902 research outputs found
Véronique Gimeno-Cabrera. Le traitement jurisprudentiel du principe de dignité de la personne humaine dans la jurisprudence du Conseil constitutionnel français et du Tribunal constitutionnel espagnol
No full textDuprat Jean-Pierre. Véronique Gimeno-Cabrera. Le traitement jurisprudentiel du principe de dignité de la personne humaine dans la jurisprudence du Conseil constitutionnel français et du Tribunal constitutionnel espagnol. In: Revue internationale de droit comparé. Vol. 57 N°3,2005. pp. 833-838
A. Gimeno y Cabañas: “Quando incontrai Marcel Proust” (1932)
No full textThe spanish reception of Proust’s work between the 1920s and the 1930s is lively and marked
not only by the first translation of the Recherche in order of appearance (1920), but also by a
large number of articles published in newspapers and periodicals. In this scenario, we can meet
the evocation of a dinner at Proust’s home by a Spanish nobleman and doctor, Amalio Gimeno
y Cabañas. The dinner took place in 1894, within the 9th International Sanitary Conference in
Paris, in respect of which the Count Gimeno was part of the Spanish delegation. He was invited
by Professor Adrien Proust, father of the future author of the Recherche, and a key figure
in the Conference itself. It was on that evening that the Spanish doctor met French professor’s
wife, and also the young Marcel, who was 22 years old. Some years later, Gimeno y Cabañas
rebuilt that episode and finely outlined the figures of Madame Weil and his son Marcel
Abstract 2671: Omics unveils a specific signature of tumor dormancy in two murine models of leukemia and melanoma
No full textInternational audienceAbstract The goal of the project was to integrate “omics” data, including genomic, epigenetic, transcriptomic and proteomic profiles, to identify a specific signature of tumor dormancy. Materials and Methods: Two murine models of tumor dormancy, B16F1 malignant melanoma and DA1-3b myeloid leukemia, were generated and exome sequencing of dormant cells and parental cells was performed.Mutations were identified. Epigenetic alterations were detected by ChIP sequencing. Briefly, repressed and activated genes were identified by sequencing DNA fragments obtained after immunoprecipitation with antibodies against H3K9 and H3K27 and against histone H3K4me3, respectively. DNA Methylation analysis was assessed by Methylation Specific PCR (MSP). Transcriptomic analysis was conducted using Agilent arrays. Proteomes were compared by mass spectrometry. For the calcium homeostasis analysis, time courses of cytosolic Ca2+ concentration were measured using the ratiometric dye Fura-2. Results: Exome analysis identified a specific gene signature of tumor dormancy in each model. Previously characterized mutations in human melanoma and myeloid leukemia were found in the murine models of B16F1 melanoma (e.g., Pten, Brca2, and CKit) and myeloid leukemia (e.g., Flt3 and Dnmt3b), thus reinforcing the relevance of these models for translational research on human pathology. ChIP sequencing revealed a specific epigenetic signature of dormant cells compared to parental cells. Global proteomic analysis showed a deregulation of proteins involved in many metabolic pathways in both models. Despite the absence of common gene mutations in the two models tested, several genes involved in calcium homeostasis were found to be mutated (Transient Receptor Potential, Store Operated calcium channels ). Regarding their epigenetic regulation assessed by MSP, no difference was observed in methylation level. Nevertheless, functional assays showed profound alterations in calcium homeostasis in the two dormant cell lines compared to the parental cell lines, suggesting a functional role of one or several receptors or ion channels in calcium signaling in tumor dormancy. Conclusions: Taken together, “omics” analyses indicate that the regulation of tumor cell dormancy is extremely complex. Therefore, an integrated approach is crucial to fully understand tumor dormancy. Bioinformatics and integrative analyses will provide a better understanding of mechanisms controlling dormancy. Finally, functional analysis of calcium homeostasis revealed a common calcium signature in dormant tumor cells compared to parental cells. The genes involved in this altered intracellular calcium flux are currently being elucidated. Citation Format: Yasmine Touil, Loïc Lemonnier, Pascaline Segard, Martin Figeac, Frédéric Leprêtre, Audrey Vincent, Lucile Noyer, Maxence Wisztorski, Jean-Pascal Gimeno, Jean-Pascal Meneboo, Guillemette Marot, Isabelle Fournier, Thierry Idziorek, Bruno Quesnel. Omics unveils a specific signature of tumor dormancy in two murine models of leukemia and melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2671
La Révolution et l'espace français : Marie-Vic Ozouf-Marignier, La formation des départements, la représentation du territoire français à la fin du XVIIIe siècle ; Daniel Nordman, Marie-Vic Ozouf-Marignier, Roberto Gimeno, Alexandra Laclau, Atlas de la Révolution Française, t. 4 : Le territoire (1), réalités et représentation
No full textPerouse Jean-François. La Révolution et l'espace français : Marie-Vic Ozouf-Marignier, La formation des départements, la représentation du territoire français à la fin du XVIIIe siècle ; Daniel Nordman, Marie-Vic Ozouf-Marignier, Roberto Gimeno, Alexandra Laclau, Atlas de la Révolution Française, t. 4 : Le territoire (1), réalités et représentation. In: Revue géographique des Pyrénées et du Sud-Ouest, tome 63, fascicule 1, 1992. Risques à l'Est des Pyrénées. pp. 122-124
Supplemental Material, Gimeno_#1_Appendix_A_Supplementary_FINAL - Protocol for <i>N</i>-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1
No full textSupplemental Material, Gimeno_#1_Appendix_A_Supplementary_FINAL for Protocol for N-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1 by Hortensia Gimeno, Helene J. Polatajko, Victoria Cornelius, Jean-Pierre Lin, and Richard G. Brown in Canadian Journal of Occupational Therapy</p
Supplemental Material, Gimeno_#1_Appendix_B_FINAL_FINAL - Protocol for <i>N</i>-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1
No full textSupplemental Material, Gimeno_#1_Appendix_B_FINAL_FINAL for Protocol for N-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1 by Hortensia Gimeno, Helene J. Polatajko, Victoria Cornelius, Jean-Pierre Lin, and Richard G. Brown in Canadian Journal of Occupational Therapy</p
Supplemental Material, Gimeno_#2_Appendix_A_FINAL - Protocol for <i>N</i>-of-1 trials with replications across therapists for childhood-onset dystonia rehabilitation: Study 2
No full textSupplemental Material, Gimeno_#2_Appendix_A_FINAL for Protocol for N-of-1 trials with replications across therapists for childhood-onset dystonia rehabilitation: Study 2 by Hortensia Gimeno, Helene J. Polatajko, Victoria Cornelius, Jean-Pierre Lin, and Richard G. Brown in Canadian Journal of Occupational Therapy</p
The social class struggles concept with an interdisciplinary approach: a paramount concept for research in library and information science (LIS)
No full textThis paper analyses the social class struggles concept with an interdisciplinary approach to be used by theorists and practitioners of library and information science (LIS). This concept emerged as part of the theoretical framework employed by the author in his doctoral thesis (Muela-Meza, 2010): An Application of Community Profiling to Analyse Community Information Needs, and Providers: Perceptions from the People of the Broomhall Neighbourhood of Sheffield, UK. This concept is complemented from philosophy (Marx and Engels, [1848] 1976a), and the natural sciences (Hauser, 2006; Sagan and Druyan, 1992), and it served the author to understand better the bigger dimensions of the underlying issues behind social classes and human conflicts. It also served to understand better the contradictions between people (e.g. LIS users with contradictory and mutually exclusive information needs to be provided by libraries and other institutions of information recorded in documents), and how these intensify when these are interrelated with the social class they belong to (Muela-Meza, 2007). This paper also criticises some competing views whose proponents by pretending fallaciously and deceitfully to deny the presence of social class divides in society, such as those rhetorical ploys of post-modernism that propose capitalist-class-driven ideologues of “community cohesion” based on “social capital” (Putnam, 1999). It shows evidence of how those followers (e.g. Pateman, 2006; Contreras Contreras, 2004; Bryson, Usherwood and Proctor, 2003) of capitalist-class ideologues, by doing so they aligned their discourse to that of dominance hierarchies and hegemony against working class people, in LIS and other sciences, and the humanities. It also criticises the postmodern pseudoscience because it pretends to undermine the logical rationality fundamental in LIS and all other sciences. It recommends that LIS theorists and practitioners employ the social class struggles concept as configured here in order to understand better contradictions, conflicts, and struggles within LIS theory and practice, and also to search for broader epistemological aims such as justice and wisdom (Fleissner and Hofkirchner, 1998), concealed by the capitalist or bourgeois and middle classes for their benefit against working class
Supplemental Material, Gimeno_#1_Appendix_C_Supplementary_FINAL_FINAL - Protocol for <i>N</i>-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1
No full textSupplemental Material, Gimeno_#1_Appendix_C_Supplementary_FINAL_FINAL for Protocol for N-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1 by Hortensia Gimeno, Helene J. Polatajko, Victoria Cornelius, Jean-Pierre Lin, and Richard G. Brown in Canadian Journal of Occupational Therapy</p
Concepción Gimeno, agente doble cultural hispano-mexicana (1883-1909)
No full textAbstract: Concepción Gimeno de Flaquer moved to Mexico from Spain in 1883, where she founded El Álbum de la Mujer (1883-1890), one of the most important feminist journals of the epoch. This article studies the troubled waters that Gimeno had to navigate shortly after her arrival in the country, and the impact that her unconditional support of the porfiriato had on her standing, with both the press and portions of society of the period. This text identifies several previously unknown texts and pseudonyms of the author, proposes that interdependence with the porfiriato extended to her subsequent editorial project —El Álbum Ibero-Americano (Madrid, 1890-1909) until this relationship conclusion—, and that it may explain why the journal stopped abruptly its publication in 1909, after two decades of existence.Resumen: Proveniente de España, Concepción Gimeno de Flaquer se instala en México en 1883, donde funda El Álbum de la Mujer (1883-1890), una de las revistas feministas más importantes del periodo. En este texto se estudian las tormentosas aguas que tuvo que navegar al poco tiempo de su llegada al país, y el impacto que su apoyo incondicional al porfiriato tuvo en su relación con los medios de prensa y una parte de la sociedad coetánea. El artículo identifica varios textos y pseudónimos no conocidos de la autora, propone que la interdependencia con el porfiriato se extendió también hasta el final de su siguiente proyecto -El Álbum Ibero-Americano (Madrid, 1890-1909)-, y que esa relación con el régimen explica por qué la revista concluye inesperadamente en 1909, tras más de dos décadas de existencia
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