57 research outputs found
The role of cardiovascular imaging for myocardial injury in hospitalized COVID-19 patients
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal - Cardiovascular Imaging, following peer review. The version of record: Bernard Cosyns, Stijn Lochy, Maria Luiza Luchian, Alessia Gimelli, Gianluca Pontone, Sabine D Allard, Johan de Mey, Peter Rosseel, Marc Dweck, Steffen E Petersen, Thor Edvardsen, on behalf of the European Association of Cardiovascular Imaging (EACVI), The role of cardiovascular imaging for myocardial injury in hospitalized COVID-19 patients, European Heart Journal - Cardiovascular Imaging, Volume 21, Issue 7, July 2020, Pages 709–714, https://doi.org/10.1093/ehjci/jeaa136
is available online at: https://doi.org/10.1093/ehjci/jeaa13
COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in Cardiovascular Research following peer review. The version of record Helge Skulstad, Bernard Cosyns, Bogdan A Popescu, Maurizio Galderisi, Giovanni Di Salvo, Erwan Donal, Steffen Petersen, Alessia Gimelli, Kristina H Haugaa, Denisa Muraru, Ana G Almeida, Jeanette Schulz-Menger, Marc R Dweck, Gianluca Pontone, Leyla Elif Sade, Bernhard Gerber, Pal Maurovich-Horvat, Tara Bharucha, Matteo Cameli, Julien Magne, Mark Westwood, Gerald Maurer, Thor Edvardsen, COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel, European Heart Journal - Cardiovascular Imaging, , jeaa072, https://doi.org/10.1093/ehjci/jeaa072 is available online at: https://doi.org/10.1093/ehjci/jeaa072
Update of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance Certification Exam.
No full textAn updated version of the European Association of Cardiovascular Imaging (EACVI) Core Syllabus for the European Cardiovascular Magnetic Resonance (CMR) Certification Exam is now available online. The syllabus lists key elements of knowledge in CMR. It represents a framework for the development of training curricula and provides expected knowledge-based learning outcomes to the CMR trainees, in particular those intending to demonstrate CMR knowledge in the European CMR exam, a core requirement in the CMR certification process
Egyptian scarab-shaped seals from the Northern levant and Cyprus: current state of research
No full textSince the mid-1970s, scarab-shaped seals have been the subject of an increasing number of publications, the great majority of which concentrate on Egyptian or Palestinian series. The latter emphasize the need for further studies on the glyptic evidence from the Northern Levant, Mesopotamia, Cyprus, and Anatolia, especially because of their importance to the study of Egyptian-Levantine relations. Although in recent years some progress has been made as regards scarabs found outside Egypt, most publications focus on a specific site, a particular collection, or a defined period and more panoramic approaches remain scarce.
The PhD under preparation by the author (2005-...) – on scarabs from Syria and Lebanon – intends to complete the existing corpus. By differentiating between imported and locally produced scarabs and establishing their geographical distribution per period, it becomes possible to characterize the nature (intensity) and evolution (periodicity) of the relations between Egypt and the Northern Levant, from the late third millennium to the late Iron Age. Using the same methodology, the same results can be expected for Cyprus once a detailed catalogue is realised. The paper offers a synopsis of the current state of research for the Northern Levant and Cyprus, the applied methods and preliminary results, all the while addressing some problems regarding the study of this type of seals
La Neefsteeg à Anvers
No full textL’auteur de l’article relate les étapes d’une lutte menée par des habitants menacés d’expulsion, dans un quartier d’Anvers.On y découvre comment, à travers leurs difficultés, leurs échecs, leurs victoires, les personnes concernées sont arrivées à se mobiliser, à s’organiser; comment elles en sont venues à faire appel à la solidarité ouvrière au delà du quartier et à donner des prolongements à l’action ponctuelle.On y lit comment le passage d’une position de défense à une action offensive appuyée sur la législation permit d’obtenir des résultats positifs.The author relates the struggle against eviction procedures in a neighbourhood in Anvers. The successes and failures of the residents in their attmpts to organize widespread, long term struggles in conjunction with various workers' movements are described in detail.The article describes how the citizens were able to take the initiative in their struggle using legal means.El autor del artículo relata las etapas de una lucha de los habitantes de un barrio de Anvers amenazados con desalojo. Se descubre cómo, a través de dificultades, de fracasos y de victorias, estas personas consiguen movilizarse y organizarse, y cómo llegan a apelar a la solidaridad obrera más allá del barrio, y a ir más allá de la acción limitada. Se analizá cómo el paso de una acción de defensa a una de tipo ofensivo, basada en la legislación, ha permitido obtener resultados positivos
Renal insufficiency, a frequent complication with age in oral-facial-digital syndrome type I.
No full textpeer reviewedSaal S, Faivre L, Aral B, Gigot N, Toutain A, Van Maldergem L, Destree A, Maystadt I, Cosyns J-P, Jouk P-S, Loeys B, Chauveau D, Bieth E, Layet V, Mathieu M, Lespinasse J, Teebi A, Franco B, Gautier E, Binquet C, Masurel-Paulet A, Mousson C, Gouyon J-B, Huet F, Thauvin-Robinet C. Renal insufficiency, a frequent complication with age in oral-facial-digital syndrome type I. The oral-facial-digital syndrome type I (OFD I) is characterized by multiple congenital malformations of the face, oral cavity and digits. A polycystic kidney disease (PKD) is found in about one-third of patients but long-term outcome and complications are not well described in the international literature. Renal findings have been retrospectively collected in a cohort of 34 females all carrying a pathogenic mutation in the OFD1 gene with ages ranging from 1 to 65 years. Twelve patients presented with PKD - 11/16 (69%) if only adults were considered -with a median age at diagnosis of 29 years [IQR (interquartile range) = (23.5-38)]. Among them, 10 also presented with renal impairment and 6 were grafted (median age = 38 years [IQR = (25-48)]. One grafted patient under immunosuppressive treatment died from a tumor originated from a native kidney. The probability to develop renal failure was estimated to be more than 50% after the age of 36 years. Besides, neither genotype-phenotype correlation nor clinical predictive association with renal failure could be evidenced. These data reveal an unsuspected high incidence rate of the renal impairment outcome in OFD I syndrome. A systematic ultrasound (US) and renal function follow-up is therefore highly recommended for all OFD I patients
Prognostic Implications of Right Ventricular Size and Function in Patients Undergoing Cardiac Resynchronization Therapy
No full textC ardiac resynchronization therapy (CRT) is an established treatment for patients with symptomatic chronic heart failure, reduced left ventricular ejection fraction (≤35%), and a QRS duration ≥130 ms. 1 Furthermore, chronic left ventricular failure is the most frequent cause of right ventricular (RV) adverse remodeling, a complex process consisting of progressive RV dilatation and dysfunction. 2 Both parameters individually, RV dilatation and RV dysfunction, are important prognostic markers in CRT-recipients. 3,4 However, the prognostic value of both parameters in a single model has not been evaluated. Accordingly, this study evaluated the prognostic value of RV remodeling in CRT-recipients. CRT-recipients with echocardiographic data on RV remodeling, before CRT implantation (both CRT-D and CRT-P), were identified from the departmental database of the Leiden University Medical Center (Leiden, The Netherlands). RV remodeling was assessed by RV size (measured by indexed RV end-diastolic area [right ventricular end-diastolic area−indexed for body surface area] using sex-specific cutoff values to define RV dila-tation: right ventricular end-diastolic area−indexed for body surface area >12.6 cm 2 /m 2 for men and right ven-tricular end-diastolic area−indexed for body surface area >11.5 cm 2 /m 2 for women) and RV function (measured by tricuspid annular plane systolic excursion) with tricus-pid annular plane systolic excursion <17 mm considered as a reduced RV function). 5 Subsequently, patients were classified into 4 remodeling patterns: (1) normal RV size and function; (2) RV dilatation and normal RV function; (3) normal RV size and RV dysfunction; (4) RV dilatation and RV dysfunction (Figure). The primary end point was all-cause mortality. Cumulative survival rates were calculated using the Kaplan-Meier method. To investigate the association between RV size and RV function with all-cause mortality , multivariable Cox proportional hazards regression analysis was performed, adjusting for variables known to have an impact on prognosis. The incremental prognos-tic value of RV size and RV function was assessed by likelihood-ratio testing evaluating the change in global χ 2 values. This retrospective analysis was approved by the institutional review board of the Leiden University Medical Center, and the need for patient written informed consent was waived. The research reported in this article adhered to the Helsinki Declaration. The data that support the findings of this study are available from the corresponding author upon reasonable request. Of the 773 patients (mean age 66±10 years, 75% males) included, 264 (34%) patients had pattern 1, 101 (13%) had pattern 2, 256 (33%) had pattern 3, and 152 (20%) had pattern 4, prior to CRT implantation. A total of 414 (54%) patients had an ischemic cause of heart failure. A total of 739 (96%) patients received CRT-D, and only 34 (4%) patients had CRT-P with a comparable distribution among the 4 remodeling patterns. Overall, 130 (17%) patients had atrial fibrillation, and the mean QRS duration was 168±26 ms. Mean left ventricular ejection fraction was 27±8%, mean right ventricular end-diastolic area−indexed for body surface area was 11.5±3.5 cm 2 /m 2 , and mean tricuspid annular plane sys-tolic excursion was 16±5 mm. When comparing the 4 RV remodeling patterns, ischemic cause varied significantlyThe Department of Cardiology, Heart Lung Center, Leiden University Medical Center has received research grants from Abbott Vascular, Bayer, Biotronik, Bioventrix, Boston Scientific, Edwards Lifesciences, GE Healthcare, Ionis and Medtronic. Dr Stassen received an European Society of Cardiology Training Grant (App000064741). Dr Hirasawa received an European Society of Cardiology Research Grant (R-2018-18122). Dr Delgado received speaker fees from Abbott Vascular, Edwards Lifesciences, GE Healthcare, Medtronic, MSD and Novartis. Dr Ajmone Marsan received speaker fees from Abbott Vascular and GE Healthcare. Dr Bax received speaker fees from Abbott Vascular. The remaining authors report no conflicts
The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression
No full textExamined immune-deficiency markers, i.e., serum interleukin-6 (IL-6), IL-8, IL-6 receptor (IL-6R), IL-1R antagonist (IL1RA), gp130, and prostaglandin E2 (PGE2) production by mitogen-stimulated whole blood and the availability of plasma tryptophan in 10 patients with primary sleep disorders, 6 patients with major depression, and 14 healthy volunteers
Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial.
No full textOBJECTIVE: In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors. METHODS: Renal function was prospectively assessed quarterly in all 90 patients except 5 who were lost to followup. Survival curves were derived using the Kaplan-Meier method. RESULTS: After a median followup of 73 months, there was no significant difference in the cumulative probability of end-stage renal disease or doubling of the serum creatinine level in patients who received the low-dose IV CYC regimen versus those who received the high-dose regimen. At long-term followup, 18 patients (8 receiving low-dose and 10 receiving high-dose treatment) had developed permanent renal impairment and were classified as having poor long-term renal outcome. We demonstrated by multivariate analysis that early response to therapy at 6 months (defined as a decrease in serum creatinine level and proteinuria <1 g/24 hours) was the best predictor of good long-term renal outcome. CONCLUSION: Long-term followup of patients from the ELNT confirms that, in lupus nephritis, a remission-inducing regimen of low-dose IV CYC followed by AZA achieves clinical results comparable with those obtained with a high-dose regimen. Early response to therapy is predictive of good long-term renal outcome
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