6,405 research outputs found
Total synthesis of cavicularin and riccardin C: addressing the synthesis of an arene that adopts a boat configuration
No full textA transannular ring contraction induced by the addition of an aryl radical intermediate to a proximal arene facilitated the construction of the highly strained macrocyclic core of cavicularin (1). The precursor, an iodinated derivative of another natural product, riccardin C, was prepared from four commercially available arenes in a highly convergent sequence
The Concept of Genius in D. A. Granin’s Work (Based on the Novel “Evenings with Peter the Great”)
No full textThe article deals with D. A. Granin’s concept of history as presented in the novel “Evenings with Peter the Great”. The author of the novel argues that historical process is driven and streamlined by people endowed with rare gifts and deep urge to create such as the first Russian emperor Peter the Great
MONO(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES AND BIS(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES - SYNTHESIS, STRUCTURE, AND PROPERTIES
No full textJutzi P, KANNE D, HURSTHOUSE M, HOWES AJ. MONO(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES AND BIS(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES - SYNTHESIS, STRUCTURE, AND PROPERTIES. CHEMISCHE BERICHTE-RECUEIL. 1988;121(7):1299-1305
Zechariah 9-14 as the substructure of 1 Peter’s eschatological program
No full textThe principal aim of this study is to discern what has shaped the author of 1 Peter to regard Christian suffering as a necessary (1.6) and to-be-expected (4.12) component of faithful allegiance to Jesus Christ. Most research regarding suffering in 1 Peter has limited the scope of inquiry to two particular aspects—its cause and nature, and the strategies that the author of 1 Peter employs in order to enable his addressees to respond in faithfulness. There remains, however, the need for a comprehensive explanation for the source that has generated 1 Peter’s theology of Christian suffering. If Jesus truly is the Christ, God’s chosen redemptive agent who has come to restore God’s people, then how can it be that Christian suffering is a necessary part of discipleship after his coming, death and resurrection? What led the author of 1 Peter to such a startling conclusion, which seems to runs against the grain of the eschatological hopes and expectations of Jewish restoration ideology?
This thesis analyzes the appropriation of shepherd and fiery trials imagery,
and argues that the author of 1 Peter is dependent upon Zechariah 9-14 for his
theology of Christian suffering. Said in another way, the eschatological program of
Zechariah 9-14, read through the lens of the Gospel, functions as the substructure
for 1 Peter’s eschatology and thus its theology of Christian suffering.
In support of this hypothesis, this study highlights the fact that Zechariah 9-
14 was available and appropriated in early Christianity, in particular in the Passion
Narrative tradition; that the shepherd imagery of 1 Pet 2.25 is best understood
within the milieu of the Passion Narrative tradition, and that it alludes to the
eschatological program of Zechariah 9-14; that the fiery trials imagery found in 1
Peter 1.6-7 and 1 Pet 4.12 is distinct from that which we find in Greco-Roman and OT
wisdom sources, and that it shares exclusive parallels with some unique features of
the eschatological program of Zechariah 9-14; that Zechariah 9-14 offers a more
satisfying explanation for the modification of Isa 11.2 in 1 Pet 4.14, the transition
from 4.12-19 to 5.1-4, why Peter has oriented his letter with the term διασπορά,
and why he has described his addresses as οἶκος τοῦ θεοῦ; and finally that 1 Peter
contains an implicit foundational narrative that shares distinct parallels with the
eschatological program of Zechariah 9-14.
We can conclude that 1 Peter offers a unique vista into the way in which at
least one early Christian witness came to understand and to communicate the fact
that Christian suffering was a necessary feature of faithful allegiance to Jesus Christ
The synthesis of a natural product family: from debromoisolaurinterol to the aplysins
No full textTotal syntheses of (+/-)-aplysin 1, (+/-)-debromoaplysin 2, (+/-)-isoaplysin 3, (+/-)-aplysinol 4, (+/-)-debromoaplysinol 5, (+/-)-aplysinal 6, (+/-)-isolaurinterol 7 and (+/-)-debromoisolaurinterol 8 are described. Key features are a diastereoselective, sulfur mediated radical cyclisation of diene 12 to give 35; a new radical to polar crossover sequence mediated by Bu3Sn that transforms diene 12 into (+/-)-debromoisolaurinterol 8; and a series of biomimetic cyclisation and oxidation reactions
A total synthesis of (+/-)-1-desoxyhypnophilin: using ring closing metathesis for the construction of cyclic enones
No full textThe paper describes the first total synthesis of (+/-)-1-desoxyhypnophilin, a linear triquinane isolated from the East African mushroom Lentinus crinitus which displays promising antimicrobial activity. The key strategic feature is a new cyclopentannulation method for appending cycloalkenones onto ketones involving sequential use of a ring closing metathesis reaction with a tertiary allylic alcohol and a PCC induced oxidative rearrangement
Copyright & Your Research
No full textAs publishing options increase in number, it is ever more important that university authors manage their copyrights in a way that ensures maximum benefit to them and to the university. Peter Hirtle, Senior Policy Advisor in the Cornell University Library and a Research Fellow at the Berkman Center for Internet & Society at Harvard University, will give an overview of the sometimes puzzling issues surrounding creating, securing, owning, and using copyrighted works. Topics will include author agreements and contracts, the public access requirements in some federal grants, new publishing options, and the management of your copyrights. The session will benefit those who want to gain a better understanding of the changing nature of scholarly communications. PRESENTATION BY Peter B. Hirtle, Senior Policy Advisor, Cornell University Library, and Research Fellow, Berkman Center for Internet Security and Society, Harvard Universit
Consensus statement on the use of clozapine during the COVID-19 pandemic
No full textPublished online on April 3, 2020.
Psychopharmacology for the Clinician.
To be published in vol. 45, no. 4?Dan Siskind, William G. Honer, Scott Clark, Christoph U. Correll, Alkomiet Hasan, Oliver Howes, John M. Kane, Deanna L. Kelly, Robert Laitman, Jimmy Lee, James H. MacCabe, Nick Myles, Jimmi Nielsen, Peter F. Schulte, David Taylor, Helene Verdoux, Amanda Wheeler, Oliver Freudenreic
Music and Dance. volume 53 issue 6, 1962
No full textAdrian Boult (Boult, Adrian, Sir, 1889-1983); Chih Fu-jen; Covent Garden Opera House (Royal Opera House (London, England)); David Simon (Simon, David); Elizabethan Theatre Trust (Australian Elizabethan Theatre Trust); Frank Howes (Howes, Frank); Frederick Sharp (Sharp, Frederick, 1911-1988); Harold Rosenthal (Rosenthal, Harold D.); James Penberthy (Penberthy, James, 1917 - 1999); Peter Heyworth (Heyworth, Peter, 1921-); Rennie Simmons (Simmons, Rennie); South Street Competitions (Royal South Street Society (Ballarat, Vic.)); Victorian Council for Musical Education (Victorian Council for Music Education
Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [11C]PBR28 study
No full textPatients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem and in vivo studies in schizophrenia show evidence for elevated microglial activation compared to matched controls. However, it is currently unclear how these results relate to changes in cortical structure.METHODS: Fourteen patients with schizophrenia and 14 ultra high risk for psychosis (UHR) subjects alongside two groups of age and genotype matched healthy controls received [(11)C]PBR28 PET scans to index TSPO expression, a marker of microglial activation and a 3T MRI scan. We investigated the relationship between the volume changes of cortical regions and microglial activation in cortical GM (as indexed by [(11)C]PBR28 distribution volume ratio (DVR).RESULTS: The total cortical GM volume was significantly lower in SCZ than the controls [mean (SD)/cm(3): SCZ=448.83 (39.2) and controls=499.6 (59.2) (p=0.02) but not in UHR (mean (SD)=503.06 (57.9) and controls=524.46 (45.3) p=0.3). Regression model fitted the total cortical GM DVR values with the cortical regional volumes in SCZ (r=0.81; p<0.001) and in UHR (r=0.63; p=0.02). We found a significant negative correlation between the TSPO signal and total cortical GM volume in SCZ with the highest absolute correlation coefficient in the right superior-parietal cortex (r=-0.72; p=0.006).CONCLUSIONS: These findings suggest that microglial activity is related to the altered cortical volume seen in schizophrenia. Longitudinal investigations are required to determine whether microglial activation leads to cortical gray matter loss
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