2,364 research outputs found
Subungual Spitz Nevus in a Hispanic Infant.
No full textDermatol Surg. 2008 Sep 15. [Epub ahead of print]Links
Subungual Spitz Nevus in a Hispanic Infant.Dominguez-Cherit J, Toussaint-Caire S, Kamino H, Iorizzo M, Tosti A.
Department of Dermatology, Hospital General "Dr Manuel Gea Gonzalez," México City, Mexico.
The authors have indicated no significant interest with commercial supporters.
PMID: 18798747 [PubMed - as supplied by publisher
Spitz naevus is rare in Korea
No full textBACKGROUND: Spitz naevi have not been widely studied in Asians.
AIM: To compare the epidemiology and clinicopathological features of Spitz naevi in Koreans with lesions in western countries.
METHODS: In total, 80 Spitz naevi in 77 patients diagnosed over 10 years at 17 university hospitals in Korea were analysed.
RESULTS: The relative incidence of Spitz naevus vs. MM was 1 vs. 10.9. In most patients (75%) the Spitz naevi had been present for > 6 months. The size of the lesion was relatively large. Histologically, most of the lesions (54%) were the dermal type and pigmentation was common (49% of lesions). Immunohistochemical study found that all of the 34 lesions were positive for S-100 protein but only 14 (47%) were positive for HMB-45.
CONCLUSION: Spitz naevus is rare in Korea. The lesions were more commonly larger, pigmented, and of the dermal type than reported in western countries.ope
Article (C-1-n) remarques sur histoire d’une vision conservatrice contre l’égalité de J F Spitz
No full textCet article est directement accessible en cliquant ICI Cet article mobilise le riche article « L’histoire d’une vision conservatrice contre l’égalité » de Jean-Fabien Spitz publié pour la première fois le 20 octobre 2022 dans le quotidien AOC (Analyse Opinion Critique), en ajoutant des remarques aux sept extraits cités. Toutes ces remarques se rapportent à « l'égalité des droits » que « la droite conservatrice » trouve suffisante et que J-F Spitz trouve insuffisante pour répondre aux lég..
Absence of BRAF and HRAS mutations in eruptive Spitz naevi
No full textP>Background Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. Objectives To investigate the genetic changes underlying eruptive Spitz naevi. Methods We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. Results None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome
Simulations of pion production in the Daedalus targets
No full textDAEDALUS, the Decay At-rest Experiment for DCP at a
Laboratory for Underground Science will look for evidence
of CP-violation in the neutrino sector, an ingredient in theories
that seek to explain the matter/antimatter asymmetry
in our universe. It will make a precision measurement of
the oscillations of muon antineutrinos to electron antineutrinos
using multiple neutrino sources created by low-cost
compact cyclotrons. The experiment utilizes decay-at-rest
neutrino beams produced by 800 MeV protons impinging
a beam target of graphite and copper. Two well established
Monte Carlo codes, MARS and GEANT4, have been used
to optimise the design and the performance of the target. A
study of the results obtained with these two codes is presented
in this paper
Elisa Spitz and Kitty Carruthers
No full textPhoto of figure skaters Elisa Spitz and Kitty Caruthers in Japan in 198
Three contemporary hunting spitz breeds representing breeds with Finnish origins.
No full textThe Nordic Spitz (left), although officially Swedish, the breed originates from feral dogs typical for norther Finland and was brought to Sweden by Finnish settlers. The breed almost went to extinction prior to its recognition in 1966. Finnish Spitz (center) is the Finnish national dog and was established as a breed already in 1892. Karelian Bear Dog (right), a much larger spitz type used for large game hunting, was recognized as a breed in 1936 but registered only in 1946. All photos by the first author.</p
HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features.
No full textContains fulltext :
88443.pdf (Publisher’s version ) (Open Access)It is often very difficult to confidently distinguish benign and malignant Spitz lesions, and a diagnosis of Spitz tumor of unknown malignant potential (STUMP) is rendered. To address this problem, we performed molecular genetic analysis in a large group of Spitz tumors (93 Spitz nevi and 77 STUMPs) and identified a subgroup of 24 lesions harboring a HRAS mutation. This subgroup lay predominantly in the dermis, had a relatively low cellularity, showed desmoplasia (with single cells interspersed between the collagen bundles), and had an infiltrating base. In 7 of these 24 cases (29%) melanoma had been the initial diagnosis, or an important differential diagnostic consideration, mainly based on the presence of multiple or deeply located mitotic figures, especially in adult patients. In our series none of the patients with the HRAS-mutated lesions developed recurrences or metastases (mean and median follow-up: 10.5 y). This was in accordance with the literature: review showed that no HRAS mutations had so far been reported in Spitzoid melanomas. We therefore conclude that HRAS mutation analysis may be a useful diagnostic tool to help differentiate between Spitz nevus and Spitzoid melanoma, thereby reducing the frequency of overdiagnosis of melanoma, and to help predict the biological behavior of a STUMP. Moreover, this might be a first step toward a more reproducible classification of Spitz tumors combining histological and genetic data.01 oktober 201
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