64 research outputs found
We Need Them. They Will Do Much Better Without Us. : A Review of Survival at Stake, by Poorva Joshipura.
No full text‘Zoo-ethics’is a subset of bioethics,and zoology may be looked upon as a subset of ecology...that is how the review of Survival at Stake, by Poorva Joshipura, falls well and truly within the scope of this journal.There is also an interesting link between this one and another review of a book steeped in science, published recently by this author. Survival at Stake, on the other hand, primarily, has a moral, ethical, and practical force embedded within the scientific. This is understandable when one notes that Joshipura is an animal welfare activist associated with the NGO, People for the Ethical Treatment of Animals (PETA), and committed to the cause espoused by it
Can routinely collected primary care data determine the prevalence of chronic kidney disease and predict clinical events in patients with stages 3 of the disease?
No full textIntroduction
Chronic Kidney Disease (CKD) is common and associated with cardiovascular morbidity and mortality. Few studies have assessed the real prevalence of CKD and the predictors of morbidity and mortality in this cohort.
Methods
Using THIN data, the prevalence of CKD 1-5 was ascertained .This was compared to the prevalence on the practice register using QOF Read codes in 2009. Cox proportional hazard models using routinely collected primary care were used identify predictors of i) all-cause mortality and ii) the composite of cardiovascular disease and all-cause mortality.
Results
The prevalence of CKD 1-5 was 5.01%. Patients with CKD not on the practice register were associated with worse management than those on the practice register. Increasing age and co-morbidity were associated with worse outcomes. Continuous variables such as hypertension, BMI, haemoglobin and cholesterol were associated with an inverse J shaped relationship with log relative hazard ratio. Antihypertensives and lipid lowering drug usage, and non white ethnicity was associated with improved outcomes. Blood thinning agents and diuretics were associated with worse outcomes.
Conclusions
CKD is common in UK. Many practices mis-label CKD which impacts upon management. Some predictors of mortality and morbidity is different to previous reports and this requires further investigation
A Role for the Potassium Channel Seizure in Regulating Intrinsic Neuronal Stress Response in Drosophila melanogaster
No full textFrom the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Yehuda Ben-Shahar and Alexis Hil
The Role of the Potassium Ion Channel Seizure (sei) in Regulating Behavior in Drosphila melanogaster
No full textFrom the Washington University Undergraduate Research Digest: WUURD, Volume 11, 2015-2016. Published by the Office of Undergraduate Research, Joy Zalis Kiefer Director of Undergraduate Research and Assistant Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Kristin Sobotka, Editor; Jennifer Kohl.
Mentor: Yehuda Ben-Shaha
Potrzebujemy ich. Oni poradzą sobie bez nas znacznie lepiej. Recenzja książki autorstwa Poorva Josipura pt. „Survival at Stake”
No full textPoorva Joshipura’s book Survival at Stake embarks on an interdisciplinary examination of ethical and scientific issues related to the treatment of animals, highlighting their impact on human well-being and the future of civilisation. The author, a dedicated activist affiliated with PETA, underscores the challenges posed by the exploitation of animals within the frameworks of intensive farming, laboratory experimentation, and the illegal wildlife trade. The critique illustrates how unethical practices can give rise to pandemics, the deterioration of biodiversity, and ecological imbalances. Moreover, the text advocates for a comprehensive, humanistic, and cross-disciplinary approach that reassesses and transforms the relationship between humanity and the animal world.Książka „Survival at Stake” autorstwa Poorvy Joshipura podejmuje interdyscyplinarną analizę zagadnień etycznych oraz naukowych dotyczących traktowania zwierząt, wskazując na ich wpływ na kondycję ludzką i przyszłość cywilizacyjną. Autorka – aktywistka zrzeszona z PETA – uwypukla problem zwierząt w kontekście intensywnych metod hodowli, eksperymentów laboratoryjnych oraz nielegalnego handlu dziką fauną. W recenzji przedstawiono, jak nieetyczne praktyki mogą skutkować powstawaniem pandemii, degradacją bioróżnorodności oraz zaburzeniami równowagi ekologicznej. Tekst podkreśla konieczność wdrażania holistycznych, humanistycznych i interdyscyplinarnych rozwiązań, które umożliwią gruntowną rewizję relacji między człowiekiem a światem zwierząt
First principle study of heterostructure of BaBi3-stanene for topological superconductor applications
No full textFirst principle study of electronic and optical properties of molecular ion (BF4−) substituted hybrid perovskite (CH3NH3PbI3)
No full text
A REVIEW ON TREATMENT AND PREVENTION OF DIABETES MELLITUS
No full textDiabetes mellitus is an endocrinological and metabolic disorder with an increasing global prevalence and incidence. High blood glucose levels are symptomatic of diabetes mellitus as a consequence of inadequate pancreatic insulin secretion or poor insulin-directed mobilization of glucose by target cells. Diabetes mellitus is aggravated by and associated with metabolic complications that can subsequently lead to premature death. The diagnosis of diabetes in an asymptomatic subject should never be made on the basis of a single abnormal blood glucose value. For the asymptomatic person, at least one additional plasma/blood glucose test result with a value in the diabetic range is essential, either fasting, from a random (casual) sample, or from the oral glucose tolerance test (OGTT). If such samples fail to confirm the diagnosis of diabetes mellitus, it will usually be advisable to maintain surveillance with periodic re–testing until the diagnostic situation becomes clear. In these circumstances, the clinician should take into consideration such additional factors as ethnicity, family history, age, adiposity, and concomitant disorders, before deciding on a diagnostic or therapeutic course of action. An alternative to blood glucose estimation or the OGTT has long been sought to simplify the diagnosis of diabetes. Diabetes is a metabolic disorder that can be prevented through lifestyle modification, diet control, and control of overweight and obesity. Education of the populace is still key to the control of this emerging epidemic. Novel drugs are being developed, yet no cure is available in sight for the disease, despite new insight into the pathophysiology of the disease
SYNTHESIS AND CHARACTERIZATION OF AZO CONJUGATES OF FENOPROFEN FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE THROUGH COLON TARGETING
No full textObjective: The objective of this research was to synthesize azo conjugates of fenoprofen (FP) for treatment of inflammatory bowel disease through colon targeting.
Methods: Six prodrugs of FP were synthesized by diazotisation with ethyl esters of amino acids, namely, glycine, tyrosine L-phenylalanine, L-tryptophan, L-valine, L-alanine, amino acid. Methyl ester hydrochloride prepared by thionyl chloride, methanol and amino acids, followed by diazotization and then Coupling of diazotized amino acid methyl ester with fenoprofen. Six azo prodrug of fenoprofen was synthesized by using amino acid. Further, the synthesized prodrugs were characterized by TLC, IR, NMR spectroscopic analysis and subjected to in vitro drug release, TNBS induced ulcerative colitis and ulcerogenic index.
Results: All synthesized prodrugs showed excellent pharmacological response and targeting to colon. The FTIR and NMR study confirmed the structure of all azo linkage prodrugs. In vitro drug release studies revealed that FP was not release in gastric fluid. 12-15% drug were released in intestinal fluid and 65-85% drug was released in the colon because of azo reductases enzyme, secreted by colonic microflora. The azo prodrugs proved their potential in reducing the inflammation proved by the histopathology of the resected colon from every group of animals.
Conclusion: The results obtained in this research work clearly indicated a promising potential for treatment of inflammatory bowel disease through colon targeting for the effective treatment of IBD
- …
