veronica Xin -- Character / H. Porter Abbott -- Consciousness / Maria Mäkelä -- Metaphor / Greta Olson -- Paratext / Louise Brix Jacobsen -- Intertextuality / Rikke Andersen Kraglund -- Metafiction and metalepsis / Richard Walsh -- The novel / Catherine Gallagher and Simona Zetterberg-Nielsen -- Poetry / Lasse R. Gammelgaard -- Literary nonfiction / James Phelan -- Ethics / Jakob Lothe -- Social justice / Susan S. Lanser.Item embargoed for five year
The Rating Game: Sentiment Rating Reproducibility from Text
No full textSentiment analysis models often use rat-ings as labels, assuming that these rat-ings reflect the sentiment of the accom-panying text. We investigate (i) whether human readers can infer ratings from re-view text, (ii) how human performance compares to a regression model, and (iii) whether model performance is affected by the rating “source ” (i.e. original author vs. annotator). We collect IMDb movie reviews with author-provided ratings, and have them re-annotated by crowdsourced and trained annotators. Annotators re-produce the original ratings better than a model, but are still far off in more than 5 % of the cases. Models trained on annotator-labels outperform those trained on author-labels, questioning the useful-ness of author-rated reviews as training data for sentiment analysis.
Optimal high-dimensional and nonparametric distributed testing under communication constraints
No full textWe derive minimax testing errors in a distributed framework where the data is
split over multiple machines and their communication to a central machine is
limited to bits. We investigate both the - and infinite-dimensional
signal detection problem under Gaussian white noise. We also derive distributed
testing algorithms reaching the theoretical lower bounds.
Our results show that distributed testing is subject to fundamentally
different phenomena that are not observed in distributed estimation. Among our
findings, we show that testing protocols that have access to shared randomness
can perform strictly better in some regimes than those that do not. We also
observe that consistent nonparametric distributed testing is always possible,
even with as little as -bit of communication and the corresponding test
outperforms the best local test using only the information available at a
single local machine. Furthermore, we also derive adaptive nonparametric
distributed testing strategies and the corresponding theoretical lower bounds.Comment: 53 page
Finn Søeborg - a forgotten welfare voice
No full textThis thesis examines popular Danish author Finn Søeborg’s relation to the public literary andhistorical debate surrounding the idea and consequences of the Danish welfare state during itsfoundation and heyday around 1950 to 1970. Through a thematic reading of all nine Søeborgnovelsthe thesis aims to clarify his specific contribution if any and present an educated guessas to why he has largely been passed over by previous research – has this been warranted?The broad themes chosen for the readings are materialism, conformism and bureaucracy, sochosen because they are believed to be concurrent and important within the debateindependently of the author himself. Any contribution is worth considering since currentresearch into Søeborg is scarce. The thematic readings are then cross-referenced with literaryhistoricalresearch by Lasse Horne Kjældgaard and Søren Schou among others, as well asprominent welfare state-commentary and fiction from that period. The studies find thatSøeborg did in fact write fully within the welfare-fiction framework and used the themesoutlined above and related welfare-tropes to weigh in.He writes fiction to further a moralistic anti-conformity and anti-state agenda where thosewho resist the onslaught of historicist conformity are elevated. Apart from these few themasses are an unfree, sorry lot and the future looks gloomy. Søeborg shares existentialistattitudes with Hans Jørgen Lembourn and anarchist attitudes with Johan Fjord Jensen –prominent welfare-commentators. He is different from them both however, in that he refusesall power-structures making literary alliances, recognition and categorization very difficult.The thesis concludes that Søeborg was a forerunner in terms of exploring in fiction some ofthe negative lifestyle effects resulting from the welfare state’s materialistic and bureaucraticexcesses, and should be held in higher regard historically for that reason; but his obstinatemoralism, mostly copying subject matter from the 1930s literature and not being able to fullyexpress his insights before they were displayed in a better way by others, is to his historicaland literary detriment
Optimal Distributed Composite Testing in High-Dimensional Gaussian Models With 1-Bit Communication
No full textIn this paper we study the problem of signal detection in Gaussian noise in a distributed setting where the local machines in the star topology can communicate a single bit of information. We derive a lower bound on the Euclidian norm that the signal needs to have in order to be detectable. Moreover, we exhibit optimal distributed testing strategies that attain the lower bound. </p
Data for: Polity age and political budget cycles: Evidence from a Danish municipal reform
No full textFor any questions about the data and replication please contact author Lasse Aaskoven [email protected]
Continuing development of nettilasku.fi front-end based on the updated design
No full textEpic Invoicing needed for the development of the new nettilasku project by adding
new features and integrating features from the older nettilasku project. The thesis
aimed at discovering the principles of the older application features realization
together with the issues in the current project and finding methods for
implementing enhanced solutions applying required tools in order to improve user
experience in the building product. The work was commissioned by Epic
Invoicing.
The work was going repeatedly in the following way: the management gives a
task of feature development to the author, the author investigates the issue and
finds methods of its implementation, the author builds the solution.
All the features that were implemented were accepted by the management.
Three of them were put into production and two of them were put to the open
test stage
Reviewing the EU Emissions Trading Scheme: Priorities for Short-Term Implementation of the Second Round of Allocation (Part I). CEPS Task Force Reports No. 56 (57?), 1 December 2005
No full textThis report presents the findings of a multi-stakeholder CEPS Task Force, co-chaired by David Hone, Shell and Lasse Nord, Norsk Hydro. After taking stock of the EU ETS, the report examines the need and potential for short-term adaptation of the second round of allocation and makes concrete and operational recommendations to EU member states and the European Commission
- …
