1,720,990 research outputs found
Knowledge and critical thinking skills increase clinical reasoning ability in urogenital disorders: a Universitas Sriwijaya Medical Faculty experience
Full text linkAim Clinical reasoning is one of the essential competencies for medical practitioners, so that it must be exercised by medical students. Studies on quantitative evidence of factors influencing clinical reasoning abilicy of students are limited. The aim of this study was to determine the influence of knowledge and other factors on the clinical reasoning abiliry ofthe students, which can serve as reference to establish methods for learning ctinical reasoning.
Methods This is a cross-sectional study on fourth semester students enrolled in the Competency-based Curriculum of the Medical Faculty, University of Sriwijaya. Data on clinical reasoning abilily and risk factors during urogenital blockwere collected inApril 2008, when the students have just completed the btock. Clinical reasoning abiliry was tested using the Script Concordance test and the risk factors were evaluated based on formative tests, block summative assessments, and student characteristics. Data were analyzed by Cox regression.
Results The prevalence of low clinical reasoning ability of the 132 students was 38.6%. The group with low basic knowledge was found to have 63% risk ol low clinical reasoning abiliry when compared to those with high basic knowledge (adjusted RR = 1.63; 95% conidence intewal (Ct): 1.10 -2.42). When compared to students with high critical thinking skitls, those with lory critical thinking skills had 2.3 time to be low clinical reasoning abitity (adjusted RR : 2.30; 95% CI: 1.55 - 3.41).
Conclusion Students with low critical thinking skills or with inadequate knowledge had a higher risk of low clinical reasoning ability. (Med J Indones 2009; 18: 53-9)
Keywords: clinical reasoning, basic knowledge, critical thinking, competency-based curriculu
Is T-Wave Alternans a Repolarization Abnormality Marker in COVID-19? An Investigation on the Potentialities of Portable Electrocardiogram Device
Full text linkBackground: Cardiac arrhythmias are significantly associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients. Microvolt T-wave alternans (TWA) can be automatically quantified and has been recognized as a representation of repolarization hetero-geneity and linked to arrhythmogenesis in various cardiovascular dis-eases. This study aimed to explore the correlation between microvolt TWA and COVID-19 pathology. Methods: Patients suspected of COVID-19 in Mohammad Hoesin General Hospital were consecutively evaluated using Alivecor (R) Kar-diamobile 6LTM portable electrocardiogram (ECG) device. Severe COVID-19 patients or those who are unable to cooperate in active ECG self-recording were excluded from the study. TWA was detected and its amplitude was quantified using the novel enhanced adaptive match filter (EAMF) method. Results: A total of 175 patients, 114 COVID-19 patients (polymer-ase chain reaction (PCR)-positive group), and 61 non-COVID-19 pa -tients (PCR-negative group) were enrolled in the study. PCR-positive group was subdivided according to the severity of COVID-19 pathol-ogy into mild and moderate severity subgroups. Baseline TWA levels were similar between both groups during admission (42.47 +/- 26.52 mu V vs. 44.72 +/- 38.21 mu V), but higher TWA levels were observed during discharge in the PCR-positive compared to the PCR-negative group (53.45 +/- 34.42 mu V vs. 25.15 +/- 17.64 mu V, P = 0.03). The correlation between PCR-positive result in COVID-19 and TWA value was sig-nificant, after adjustment of other confounding variables (R2 = 0.081, P = 0.030). There was no significant difference in TWA levels between mild and moderate severity subgroups in patients with COVID-19, both during admission (44.29 +/- 27.14 mu V vs. 36.75 +/- 24.46 mu V, P = 0.34) and discharge (49.47 +/- 33.62 mu V vs. 61.09 +/- 35.99 mu V, P = 0.33). Conclusions: Higher TWA values can be observed on follow-up ECG obtained during discharge in the PCR-positive COVID-19 patients
THE BIOMOLECULAR CHARACTERISTICS OF ANGIOTENSIN II TYPE 1 RECEPTORS AS PARAMETERS IN KIDNEY FIBROSIS: A BIOINFORMATICS ANALYSIS
Full text linkAGTR1 is a modulator of angiotensin II-induced signal transduction. This article aims to examine the biomolecular characteristics of AGTR1 and the role of AGTR1 in the renal fibrosis pathway in Rattus norvegicus rats. The gene ID NC 051352.1 and protein ID NP 112271.2 for AGTR1 were retrieved from the National Center for Biotechnology Information's website. The 'NCBI' website has details on AGTR1's structure, location, and expression. Protease prediction using 'PEPTIDE CUTTER'; glycosylation index prediction using NETNGLYC; and target protein location evaluated on the 'TARGETP' homepage. AGTR1 in Rattus norvegicus is located on chromosome 17p12, This protein has a stability score of 34.48. The aliphatic index was 114.62. AGTR1 is found inside, outside, and on the transmembrane, as determined by the THMM. Only 21 enzymes were predicted to be capable of cleaving the AGTR1 protein, out of a total of 37 protease. AGTR1 protein has four glycosylated amino acid sequences. AGTR1 protein is primarily at other location 0.850, secretory pathway (0.590), and a little amount in mitochondria (0.018AGTR1/AT1R is a marker for renal fibrosis in the renin angiotensin system, which can lead in vasoconstriction, inflammation, fibrosis, sodium retention, and water retention. The AGTR1 protein's molecular feature is a determinant in the progression of renal fibrosis, revealed to a bioinformatics study
Analisis Atrofi Otot Akibat Bedrest Lama pada Pasien Stroke di RSUD Palembang Bari
Full text linkPenyakit stroke telah menjadi masalah kesehatan yang selain menyebabkan kematian juga merupakan penyebab utama kecacatan dan penyebab seseorang dirawat di rumah sakit dalam waktu lama. Keadaan imobilisasi pasca stroke dapat menyebabkan atrofi otot. Penelitian ini bertujuan untuk menganalisis hubungan bedrest lama pada pasien stroke dengan atrofi otot di RSUD Palembang BARI. Jenis penelitian ini adalah penelitian observasional analitik potong lintang. Penelitian ini dilakukan di RSUD Palembang BARI. Pengambilan data dilakukan dengan metode total sampling dengan jumlah sampel sebesar 9 pasien. Data lingkar paha pasien diambil dengan menggunakan meteran elastis satuan cm dan diikuti selama kurang lebih 2 minggu. Data dianalisa dengan menggunakan uji t berpasangan. Hasil uji t berpasangan mendapatkan nilai p 0,13 untuk perbandingan pengukuran hari ke-1 dan hari ke-4 sehingga disimpulkan bahwa tidak ada perbedaan yang signifikan antara lingkar paha hari ke-1 dan hari ke-4. Pengukuran hari ke-1 dan hari ke-8 mendapatkan nilai p 0,01 dan untuk perbandingan pengukuran hari ke-1 dan hari ke-12 mendapatkan nilai p 0,001, sehingga dapat disimpulkan bahwa terdapat perbedaan yang signifikan antara lingkar paha hari ke-1 dan hari ke-8 serta lingkar paha hari ke-1 dan hari ke-12. Berdasarkan hasil penelitian di atas, maka dapat disimpulkan terdapat hubungan antara bedsrest lama pada pasien stroke dengan atrofi otot
Perbedaan Kapasitas Vital Paru Mahasiswa Laki-Laki Perokok dan Tidak Perokok di Fakultas Kedokteran Universitas Muhammadiyah Palembang Tahun 2012
Full text linkRokok memiliki lebih dari 4000 substansi yang telah diidentifikasi, menyebabkan terhambatnyalaju pertumbuhan dan turunnya fungsi paru- paru bila dikonsumsi. Di lingkungan FakultasKedokteran Universitas Muhammadiyah Palembang (FK UMP) masih ada mahasiswa laki- lakiperokok. Tujuan penelitian ini adalah mengetahui perbedaan Kapasitas Vital Paru perokok dantidak perokok mahasiswa FK-UMP. Desain penelitian ini adalah observasional potong lintang.Didapatkan 60 sampel dari 75 populasi mahasiswa laki- laki FK UMP. Data diambil darikuesioner serta pemeriksaan spirometri. Hasil penelitian dibandingkan secara statistik dengan ujidua kelompok populasi independen. Hasil penelitian menunjukkan 23,3% mahasiswa merokokfilter dengan 50% mahasiswa merokok selama 5 tahun dengan 57,2% mahasiswa mengonsumsirokok sebanyak 6-10 batang/hari. 78,6% mahasiswa belum pernah berhenti merokok ? 1 tahun.Hasil uji dua kelompok populasi independen menunjukkan FEV1 p=0,457; FVC p=0,829;FEV1/FVC p=0,116; VC p=0,119 sehingga H0 diterima. Disimpulkan tidak ada perbedaan yangbermakna kelompok mahasiswa merokok dan tidak merokok. Untuk mengubah kebiasaan merokokyang dilakukan mahasiswa, tetap perlu diungkap fakta-fakta gambaran fungsi paru-paru padaperokok dan bukan perokok
Pengaruh Latihan Fisik Intensitas Ringan Dan Sedang Terhadap Perubahan Kadar Hormon Beta–Endorphin Mencit (Mus Musculus L.) Hamil
Full text linkWanita hamil sangat dianjurkan untuk tetap melakukan kegiatan sehari-hari secara rutin, termasuk olahraga. Olahraga atau latihan fisik dapat menghasilkan hormon endorphin. Beta-endorphin merupakan salah satu dari kelompok alami opiat yang salah satu manfaatnya dapat mengurangi rasa nyeri dan mengendalikan perasaan frustasi /stress. Tujuan dari penelitian ini untuk melihat pengaruh latihan fisik intensitas ringan dan sedang terhadap perubahan kadar hormon beta- endorphin mencit (Mus musculus L.) hamil. Penelitian ini merupakan penelitian eksperimental. Pelaksanaan penelitian dengan pemeriksaan di Laboratorium Terpadu Biologi Molekuler Fakultas Kedokteran Universitas Sriwijaya dengan total 30 sampel. Terdiri dari 2 kelompok perlakuan dan 1 kelompok kontrol. Dari uji ANOVA Nilai Sig. (Signifikasi) kelompok sebesar 0,117 (p value ? 0,05 ini membuktikan bahwa tidak ada pengaruh pada latihan fisik intensitas ringan dan juga sedang terhadap perubahan kadar hormon beta–endorphin mencit hamil. Kesimpulan dari uji Post Hoc pada kelompok perlakuan latihan fisik intensitas ringan dan sedang tidak terdapat perbedaan / pengaruh yang bermakna terhadap kadar beta–endorphin 0,630 (p value > 0,05). Disimpulkan bahwa tidak ada pengaruh latihan fisik intensitas ringan dan latihan fisik intensitas sedang terhadap perubahan kadar hormon beta–endorphin pada mencit (Mus musculus L.) hamil
Pengaruh Penyuluhan Personal Hygiene terhadap Tingkat Pengetahuan tentang Menstruasi dan Praktik Personal Hygiene Pada Siswi Kelas IX di SMP Negeri 24 Palembang danSMP Negeri 45 Palembang
Full text linkRemaja merupakan masa peralihan dari masa anak-anak ke masa dewasa yang mengalami perubahan fisiologis, psikologis dan kognitif. Kemampuan kognitif remaja pada tahap perkembangan intelektual sangat mempengaruhi kemampuan mengamati ilmu pengetahuan. Pengetahuan adalah faktor terpenting dalam pembentukan perilaku dan tindakan. Remaja yang telah mengalami menstruasi akan berperilaku sehat seperti memelihara kesehatan dan kebersihan selama menstruasi. Menstruasi adalah kejadian alamiah yang terjadi pada wanita normal. Selama menstruasi, hal yang penting dilakukan adalah Personal hygiene seperti pembersihan area genitalia, penggunaan pembalut yang tidak terlalu lama, dan kebiasaan mencuci tangan setelah mengganti pembalut untuk mencegah infeksi yang ditimbulkan selama menstruasi.Penelitian ini merupakan suatu penelitian analitik dengan rancangan pre- dan post-intervention dengan control. Data penelitian ini didapat dengan cara dilakukan penyuluhan dan menggunakan kuesioner. Hasil yang diperoleh dianalisis menggunakan Uji Wilcoxon, Uji Paired t-Test, Uji Mann whithney dan Uji Independent t-Test.Hasil penelitian didapatkan tingkat pengetahuan tentang menstruasi pada kelompok yang diberi penyuluhan termasuk baik yaitu sebanyak 75% yang mendapatkan nilai ?70 mengenai pengetahuan tentang menstruasi dan 85% yang mendapatkan nilai ?70 mengenai praktik personal hygiene. Dari hasil uji hipotesis menunjukkan terdapat perbedaan yang signifikan antara skor pengetahuan tentang menstruasi sebelum dan setelah penyuluhan personal hygiene (p=0,000), serta terdapat perbedaan yang signifikan antara skor praktik personal hygiene sebelum dan setelah penyuluhan personal hygiene (p=0,001).Terdapat pengaruh penyuluhan personal hygiene terhadap tingkat pengetahuan tentang menstruasi dan praktik personal hygiene pada siswi kelas IX yang diberi penyuluhan di SMP Negeri 24 Palembang
CHARACTERISTICS, PATTERNS OF PATHOGENS, AND ANTIBIOTICS RESISTANCE OF BACTERIAL MENINGITIS AT RSUP DR. MOHAMMAD HOESIN PALEMBANG
Full text linkBacterial meningitis is an inflammation of the meninges, especially arachnoid and pia mater, which occurs due to the invasion of bacteria into the subarachnoid space. Bacterial meningitis cases are distributed throughout the world, with an incidence of 2-6 / 100,000 people per year with a peak incidence in infants, adolescents, and the elderly. This study was a retrospective cross-sectional descriptive study to look for sociodemographic characteristics, pathogens and resistance patterns, and clinical outcomes of bacterial meningitis patients at dr. Mohammad Hoesin Palembang. There were 43 cases of bacterial meningitis, and only 13 cases met the inclusion and exclusion criteria. Most cases of bacterial meningitis were in the 30-45 years (30%) and 46-55 years (30%) age groups, with predominantly female patients (69%). The most noted clinical manifestations were fever and neck stiffness (100%). decreased consciousness (92%), hemiparesis (77%), headache (70%) and seizures (54%). The mortality rate of bacterial meningitis patients reached 53% with a disability rate reaching 39%. Pathogens found based on culture results were Staphylococcus sp. (69%), Acinetobacter baumanii (5.3%), Klebsiella pneumonie (15%), Shigella somnei, and E. coli (5.3%). Antibiotic resistance to Staphylococcus sp. Was quite high, namely Erythromycin and Oxacillin reaching 77%, Trimethoprim / Sulfamethoxazole 55%, Ciprofloxacin, Clindamycin, levofloxacin reached 33%. Higher mortality was found in patients with drug resistance
PENGARUH DIET KETOGENIK TERHADAP EKSPRESI Ki-67, CASPASE-3, DAN MDA PADA JARINGAN HATI
Full text linkObesity is a problem of global epidemics and arise a health threat to people. The prevalence of obesity in the United States in 2016 was around 39.8% in adults aged 40-59 years and 18.5% in young adults aged 20-39 years. One of the dietary patterns used to overcome obesity is the ketogenic diet. The main metabolic reaction due to the ketogenic diet occurs in the liver which make lesion.
The ketogenic diet is a high-fat diet, quite protein, low in carbohydrates (usually less than 50 g / day). The effect of the ketogenic diet on the liver is help maintain TCA cycle homeostasis, prevents the accumulation of intermediate fatty acids that are not oxidized, maintains the redox balance of the liver, and supplies energy to extrahepatic organs in the glucose deficiency stage.
The ketogenic diet can reduce cell proliferation which is characterized by a decrease in the percentage of cells in ki-67 positive staining and increase cell apoptosis which is characterized by an increase in caspase-3 positive staining and reduce oxidative stress as assessed by MDA reduction.
Key Words : Obesity, Ketogenic Diet, Ki-67, Liver, Caspase-3, MD
Incidence And Characteristics Intradialytic Hypertension Among Chronic Hemodialysis Patients Caused By Chronic Kidney Failure At Rsmh Palembang Period November 2018
Full text linkIntradialytic hypertension have 5 – 15 % incidence among chronic hemodialysis patients caused by chronic kidney failure. But, mostly medical practician focused only at intradialytic hypotension than intradialytic hypotension as the most frequent cardiovascular complications. Intradialytic hypertension itself is one of the cause of mortility and morbidity hemodialytic patients, that’s why patients should be aware of intradialytic hypertension. This study aims to know the frequencies of patients with intradialytic hypertension at RSMH Palembang period November 2018, and the characteristics of the patients based on patients sosiodemography, etiology of their chronic kidney disease, their hemodialysis period, and their activity during hemodialysis.Method : This study is descriptive analysis with total sampling, with primary data from patients blood pressure measurement, and interview with patients in hemodialysis installation at RSMH Palembang. In this study,305 samples were found, with 198 patients fulfilled inclusion criteria. Result : The result of this study shows that from 198 subjects, there are 116 (58,6%) of them who suffer intradialytic hypertension. Intradialityc hypertension patients mostly in the group age 46 – 65 years old (51%), male patients (61.2%) are more likely develop intradialytic hypertension than female patients (38.8%), patients with high educational backgroud also more likely to develop this complications. Their chronic kidney diseases cause are mostly hypertension (67,2%), and the higher activities patients during hemodialysis also more likely to develop intradialytic hypertension.Conclusion : Patients in hemodialysis installation at RSMH Palembang with intradialytic hypertension are more than the patients without the intradialytic hypertension (normotension and intradialytic hypotension patients are included), patients in old age group, male patients, and the higher patients activities during hemodialysis process the more highly patients develop intradialytic hypertension as complication
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