1,002 research outputs found
Convergent repression of Foxp2 3'UTR by miR-9 and miR-132 in embryonic mouse neocortex: implications for radial migration of neurons.
No full textTargeting families and teens: Television violence on the WB
No full textThe author investigates the amount of violence contained within WB primetime programs in order to determine The WB\u27s number of violent acts per program and per program hour as well as determine some of the possible effects of The WB\u27s violence. The author sampled one week of WB primetime programming. A definition of violence similar to other violence studies was employed for comparability. The unit of analysis used for coding was the violent act. The author found all WB primetime programs to contain some violence. The most violent WB primetime program was Buffy the Vampire Slayer and the highest number of violent acts aired was found on Tuesday night. The author concludes the majority of WB primetime programs contain a low amount of violence. The author suggests future violence studies employ a single accepted definition of violence and include The WB and UPN programming in their samples
An assessment of the impact of possible CAP reform scenarios on Romanian agriculture
No full textUsing a simplified model, with key-variable the prices of two different possible scenarios of CAP reform after 2013 (moderate and radical), this paper present a comparison between the price effects of implementation of each reform scenario at 2015 horizon on Romanian agriculture. This short analysis shows that, under the presented hypotheses, the net welfare effect, due to the price changes, for the selected products, is positive in both reform scenarios, yet greater in the case of the radical reform. Integrated in the large context of Romanian development, it seems that the influence of CAP reform upon agriculture and rural areas will be most likely a gradual one: an interpenetration between the two scenarios is foreseeable, starting with the moderate reform that will dominate the period around 2013, the reform measures acquiring a more radical character afterwards.CAP reform, Romania, welfare effects, Agricultural and Food Policy,
N-cadherin specifies first asymmetry in developing neurons
No full textThe precise polarization and orientation of developing neurons is essential for the correct wiring of the brain. In pyramidal excitatory neurons, polarization begins with the sprouting of opposite neurites, which later define directed migration and axo-dendritic domains. We here show that endogenous N-cadherin concentrates at one pole of the newborn neuron, from where the first neurite subsequently emerges. Ectopic N-cadherin is sufficient to favour the place of appearance of the first neurite. The Golgi and centrosome move towards this newly formed morphological pole in a second step, which is regulated by PI3K and the actin/microtubule cytoskeleton. Moreover, loss of function experiments in vivo showed that developing neurons with a non-functional N-cadherin misorient their cell axis. These results show that polarization of N-cadherin in the immediate post-mitotic stage is an early and crucial mechanism in neuronal polarity.sponsorship: We thank C Kalcheim, O Griesbeck, F Calderon de Anda and RY Tsien for providing material; C Haffner and F Calderon de Anda for technical help and A Attardo for providing the tub-mGFP mouse line. This work was made possible by the type 3 large-infrastructure support InfraMouse by the Flanders Hercules Foundation (ZW09-03). This work was partially supported by the Flanders Fund for Scientific Research (FWO G 0.666.10N), the Federal Office for Scientific Affairs (IUAP p6/43) and Flemish Government Methusalem Grant to CGD. EFF has been in part supported by an EMBO fellowship (ASTF: 369.00-2007). FV was supported by the Italian Institute of Technology (Satellite Unit in Molecular Neuroscience). (Flanders Hercules Foundation|ZW09-03, Flanders Fund for Scientific Research (FWO)|G 0.666.10N, Federal Office for Scientific Affairs (IUAP)|p6/43, Flemish Government, EMBO|ASTF: 369.00-2007, Italian Institute of Technology (Satellite Unit in Molecular Neuroscience))status: Publishe
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei
No full textBackground: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN). Dopaminergic and RN neurons have been shown to arise from ventral mesencephalic precursors that express Sonic Hedgehog (Shh). However, Shh expression, which is initially confined to the mesencephalic ventral midline, expands laterally and is then downregulated in the ventral midline. In contrast, expression of the Hedgehog target gene Gli1 initiates in the ventral midline prior to Shh expression, but after the onset of Shh expression it is expressed in precursors lateral to Shh-positive cells. Given these dynamic gene expression patterns, Shh and Gli1 expression could delineate different progenitor populations at distinct embryonic time points. Results: We employed genetic inducible fate mapping (GIFM) to investigate whether precursors that express Shh (Shh-GIFM) or transduce Shh signaling (Gli1-GIFM) at different time points give rise to different ventral midbrain cell types. We find that precursors restricted to the ventral midline are labeled at embryonic day (E)7.5 with Gli1-GIFM, and with Shh-GIFM at E8.5. These precursors give rise to all subtypes of midbrain dopaminergic neurons and the anterior RN. A broader domain of progenitors that includes the ventral midline is marked with Gli1-GIFM at E8.5 and with Shh-GIFM at E9.5; these fate-mapped cells also contribute to all midbrain dopaminergic subtypes and to the entire RN. In contrast, a lateral progenitor domain that is labeled with Gli1-GIFM at E9.5 and with Shh-GIFM at E11.5 has a markedly reduced potential to give rise to the RN and to SN dopaminergic neurons, and preferentially gives rise to the ventral-medial VTA. In addition, cells derived from Shh- and Gli1-expressing progenitors located outside of the ventral midline give rise to astrocytes. Conclusions: We define a ventral midbrain precursor map based on the timing of Gli1 and Shh expression, and suggest that the diversity of midbrain dopaminergic neurons is at least partially determined during their precursor stage when their medial-lateral position, differential gene expression and the time when they leave the ventricular zone influence their fate decisions
Author's gift inscription in The Illini: A Story of the Prairies
No full textEdition includes a gift inscription from author Clark E. Carr, "Presented to my friend Hon. WB. Brinton with my sincere regards. Clark Elarr. Christmas 1905."Carr, Clark Ezra, 1836-1919
Compassionate care in radiography recruitment, education and training: A post-Francis Report review of the current literature and patient perspectives
No full textThis is the author accepted manuscript. The final version is available from WB Saunders via the DOI in this record.Compassion is elemental in the care of a patient during their medical imaging (MI) procedure and is highly topical in the light of the Francis Report. The patient–practitioner interaction is an amalgam of context, communication and individual differences, and whilst compassion is a term in common parlance in the media, policy and radiographers' professional documents, its meaning and manifestation in radiography recruitment, education and practice are less clearly articulated. A review of the existing literature was undertaken, including a small scale study exploring patients' experiences in diagnostic medical imaging. Themes from the study included communication; competence; emotions; attitudes and relationships, but notably absent was any mention of compassion per se. Radiography research would benefit from further exploratory work into the nature of compassionate patient care in the unique context of the medical imaging encounter; offering an evidence-based contribution to radiography in the light of the Francis Report.Funding for the preliminary study came from the Higher Education Academy. The doctoral research from which this review article was written is self-funded by the corresponding author
Optical map of the genotype A1 WB C6 Giardia lamblia genome isolate
No full textAuthor Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Molecular and Biochemical Parasitology 180 (2011): 112-114, doi:10.1016/j.molbiopara.2011.07.008.The Giardia lamblia genome consists of 12 Mb divided among 5 chromosomes ranging in size from approximately 1 to 4 Mb. The assembled contigs of the genotype A1 isolate, WB, were previously mapped along the 5 chromosomes on the basis of hybridization of plasmid clones representing the contigs to chromosomes separated by PFGE. In the current report, we have generated an MluI optical map of the WB genome to improve the accuracy of the physical map. This has allowed us to correct several assembly errors and to better define the extent of the subtelomeric regions that are not included in the genome assembly.This work was funded in part by the Woods Hole Center for Oceans and Human Health, jointly funded by the National Science Foundation (OCE-0430724) and the National Institute for Environmental Health Sciences (P50 ES012742)
Right-Wing and Left-Wing Critiques of the International Monetary Fund (IMF) and the World Bank (WB)
No full textThis paper discusses the critiques forming the debate on the future of the two major global financial institutions – the IMF and the WB. The author does not claim what the IMF and the WB really are, but reviews how they are seen by their critics. The article describes and summarizes the multifaceted critical discussion and proposes an elementary scheme formed by four basic positions. These are based on two variables: (1) moderation or radicalism of the critiques; (2) their affiliation with the right or the left side of the political spectrum. As a result, four basic critical positions emerge: right reformers, right radicals, left reformers, and left radicals. This paper characterizes each of them by overviewing the opinions of two representative participants of the discussion
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