482 research outputs found
A Bibliography of Ryuji Hattori, Japan at War and Peace:Shidehara Kijūrō and the Making of Modern Diplomacy(Canberra: Australian National University Press, 2021)
No full textapplication/pdfThe author recently published a book, Japan at War and Peace: Shidehara Kijūrō and the Making of
Modern Diplomacy (Canberra: Australian National University Press, 2021). It is open-access in multiple
formats at the URL https://press.anu.edu.au/publications/japan-war-and-peace. This book is based on
Ryuji Hattori, Zōhoban Shidehara Kijūrō: Gaikō to Minshushugi [Shidehara Kijūrō: Diplomacy and
Democracy, enlarged edition] (Tokyo: Yoshida Shoten, 2017). The English version was updated with a new
introduction and other information. However, due to the word limit, the bibliography was omitted.
Therefore, this paper provides that bibliography for the benefit of its readers.departmental bulletin pape
Depth dependence and exponential models of permeability in alluvial-fan gravel deposits
No full textTo determine depth dependence of permeability in various geologic deposits, exponential models have often been proposed. However, spatial variability in hydraulic conductivity, K, rarely fits this trend in coarse alluvial aquifers, where complex stratigraphic sequences follow unique trends due to depositional and post-depositional processes. This paper analyzes K of alluvial-fan gravel deposits in several boreholes, and finds exponential decay in K with depth. Relatively undisturbed gravel cores obtained in the Toyohira River alluvial fan, Sapporo, Japan, are categorized by four levels of fine-sediment packing between gravel grains. Grain size is also analyzed in cores from two boreholes in the mid-fan and one in the fan-toe. Profiles of estimated conductivity, , are constructed from profiles of core properties through a well-defined relation between slug-test results and core properties. Errors in are eliminated by a moving-average method, and regression analysis provides the decay exponents of with depth. Moving-average results show a similar decreasing trend in only the mid-fan above 30-m depth, and the decay exponent is estimated as a parts per thousand 0.11 m(-1), which is 10- to 1,000-fold that in consolidated rocks. A longitudinal cross section is also generated by using the profiles to establish hydrogeologic boundaries in the fan
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
No full textPreKURA:1124*Japan Prospective Studies Collaboration for Aging, Dementia (JPSC-AD) study group:
Jun Hata, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Masato Akiyama, Koichi Murashita, Tatsuya Mikami, Songee Jung, Mina Misawa, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Masahito Yamada, Kazuo Iwasa, Sohshi Yuki-Nozaki, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Yasuyo Fukada, Hisanori Kowa, Kenji Wada, Masafumi Kishi, Takaaki Mori, Yuta Yoshino, Hideaki Shimizu, Ayumi Tachibana, Shu-ichi Ueno, Tomohisa Ishikawa, Ryuji Fukuhara, Asuka Koyama, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Midori Esaki, Yuji Takano, Koji Yonemoto, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo & Yutaka Kiyoharajournal articl
Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract
No full textDiclofenac instillation is useful in preventing intraoperative miosis and macular edema caused by postoperative inflammation in cataract surgery; however, optimum efficacy is not attained when the instilled diclofenac strongly binds to albumin in patients’ aqueous humor. Therefore, a method that inhibits diclofenac binding and increases the concentration of its free fraction is needed. We conducted a basic study regarding the effects of inhibitors on the binding of instilled diclofenac to albumin and endogenous substances in aqueous humor. Aqueous humor samples from 16 patients were pooled together for analysis. The free fraction of diclofenac was measured using ultrafiltration methods in various experiments with pooled and mimic aqueous humor. Free fraction of diclofenac, a site II drug, in pooled aqueous humor was 0.363 0.013. The binding of diclofenac in the presence of phenylbutazone (PB), a site I inhibitor, was significantly inhibited (free fraction 0.496 0.013); however, no significant inhibition by ibuprofen, a site II inhibitor, (free fraction 0.379 0.004), was observed. The unexpected result was due to free fatty acids (FFAs; palmitic acid (PA)) and L-tryptophan (Trp). The inhibition of diclofenac binding by PB in the mimic aqueous humor containing these endogenous substances revealed significant binding inhibition in the presence of PA and Trp. Diclofenac is strongly rebound from site II to site I in the presence of FFAs and Trp in the aqueous humor because FFAs and Trp induce a conformational change in albumin. Therefore, PB significantly inhibits the binding of diclofenac to albumin.Citation: Saya Ishii, Mineo Ozaki, Norito Takamura, Kenji Ogata, Jin Tokunaga, Ryuji Ikeda, Influence of Endogenous Substances on Site-II to Site-I Displacement of Diclofenac Bound to Albumin in the Aqueous Humor of Patients with Cataract, Biological and Pharmaceutical Bulletin, 47(1), 213-220, 2024-01-20, https://doi.org/10.1248/bpb.b23-0030
Very deep, thermally stratified lakes
No full textIn very deep freshwater lakes, deep recirculation presents itself with remarkable differences to shallower lakes. We consider the stratification where density gradients are exclusively due to temperature differences. The annual circulation patterns are discussed for various climatic conditions. Very deep lakes do not necessarily produce full overturns during Tmd transition in autumn and spring. Peculiarities of the stratification are derived for cases, in which surface temperatures cross 4℃ during the annual cycle: Firstly, the asymmetry between autumn and spring circulation, secondly, the proximity of temperature to the Tmd profile, and thirdly, the isothermal deep water. We compare conceptual model results of horizontally homogeneous lakes with measurements in very deep caldera lakes in Japan (Lakes Ikeda, Tazawa, Toya, Kuttara and Shikotsu). Between oligomictic lakes and thermobarically stratified lakes, we have found lakes circulating reliably despite their enormous depth. We discuss susceptibility to climate variability supported by comparisons with single point measurements from the 1920s and 1930s
Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11-/- mice
No full textAquaporin-11 (AQP11) is an intracellular AQP. Several studies with Aqp11-/- mice have shown that AQP11 has a role in normal development of the kidney after birth. Our previous studies have suggested that alteration of oxygen homeostasis may be involved in the kidney injury caused by AQP11 deficiency, although the underlying mechanism is largely unknown. To clarify this issue, we examined genes that are related to oxygen homeostasis in Aqp11-/- mice. Among 62 genes that are involved in oxygen homeostasis, 35 were upregulated by more than 2-fold in Aqp11-/- mice in comparison with wild-type mice. Pathway analysis using these genes extracted the pathway responsible for production of reactive oxygen species in macrophages. As expression of the genes involved in the NADPH oxidase 2 (NOX2) complex was dramatically increased by more than 14-fold, we further analyzed NOX2 at the protein level. Immunoblotting analysis demonstrated a dramatic increase of NOX2 protein in the kidney of Aqp11-/- mice, and immunohistochemistry showed that NOX2 protein and a marker protein for macrophages were increased in the renal interstitium. These results indicate that NOX2-induced oxidative stress accompanied by macrophage infiltration plays an important role in alteration of oxygen homeostasis in Aqp11-/- mice.Yuya Hoshino, Hiroko Sonoda, Ryuji Nishimura, Kazuya Mori, Kenichi Ishibashi, Masahiro Ikeda,
Involvement of the NADPH oxidase 2 pathway in renal oxidative stress in Aqp11-/- mice,
Biochemistry and Biophysics Reports, Volume 17, 2019, Pages 169-176, ISSN 2405-5808,
https://doi.org/10.1016/j.bbrep.2019.01.003
Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis
No full textIntra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. However, the association between the time in therapeutic range of tacrolimus blood concentrations and its efficacy in preventing graft-versus-host disease remains unknown. In this study, we analyzed the relationship between the time in therapeutic range of tacrolimus blood concentrations and its efficacy in acute graft-versus-host disease prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation. Eligible patients administered tacrolimus were categorized into two groups based on the grade of acute graft-versus-host disease, and propensity score matching was performed using graft-versus-host disease prophylaxis protocols and days to the disease onset to compare time in therapeutic range. In patients with tacrolimus blood concentration therapeutic range ≥ 10 ng/mL, time in therapeutic range during the first 4 weeks post-transplantation was significantly lower in the Grade II–III than in the Grade 0–I group. Among propensity score matching-extracted patients, the Grade II–III group had significantly lower time in therapeutic range during the first 2 and 4 weeks post-transplantation. Our results suggest that high time in therapeutic range early post-transplantation, particularly within 4 weeks, may avert the severity of acute graft-versus-host disease.Citation: Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda, Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis, Scientific Reports, 15(1), 2025-01-27, https://doi.org/10.1038/s41598-025-87801-
Metalorganic Vapor-Phase Epitaxy of +c/−c GaN Polarity Inverted Bilayer for Transverse Quasi-Phase-Matched Wavelength Conversion Device
No full textIkeda K., Malik S., Uemukai M., et al. Metalorganic Vapor-Phase Epitaxy of +c/−c GaN Polarity Inverted Bilayer for Transverse Quasi-Phase-Matched Wavelength Conversion Device. Physica Status Solidi (B) Basic Research, (2024); https://doi.org/10.1002/pssb.202400161.Photon-pair generation based on optical parametric down-conversion has attracted for the application as a light source for quantum information. Highly efficient wavelength-conversion devices require a polarity-inversion structure when using nitride semiconductors. A transverse quasi-phase-matching (QPM) polarity-inverted GaN bilayer channel waveguide device is suitable for efficient wavelength conversion. This study designed a cross-section device to satisfy the modal dispersion phase-matching condition between the TM₀₂ mode pump light and the TM₀₀ mode signal/idler light. Moreover, an AlN oxidation interlayer fabricates the Ga-polar/N-polar (+c/−c) GaN layers via metalorganic vapor-phase epitaxy (MOVPE). A 145 nm thick film layer with a macro-step-free surface is grown by optimizing the −c-GaN growth conditions and reducing the substrate off-angle to 0.2°. Next, the AlN layer is oxidized in an electric furnace and MOVPE is used to regrow a 1500 nm thick +c-GaN layer. A macrosteps-free surface can be achieved by reducing the off-angle to 0.2° and optimizing the −c-GaN growth conditions to avoid hillock formation. These results pave the way for improving the efficiency of GaN transverse QPM wavelength-conversion devices
Markers for Guillain-Barré syndrome with poor prognosis : a multi-center study
No full text学位の種類：医学 学位授与年月日：平成30年3月20日 主査：池上,博司 教授 報告番号：甲第1353号 学内授与番号：医第1244号
This is the peer reviewed version of the following article: Markers for Guillain‐Barré syndrome with poor prognosis: a multi‐center study, Yuko Yamagishi, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Kenichi Kaida, Shu‐ichi Ikeda, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Journal of the Peripheral Nervous System, Volume22, Issue4, December 2017 ,Pages 433-439, Susumu Kusunoki, which has been published in final form at https://doi.org/10.1111/jns.12234. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." 掲載application/pdfdoctoral thesi
Molecular Basis for the Inhibition of Anticancer Agents‐Induced Apoptosis by Thymidine Phosphorylase
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