16 research outputs found
Advanced Laparoscopy
No full textThe present book, published by InTech, has been written by a number of highly outstanding authors from all over the world. Every author provides information concerning treatment of different diseases based on his or her knowledge, experience and skills. The chapters are very useful and innovative. This book is not merely devoted to urology sciences. There are also clear results and conclusions on the treatment of many diseases, for example well-differentiated papillary mesothelioma. We should not forget nor neglect that laparoscopy is in use more extensively than before, and in the future new subjects such as use of laparascopy in treatment of kidney cysts, simple nephrectomy, pyeloplasty, donor nephrectomy and even robotic laparoscopy will be researched further
Commitment to autogamy in Paramecium blocks mating reactivity: Implications for regulation of the sexual pathway and the breeding system
No full textCommitment to autogamy blocks mating reactivity in Paramecium. Cells which had previously developed mating reactivity, lost reactivity 30–90 min prior to the preautogamous fission. Mating reactivity develops at a standard level of starvation when cells are allowed to exhaust their food supply naturally. In abruptly starved cultures, mating reactivity appears 3.3 h after downshift. Autogamy is also triggered by starvation. The level of starvation required for initiation of autogamy decreases progressively as cells age. When the autogamy starvation threshold drops to such a low level that all cells become committed to autogamy before any of them develop mating reactivity, reactivity does not occur under natural starvation conditions and the period of maturity for conjugation has come to an end. There is no absolute immature period for autogamy.Peer reviewedFinal article publishe
Advanced Laparoscopy
No full textThe present book, published by InTech, has been written by a number of highly outstanding authors from all over the world. Every author provides information concerning treatment of different diseases based on his or her knowledge, experience and skills. The chapters are very useful and innovative. This book is not merely devoted to urology sciences. There are also clear results and conclusions on the treatment of many diseases, for example well-differentiated papillary mesothelioma. We should not forget nor neglect that laparoscopy is in use more extensively than before, and in the future new subjects such as use of laparascopy in treatment of kidney cysts, simple nephrectomy, pyeloplasty, donor nephrectomy and even robotic laparoscopy will be researched further
LC Ladder Based Orthonormal Filter for Impulse-Radio UWB Pulse Generation.
No full textIn this thesis, a UWB pulse generator is designed to be implemented in IBM 0.13 um technology. The pulse generator has a high spectral efficiency. Using amplitude control, any mismatch, process variation or temperature variation can be compensated for to comply with the UWB FCC mask. The pulse has an approximate duration of 2ns. The current consumption is 13mA per pulse. The power consumption per pulse is 19.5 mW. The next stage can be a power amplifier or an antenna. In case of an antenna, the effect of bond pads and bond wires are taken into account. A challenging aspect of UWB systems is their interference with narrow-band systems. Narrow-band systems send very high power signals compared to the UWB signals and thus may saturate the UWB receiver and/or prevent reliable detection of the UWB pulses. A possible solution to this problem is filtering. In this thesis, a Wireless Local Area Network (WLAN) band rejection filter for UWB applications is designed using IBM 0.13 um technology. A new filter topology is used to implement the filter. This topology has the ability to actively read all the states of an LC filter without using extra inductors. Both AC and impulse responses are presented. The filter has a notch of approximately 14dB. It can operate over the military temperature range (-40 C to 125 C). The effects of mismatch and process variations on this design are acceptable.Microelectronics & Computer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Commitment to autogamy in Paramecium blocks mating reactivity : implications for regulation of the sexual pathway and the breeding system
No full textThe ciliate Paramecium tetraurelia exhibits two major developmental pathways - the vegetative cell cycle and the sexual pathway. The latter manifests itself in two forms -autogamy (self- fertilization) and conjugation (cross-fertilization) between cells of complementary mating types. In the normal life history young cells are immature for autogamy, but enter conjugation readily. Autogamy first occurs normally at about 20 fissions of age and conjugation disappears by 25. This study documents and analyzes the two major phenomena underlying this unusual life history. It shows how their interaction produces the observed pattern of immaturity, maturity, and senescence (Fig. 1). There are two principal findings of this study. First that commitment to autogamy leads to rapid loss of mating reactivity and second, that there are different starvation thresholds for initiation of mating reactivity and autogamy. The starvation threshold for initiation of mating reactivity is constant, while that for initiation of autogamy decreases progressively as clonal age increases. During the immature period for autogamy the lag between onset of mating reactivity and induction of autogamy decreases with increasing clonal age. The progressive decrease in the starvation threshold required for induction of autogamy brings about the end of the mature period for conjugation. As autogamy is initiated at progressively earlier stages in the growth of a culture, fewer and fewer cells reach the level of starvation required for initiation of mating reactivity prior to induction of autogamy. When the threshold for induction of autogamy becomes so low that no cells develop mating reactivity prior to entering autogamy, the period of maturity for conjugation is over and autogamy becomes the sole sexual process for the remainder of the life history
Assessing the Navigational Abilities of an Acoustically Active Cannula
No full textabstract: The purpose of this thesis experiment was to design and create an Acoustically Active Cannula (AAC), which is furnished by a piezoelectric crystal placed at its tip that produces an acoustic navigation signal. I tested the functionality of the cannula in vitro and demonstrated its navigational abilities in vivo in anesthetized pigs. This experiment was based upon ultrasound science and technology, and thus some practical experience with conventional (B-mode) and Doppler ultrasound was achieved as well. The results of bench and experimental animal studies indicated proper functionality of the AAC for identification and spatial navigation of its tip with color Doppler ultrasound imaging
Douglas College Human Anatomy & Physiology II
No full textThis textbook is a project under development by our Biology faculty to ultimately provide students with all the factual information they need to succeed in the BIOL 1203 and BIOL 1209 courses at Douglas College in BC, Canada. It was developed initially as an adaptation of the OpenStax Anatomy & Physiology textbook, freely available online at http://cnx.org/content/col11496/latest/. The original adaptations of that OpenStax textbook for Douglas College are accessible online at https://pressbooks.bccampus.ca/dcbiol11031109/ and https://pressbooks.bccampus.ca/dcbiol12031209/ In the first edition of the Douglas College adaptations the chapter and section numbers were left as they were in the version of the OpenStax A&P textbook, from which they were largely drawn. However, this second edition has been more extensively edited and rearranged to correspond with the curriculum used at Douglas College, so chapter and section numbers are no longer aligned specifically with the OpenStax A&P textbook.publishe
Relationship between Urolithiasis and Nutrition in Patients with Urinary Stones in Ardabil City
No full textBackground & Objectives: Urolithiasis is the third common urinary disease. While,
relationship between the urinary stones and diet is known to some extent, but there are
controversies about it. The aim of this study was to determine the association between food
habit, nutrients intake and kinds of urinary stone disease.
Methods: This cross-sectional and descriptive analytical study was performed on 150 patients
(91 male and 59 females) with urinary stone disease in Ardabil during 2008-2009. Data of
urinary stones analysis, type of stone in the graph, type of stone, preventive emprise and type
of drinking water were recorded. Food data were recorded using 24-hour dietary recalls three
days in week and food frequency questionnaires. Data were analyzed using SPSS, Food
Processor III software, and ANOVA Statistical program.
Results: Findings showed that the most common and lowest form of urinary stone disease in
men and women were calcium oxalate and ammonium phosphate, respectively. There was
significant inverse association between beta-carotene intake and the percentage of uric acid
stone disease (p<0.05). We observed significant relationship between vitamin A and folacin
intake with percentage of uric acid stone disease (p<0.05). There was significant relationship
between consumption of cheese and pickles with calcium phosphate stone disease (p<0.05).
There was no significant association between other foods and nutrients intake with types of
urinary stone disease.
Conclusion: This study showed the consumption of some nutrients including folacin, vitamin
A and some foods such as cheese was associated with the incidence of urinary stone disease.
Therefore, taking accurate diet could possibly prevent the incidence of urinary stone diseases
Computational prediction for designing novel ketonic derivatives as potential inhibitors for breast cancer: A trade-off between drug likeness and inhibition potency
No full textUnlike simple molecular screening, a combined hybrid computational methodology has been applied which includes quantum chemical methods, molecular docking, and molecular dynamics simulations to design some novel ketonic derivatives. The current study contains the derivatives of an experimental ligand which are designed as a trade-off between drug likeness and inhibition strength. We investigate the interaction of various newly designed ketonic compounds with the breast cancer receptor known as the Estrogen Receptor Alpha (ERα). The molecular structures of all newly designed ligands were studied quantum chemically in terms of their fully optimized structures, 3-D molecular orbital distributions, global chemical descriptors, molecular electrostatic potentials and energies of frontier molecular orbitals (FMOs). All ligands under study show good binding affinities with the ERα protein. The ligands CMR2 and CMR4 exhibit improved molecular docking interactions. The intermolecular interactions indicate that CMR4 demonstrates better hydrophobic and hydrogen bonding interactions with protein (ERα). Furthermore, molecular dynamics simulations were conducted on ligands and reference drugs interacting with the ERα protein over a time span of 120 nanoseconds. The molecular dynamics results are interpreted in terms of ligand-protein stability and flexible behaviour based on their respective values of RMSD, RMSF, H-bonds, the radius of gyration, and SASA graphs. To analyse ligand-protein interactions throughout the entire 120 ns trajectory, a more advanced MM/PBSA method is utilized, where six selected ligands (CMR1, CMR2, CMR3, CMR4, CMR5 and CMR9) illustrate promising results for inhibition of the ERα receptor as assessed through MM/BBSA analysis. The CMR9 has the highest MM/BBSA binding free energy (−14.46 kcal/mol). The ADMET analysis reveals that CMR4 has maximum intestinal absorption (6.68) and clearance rate (0.1). All the compounds are non-toxic and safe to use. These findings indicate the potential of involving different computational techniques to design the ligand structures and to study the ligand-protein interactions for better understanding and achieving more potent synthetic inhibitors for breast cancer.The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding the work. The author from University of Bisha is thankful to the Deanship of Graduate Studies and Scientific Research at University of Bisha for supporting the work through the Fast-Track Research Support Program. For computer time, this research used the resources of Supercomputing Laboratory at King Abdullah University of Science & Technology (KAUST) in Thuwal, Saudi Arabia. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
Exploring the potential of novel phenolic compounds as potential therapeutic candidates against SARS-CoV-2, using quantum chemistry, molecular docking and dynamic studies
No full textIn the current study, the interaction of SARS-CoV-2 protein (A and B chains of nsp13) with different recently synthesized phenolic compounds (Sreenivasulu et al., Synthetic Communications, 2020, 112–122) has been studied. The interactions have been investigated by using molecular docking, quantum chemical and molecular dynamics simulations methods. The molecular structures of all the ligands are studied quantum chemically in terms of their optimized structures, 3-D orbital distributions, global chemical descriptors, molecular electrostatic potential plots and HOMO-LUMO orbital energies. All the ligands show reasonably good binding affinities with nsp-13 protein. The ligand L2 shows to have better binding affinities to Chain A and Chain B of nsp13 protein, which are −6.7 and −6.4 kcal/mol. The study of intermolecular interactions indicates that L2 shows different hydrophobic and hydrogen bond interactions with both chains. Furthermore, molecular dynamic simulations of the nsp13-L2 complex are obtained over a time scale of 60 ns, which indicates its stability and flexibility behavior as assessed in terms of its RMSD and RMSF graphs. The ADMET analysis also shows no violation of Lipinski rule (RO5) by studied phenolic compounds. We believe that the current findings will be further confirmed by in vitro and in vivo studies of these recent phenolic compounds for their potential as inhibitors for SARS-Co-V-2 virus.The author from the University of Bisha extends their appreciation to the Deanship of Scientific Research at the University of Bisha Saudi Arabia for funding this work through COVID-19 Initiative Project under Grant Number (UB - COVID - 32 - 1441). The authors from King Khalid University of Saudi Arabia extend their appreciations to the Deanship of Scientific Research at King Khalid University for funding the work through Project (RGP.1/168/42). For computer time, this research used the resources of the Supercomputing Laboratory at King Abdullah University of Science & Technology (KAUST) in Thuwal, Saudi Arabia
