10 research outputs found
sj-docx-1-tag-10.1177_17562848231168714 – Supplemental material for Real-world outcomes associated with vonoprazan-based versus proton pump inhibitor-based therapy for Helicobacter pylori infection in Japan
No full textSupplemental material, sj-docx-1-tag-10.1177_17562848231168714 for Real-world outcomes associated with vonoprazan-based versus proton pump inhibitor-based therapy for Helicobacter pylori infection in Japan by Colin W. Howden, Erin E. Cook, Elyse Swallow, Karen Yang, Helen Guo, Corey Pelletier, Rinu Jacob and Kentaro Sugano in Therapeutic Advances in Gastroenterology</p
Deep Reinforcement Learning methods for StarCraft II Learning Environment
Get PDFReinforcement Learning (RL) is a Machine Learning framework in which an agent learns to solve a task by trial-and-error interaction with the surrounding environment.
The recent adoption of artificial neural networks in this field pushed forward the boundaries of the tasks that Reinforcement Learning algorithms are able to solve, but also introduced great challenges in terms of algorithmic stability and sample efficiency.
Game environments are often used as proxies for real environments to test new algorithms, since they provide tasks that are typically challenging for humans and let the RL agents make experience much faster and at a cheaper price than if they were to make it in the real world.
In this thesis state-of-the-art Deep Reinforcement Learning methods are presented and applied to solve four mini-games of the StarCraft II learning environment.
StarCraft II is a real-time strategy game with large action and state space, which requires learning complex long-term strategies in order to be solved; StarCraft mini-games are auxiliary tasks of increasing difficulty that test an agent's ability to learn different dynamics of the game.
A first algorithm, the Advantage Actor-Critic (A2C), is studied in depth in the CartPole environment and in a simple setting of the StarCraft environment, then is trained on four out of seven StarCraft mini-games.
A second algorithm, the Importance Weighted Actor-Learner Architecture (IMPALA), is introduced and trained on the same mini-games, resulting approximately 16 times faster than the A2C and achieving far better scores on the two hardest mini-games, lower score on one and equal score on the easiest one.
Both agents were trained for 5 runs for each mini-game, making use of 20 CPU cores and a GPU and up to 72 hours of computation time.
The best scores from the 5 runs of IMPALA are compared with the results obtained by the DeepMind team author of the paper StarCraft II: A New Challenge for Reinforcement Learning, which report the best scores out of 100 runs that used approximately two orders of magnitude more of training steps than our runs.
Our IMPALA agent surpasses the performance of the DeepMind agent in two out of the four mini-games considered and obtains slightly lower scores on the other two.ope
Diagnosis and treatment patterns among patients with newly diagnosed Helicobacter pylori infection in the United States 2016–2019
Get PDFApproximately 36% of the United States (US) population is infected with Helicobacter pylori (HP), a known major risk factor for peptic ulcer disease and gastric cancer. HP eradication reduces the rate of complications; however, the benefits are undermined by rising rates of HP eradication treatment failure. This real-world observational cohort analysis aims to describe HP diagnostic and treatment patterns among insured patients in the US. Using diagnoses, lab results, and treatment patterns, we identified adults (18+) with new diagnoses of HP in the Veradigm Health Insights EHR Database linked to Komodo claims data (1/1/2016–12/31/2019). Patients were required to have ≥ 12 months of data pre-/post-index. We captured patient characteristics, HP-related diagnostic testing, and the use of US guideline-recommended HP eradication regimens. HP eradication rates following first-line eradication treatment were measured among patients with available lab results. Overall, 31.8% of the 60,593 included patients did not receive guideline-recommended treatment. Among the 68.2% (41,340) with first-line treatment, 80.2% received clarithromycin-based triple therapy, and 6.6% received bismuth quadruple therapy. Of the 4569 patients with a repeated course of eradication therapy, 53.4% received the same regimen as their first-line, the majority (90.7%) of whom received two rounds of clarithromycin-based triple therapy. Among the 2455 patients with results of HP non-serology testing following first-line treatment, the 180-day eradication rate was 80.2% overall, with differences based on treatments and demographics. This study highlights gaps between guideline-recommended HP management and real-world patterns, underscoring the need to improve HP testing, treatment, and follow-up practices
Diagnosis and treatment patterns among patients with newly diagnosed Helicobacter pylori infection in the United States 2016-2019.
No full textPatient journey in erosive oesophagitis: real-world perspectives from US physicians and patients
No full textOBJECTIVE: Management of erosive oesophagitis (EE) remains suboptimal, with many patients experiencing incomplete healing, ongoing symptoms, and relapse despite proton pump inhibitor (PPI) treatment. The Study of Acid-Related Disorders investigated patient burden of individuals with EE in a real-world setting. DESIGN: US gastroenterologists (GIs) or family physicians (FPs)/general practitioners (GPs) treating patients with EE completed a physician survey and enrolled up to four patients with EE for a patient survey, with prespecified data extracted from medical records. RESULTS: 102 GIs and 149 FPs/GPs completed the survey; data were available for 73 patients (mean age at diagnosis, 45.4 years). Omeprazole was healthcare professional (HCP)-preferred first-line treatment (60.8% GIs; 56.4% FPs/GPs), and pantoprazole preferred second line (29.4% and 32.9%, respectively). Price and insurance coverage (both 55.5% HCPs) and familiarity (47.9%) key drivers for omeprazole; insurance coverage (52.0%), price (50.0%), familiarity (48.0%), initial symptom relief (46.0%), and safety (44.0%) key drivers for pantoprazole. Only 49.3% patients took medication as instructed all the time; 56.8% independently increased medication frequency some of the time. Despite treatment, 57.5% patients experienced heartburn and 30.1% regurgitation; heartburn was the most bothersome symptom. 58.9% patients believed that their symptoms could be better controlled; only 28.3% HCPs were very satisfied with current treatment options. 83.6% patients wanted long-lasting treatment options. Fast symptom relief for patients was a top priority for 66.1% HCPs, while 56.6% would welcome alternatives to PPIs. CONCLUSION: This real-world multicentre study highlights the need for new, rapidly acting treatments in EE that reduce symptom burden, offer durable healing and provide symptom control
Real-world outcomes associated with vonoprazan-based proton pump inhibitor-based therapy for infection in Japan
No full textBackground: Japanese guidelines recommend triple therapy with vonoprazan or a proton pump inhibitor (PPI) in combination with antibiotics to treat Helicobacter pylori ( H. pylori ) infection. While studies have shown improved eradication rates and reduced costs with vonoprazan versus PPIs, there is little data describing healthcare resource use (HCRU) and treatment patterns. Objectives: To compare patients treated with a vonoprazan-based or PPI-based regimen for H. pylori infection in Japan in terms of their characteristics, HCRU, healthcare costs, clinical outcomes, and treatment patterns. Design: Retrospective matched cohort. Methods: We used data from the Japan Medical Data Center claims database (July 2014–January 2020) to identify adult patients with H. pylori infection and a first observed use of vonoprazan or a PPI in 2015 or later (index date). Patients prescribed a vonoprazan-based or a PPI-based regimen were matched 1:1 using propensity score matching. HCRU, healthcare costs, diagnostic tests, a proxy for H. pylori eradication (i.e. no triple therapy with amoxicillin in combination with metronidazole or clarithromycin >30 days after the index date), and second-line treatment were described during the 12-month follow-up period. Results: Among 25,389 matched pairs, vonoprazan-treated patients had fewer all-cause and H. pylori- related inpatient stays and outpatient visits than PPI-treated patients, resulting in lower all-cause healthcare costs [185,378 Japanese yen (JPY) versus 230,876 JPY, p < 0.001]. Over 80% of patients received a post-treatment test for H. pylori . Fewer vonoprazan-treated than PPI-treated patients subsequently received an additional triple regimen for H. pylori infection (7.1% versus 20.0%, p < 0.001) or a prescription for vonoprazan or a PPI as monotherapy (12.4% versus 26.4%, p < 0.001) between 31 days and 12 months after the index date. Conclusion: Patients with H. pylori infection who were treated with vonoprazan-based therapy had lower rates of subsequent H. pylori treatment, lower overall and H. pylori -related HCRU, and lower healthcare costs than patients treated with PPI-based therapy
Healthcare costs among patients with newly diagnosed <i>helicobacter pylori</i> infection in the United States: a linked claims-EHR study
No full textThe study objectives were to 1) characterize the cost drivers of patients with Helicobacter pylori (HP) and 2) estimate HP-related cost savings following lab-confirmed HP eradication with US guideline-recommended treatment compared to failed eradication. We identified adults newly diagnosed with HP between 1/1/2016-12/31/2019 in the Veradigm Electronic Health Record Database linked to claims data (earliest HP diagnosis = index date). For the overall costs analysis, we required patients to have data available for ≥12 months before and after the index date. Then, we used multivariable modeling to assess the marginal effects of comorbidities on all cause-healthcare costs in the 12 months following HP diagnosis. For the eradication savings analysis, we identified patients with ≥1 HP eradication regimen, a subsequent HP lab test result, and ≥1 year of data after the test result. Then we used multivariable modeling to estimate HP-related cost while adjusting for eradication status, demographics, post-testing HP-related clinical variables, and the interactions between eradication status and each HP-related clinical variable. The overall costs analysis included 60,593 patients with HP (mean age 54.2 years, 65.5% female). Mean (SD) 12-month unadjusted all-cause costs were 78,089). Rare comorbidities demonstrated the highest marginal effect. The marginal effects of gastric cancer and PUD were 7,323, respectively. In the eradication savings analysis, 1,835 (80.0%) of the 2295 patients had lab test-confirmed HP eradication. Compared to failed eradication, there were significant one-year cost savings among patients with successful HP eradication and select conditions: 518 for atrophic gastritis, 352 for gastritis. The healthcare costs of patients with HP are partially confounded by their burden of high-cost comorbidities. In the subset of patients with available results, confirmed vs. failed eradication of HP was associated with short-term cost offsets among those with specific to HP-related sequelae. Helicobacter pylori (HP) is a common infection. We aimed to better understand healthcare costs for people infected with HP. Specifically, we were interested in 1) investigating whether complications from HP were causing high costs. 2) whether successful eradication of HP would lead to lower healthcare costs. We captured data on adults diagnosed with HP between 2016 and 2019. The data used in this study came from medical records and insurance bills. In the first part of the study, we found that patients with HP often have other health issues, and these other health issues were driving high healthcare costs. The majority of cost savings associated with HP eradication accrue from prevention of potential complications of long-term infection, such as peptic ulcer disease and, rarely, gastric cancer.</p
Off-pump coronary artery bypass grafting using continuous heparin infusion
No full textAbstractObjectivesLevels of anticoagulation during off-pump coronary artery bypass grafting (OPCAB) remain controversial. Prolonged activated clotting time (ACT) during OPCAB increases blood loss during surgery and can also cause paradoxical increase in postoperative myocardial infarction. Shorter ACT can increase thrombotic complication. Maintaining a steady ACT level is challenging. We have used continuous heparin infusion after initial bolus during OPCAB to maintain a steady low target ACT. The objective of the present study was to assess the effectiveness and safety of heparin infusion in maintaining a steady target ACT level.MethodsThis was a prospective study of consecutive OPCAB patients. ACT was measured after initial bolus dose of heparin. Once ACT of more than 200seconds was achieved, heparin infusion was started to maintain the required level of anticoagulation. CPK-MB was measured in operation room, 6 and 24hours postoperatively to rule out ischemic complication.ResultsACT could be maintained in target range with heparin infusion in 80.1% patients (161/201). Of the 40 patients with one or more ACT reading less than 200seconds, 38 patients were managed by increasing the dose of heparin infusion and only 2 patients required additional bolus dose of heparin.ConclusionsHeparin infusion maintains a steady target ACT level and avoids peaks and troughs associated with bolus doses. Lower level of anticoagulation using continuous heparin infusion does not increase ischemic complications. This is the first ever study of use of heparin infusion during OPCAB. We may conclude that heparin infusion is a safe anticoagulation strategy for OPCAB
Characterization of a Human Respiratory Mucosa Model to Study Odorant Metabolism
No full textCorresponding author: [email protected] audienceNasal xenobiotic metabolizing enzymes (XMEs) are important for the sense of smell because they influence odorant availability and quality. Since the major part of the human nasal cavity is lined by a respiratory mucosa, we hypothesized that this tissue contributed to nasal odorant metabolism through XME activity. Thus, we built human respiratory tissue models and characterized the XME profiles using single-cell RNA sequencing. We focused on the XMEs dicarbonyl and l-xylulose reductase, aldehyde dehydrogenase (ALDH) 1A1, and ALDH3A1, which play a role in food odorant metabolism. We demonstrated protein abundance and localization in the tissue models and showed the metabolic activity of the corresponding enzyme families by exposing the models to the odorants 3,4-hexandione and benzaldehyde. Using gas chromatography coupled with mass spectrometry, we observed, for example, a significantly higher formation of the corresponding metabolites 4-hydroxy-3-hexanone (39.03 ± 1.5%, p = 0.0022), benzyl alcohol (10.05 ± 0.88%, p = 0.0008), and benzoic acid (8.49 ± 0.57%, p = 0.0004) in odorant-treated tissue models compared to untreated controls (0 ± 0, 0.12 ± 0.12, and 0.18 ± 0.18%, respectively). This is the first study that reveals the XME profile of tissue-engineered human respiratory mucosa models and demonstrates their suitability to study nasal odorant metabolism
0001
No full textDAltY PALO ALTO TIMES. MONDAY. DECEMBER 17,1917.
■\ r
Daily Jimes Editorial Page
H. W. 81MK1NS-
-W. H. K ELLT
THE FICKERT RECALL
WAR FACTS
By 0. F. Evans
The' first deii.tr/ of the perfected Liberty alrplans motors
are soon to be made. The U. ft.
will use thousands of thess snd
supply thoi/sands to ths sides.
Whatever may be the result of tbe recall election tomorrow In San Fran-
Cisco where tbe district attorneyship!
Is to be decided. It Is sure to leave a ■
bad lame lathe mouth. The two can-j
dldatua huve givii a campaign exhlbf-
fli-u ot the pot calling the kettle black, j
If ■■•■-ii a fraction of wh*t they say
be true neither of tbem is fit to be
district attorney.
While we.hope thai the recall will
nut succeed. It la u**lt!i**r b--cnu*-*(or
any approval of, nor partisanship for
Flckert. Flckert !• a Stanford football hero gone wrong. He rode Into
tjftict' with the backwash of a sm**lly
tide of react Inn agaliist tin* grail
prosecutions. }]•• defeated Honey
because the fickle public had grown
tired of the year of long drawn out
litigation over ■*;•• -*ffons lo ronvici
tint "higher up*" wliuse mom')' and
luftuence prevented their conviction.
.Nol only did Bun Francisco elect
Flckert over Heoej In 1911. but In
1!"15 he was rt* elected for four years,
mure. So it cannot be said that the ^*>»™-"" "* **»****. «»**« W»
very difficult. We may feel morally
sure of a roan's guilt, but unless we
can legally prove It we must acquit
him. But such an acquittal bears a
far different Interpretation than the
one tbe Bulletlu Insists upon placing
upon It
STANFORD TRADITIONS
In the valedictory for the quarter
the Daily Palo Alto. Ibe university
dally paper, makes a plea for the
riialiitenaiic-i of the traditions of
Stanford University next quarter wben
Hie retclntrution of tui'R la expected to
light, especially among the upper
cliy chose him in u moment of Indiscretion. Upon the theory that Hie
v 'ft" are entitled to >:•■< what Ihey
voted for there Ik no logic In ths recall movement t> grounds of g-n
crml unhtness.
The side of the iimtl-r whlrh ap
ii iimlntalii tradltli
The outsider may Imve only u haiy
iili'H uf what (he present trndltious of
tin* uulvemlty are. hut a number of
traditions hat.* dl*>ai>pi*ared during
the ImS-X 1*1. Tt+t*. l*J the geol utls-
factton of Hi** community, For exam<
posli moat strongly io us Is Die ran I P-«» ***** drinking and the plug ugly,
that the recall was started hy th.*! While t-yuipaihixlng with student
rat!kit]* who object to the protean- [leaders In their d*-*.lri- to see whole-
Ilea of tbe .Mooney crowd of anar .-onto tradition* prenervt-0. It Is yet
chl-tiv It will cost the city taxpay- (|«»nlble lo look with coniplaceiiey
•Tt the neat sum of l3'-.000 to tiuld upon the |n.*i*itile elimination of cor-
thf elation. This does not cone out tain other imdltlutiK In the future, for
of the pocknts of Ihe agitatum who uxauiple. tin* luit relics of the Imrb-tr
foisted the recall upon the city. Oh, • ity of liaiing trasbmea and nil al<
na If It did then would be no re-j tempts to reform tbe manners of fel
I low students by any form of negative
rilJclMii. Whether It lake the form of
OUR FLOUR RIOTS
When Mob Law Ruled For Awhile
In New York City.
DURING THE PANIC OF 1837.
r g--»-1
calL
Tlie Hme to uvf.-ul Ficken tn
crtl tinilluei.it In ul Do* regular election. To defeat hint now would l»*
simply a victory for tht* snare, hints.
That ts the Issue now on trial It h
trnt* thai a large body of goud peo
pie have joined lu thr recall light on
ruber Isbucs. If they would only hn
j»f active lu tb>* regular electluns we
would have better"governm*,nt. Mui
it in highly Illogical to mix up, a red
light issue with the red Rag IstOS in
a city that recently recalled Senator
Omni bernUHe he was the author of
the red light bill. Let us take up one
lo*ue at a time
Another great pity Is the attempt
to drag union labor Into the -uppori
uf anurchy by plnylng upon tht hatred of corporations. Mooney nnd
liillliigs are not real unlun men Tltey
had no labor status at all. They
were simply anarchistic agitator*,
lltil because tbey tried to dynamite
tin* 1'nlled it.ilirn.nl*- power Hoe, tho
despicable Bulletin makes heroes of The following is a u-t of letters re
them. Day In and day out It lias fos »»-0-»a unrlalmed tn the posiofflce at
Um) the innuendo that men who; I,»,,» ■*-"*» for *h* P*r-*- 4)*Se*, ■>■
were so patriotic and virtuous as lo!-***0*' -*■■ --**-"- W *"*" 0***M lor be
physical force or mental brutality.
A new tradition that the world nt
largt would love to see established In
•■very university would tie a complete
quietude of the anvil chorus In any
form and the establishment of a spirit
■>f heartier hj-in pa thy mid fellowship
.Hid confluence between students n>
gnnlles-i of their origin, wealth or
Ktoup retstlonthlpK
War sometime* bring* about quirk
itiM-lnl renrg-Jiilnitlthi Hint [n*»fp
itifght nol J-rioii.pl I nil lu years. I^'t
uk hop.* tlmf tlie under clmtxiii.-n who
are left lo make tin* new spirit jot
Stanford --III Ih* hound by no tradition
that is nol -approved by their own best
jii'lKiuenf nnd not in perfect harmony
with Ihe democratic nl-.mii.nl- for
Which this war Is being fought.
ADVERTISED LETTERS
dynamite a corporation could hoi
possibly be guilty of dynamiting anything else. 11 Is clearly a case of
corporation "frame-up." ot course. In
spile of tbe fact thst two separate
Juries declared the defendants gullty
beyotid the shadow of a dotibl. upon
ih" evidence presented.
la this case as lu every other ot
similar kind the matter of proof Is
"on* Deofmber ;**. ikit. theey will be
isetll Io the dead teller office;
t'oons. Lillian Mny.
f'ovno. Hregorto i" _ 8'enforil Park
Holloway, Mrs Helen E.
Mallllla Mrs. Tom.
Wilbur. Mlllau May Coons
Wll spy. Miss Pauline.
W H. KEl.I.V. Postmaster.
W'WAKE UP"
and Order Your Xmas Turkey
Order early and
we will save you
the choicest of the
choice.
INDEPENDENT MARKET
552 EMERSON ST. PHONE 772M
G. W. WAGNER, The Meat Man
Short Crops and Hiffh Price* Added ta
tha Terrors ef ths Fl-isnolsl Disastsr.
and Wir.ho.Mi w#r. Wr..ck,d by
ths Freoiied Populace.
The panic or IST.7 waa oue of the
most eevere this country haa ever es-
[-erienced. Owing to the scarcity nf
iu.>[• every sort of bus I u eta received
a sudden and »<■■ <■:<■ check. Tbe price
of money rote, suit uoue but thine wltb
the best security could g*t It at any
terms.
The Unsocial ■inTering was still fur
ther aggravate.! hy tbe scarcity aod
hlgb price of Hour in tbe ranters cKlet
Tbe Hessian Hy bsd made aocb ravages that the STOPS slong tbe Atiantlr
coast states were almost a complete
failure. In ccrtslH aectlOOJ It was ree
■jiiiiii.-fulfil that the leKlvteture estate
llsh public ;■- .ir. .:■:■--. for ttie storage ot
wheat.
Affairs la New; T«k were 'tmshi t-
a crisis hy Hie leaders of ibe Anii-tno
uo|K>ly. K.iiial Ktithts or l^n-of.M-o jiar
t.v, who plustereil tlie waIN snd fen.--,
uf the city with a lid in! bill calling a
UieetllliC or the f**Ople to l>* held In thr
City psrk.
on tbe tM-vtaied sftem<-»n sotDe
.I.OOti imsoot, ii»'-t!y forelgpeta, gath
en-d tn front »r the city hall, U**s*M
$*CHae» Wtt '■linsi'd .-ImlriUHli, but tlie
crowd wss 'illicitly ; mm.-,| Iiiio groti).*
and attdressnl by several apeaker*.
CouspKUi.Ut aUiitikC the ••■.'■■•:• mu
Air under Ulng, Jr. manv times a
rnmllilsie fur city recorder, He cioseti
his liaratifUq bj offering s set of rfso-
liiHi.t)-. i.i \*t plWuteil tu the lefilsla
lure and praying for a Un prohibiting
the circulation uf hunk notea uu-lcr
fluO. Tliey were adopted, aud Mlu*.
was <-srrl<s| ..ff oa the - "mill derm of hl-
R-Jmtran,
Another spetker meanwhile was ad
ilressitii* • not Iter (.'roup of ILstrner-
ninl, earned twaj by the denunciation
of tbe holders of flour, exclilnit-d: "t"el
uw cllitens. Mr. II»in bas now B3.P0'1
barrels of flour In his store l^t us c»
and offer iiliu fs a barrel, anil If he
tli.es not lake It**—her-* MntelkMjy
ii.u- bit! hiui on ihe *.li.>itliler-"w» char
'■'I'-irt from him to pesc-*."
Tbe bint wa* rDotagb. ■-■ .1 his hearer,
-et on In a lusty for the warehouse o*
Ull Hnrt A Co. In Washlngtmi street
rim clerk-, on Ihe Ipptoseh of the
mob. hnst h! m shut the tlitort, but
one was bur*! In snd barrels of Qoui
wen* rwllcil litl» the >itre*t and openeil
Mr. Han, with a few police, nuv.
srrired on the scene, but they weie ml
is.-1.eil wlili itavpi an.1 ttooot and drh
nt from the seem*. Itarrcls of Ilour anil
Racks of wheat men mime hsd been
■ brown from the window by acore--
aii.l the flour catfrrty gsiherrtl up by
tvotnen ami cblhitvu. A thousand
busbttll of wheat and 500 barrels of
flour are said to bSTS been destroyed.
While the moh was tbus engaged the
"ry "Meech, Meeck"* was rslaed, snd
a party went off toward the Esst riv
rr to atta.-k lbe warehouse of Meecb A
- -i. hut stopiwsl on tbe way and sack-
c| the warebotttt of Ilrrrlck s\ Co..
and drstroyr4 thirty barrels.
la a card publUbed ta tbe newspa
pert Hart A Co rtHuarkptl that tbe Im
pn-sslun prevslled thai they wetw mo
nopollzlug dour. Tbe truth was. all
dour lu tbe city was the property of
Hie miller* and wat held uu.ler tbe
control of the owners. It ws» iieedieni
to say that Ihe destruction of an artl
•le could not tend to reduce tbe price
Nor did It, for dour at once went ut
M cents a barrel.
At a second meeting ln the park •■
few weeks later the crowd came bear
Ing flags Inscribed "No rag money-
glvu us gold or stiver,™ "L>own wltb
chartered iuouoi-.ll.-s," "We go for prtn
•*lpie: no m.iuopollt-s,*" "We will enjoy
our liberties or die In tbe last ditch.**
A Carpenter's bench was used for a
pisiform, and mounted on this Ming
urged hLs nearer* nol to use nig money
which was the ftiuudatlou of artUtoc
mcy and monopoly. Another speaker
Sdrtaed the crow,l to go west lu a t«siy
bojf laud al fl.23 «n acre, found a new
-lute nnd let the nrtsi.KTSts toilld tnett
-wii houses This lime the Srilller?
'.mi.iisi. nti.i tio disonler occurred
The runic of 1SS7 patwnl Into btstOfJ
to probably the most sa**>**e DHMietaq
ti-U tbe country has ever egpMtBtMd
Itanl;s all over the country falltil, anil
most of the UOtitS In circulation iH-cmm*
valuelos. Many large business Smut
also faltetl. tnd mills and factories shut
down t .-■..•!-.- their produots could n«t
l*e sold. Hlcb men became poor, and
jKK»t j-.- >;>;.' i ■- -«-i-i- there was no work
to Ite had suffered for lack of rood. In
no place was the panic more keenly felt
than tn New York, where alt the hanks
tuapeaded May id. isa7.-Philadelphia
Press.
Suggestions for Christmas
Ghre tome piece of fnrniture u a Chrittmat gift, tometliing that wil estlare.
Amonf the many taefni artklet we hare the foBowins:
FOR MOTHER
Tea Wagon.
Martha Washington sewing table
Pathe Talking Machine.
Perfection ofl stove.
Hoosier Kitchen Cabinet.
A. B. gas range.
Serving tray.
Vacuum sweeper.
FOR SISTER
Lady's desk.
Indestructible doll.
Doll carriage.
FOR BABY
Choo Qioo car.
Coaster.
Wheelbarrow.
Velocipede.
Toy wagon.
Speedy car.
Red rocker.
Baby jumper.
FOR BROTHER .. & ]
' Book ends.
Reading lamp.
Smoking stand.
Doll bed. Globe Wernicke book case.
Doll Furniture. Reading table.
Bedroom rug. Arm rocker.
Doll stove. Glass top (or desk.
'j^-:--^ FOR OUR SOLDIER BOY
A Collapsible Bed Desk—Easy to attach to bed or tent pott,inexpensive, handy
for letter writing, cleaning equipment and pressing clothes.
Open Evenings Until Christmas
Palo Alto Furniture Co. Inc.
"The Quality House"
PHONE PALO ALTO 12 300 UNIVERSITY AVE.
FIRE
very often occurs during tbe
Christmas holidays, when treat
are lit up by eandlee.
l<ook over your papers and
make sure you have your furniture covered as well as your
house. 1 write insurance.
W. L SOUTHWOOD
Nsst to Bank of Palo Alto
Phone dl
E. BALSBAUC
********* Wstfcef
Estimates furnished for sll
kinds of concrate work. Orna
mental work a specialty.
7IS Wrt-n« Sc rbotae WSR |
1917 Pack
Vineyard Run
Table Raisins
10c lb.
jBuy your Xmas Supply Now
JUNK DEALER—J. Levin
DMlar la Scrap Iron. Rubbwr.
Hatal. Sack.. Rata. Psp.r, Ha-
cblnery. 8te.aa and Tools.
HbtTMw. Prtraa Paul.
018 Km«TK)n IU. Pbotw H.
CLASSIFIED
PHONE DIRECTORY
FULLER & CO.
The Leading
State.*
162 University Ave.
The beading Grocers
SIIK. 1./
Phone 751-2
HENRY A. HOYT,
BUILDING CONTRACTOR
1119 Webster St. Phone 121
CARTKT 'I.KAMNG
t-t>rnpr.---4Ml Jte or vacatun.
tUhM)n. St7 Alma. Ph. UW*.
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Firth of F^rth Br.d-f*.
Tbe brtd-*S acr.«* tbp I'lrtti t.f Forth
i*i Sctitiauii is n catulIeTer ItHdso erected 1SS3-9D, Tin- mo main *.p«tis mm-
eocb l.TIo feet toiaj--. Ths t.nal U-nstt.
■>f tbe t-rldj-o Is SSSft f«t: the tuwcr.t
in* ■'■■3 feet Will: Ibe brMre ct-atsln>- .
M.i*-' tons *tt stt-el and cost about !
-r; ...l •».»-.
I'AU) AI.TO
.Al'MiHl
rinu-l". wiwl.
ITumpt
ee*>
ifH'tlon a»**I (Jt-li.iM^. PfMHse
r\»
ELITE MARKEf
PRANK I'tllM.IPS
SIB I'alverslty Ave. 1>Tk-*S 7
Inspected meat* No", fpade
hams and b.-irqp, ilsli, poultry
and delicacies.
AUTO PEUVKBT
BASKETBALLS and
FOOTBALLS
Wc arc cleaning out our
stock of Basketballs and
Footballs at reduced prices.
SPAULDING—GROCER
528 Channlng Avenue, near
HlBh School
PHONE 141
OICY A. BAUah
Notary Public
257 University Ave
Hotel Larkin
PALO ALTO
EVROPEtX 1-I.1
