565 research outputs found
Story of Adeline Yen Mah
No full textProducer, Eleanor Morris ; narrator, Connie Booth.Adeline Yen Mah, the author of Falling leaves, traces her and her family's life from Shanghai of the 1930s to the Cultural Revolution, through her life as a doctor in California
Wallastra elenderae Mah 2018, n. gen.
No full textWallastra elenderae n. gen. n. sp. Figure 37 A–G Type species. Wallastra elenderae n. sp. by monotypy. Etymology. This genus and species are named for dear friend, opera singer, and co-author of the textbook Introductory Physics, Ms. Elender Wall (1969–2016). Diagnosis. Body strongly stellate (R/r=3.46) with elongate, slender arms, weakly curved interradial arcs (Fig. 37A, F). Abactinal plates bare, surface mostly bare and smooth (Fig. 37B), especially on distal disk regions adjacent to superomarginals and along arms. Central disk plates with one to several, widely distributed button-like granules. Superomarginals wide to quadrate in shape, with mostly bare surface, or widely distributed coarse granules occur (Fig. 37D). Each actinal plate covered with closely articulated granules, most plates with a single large bivalve pedicellaria (Fig. 37E). Furrow spines four or five (Fig. 37G). Comments. Based on comparisons with other goniasterid taxa, the species described here cannot be easily reconciled with known goniasterid genera, and therefore the new genus Wallastra is recognized. Wallastra n. gen. lacks the crystalline tubercles embedded in the surface of the abactinal plates, which identifies all species of Astroceramus as well as the superomarginals abutted over the radius of each arm. Most species of Astroceramus also possess one or two enlarged subambulacral spines that are absent from Wallastra. Abactinal plates on Wallastra n. gen. possess one to approximately eight to 10 coarse granules embedded in the plate surface but are otherwise bare and smooth. Granules abruptly disappear on arm plates where abactinal plates become flatter and are entirely devoid of surficial accessories. This character is reminiscent of the abrupt change between plates that defines the difference between Circeaster and Lydiaster. In Circeaster, abactinal arm plates are abruptly larger whereas those in Lydiaster remain relatively similar in size on the arm and disk. However, Lydiaster possesses much larger and wider marginal plates with a stronger abactinal facing, a thicker and more stout body shape and widespread spinelets that are absent from Wallastra n. gen. Two species of Circeaster, C. sandrae (South and Central Pacific) and especially C. pullus (North Pacific) display similar abactinal and marginal plate patterns to both Wallastra n. gen. and Astroceramus. Occurrence. Solomon Islands and Western Indian Ocean, between Mayotte and the Glorioso Islands, 550–836 m. Description. Body strongly stellate (R/r=3.46), arms elongate, tapering. Interradial arcs weakly curved to nearly straight (Fig. 37A). Abactinal surface flat, composed of round to polygonal abutted plates (Fig. 37A, B), which are flush with superomarginal plate surface (Fig. 37D). Approximately three rows of abactinal plates (at R= 10.4 cm) extending along arm to terminus (Fig. 37C), decreasing in number to a single row of wide then very narrow, irregularly shaped, strongly convex plates along distalmost arm region. Plates largest and most polygonal along papular (radial regions) with smallest and most irregular plates occurring interradially. Plates with discrete peripheral row of quadrate to polygonal shaped granules,12–30, mostly 15–25, with approximately four to five granules present per side (Fig. 37B). Peripheral granules largest on disk occupying 1/3 to 1/5 of the total width of each plate becoming substantially smaller on arm plates, occupying only approximately 1/6 to 1/10 of the total plate distance. Peripheral granules on arm more rounded and nearly flush with plate surface versus those on disk which are raised and sit above the plane of the abactinal plate surface. Abactinal plate surfaces on the disk possess one to 15 (mostly two to six) large, coarse widely spaced granules but are otherwise smooth, bare and are mostly devoid of other structures or accessories. Granules are widely spaced on all but the plates flanking the polygonal shaped madreporite. Of the seven plates which flank the madreporite, four possess abundant and closely spaced coarse granules all but covering the plate surface. This side of the madreporite with granule-covered plates with one to two irregularly spaced rows of plates with similarly abundant granule-covered plates. Two plates observed each with a large paddle-shaped pedicellaria (approximately 1.5–2.0 mm width) present in the center of each plate. These large coarse button-like granules decrease in number farther away from the center of the disk, disappearing completely on the disk edge, arm base and along the surface of the arm plates. The absence of the button-like granule leaves a distinct concavity on the plate where it has been removed, otherwise the surface is flat and smooth. Papulae were extended on specimen examined with six numbering around each plate along radial regions at the base of each arm extending from the radial region of the disk. Superomarginal and inferomarginal plates, approximately 62–66 per interradius. Plates wide, quadrate in shape with flattened surface interradially but becoming more elongate and tumid distally, becoming much more strongly convex adjacent to arm tip. Superomarginals and inferomarginals with 1:1 correspondence interradially becoming more offset distally, showing a more zigzag contact along the arm. Distalmost three to four superomarginals abutted over midline. Superomarginals with one to approximately 25 coarse, round button-like, widely spaced granules present on each plate surface, granules are most abundant interradially, gradually decreasing and then disappearing completely along plates present on the arm (Fig. 37D). When removed, disk granules leave a distinct, concave pitting on the superomarginal plate surface. Inferomarginal plate surfaces show same general pattern but interradial plates also possess a dense row of coarse, polygonal granules identical to those which compose the peripheral granule layer around the marginal plates (Fig. 37D). Peripheral granules around superomarginals, polygonal to narrowly quadrate, approximately 30–80, mostly 40–60 forming (15 per edge) narrow border around superomarginal plates becoming nearly indistinct near arm terminus. Peripheral granules around inferomarginals similar in size and number except for those in contact with granules on the actinal plate surface, which are slightly larger than those on the other sides of the inferomarginal plate. Granules on the inferomarginal/actinal plate contact are much larger, coarser, in close contact, and similar in overall appearance. As with superomarginals, granules are most numerous interradially, with numbers decreasing and disappearing entirely on inferomarginal plate surface along the arm, especially distally adjacent to the arm terminus. Terminal plate is large, triangular in shape, approximately the size of four adjacent superomarginal plates, with bare surface and a large blunt spine on the tip. Actinal surface composed of approximately three full series in chevron-like pattern, with irregular incomplete series adjacent to contact with inferomarginal plates (Fig. 37E). Actinal plates quadrate to polygonal in outline, all plates on disk covered by coarse, closely distributed polygonal to round granules, four to 12 per plate. Approximately 1 granule counted along a 1.0 mm line. Actinal plates along arm with decreasing number of granules, in some cases disappearing from plate surface. Large (1.0–2.0 mm wide) trapezoid shaped pedicellariae (Figs. 37E, G), each with short, jagged complimentary valves, numbering one per plate, occurring on approximately 50% of actinal plates, variably present throughout each interradius. Furrow spines four in a linear series increasing to five distally, quadrate to triangular in cross-section with spines flattening out farther along arm, becoming individually narrower and more prominent (Fig. 37G). Variably, some spines are flattened and are more wedge-shaped. Furrow spines mostly blunt and smooth but most proximal spines with notches or some texturing on each spine tip. Furrow spines are set off by a discrete space, then two to four short triangular to rounded subambulacral spines, less than 25% of the length of each furrow spine. When only two subambulacrals are present, they occur on either side of the adambulacral plate, flanking a large bivalve pedicellaria with large rectangular valves with jagged tips, similar to those on actinal surface (Fig. 37G). Subambulacral spines transition from two short enlarged granules to a single enlarged blunt spine on distalmost adambulacral plates. Subambulacral pedicellariae occur in a continuous series along the adambulacral plates on the disk but gradually disappear along the transition from disk to arm. Pedicellariae are in turn, flanked by a row of three, large, blunt spines, quadrate to rounded in cross-section, which are two to three times as thick as the adjacent actinal granules. Pedicellariae set off from both the furrow spines and the thickened subambulacrals by discrete bare spaces. Pedicellariae are absent on a minority of plates, and are replaced by a series of two to four small polygonal granules similar to those on the actinal surface. Remainder of adambulacral surface covered by four to 20 thick, mostly 10 to 15 polygonal granules, best developed along arm after pedicellariae series has terminated. Oral plates with six to eight thick spines, ranging from thickened quadrate to flattened and triangular in crosssection with thin, flattened paddle like spines projecting into oral region from each paired oral plate. Oral plates with four or five thick subambulacral spines, each two to four times as thick as the furrow spines with six to eight, short paired, irregular, triangular granules on each side of the oral plate contact along the midline. Color in life, disk is light orange with darker orange arms and solid dark marginal plates. Material Examined. Holotype: MNHN-IE-2013-17165. Western Indian Ocean, between Mayotte and the Glorioso Islands, 12° 18 'S, 46° 27' E to 12 ° 17 'S, 46 ° 28' E, 842– 836m, Coll. S. Samadi et al. BIOMAGLO DW 4792, 22 Jan 2017, leg 1. 1 wet spec. R=10.4 r=3.0. Paratype: IE-2007-1291. Solomon Islands 8°16’S 160° 43’E, 550 m, Coll. Richer & Boissellier, 15 Sept. 2007. N/ O Alis, SALOMONBOA 3 DW 2792 1 wet spec. R=9.3 (arm twisted) r=3.2Published as part of Mah, Christopher L., 2018, New genera, species and occurrence records of Goniasteridae (Asteroidea; Echinodermata) from the Indian Ocean, pp. 1-116 in Zootaxa 4539 (1) on pages 98-100, DOI: 10.11646/zootaxa.4539.1.1, http://zenodo.org/record/261591
A way to communicate: A new signage system for the Mah Meri Indigenous community
No full textToday, designers use a diverse range of alternative media to have a more efficient form of communication. This research is to investigate the potential of traditionally-inspired contemporary communication design to bridge cultural understandings between and among Malaysians of diverse racial and ethnic backgrounds. Specifically, I propose to design a new signage system in the Mah Meri indigenous community in Malaysia. This is in view that despite the development of the latest media alternatives in use today, the Mah Meri community still lags behind in terms of utilization of these new communication facilities. This project aims to improve social interactions between this community and visitors. The signage system that I propose will help outsiders to navigate in and around the Mah Meri settlements easier and faster because the system provides relevant information in a simple and easy to understand method. Without this signage system visitors will have difficulty in finding the right directions. This work also endeavours, through the notion of creating a new signage system to enrich the cultural identity of the Mah Meri community based on their beliefs in the elements of nature. This, in turn, will create a niche for the community to promote the uniqueness of their culture and identity to outsiders
INDUSTRI PELANCONGAN MAH MERI KE ARAH KEUSAHAWANAN TEKNO DI MALAYSIA
No full textIndustri pelancongan merupakan antara penyumbang utama kepada pertumbuhan ekonomi negara. Sumber manusia industri pelancongan memainkan peranan utama dalam pembangunan industri pelancongan. Kajian ini bertujuan untuk meneroka sumber manusia Industri Pelancongan Mah Meri ke arah teknousahawan di Malaysia. Kajian kualitatif digunakan sebagai pendekatan kepada kertas kerja ini, reka bentuk menggunakan kajian kes tunggal. Semasa pengkaji menggunakan pendekatan ini, pengkaji adalah instrumen yang merupakan responden yang aktif dalam proses penyelidikan ini. Temu bual diadakan bersama orang asli iaitu orang Mah Meri yang berkecimpung dalam industri pelancongan. Seterusnya, data juga dikumpul menggunakan pemerhatian dan dokumen daripada JAKOA, KPWKM, Kraftangan Malaysia dan lain-lain. Triangulasi digunakan. Data dianalisis menggunakan analisis tematik. Berdasarkan penyelidikan ini, hasil yang diperoleh boleh membantu wanita orang asli lain yang ingin diperkasakan ke arah teknousahawan dan membentuk komuniti berkemahiran sedia untuk bekerjasama. Tambahan pula, bagi sesebuah organisasi, kajian ini akan berkesan dalam pengurusan sumber dan mampu bekerjasama dengan organisasi lain untuk mencapai matlamat yang sama.
The tourism industry is one of the major contributors to the country\u27s economic growth. Human resources of the tourism industry play a major role in the development of the tourism industry. This study aims to explore the human resources of the Mah Meri Tourism Industry towards technopreneurship in Malaysia. Qualitative research is used as an approach to this paper, the design is using a single case study. As we are using this approach, the researcher is instruments which are researcher as an active respondent in this research process. The interview is held with aboriginal people which is the Mah Meri people who are in the tourism industry. Furthermore, data were also collected using observation and documents from JAKOA, KPWKM, Kraftangan Malaysia etc. Triangulation is used. The data were analyzed using thematic analysis. This research, this is may help other aboriginal women who want to be empowered towards technopreneurship and form a skilled community ready to work together. Furthermore, for an organization, this study will be effective in resource management and able to work with other organizations to achieve the same goals
A way to communicate: a new sculptural signage system for the Mah Meri indigenous community in Malaysia
No full textToday, designers use a diverse range of media to make more of an impact as well as producing a more efficient form of communication. As a designer and academic, concerned about my responsibility of communicating more effectively across society, my aim in undertaking this research is to investigate and demonstrate how traditional and contemporary values embedded in current design work can be expressed into a creative art form. This practice-based research conducted in Kampung Sungai Bumbun, Pulau Carey, Malaysia, is to assess whether the combination of traditionally inspired and contemporary design, will strengthen cultural identity by synthesising the indigenous cultural information into a new sculptural signage form. Specifically, I respond to the Mah Meri indigenous culture by proposing to design a new sculptural signage system as a communication tool. Even though, the Malaysian government has developed many infrastructures in this settlement, the Mah Meri community still lags behind in using new communication technology and, in my opinion, promotional media to inform and educate outside visitors is highly desirable. The research methodology undertaken in this project consists of design processes: sketches, illustration, two-dimensional and three-dimensional modeling, multimedia, forms fabrication, and fieldwork: interviews, photographs, observations made in Malaysia and Australia. This study endeavours to enrich the cultural identity of the Mah Meri community, based on their beliefs and their deep connection to nature, and their unique use of natural materials such as wood and fibre used in masks, sculptures and woven craft. In the preliminary design process all the design works are influenced by wood art and woven craft. After several design studies, fibre woven craft and its associated techniques best influenced the creation of the new signage system. In the construction of this design work, I define the term as a new sculptural signage system because the work can be experienced as both a sculpture and a sign. The final design project will provide relevant information and help outsiders become more aware and learn about the Mah Meri’s cultural practices. In designing this sculptural signage work, my aim is to engage the audience with the design work in its environment as a site-referential object. The way the signage work functions is to communicate and benefit design principles in all features of the built environment, which relate to the purposeful circulation of people and their ability to mentally situate themselves in unfamiliar environmental settings. Furthermore, the combination of techniques, both traditional and contemporary, will create an aesthetic value in design principles, which utilises audience interpretations of the sculptural signage system in a public space. This project, in turn, will create a better opportunity to promote the uniqueness of the Mah Meri’s art and crafts, establishing their identity and leaving a legacy to the community and those who visit the site
A way to communicate: a new sculptural signage system for the Mah Meri indigenous community in Malaysia
No full textToday, designers use a diverse range of media to make more of an impact as well as producing a more efficient form of communication. As a designer and academic, concerned about my responsibility of communicating more effectively across society, my aim in undertaking this research is to investigate and demonstrate how traditional and contemporary values embedded in current design work can be expressed into a creative art form. This practice-based research conducted in Kampung Sungai Bumbun, Pulau Carey, Malaysia, is to assess whether the combination of traditionally inspired and contemporary design, will strengthen cultural identity by synthesising the indigenous cultural information into a new sculptural signage form. Specifically, I respond to the Mah Meri indigenous culture by proposing to design a new sculptural signage system as a communication tool. Even though, the Malaysian government has developed many infrastructures in this settlement, the Mah Meri community still lags behind in using new communication technology and, in my opinion, promotional media to inform and educate outside visitors is highly desirable.
The research methodology undertaken in this project consists of design processes: sketches, illustration, two-dimensional and three-dimensional modeling, multimedia, forms fabrication, and fieldwork: interviews, photographs, observations made in Malaysia and Australia. This study endeavours to enrich the cultural identity of the Mah Meri community, based on their beliefs and their deep connection to nature, and their unique use of natural materials such as wood and fibre used in masks, sculptures and woven craft. In the preliminary design process all the design works are influenced by wood art and woven craft.
After several design studies, fibre woven craft and its associated techniques best influenced the creation of the new signage system. In the construction of this design work, I define the term as a new sculptural signage system because the work can be experienced as both a sculpture and a sign. The final design project will provide relevant information and help outsiders become more aware and learn about the Mah Meri’s cultural practices.
In designing this sculptural signage work, my aim is to engage the audience with the design work in its environment as a site-referential object. The way the signage work functions is to communicate and benefit design principles in all features of the built environment, which relate to the purposeful circulation of people and their ability to mentally situate themselves in unfamiliar environmental settings. Furthermore, the combination of techniques, both traditional and contemporary, will create an aesthetic value in design principles, which utilises audience interpretations of the sculptural signage system in a public space. This project, in turn, will create a better opportunity to promote the uniqueness of the Mah Meri’s art and crafts, establishing their identity and leaving a legacy to the community and those who visit the site
Developing a Novel Clinically Representative Biofilm Based Gram-Negative Prosthetic Joint Infection Rat Hip Hemiarthroplasty Model
No full textIntroduction: Gram-negative prosthetic joint infections (GN-PJI) present unique challenges in management due to their distinct pathogenesis of biofilm formation on implant surfaces. The purpose of this study is to establish a clinically representative GN-PJI model that can reliably recapitulate biofilm formation on titanium implant surface in vivo. I hypothesized that biofilm formation on an implant surface will affect its ability to osseointegrate. Methods: The model was developed using 3D-printed titanium hip implants, to replace the femoral head of male Sprague-Dawley rats using a posterior surgical approach. GN-PJI was induced using two bioluminescent Pseudomonas aeruginosa (PA) strains: a reference strain (PA14-lux) and a mutant strain that is defective in biofilm formation (flgK-lux). Infection was assessed in real-time using the in vivo imaging system (IVIS) and Magnetic Resonance Imaging (MRI) and in vitro by quantifying bacterial loads on collected implants surface and in periprosthetic tissues as well as biofilm visualization using the Field emission scanning electron microscopy (FE-SEM). The implant stability, as an outcome, was directly assessed by quantifying the osseointegration in vitro using microCT scan, and indirectly assessed by identifying the gait pattern changes using DigiGaitTM system in vivo. Results: Bioluminescence detected by IVIS, was focused on the hip region, demonstrating localized-infection, with the ability of PA14-lux to persist in the model compared to flgK-lux defective in biofilm formation. This was corroborated by MRI as the PA14-lux induced relatively larger implant-related abscesses. Biofilm formation at the bone-implant-interface induced by the PA14-lux was visualized using FE-SEM versus defective-biofilm formation by flgK-lux. This could be quantitatively confirmed, by average viable-colony-count of the sonicated implants, 3.77x108CFU/ml versus 3.65x103CFU/ml for PA14-lux and flgK-lux, respectively (p=0.0025; 95%CI: -6.08x108 to -1.45x108). This difference in the ability to persist in the model was reflected significantly on the implant osseointegration with a mean intersection surface 4.1x106μm2 1.99x106 for PA14-lux versus 6.44x106μm2 2.53x106 for flgK-lux and 7.08x106μm2 1.55x106 for non-infected control (p=0.048). Conclusions: To date, the proposed in vivo biofilm-based model is the most clinically representative for GN-PJI since animals can bear weight on the implant and poor osseointegration correlates with biofilm formation. Clinical Relevance: The current model will allow for reliable testing of novel biofilm-targeting therapeutics
Análise da gestão do Museu de Anatomia Humana da Faculdade de Medicina da Universidade de Brasília MAH/UnB (2015-2020)
No full textTrabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Ciência da Informação, 2021.O presente trabalho vai fazer uma análise da gestão do Museu de Anatomia Humana da
Universidade de Brasília - MAH/UnB, entre os anos de 2015-2020. Através do histórico da
instituição, análise do tratamento do acervo, relato de funcionários e ex-funcionários, a autora
pretende verificar como o trabalho técnico do profissional de museu proporciona mudanças ao
ambiente museológico.The following work will presents an analysis of the management of the Museum of Human
Anatomy of the University of Brasilia - MAH / UnB (Museu de Anatomia Humana da
Universidade de Brasília MAH - UnB), between the years 2015-2020. Through the history of
the institution, analysis of the treatment of the collection, reports from employees and former
employees, the author intends to verify how the technical work of the museum professional
provides changes to the museum environment
HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis
No full textNecroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity is essential for downstream necroptotic signaling events. Since RIP3 kinase activity has been associated with various diseases, the development of specific RIP3 inhibitors is an attractive strategy for therapeutic application. In this study, we identified a potent RIP3 inhibitor, HS-1371, by the extensive screening of chemical libraries focused on kinases. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. Our results suggest that HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation © The Author(s) 201
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