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Surat tugas no. 019/UN16.10.D/TD.06/KPT/2020 Pembimbing praktek kerja profesi apoteker bidang apotek angkatan III
Get PDFPhytochimie de lichens du genre Stereocaulon : étude particulière de S. Halei Lamb et S. montagneanum Lamb, deux lichens recoltés en Indonésie
No full textMorphological and phylogenetic along with phytochemical analysis have been conducted on nine species of fruticose lichens. Stereocaulon samples have been collected from tropical (Indonesia, Reunion Island) and boreal areas (France, Italy). Series of records and observations were compared to clarify the taxonomy and the botanical identification of these lichens and resulted in the selection of two species for extensive investigation of their secondary metabolites. The phytochemical study was conducted on S. halei and S. montagneanum, which were collected from the Sumatra Island. Among the fourteen metabolites isolated, some are common to these two species and correspond to the abundant depside atranorin and associated mono-aromatic derivatives. Depsidones differnetiated theses species as lobaric acid and derivatives where found in S. halei while stictic acid and derivatives have been identified in S. montagneanum. The lobariol carboxylic acid was isolated for the first time from lichens and characterized as conformers. The different metabolic profiles of S. halei and S. montagneanum were in accordance with the phylogeny studies distinguishing these two related species in the Aciculisporae and Holostelidium subgenera, respectively. Despite uneven activities as photoprotective compounds, the 6 metabolites obtained in suitable amounts to be tested failed to be active. Some mycosporine-like compounds were characterized in various parts of the pseudopodetion and may also be of interest to have a better understanding of the metabolic distribution in tripartite lichens.Des études morphologiques, phylogénétiques et des analyses phytochimiques ont été menées sur neuf espèces de lichens fruticuleux du genre Stereocaulon à partir d'échantillons provenant de zones tropicales (Indonésie, Île de la Réunion) et de zones tempérées (France, Italie). Les divers résultats et la comparaison des observations ont permis de préciser certains éléments pour la classification et la diagnose très délicate de ces lichens et de sélectionner deux espèces pour une analyse plus approfondie de leurs métabolites secondaires. L'étude phytochimique a été conduite sur S. halei et S. montagneanum, qui ont été récolté dans l'île de Sumatra. Parmi la quinzaine de métabolites isolés, certains sont communs à ces deux espèces et correspondent à un depside abondant, l'atranorine et des dérivés mono-aromatiques associés. Des depsidones différencient les deux espèces comme l'acide lobarique et des dérivés dans S. halei, l'acide lobariolcarboxylique étant isolé pour la première fois et caractérisé sous forme de conformères. Dans S. montagneanum, ce sont l'acide stictique et des dérivés qui ont été identifiés. Ces profils métaboliques différents rejoignent les résultats de l'étude phylogénétique qui distingue respectivement S. halei et S. montagneanum dans les sous-genres Aciculisporae et Holostelidium. Malgré des activités inégales, aucun des 6 composés obtenus en quantité suffisante pour des test à visée photoprotective ne montre de résultat remarquable. Certains composés de type mycrosporine ont été caractérisés dans diverses parties du pseudopodétion et pourraient aussi présenter un intérêt pour la compréhension des répartitions métaboliques au sein des lichens tripartites
SK dekan Tim Badan Penjaminan Mutu dan Gugus Kendali Program Studi S1, S2, S3 dan profesi periode 2019-2022 Fakultas Farmasi
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Peningkatan Laju Disolusi Piperine dengan Pembentukan Multikomponen Kristal Menggunakan Asam Nikotinat
No full textTujuan penelitian ini adalah untuk meningkatkan laju disolusi piperin dengan pembentukan multikomponen kristal piperin dan asam nikotinat (1:1) dengan metode pelarutan menggunakan pelarut etanol. Multikomponen kristal dikarakterisasi sifat padatannya dengan Difraksi sinar-X, analisa termal Differential Scaning Calorimetry (DSC), spektroskopi FT-IR, analisa mikroskopik Scanning Electron Microscopy (SEM), uji kelarutan dan profil laju disolusi menggunakan Aparatus USP 2. Dari penelitian serbuk multikomponen kristal piperin-asam nikotinat diperoleh hasil pola difraksi sinar-X menunjukkan puncak difraksi yang baru, analisa termal termogram DSC menunjukkan puncak endotermik pada 126,117 ºC, spektrum FTIR terdapat bilangan gelombang 3349,94 cm-1, analisa mikroskopik SEM menunjukkan sudah terbentuk agregat, uji kelarutan menunjukkan peningkatan 1,5 kali lipat dibandingkan piperin murni, profil laju disolusi piperin menunjukkan peningkatan secara signifikan dibandingkan piperin murni yaitu sekitar 2,5 kali lipat. Secara umum preparasi multikomponen kristal piperin-asam nikotinat dapat meningkatkan laju disolusi piperi
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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