3,350 research outputs found
Waves at South Uist - August 1980 to August 1981. Some results of relevance to the wave energy programme
No full text
SICAPv2 - Prostate Whole Slide Images with Gleason Grades Annotations
No full textA database containing prostate histology whole slide images with both annotations of global Gleason scores and path-level Gleason grades.
Data associated with the paper:
Silva-Rodríguez, J., Colomer, A., Sales, M. A., Molina, R., & Naranjo, V. (2020). Going deeper through the Gleason scoring scale : An automatic end-to-end system for histology prostate grading and cribriform pattern detection. Computer Methods and Programs in Biomedicine, 195. https://doi.org/10.1016/j.cmpb.2020.10563
A retrospective histopathological study and selected molecular genetics of archival prostatic cancer tissue
No full textIncludes bibliographical references (leaves 40-44).The aims of this study were to determine the age at presentation and the racial distribution of prostatic adenocarcinoma in the Western Cape region and correlate this with histological grade; to correlate the expression of androgen receptor, bcl-2, p53 and Cox-2 with the Gleason grade of disease and patient demographic data and to establish a method to determine androgen receptor (AR) gene amplification in formalin fixed prostatic carcinoma tissue
SICAPv2 - Prostate Whole Slide Images with Gleason Grades Annotations
No full textA database containing prostate histology whole slide images with both annotations of global Gleason scores and path-level Gleason grades.
Data associated with the paper:
Silva-Rodríguez, J., Colomer, A., Sales, M. A., Molina, R., & Naranjo, V. (2020). Going deeper through the Gleason scoring scale : An automatic end-to-end system for histology prostate grading and cribriform pattern detection. Computer Methods and Programs in Biomedicine, 195. https://doi.org/10.1016/j.cmpb.2020.10563
A study of Gleason score interpretation in different groups of UK pathologists; techniques for improving reproducibility
No full textAims: To test the effectiveness of a teaching resource (a decision tree with diagnostic criteria based on published literature) in improving the proficiency of Gleason grading of prostatic cancer by general pathologists. Methods: A decision tree with diagnostic criteria was developed by a panel of urological pathologists during a reproducibility study. Twenty-four general histopathologists tested this teaching resource. Twenty slides were selected to include a range of Gleason score groups 2–4, 5–6, 7 and 8–10. Interobserver agreement was studied before and after a presentation of the decision tree and criteria. The results were compared with those of the panel of urological pathologists. Results: Before the teaching session, 83% of readings agreed within ± 1 of the panel's consensus scores. Interobserver agreement was low (κ = 0.33) compared with that for the panel (κ = 0.62). After the presentation, 90% of readings agreed within ± 1 of the panel's consensus scores and interobserver agreement amongst the pathologists increased to κ = 0.41. Most improvement in agreement was seen for the Gleason score group 5–6. Conclusions: The lower level of agreement among general pathologists highlights the need to improve observer reproducibility. Improvement associated with a single training session is likely to be limited. Additional strategies include external quality assurance and second opinion within cancer networks
Relação do antígeno prostático específico, escore do gleason e da percentagem de tumor na biópsia com estadiamento patológico no câncer de próstata.
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Dapartamento de Clínica Cirúrgica
Effect of Level of Urology Training on Gleason Score and Prostate Volume Estimation Agreement between Transrectal Ultrasound Guided Biopsy and Radical Prostatectomy Specimen
No full textIntroduction Transrectal ultrasound guided prostate biopsy may be performed by operators with various levels of training. Little is known about the impact of training level on biopsy results. We evaluated the effect of training level on the accuracy of transrectal ultrasound guided prostate biopsy findings. Methods We retrospectively reviewed 500 consecutive patients who underwent transrectal ultrasound guided prostate biopsy and subsequent radical prostatectomy. Transrectal ultrasound operators were stratified based on level of training as junior, senior, chief, fellow or staff. Linear regression was performed to analyze the effect of training level on volume estimates. A weighted Kappa statistic evaluated agreement between biopsy and pathological Gleason scores while an adjusted cumulative logistic regression model analyzed the effects of training level. Results A total of 482 patients were included in the final analysis. Transrectal ultrasound guided biopsy was performed by staff in 78 (16%) patients, by fellows in 18 (4%), chief residents in 48 (10%), senior residents in 126 (26%) and junior residents in 212 (44%). There was no significant difference between transrectal ultrasound and radical prostatectomy specimen volume estimates among the training levels. Level of training was not significantly associated with pathological features, including Gleason score, primary Gleason grade, highest single Gleason grade and estimated tumor volume. Study limitations include the retrospective design and the variability among members of the same group. Conclusions Agreement between biopsy and pathological Gleason scores is high for all levels of training. Training level has no impact on prostate volume estimations or the prediction of pathological features
Gleason grading: Past, present and future
No full textIn 1966 Donald Gleason developed his grading and scoring system for prostatic adenocarcinoma. This classification was refined in 1974 and gained almost universal acceptance, being classified as a category 1 prognostic parameter by the College of American Pathologists. Modifications to the classification were recommended at a conference convened by the International Society of Urological Pathology (ISUP) in 2005. This modified classification has resulted in a significant upgrading of tumours, although some studies have shown a greater concordance between needle biopsy and radical prostatectomy scores when compared to classical Gleason (CG) grading. The ISUP consensus conference recommended that for needle biopsies higher tertiary patterns should be incorporated into the final Gleason score, and this has been correlated with biochemical failure, tumour volume and mortality. Recently the validity of including cribriform glands as a component of Gleason pattern 3 has been questioned and it has been recommended that all tumours showing cribriform architecture should be classified as Gleason pattern 4. The recommendations arising from the 2005 Consensus Conference were largely unsupported by validating data, yet this new grading system has achieved widespread usage. It is unfortunate that recent suggestions for further modification are similarly lacking in supporting evidence. In view of this it is recommended that the Modified Gleason Scoring Classification should continue to be utilized in its original (2005) format and that any future alterations should be implemented only when mandated by tumour-related outcome studies
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