160 research outputs found
Assessment of potential predictive value of peripheral blood inflammatory indexes in 26 cases with soft tissue sarcoma treated by pazopanib: a retrospective study
No full textCem Mirili,1 Semra Paydaş,1 Isa B Guney,2 Ali Ogul,1 Serkan Gokcay,1 Mahmut Buyuksimsek,1 Abdullah E Yetisir,1 Bilgin Karaalioglu,1 Mert Tohumcuoglu,1 Gulsah Seydaoglu3 1Department of Medical Oncology, Çukurova University Faculty of Medicine, Adana, Turkey; 2Department of Nuclear Medicine, Çukurova University Faculty of Medicine, Adana, Turkey; 3Department of Bioistatistics, Çukurova University Faculty of Medicine, Adana, Turkey Purpose: The aim of this study was to evaluate the prognostic and predictive value of neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (DNLR), lymphocyte-to- monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in soft tissue sarcoma (STS) cases treated with pazopanib. Materials and methods: The study population included 26 STS cases treated with pazopanib for at least 3 months. NLR, DNLR, LMR, and PLR were evaluated at baseline, and at third month of therapy and also compared with response to pazopanib. Median measurements were taken as cutoff for NLR (4.8), DNLR (3.1), LMR (3.6), and PLR (195). The associations between these cutoff values and survival times (progression-free survival [PFS] and overall survival [OS]) were assessed by Kaplan–Meier curves and Cox proportional models. Results: Patients with low pretreatment NLR and DNLR had longer OS (P=0.022, P=0.018), but low PLR was found to be associated only with longer OS. Additionally, decrease in NLR and DNLR after 3 months of therapy as compared with pretreatment measurements was found to be associated with an advantage for OS (P=0.021, P=0.010, respectively) and PFS (P=0.005, P=0.001, respectively). Response to pazopanib; changes in NLR, DNLR, LMR, and PLR; and >3 metastatic sites were found to be independent risk factors in univariate analysis, but NLR was the only independent risk factor in multivariate analysis. Conclusion: Low pretreatment and decrease in NLR and DNLR values, and regression/stable disease after 3 months of pazopanib are predictive factors for longer OS and PFS. Keywords: soft tissue sarcoma, STS, pazopanib, angiogenesis, inflammation, neutrophil-to-lymphocyte ratio, NLR, derived neutrophil-to-lymphocyte ratio, DNL
Abstract 4154: The emerging clinical relevance of genomic profiling medicine in neuroendocrine tumors
No full textAssessment of potential predictive value o f peripheral blood inflammatory indexes in 26 cases with soft tissue sarcoma treated by pazopanib: a retrospective study
No full textWOS: 000465259600002PubMed ID: 31114378Purpose: The aim of this study was to evaluate the prognostic and predictive value o f neutrophilto-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (DNLR), lymphocyte-tomonocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in soft tissue sarcoma (STS) cases treated with pazopanib. Materials and methods: The study population included 26 STS cases treated with pazopanib for at least 3 months. NLR, DNLR, LMR, and PLR were evaluated at baseline, and at third month of therapy and also compared with response to pazopanib. Median measurements were taken as cutoff for NLR (4.8), DNLR (3.1), LMR (3.6), and PLR (195). The associations between these cutoff values and survival times (progression-free survival [PFS] and overall survival [OS]) were assessed by Kaplan-Meier curves and Cox proportional models. Results: Patients with low pretreatment NLR and DNLR had longer OS (P=0.022, P=0.018), but low PLR was found to be associated only with longer OS. Additionally, decrease in NLR and DNLR after 3 months of therapy as compared with pretreatment measurements was found to be associated with an advantage for OS (P=0.021, P=0.010, respectively) and PFS (P=0.005, P=0.001, respectively). Response to pazopanib; changes in NLR, DNLR, LMR, and PLR; and >3 metastatic sites were found to be independent risk factors in univariate analysis, but NLR was the only independent risk factor in multivariate analysis. Conclusion: Low pretreatment and decrease in NLR and DNLR values, and regression/stable disease after 3 months of pazopanib are predictive factors for longer OS and PFS
Assessment of toxic metals and phthalates in children's toys and clays
No full textToxic metals and phthalates are introduced in the manufacturing of plastic toys and modeling clays. In Lebanon, inexpensive plastic toys and modeling clays (sold in dollar stores) are affordable and popular, and there is no legislation to monitor or regulate such toys. This study aimed to assess the quality of inexpensive plastic toys and modeling clays imported in Lebanon. Metal concentrations in toys, namely, zinc [not detectable (ND) to 3,708 μg-g], copper (ND to 140), chromium (ND to 75 μg-g), tin (ND to 39 μg-g), and cadmium (Cd) (ND to 20 μg-g), were lower than the European Union (EU) Directive limits, whereas lead (ND to 258 μg-g) in 10 percent of samples and antimony (Sb) (ND to 195 μg-g) in 5 percent of samples were greater than the EU limits. In modeling clays, most of the metals were lower than the EU Directive limits except for Cd and arsenic (As). Cd was detected in 83 percent of samples, with a mean level of 9.1 μg-g, which is far greater than the EU Directive limit (1.9 μg-g). The As mean level of 4.5 μg-g was greater than the EU limit (4.0 μg-g) and was detected in 9 percent of samples. Phthalic acid esters (PAEs) were found in 60 percent of children's toys and 77 percent of modeling clays. Phthalic acid butyl ester had the highest-level PAE encountered and was ≤59.1 percent in one type of clay. However, among children's toys, di(4-octyl) ester terephthalic acid was the highest encountered phthalate at a concentration of 25.7 percent. The community survey indicated that 82 percent of households purchase their toys from inexpensive shops and that only 17 percent of parents were aware of the health hazard of such toys. Consequently, an intervention plan was proposed for the provision of safe toys to children. © Springer Science+Business Media New York 2013.ADELANTADO JVG, 1993, ANAL CHIM ACTA, V276, P39; Biedermann-Brem S, 2008, CHROMATOGRAPHIA, V68, P227, DOI 10.1365-s10337-008-0672-9; Borling P, 2006, SURVEY MIGRATION HLT; Chen ML, 2008, ENVIRON INT, V34, P79, DOI 10.1016-j.envint.2007.07.004; Earls AO, 2003, J CHROMATOGR A, V983, P237, DOI 10.1016-S0021-9673(02)01736-3; EN (British Standards), 2006, 713 BS EN EUR COMM S; Guney M, 2011, ENVIRON SCI TECHNOL, V45, P3819, DOI 10.1021-es200810s; Guney M, 2012, ENVIRON SCI TECHNOL, V46, P4265, DOI 10.1021-es203470x; Heudorf U, 2007, INT J HYG ENVIR HEAL, V210, P623, DOI 10.1016-j.ijheh.2007.07.011; Kalnicky DJ, 2001, J HAZARD MATER, V83, P93, DOI 10.1016-S0304-3894(00)00330-7; Kawamura Y, 2009, J FOOD HYG SOC JPN, V50, P93; Kevin M, 2012, REGUL TOXICOL PHARM, V62, P248; Kumar A, 2007, CURR SCI INDIA, V93, P818; NTP-CERHR, 2000, NTP CERHR EXP PAN RE; Omolaoye JA, 2010, J ENV CHEM ECOTOXICO, V2, P126; RASTOGI SC, 1992, B ENVIRON CONTAM TOX, V48, P289; Rastogi SC, 1996, B ENVIRON CONTAM TOX, V56, P527; Soares EP, 2005, J RADIOANAL NUCL CH, V264, P9, DOI 10.1007-s10967-005-0667-z; Stanley MK, 2003, HDB ENV CHEM; United States Food and Drug Administration, 2002, SAF ASS DI 2 ETH PHT34
Search for ZZ and ZH production in the final state using proton-proton collisions at = 13 TeV
No full textA search for ZZ and ZH production in the final state is presented, where H is the standard model (SM) Higgs boson. The search uses an event sample of proton-proton collisions corresponding to an integrated luminosity of 133 fb collected at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The analysis introduces several novel techniques for deriving and validating a multi-dimensional background model based on control samples in data. A multiclass multivariate classifier customized for the final state is developed to derive the background model and extract the signal. The data are found to be consistent, within uncertainties, with the SM predictions. The observed (expected) upper limits at 95% confidence level are found to be 3.8 (3.8) and 5.0 (2.9) times the SM prediction for the ZZ and ZH production cross sections, respectively
Search for ZZ and ZH production in the final state using proton-proton collisions at = 13 TeV
No full textInternational audienceA search for ZZ and ZH production in the final state is presented, where H is the standard model (SM) Higgs boson. The search uses an event sample of proton-proton collisions corresponding to an integrated luminosity of 133 fb collected at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The analysis introduces several novel techniques for deriving and validating a multi-dimensional background model based on control samples in data. A multiclass multivariate classifier customized for the final state is developed to derive the background model and extract the signal. The data are found to be consistent, within uncertainties, with the SM predictions. The observed (expected) upper limits at 95% confidence level are found to be 3.8 (3.8) and 5.0 (2.9) times the SM prediction for the ZZ and ZH production cross sections, respectively
Clinical evaluation of DIAGNOVIR SARS-CoV-2 ultra-rapid antigen test performance compared to PCR-based testing
No full textCoronavirus Disease-19 (COVID-19) is a highly contagious infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The development of rapid antigen tests has contributed to easing the burden on healthcare and lifting restrictions by detecting infected individuals to help prevent further transmission of the virus. We developed a state-of-art rapid antigen testing system, named DIAGNOVIR, based on immune-fluorescence analysis, which can process and give the results in a minute. In our study, we assessed the performance of the DIAGNOVIR and compared the results with those of the qRT-PCR test. Our results demonstrated that the sensitivity and specificity of the DIAGNOVIR were 94% and 99.2%, respectively, with a 100% sensitivity and 96.97% specificity, among asymptomatic patients. In addition, DIAGNOVIR can detect SARS‑CoV‑2 with 100% sensitivity up to 5 days after symptom onset. We observed that the DIAGNOVIR Rapid Antigen Test’s limit of detection (LoD) was not significantly affected by the SARS‑CoV‑2 variants including Wuhan, alpha (B1.1.7), beta (B.1.351), delta (B.1.617.2) and omicron (B.1.1.529) variants, and LoD was calculated as 8 × 102, 6.81 × 101.5, 3.2 × 101.5, 1 × 103, and 1 × 103.5 TCID50/mL, respectively. Our results indicated that DIAGNOVIR can detect all SARS-CoV-2 variants in just seconds with higher sensitivity and specificity lower testing costs and decreased turnover time. © 2023, The Author(s).Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Bottom quark energy loss and hadronization with B and B nuclear modification factors using pp and \PbPb collisions at = 5.02 TeV
No full textThe production cross sections of B and B mesons are reported in proton-proton (pp) collisions recorded by the CMS experiment at the CERN LHC with a center-of-mass energy of 5.02 TeV. The data sample corresponds to an integrated luminosity of 302 pb. The cross sections are based on measurements of the B J/(1020)(KK) and B J/K decay channels. Results are presented in the transverse momentum () range 7-50 GeV/ and the rapidity interval 2.4 for the B mesons. The measured -differential cross sections of B and B in pp collisions are well described by fixed-order plus next-to-leading logarithm perturbative quantum chromodynamics calculations. Using previous PbPb collision measurements at the same nucleon-nucleon center-of-mass energy, the nuclear modification factors, , of the B mesons are determined. For 10 GeV/, both mesons are found to be suppressed in PbPb collisions (with values significantly below unity), with less suppression observed for the B mesons. In this range, the values for the B mesons are consistent with those for inclusive charged hadrons and D mesons. Below 10 GeV/, both B and Bs are found to be less suppressed than either inclusive charged hadrons or D mesons, with the B value consistent with unity. The values found for the B and B are compared to theoretical calculations, providing constraints on the mechanism of bottom quark energy loss and hadronization in the quark-gluon plasma, the hot and dense matter created in ultrarelativistic heavy ion collisions
Observation of the J/K decay
No full textUsing proton-proton collision data corresponding to an integrated luminosity of 140 fb collected by the CMS experiment at = 13 TeV, the J/K decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the (2S) decay, is measured to be ( J/K)/( (2S)) = [3.38 1.02 0.61 0.03]%, where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in ((2S) J/) and ( )
Observation of the J/K decay
No full textUsing proton-proton collision data corresponding to an integrated luminosity of 140 fb collected by the CMS experiment at = 13 TeV, the J/K decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the (2S) decay, is measured to be ( J/K)/( (2S)) = [3.38 1.02 0.61 0.03]%, where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in ((2S) J/) and ( )
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