3,916 research outputs found
Fleck-like lesions in <i>CEP290-associated</i> leber congenital amaurosis: a case series
No full textTo provide a detailed ophthalmic phenotype of a small cohort of patients with Leber Congenital Amaurosis (LCA) caused by mutations in CEP290 (CEP290-LCA) with a focus on elucidating the origin of yellow-white lesions observed in 30% of patients with this condition. This is a retrospective review of records of five patients with CEP290-LCA. Patients had comprehensive ophthalmic evaluations. Visual function was assessed with full-field electroretinograms (ffERGs) and full-field sensitivity testing (FST). Multimodal imaging was performed with spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) with short- (SW) and near-infrared (NIR) excitation wavelengths. All patients showed relative structural preservation of the foveal and near midperipheral retina separated by a pericentral area of photoreceptor loss. Yellow-white, fleck-like lesions in an annular distribution around the near midperiphery co-localized with hyperreflective lesions on SD-OCT. The lesions located between the inner segment ellipsoid signal and the apical retinal pigment epithelium (RPE). The inner retina was normal. Longitudinal observations in one of the patients indicates the abnormalities may represent an intermediate stage in the degenerative process between the near normal appearing retina previously documented in young CEP290-LCA patients and the pigmentary retinopathy observed along the same region in older individuals.
We speculate that fleck-like lesions in CEP290-LCA correspond to malformed, rudimentary or degenerated, including shed, photoreceptor outer segments. The topography and possible origin of the abnormalities may inform the planning of evolving genetic therapies for this disease.</p
Italienische Kultur in Frankfurt am Main im 18. Jahrhundert / von Josefine Rumpf-Fleck
No full textITALIENISCHE KULTUR IN FRANKFURT AM MAIN IM 18. JAHRHUNDERT / VON JOSEFINE RUMPF-FLECK
Italienische Kultur in Frankfurt am Main im 18. Jahrhundert / von Josefine Rumpf-Fleck (1)
Cover (1)
Title page (8)
Titelseite (9)
Chapter (10)
Vorwort (11)
Widmung / Einleitung (12)
I Italienische Kaufmannsfamilien im Frankfurter Kultur- und Wirtschaftsleben (17)
II Italiens Einfluss auf die Bildenden Künste in Frankfurt am Main (32)
III Italienische Literatur und Musik im Frankfurter Theater- und Konzertwesen (46)
IV Frankfurter Patrizier und Gelehrte als Förderer italienischer Kultur ... (59)
Schluss (73)
Anmerkungen (76)
Anhang (80)
Literaturnachweis (105)
Verzeichnis der Abbildungen / Inhaltsverzeichnis (108)
Verlagsanzeige (109
Validació i interpretació científica. Tres propostes d'actuació : Fleck, Pike i Agar
No full textL'article té com a fonament l'anàlisi dels plantejament teòrics de Fleck (amb els conceptes de col-lectiu de pensament i estils de pensament), Pike, (amb els conceptes d'èmic i ètic) i Agar (amb els plantejaments de l'estranyament i les quiebras), en relació a la validació de les conclusions i dels canvis de posicionament que es produeixen en l'investigador durant el transcurs del treball de camp antropològic. Per tal de mostrar el procés de validació que es du a terme en el treball de camp, basaré l'anàlisi dels diferents plantejaments teòrics en diferents exemples etnogràfics (Bohannan, Wolcott, i Malighetti).The paper analyzes the Fleck's, Pike's and Agar's theoretical basis related to the validation of the resultants and changes in the researcher's ideas during the anthropological fieldwork process. Firstly, Fleck explains these changes through the concepts of thought collectives and thought styles. Secondly, Pike focuses his analyses on the concepts of emic and etic; and thirdly, Agar develops the estrangement approach and the breakdowns. In order to show the validation process that takes place in the anthropological fieldwork, we expose and analyses different ethnographic examples such as Bohannan, Wolcott, and Malighetti
fleck
No full textflat n. . . me and you is goin' out on the deck an' gettin' in the fleck and talkin' the fire-axe, to cut the boat loose. If the boat started to _sink_ ...we could cut the fleck loosePRINTED ITEMG. M. Story 1/80 JH 1/80Used I and SupNot usedNot use
Neocaledosynthemis Fleck 2024, gen. nov.
No full text<i>Neocaledosynthemis</i> <i>gen</i>. nov. <p> Type species. <i>Synthemis fenella</i> Campion</p> <p> Other included species. <i>Synthemis ariadne</i> Lieftinck</p> <p> <i>Etymology</i>. After New Caledonia and <i>Synthemis</i> Selys.</p> <i>Justification and differential diagnosis</i> <p> <i>Material examined</i>: male, female and larva (reared) of all New Caledonian species of synthemistids (female <i>C. ariadne</i> based on photos), except <i>C. pamelae</i> Davies and larva <i>C. jeanlegrandi</i>. In addition to characters accessible in literature for non-New-Caledonian synthemistids male, female and larva of <i>Synthemis tasmanica</i> Tillyard, <i>Austrosynthemis cyanitincta</i> Tillyard, <i>Tonyosynthemis claviculata</i> Tillyard, <i>Choristhemis flavoterminata</i> Martin, <i>Palaeosynthemis cyrene</i> Lieftinck, <i>Archaeosynthemis</i> spp., and <i>Eusynthemis</i> spp. were also examined.</p> <p> Carle (1995), on the supposed basis of a pair of male apomorphic characters (see below discussion), erected the genus <i>Calesynthemis</i> to accomodate all <i>Synthemis</i> species from New Caledonia ie <i>Synthemis miranda</i> (type species), <i>S. ariadne</i>, <i>S. campioni</i> Lieftinck, <i>S. fenella</i>, <i>S. flexicauda</i> Campion, <i>S. montaguei</i> Campion and <i>S. serendipita</i>. As these species are all endemic, the genus <i>Calesynthemis</i> is also restricted to New Caledonia.</p> <p> Davies (2002) did not recognize the genus <i>Calesynthemis</i> and described under <i>Synthemis</i>, a new species (<i>S. pamelae</i>). Given the available characters and the possible close affinity with <i>C. miranda</i> (being “its nearest relative” after Davies), <i>S. pamelae</i> should have probably been placed in <i>Calesynthemis</i> sensu Carle (1995).</p> <p> The New Caledonian synthemistids, even if probably rather closely related to true <i>Synthemis</i> (ie <i>S. eustalacta</i> Burmeister from South East Australia and <i>S. tasmanica</i>, from Tasmania) are nevertheless sufficiently different to be removed from this genus. Indeed, the true <i>Synthemis</i> have, among others, distinctly different male hamuli posteriores, male vesica spermalis V 1, male organisation of S2 ventral tergum, male epiproct, female ovipositor, FW relative position of arculus, HW anal loop construction, larval frontal plate, larval premental distal margin, and larval mask setal organisation.</p> <p> Fleck (2005, in Fleck <i>et al.</i> 2020) considered New Caledonian synthemistids as <i>Synthemis sensu lato</i>, because the species <i>S. ariadne</i> and <i>S. fenella</i> were not considered belonging to <i>Calesynthemis</i>, and Fleck & El Adouzi (2013) did not treat New Caledonian synthemistids and mentioned “New Caledonian synthemistids are in need of a revision and probably to be split into two genera”. In the matter of fact, the species <i>S. ariadne</i> and <i>S. fenella</i> are distinctly different from other <i>Calesynthemis</i>, not only by virtue of their smaller size, but for example their larvae are remarkable and unique among synthemistids by the absence of long body setae giving them a strong glabrous and finely granulose aspect, and by the absence of dentition on the labial palps. The following characters permit the separation of <i>S. fenella</i> and <i>S. ariadne</i> from other New Caledonian species:</p> <p> - All discoidal triangles free. They are generally free in <i>S. fenella</i>, in <i>S. ariadne</i> rarely crossed in one or even two wings. In other New Caledonian representatives discoidal triangles are crossed at least in one pair of wings (usually on both pair of wings). HW discoidal triangle is generally free in male <i>C. miranda</i> and occasionally in female.</p> <p> - Arculus not strongly shifted distal to Ax2. In <i>S. fenella</i> and <i>S. ariadne</i> the arculus is often placed slightly proximal to Ax2 or at Ax2, it is regularly shifted slightly distally (rarely distinctly in HW). In most other species, except <i>C. flexicauda</i>, the origin of arculus is distinctly shifted distal to Ax2, most of the time in both pair of wings. In <i>C. flexicauda</i> it is placed at Ax2 or slightly distally shifted. Note that in some <i>Eusynthemis</i> Förster and allied genera, the arculus is shifted distal to Ax2.</p> <p> - Male cerci not longer than S9+10. In <i>S. fenella</i> they are about as long as S9+10 and in <i>S. ariadne</i> they are slightly shorter than S9+10. In other species they are longer, most of the time distinctly so.</p> <p>- Male penis dh1 and dh2 placed on a common stem (Fig. 23, see arrow, compare with Fig. 8). In all other species they are distinctly separated or approximate on V 4, never placed on a common stem.</p> <p> - Female V 1 (vulvar lamina) short and stout with U-shaped medial notch. In New Caledonian female synthemistids the V 1 are in their proximal part parallel and contiguous, in their distal part divergent, the notch being V-shaped or U-shaped; the base of the notch presents additionally a pair of denticles. In <i>S. fenella</i> and <i>S. ariadne</i> V 1 is restricted to the basal 1/3 to basal 1/4 of S9 sternum (contra Carle, 1995) (and also shorter than 1/2 the length of S10, contra Carle, 1995) with proximal part strongly reduced, and notch U-shaped in <i>S. fenella</i>, and probably derived from the <i>S. fenella</i> type in <i>S. ariadne</i> since distal part is similar to that of <i>S. fenella</i> but basal part shows shortly divergent inner margins (apparently unique within New Caledonian synthemistids). In other species, except <i>C. serendipita</i>, the V 1 are overlapping about 1/2 of S9 sternum, their proximal part is rather long and their notch V-shaped. In <i>C. serendipita</i> the ovipositor is short, hardly longer than 1/3 of S9 (contra Carle 1995), with notch somewhat U-shaped, but with basal part having valves contiguous over a relatively long distance (considering the distal part only, probably a convergence with <i>S. fenella</i> and <i>S. ariadne</i> given the close affinity of <i>C. serendipita</i> with <i>C. campioni</i>).</p> <p> - Female cerci not longer than S9+10. In <i>S. fenella</i> they are about as long as S9, in <i>S. ariadne</i> slightly shorter than S9+10. In other species they are generally distinctly longer than S9+10 except <i>C. miranda</i> where they appear up turned and shorter than S9+10.</p> <p>- Larva glabrous, deprived of long setae and long hair-like setae and with fine granulose appearance (unique character within synthemistids). All other larvae present long setae and/or long hair-like setae at least on frontal plate, occipital lateral margins, pronotal lateral lobes, lateral margins of thorax and abdomen.</p> <p>- Larva with distal margin of labial palp lacking clear dentition (a unique character within synthemistids). All other larvae have distinct dentition.</p> <p> - Larva with only 6 or fewer antennomeres (apparently unique within synthemistids). Contrary to the claim of Lieftinck (1976), from 12 F-0 and 2 F-1 checked <i>S. fenella</i> larvae from different localities, only one F-0 seems to have 7 antennomeres on one antenna (moreover the character is not clearly cut since the interantennomeral joint is not clearly marked!); three specimens exhibit 5 antennomeres in a least one antenna. All <i>S. ariadne</i> checked larvae (6 F-0 and 2 F-1) have 6 antennomeres. Thus, <i>S. fenella</i> and <i>S. ariadne</i> larvae can be considered to have 6 antennomeres (sometimes with one less, very exceptionally, and aberrantly, with one more). All other species have 7 antennomeres, and antennae, comparatively to body dimension, longer.</p> <p>- Larva with only 2 long premental setae and 2 or 3 palpal setae (apparently unique within synthemistids). Other larvae have at least 3 long premental setae and 4 palpal setae.</p> <p> Considering all the above-mentioned characters, any of them unique among synthemistids and considered synapomorphic, <i>S. fenella</i> (type species) and <i>S. ariadne</i> are placed in the genus <i>Neocaledosynthemis</i>.</p>Published as part of <i>Fleck, Günther, 2024, A remarkable new synthemistid from New Caledonia (Odonata: Anisoptera: Synthemistidae s. str.). Taxonomic and phylogenetic note on New Caledonian Synthemistidae and erection of a new genus, pp. 320-330 in Zootaxa 5403 (3)</i> on pages 328-329, DOI: 10.11646/zootaxa.5403.3.2, <a href="http://zenodo.org/record/10561942">http://zenodo.org/record/10561942</a>
Validació i interpretació científica. Tres propostes d'actuació: Fleck, Pike, i Agar.
No full textL’article té com a fonament l’anàlisi dels plantejament teòrics de Fleck (amb els conceptes de col lectiu de pensament i estils de pensament), Pike, (amb els conceptes d’èmic i ètic) i Agar (amb els plantejaments de l’estranyament i les quiebras), en relació a la validació de les conclusions i dels canvis de posicionament que es produeixen en l’investigador durant el transcurs del treball de camp antropològic. Per tal de mostrar el procés de validació que es du a terme en el treball de camp, basaré l’anàlisi dels diferents plantejaments teòrics en diferents exemples etnogràfics (Bohannan, Wolcott, i Malighetti). Abstract:The paper analyzes the Fleck’s, Pike’s and Agar’s theoretical basis related to the validation of the resultants and changes in the researcher’s ideas during the anthropological fieldwork process. Firstly, Fleck explains these changes through the concepts of thought collectives and thought styles. Secondly, Pike focuses his analyses on the concepts of emic and etic; and thirdly, Agar develops the estrangement approach and the breakdowns. In order to show the validation process that takes place in the anthropological fieldwork, we expose and analyses different ethnographic examples such as Bohannan, Wolcott, and Malighetti
OS CONFLITOS DE GERAÇÃO NO SISTEMA DE ENSINO SUPERIOR SOB PRISMA DA EPISTEMOLOGIA DE COLETIVOS DE PENSAMENTO
No full textO objetivo deste ensaio teórico é analisar a aprendizagem escolar por meio dos conflitos de geração existentes sob o prisma da epistemologia de coletivos de pensamento de Ludwic Fleck, de modo a elucidar como a evolução nas gerações X, Y e Z influenciam em novas perspectivas de aprendizagem a partir de elementos constitutivos das relações sociais e culturais. Para esse artigo considera-se que a aprendizagem escolar sofre influencia de fatores intervenientes do contexto em que vivemos, sendo esses fatores advindos principalmente da revolução artificial do homem que derivam do impacto das tecnologias de informação sobre a natureza humana (SANTOS, 2007). Mediante o pressuposto da influência da tecnologia na aprendizagem humana, seria também oportuno considerar a evolução das gerações na aprendizagem, compreendendo que os professores precisam desenvolver a capacidade do exercício do ofício por meio das hipertecnologias, tanto no sentido de superar os fatores de desigualdade e desumanização, como também em realidades voltadas a um novo mundo que surge das tecnologias e comunicação virtual. Este contexto teórico e analítico da aprendizagem será representado em diferentes estilos de pensamento, em que a gestão integrada das diferentes gerações existentes deverá ser considerada a partir de um olhar sistêmico da aprendizagem escolar, caracterizada tanto como um círculo exotérico, que seria o sistema de ensino como um todo, como também nos diferentes estilos de pensamento que formam esse sistema, alunos, professores, pais e gestores escolares, todos eles caracterizados por Fleck como de círculos esotéricos, que estando conectados e compartilhando conhecimentos precisam contribuir efetivamente na formação de novos jovens através de um trabalho colaborativo e distribuidor de informações, melhorando a prestação de serviços de organizações escolares que buscam atender os atuais contextos da hipermídia
Dr Fleck Fighting Fleck Typhus
No full textThese comments contribute to the debate on Dr Ludwik Fleck, published in this journal in 2008, regarding his identification of typhus antigen in urine and its use in the preparation of a vaccine (Amsterdamska et al., 2008; Hedfors, 2008). As I understand it, Dr Fleck was on one side dismissed with various epithets and his research considered as poorly done, meaningless and with doubtful ethical value (Hedfors, 2007, 2008). It was alleged that Fleck had not created a workable vaccine and that his work had not led to any lasting or future benefit or drawn any followers. It was also my impression that his defenders (Amsterdamska et al., 2008) have accused his detractor of numerous inexact statements, illustrating serious shortcoming of historical scholarship and unsubstantiated accusations of participation in Nazi experiments. The debate is unpleasant to read, sought no common ground and had no satisfactory resolution. It is my wish to throw light from another angle on this debate and demonstrate a very positive outcome for humanity. The present commentary focuses on Fleck's scientific contributions while in the ghetto rather than on his wartime activities in Auschwitz and Buchenwald. Can this 'academic' debate be clarified after so many years? Can Fleck's name be cleared and his work accepted as developing a useful hypothesis? A brief overview of Fleck's career might benefit readers who are less familiar with the specifics of this debate
Validació i interpretació científica. Tres propostes d'actuació : Fleck, Pike i Agar
No full textL'article té com a fonament l'anàlisi dels plantejament teòrics de Fleck (amb els conceptes de col-lectiu de pensament i estils de pensament), Pike, (amb els conceptes d'èmic i ètic) i Agar (amb els plantejaments de l'estranyament i les quiebras), en relació a la validació de les conclusions i dels canvis de posicionament que es produeixen en l'investigador durant el transcurs del treball de camp antropològic. Per tal de mostrar el procés de validació que es du a terme en el treball de camp, basaré l'anàlisi dels diferents plantejaments teòrics en diferents exemples etnogràfics (Bohannan, Wolcott, i Malighetti).The paper analyzes the Fleck's, Pike's and Agar's theoretical basis related to the validation of the resultants and changes in the researcher's ideas during the anthropological fieldwork process. Firstly, Fleck explains these changes through the concepts of thought collectives and thought styles. Secondly, Pike focuses his analyses on the concepts of emic and etic; and thirdly, Agar develops the estrangement approach and the breakdowns. In order to show the validation process that takes place in the anthropological fieldwork, we expose and analyses different ethnographic examples such as Bohannan, Wolcott, and Malighetti
Sciences, objectivity and realism between Ludwik Fleck and contemporary debates
No full textInternational audienceIn this paper, I explore the philosophical and scientific positions of Ludwik Fleck, author of the first theory of democratic science and, at the end of the day, a scientific realist. This interpretation of his work is somewhat at odds with the more standard approach, wherein Fleck is presented as a pioneer of relativism or of social constructivism in the philosophy of sciences. In the following, I discuss Fleck's philosophical context o er an analysis of a few of his better-known interpretations and offer a final perspective by showing his commitment to the reality of scientific practice, notwithstanding his scepticism towards scientific theories. And while this paper is an attempt to o er an alternative reading of Fleck's positions, it also aims at reaffirming a stance already defended by, among others, Ian Hacking. Scientific realism needs to be understood not in opposition to a historical perspective on dynamically developing sciences, but along with this perspective
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