449 research outputs found
How ICTs Raise Manufacturing Performance: Firm-level Evidence in Southeast Asia.
Get PDFThis paper examines the effects of information and communication technologies (ICTs) on business performance, using firm-level data obtained through a questionnaire survey in four ASEAN countries (Indonesia, The Philippines, Thailand and Vietnam). Sources of information and new technologies exchanged via ICTs by firms are also explored to investigate the mechanism behind ICT adoption. Empirical results verify that the introduction of ICT to reorganize business processes is significantly correlated with business performance, in particular the development of export markets and improvement of production management. ICTs facilitate access to information and technologies accumulated in in-house departments and joint-venture (JV) affiliates of the respondent firms. There are considerable differences between multinational companies (MNCs)/JVs and local firms. MNCs/JVs make use of information and technologies obtainable via ICTs from their own R&D departments, JVs established with local partners and foreign-owned suppliers/customers to improve factory management, mostly for product quality improvement and production cost reduction. In contrast, local firms interconnect their own R&D departments via ICTs to enhance their business performance in broader areas than MNCs/JVs, including the development of export markets.
About the "River" Image in Yasushi Inoue's Literature
Get PDFIn Yasushi Inoue's literary works, rivers always appears as representative images. It has rich symbolic meanings, through which the author expressed his outlook on life and the development of history. The rivers are symbols of infinity and eternal nature, through the contrast between the infinity of river and the finity of human beings.departmental bulletin pape
About the "River" Image in Yasushi Inoue’s Literature
No full textIn Yasushi Inoue's literary works, rivers always appears as representative images. It has rich symbolic meanings, through which the author expressed his outlook on life and the development of history. The rivers are symbols of infinity and eternal nature, through the contrast between the infinity of river and the finity of human beings
Influence of Carbon in Iron on Characteristics of Surface Modification by EDM in Liquid Nitrogen
Get PDFMany surface modification technologies have been proposed and carried out practically by CVD, PVD et.al. Carbonized layer has been made using EDM method. In this paper, to make the nitride layer by EDM some new trials were carried out using a titanium electrode in liquid nitrogen. Experiments were carried out on carbon steel (S45C), pure iron and cast iron. TiN can be obtained on EDMed surface. Moreover, TiCN can be found on cast iron and steel (S45C) by XRD investigation. To confirm the fabrication mechanisms of modified layer on the steel, the following experimental factors were investigated by EDS
Stochastic calculus of variations for jump processes/ Yasushi Ishikawa.
No full textIncludes bibliographical references (pages 265-274) and index.This monograph is a concise introduction to the stochastic calculus of variations for processes with jumps. It is written for researchers and graduate students who are interested in Malliavin calculus for jump processes. The author provides many results on this topic in a self-contained way. The book also contains some applications of the stochastic calculus for processes with jumps to the control theory and mathematical finance.Lévy processes and Itô calculus -- Perturbations and properties of the probability law -- Analysis of Wiener-Poisson functionals -- Applications.1 online resource (x, 278 pages
Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells
No full text博士論文要旨Abstract 要約Outline 以下に掲載：Journal of Neuro-Oncology 121(2) pp.239-250 2015. Springer. 共著者：Shingo Tanaka, Mitsutoshi Nakada, Daisuke Yamada, Ichiro Nakano, Tomoki Todo, Yasushi Ino, Takayuki Hoshii, Yuko Tadokoro, Kumiko Ohta, Mohamed A.E. Ali, Yutaka Hayashi, Jun-ichiro Hamada, Atsushi Hira
Identification of RNA-binding protein LARP4B as a tumor suppressor in Glioma
No full textTransposon-based insertional mutagenesis is a valuable method for conducting unbiased forward genetic screens to identify cancer genes in mice. We used this system to elucidate factors involved in the malignant transformation of neural stem cells into glioma-initiating cells. We identified an RNA-binding protein, La-related protein 4b (LARP4B), as a candidate tumor-suppressor gene in glioma. LARP4B expression was consistently decreased in human glioma stem cells and cell lines compared with normal neural stem cells. Moreover, heterozygous deletion of LARP4B was detected in nearly 80% of glioblastomas in The Cancer Genome Atlas database. LARP4B loss was also associated with low expression and poor patient survival. Overexpression of LARP4B in glioma cell lines strongly inhibited proliferation by inducing mitotic arrest and apoptosis in four of six lines as well as in two patient-derived glioma stem cell populations. The expression levels of CDKN1A and BAX were also upregulated upon LARP4B overexpression, and the growth-inhibitory effects were partially dependent on p53 (TP53) activity in cells expressing wild-type, but not mutant, p53. We further found that the La module, which is responsible for the RNA chaperone activity of LARP4B, was important for the growth-suppressive effect and was associated with BAX mRNA. Finally, LARP4B depletion in p53 and Nf1-deficient mouse primary astrocytes promoted cell proliferation and led to increased tumor size and invasiveness in xenograft and orthotopic models. These data provide strong evidence that LARP4B serves as a tumor-suppressor gene in glioma, encouraging further exploration of the RNA targets potentially involved in LARP4B-mediatd growth inhibition.Japan Society for the Promotion of Scienc
Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells
Get PDF金沢大学博士（医学）博士論文要旨Abstract 要約Outline 以下に掲載：Journal of Neuro-Oncology 121(2) pp.239-250 2015. Springer. 共著者：Shingo Tanaka, Mitsutoshi Nakada, Daisuke Yamada, Ichiro Nakano, Tomoki Todo, Yasushi Ino, Takayuki Hoshii, Yuko Tadokoro, Kumiko Ohta, Mohamed A.E. Ali, Yutaka Hayashi, Jun-ichiro Hamada, Atsushi Hiraothesi
Molecular mechanisms of metabolic regulation of glioma stem cells by mTORC1 activationm
Get PDF金沢大学博士（理学）博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Biological Chemistry Published online in 2016.08.12 2016. American Society of Biochemistry and Molecular Biology (ASBMB). 共著者：Ahmed M. Hegazy, Daisuke Yamada, Masahiko Kobayashi, Susumu Kohno, Masaya Ueno, Mohamed A.E. Ali, Kumiko Ohta, Yuko Tadokoro, Yasushi Ino, Tomoki Todo, Tomoyoshi Soga, Chiaki Takahashi, Atsushi Hiraodoctoral thesi
Poet of Perpetuity and Stagnation: Inoue Yasushi\n―On the Resonance of Youth and Antiquity in Ikoku no Hoshi
Get PDFpdfInoue Yasushi was an author who has continuously written on the history of the West and the dialogue between Eastern and Western cultures. His literary world consists of genres such as historical novels, biographical novels, and prose poems, but each contains a storytelling structure. Ikoku no Hoshi (1984) likewise has its own form of storytelling. Recording his journey in his 70s along the Silk Road, from northern Siberia, the northern and southern roads of Tien Shan, and the Taklamakan Desert, to Pamir and Pakistan, following the path of Genjō Sanzō, and finally to Istanbul, Ikoku no Hoshi is a challenging work from late in his career. As can be seen from the titles “Gilgit Correspondence”, “Kaxgar Diary”, “Himalayan Moon”, “Letter from the Desert”, The town of Amurskaya”, “Crossing point on the Indus”, “Yumen Notebook”, “At the foot of India (Tenjiku), 1 and 2”, it is a truly grand prose poetry collection. Made up of correspondences, diaries, journals, and notebooks, it is not merely a collection of writings, but is designed to be a prose poem. The secret lies in the world of Inoue Yasushi’s dignified “prose meter”. Inside is hidden a deep and sacred philosophy-perpetuity and stagnation. Of course, the places, times, things, people, thoughts, and events he encountered act as devices for memory. Inoue Yasushi is not the kind of poet or writer who abandons a relation in order to focus on discussing himself. In Ikoku no Hoshi, he touches relentlessly on places he has been in life, experiences during wartime, and people he has met, drawing on memories of the past in order to speak to the deceased. At other times he brings his youth back from his memory to form a dialog with his present self or history of the distant past. It contains a vibrant textuality between his youth and history. This presentation looks at the infrequently examined structure and characterizations in Ikoku no Hoshi through Inoue Yasushi’s prose poems. In addition, through the many thoughts of lnoue Yasushi seen in the deceased author of The Star of Samarkand and his letters to numerous anonymous people, I will examine poet Inoue Yasushi’s philosophy of perpetuity and stagnation.conference pape
- …
